Persistent zinc depletion in the mossy fiber terminals in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.

abstract：PURPOSE:Diacylglycerol kinase epsilon (DGKepsilon) regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis. ...

journal_title：Epilepsia

authors： Musto A,Bazan NG

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To study the neuropsychological status of an epileptic patient presenting with epileptic activity triggered by eye closure in a 14-year follow-up period. METHODS:The patient was studied at 12 and 26 years of age; during this period he underwent periodical clinical evaluations and EEG investigations; brain magn...

journal_title：Epilepsia

authors： Termine C,Rubboli G,Veggiotti P

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (...

journal_title：Epilepsia

authors： Foldvary-Schaefer N,De Leon Sanchez I,Karafa M,Mascha E,Dinner D,Morris HH

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Originally derived from a Wistar rat strain, a proportion of which displayed spontaneous absence-type seizures, Genetic Absence Epilepsy Rats from Strasbourg (GAERS) represent the most widely utilized animal model of genetic generalized epilepsy. Here we compare the seizure, behavioral, and brain morphometric...

journal_title：Epilepsia

authors： Powell KL,Tang H,Ng C,Guillemain I,Dieuset G,Dezsi G,Çarçak N,Onat F,Martin B,O'Brien TJ,Depaulis A,Jones NC

更新日期：2014-12-01 00:00:00

abstract：:The relationship between dreams and epilepsy is illustrated by two patients whose awake epileptic seizures and recurrent dreams during night sleep had similar content. In both of our cases the EEG showed right anterior temporal spike discharge, suggesting a role for the temporal lobe in the association between dreams ...

journal_title：Epilepsia

authors： Reami DO,Silva DF,Albuquerque M,Campos CJ

更新日期：1991-01-01 00:00:00

abstract：:Deletions and duplications/amplifications of the α1-sodium channel subunit (SCN1A) gene occur in about 12% of patients with Dravet syndrome (DS) who are otherwise mutation-negative. Such genomic abnormalities cause loss of function, with severe phenotypes, reproductive disadvantage and, therefore, sporadic occurrence....

journal_title：Epilepsia

authors： Guerrini R,Cellini E,Mei D,Metitieri T,Petrelli C,Pucatti D,Marini C,Zamponi N

更新日期：2010-12-01 00:00:00

abstract：:All inpatients aged greater than 55 years with dementia in the Dundee Psychiatric Service were surveyed for seizure occurrence by interviewing staff and reviewing records. Of 208 patients, 19 (9.1%) were recorded as having seizures. The seizures were major in 92% and occurred at a rate of approximately 2.3 seizures pe...

journal_title：Epilepsia

authors： McAreavey MJ,Ballinger BR,Fenton GW

更新日期：1992-07-01 00:00:00

abstract：:Estrogens are essential for normal brain functions. The effects of estrogens on seizures are contradictory. More studies are necessary to determine under which conditions the estrogens have proconvulsant effects and when the estrogens may have beneficial action in patients with epilepsy. ...

journal_title：Epilepsia

authors： Velísková J,De Jesus G,Kaur R,Velísek L

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:In mesial temporal lobe epilepsy (MTLE) the epileptogenic area is confined to the mesial temporal lobe, but other cortical and subcortical areas are also affected and cognitive and psychiatric impairments are usually documented. Functional connectivity methods are based on the correlation of the blood oxygen le...

journal_title：Epilepsia

authors： Pittau F,Grova C,Moeller F,Dubeau F,Gotman J

更新日期：2012-06-01 00:00:00

abstract：:The chronic epileptic syndrome induced by injecting tetanus toxin into rat hippocampus causes functional changes that essentially are permanent, outlasting the period of active seizures by at least 1 year. These long-term changes have been characterized by an impaired performance on a range of behavioral tasks, which ...

journal_title：Epilepsia

authors： Francis PT,Lowe SL,Bowen DM,Jefferys JG

更新日期：1990-11-01 00:00:00

abstract：:We assessed the effects of phenytoin (PHT) overdosage on ballistic arm abduction movements in nine epileptic patients receiving long-term PHT treatment. During the overdosage period, all but one showed clinical abnormalities referable to impaired cerebellar function; one also had slowness of movement. Ballistic moveme...

journal_title：Epilepsia

authors： Benvenuti F,Bandinelli S,Mencarelli MA,Lunardelli ML,Campostrini R,Zaccara G,Pantaleo T

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:The Atkins diet may induce ketosis as does the ketogenic diet, without restrictions on calories, fluids, protein, or need for an inpatient fast and admission. Our objective was to evaluate the efficacy and tolerability of a modified Atkins diet for intractable childhood epilepsy. METHODS:Twenty children were t...

journal_title：Epilepsia

authors： Kossoff EH,McGrogan JR,Bluml RM,Pillas DJ,Rubenstein JE,Vining EP

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Vagus nerve stimulation (VNS) is reported to reduce the frequency of seizures in children and adults without causing serious side effects. However, clinical observation of swallowing difficulties in 2 children treated with VNS made further investigation necessary. METHODS:Seven patients aged 4-18 years and tre...

journal_title：Epilepsia

authors： Lundgren J,Ekberg O,Olsson R

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To identify the temporal lobe cortical dysplasia (CD) histopathology classification subtype and determine the seizure outcome of patients who underwent temporal lobectomy with coincident CD. METHODS:We reviewed the data of 28 patients with temporal lobe epilepsy who underwent surgery with pathologically verifi...

journal_title：Epilepsia

authors： Srikijvilaikul T,Najm IM,Hovinga CA,Prayson RA,Gonzalez-Martinez J,Bingaman WE

更新日期：2003-11-01 00:00:00

abstract：:Aminophylline (50 and 100 mg/kg) and CGS 8216 (20 and 40 mg/kg) decreased the anticonvulsant potency of diazepam (5 and 10 mg/kg) against electroshock-induced seizures. It should be emphasized that aminophylline moderately affected the protective action of the benzodiazepine at a dose of 5 mg/kg, whereas it was equipo...

journal_title：Epilepsia

authors： Czuczwar SJ,Turski WA,Ikonomidou C,Turski L

更新日期：1985-11-01 00:00:00

abstract：PURPOSE:We wished to determine the effects of seizure type, age at onset, and family history of epilepsy on risk of spontaneous abortion in the pregnancies of adults with idiopathic/cryptogenic epilepsy. METHODS:We examined pregnancy outcomes in 812 adults with idiopathic/cryptogenic epilepsy who had ever had or fathe...

journal_title：Epilepsia

authors： Schupf N,Ottman R

更新日期：1997-07-01 00:00:00

abstract：PURPOSE:Previously we demonstrated that L-(+)-beta-hydroxybutyrate (L-BHB), acetoacetate (ACA), acetone, and dibenzylamine (DBA) were anticonvulsant in an audiogenic seizure-susceptible model, and that DBA was a bioactive contaminant identified in commercial lots of L-BHB. In the present study, we asked whether these e...

journal_title：Epilepsia

authors： Donevan SD,White HS,Anderson GD,Rho JM

更新日期：2003-10-01 00:00:00

abstract：:Study of patients with temporal lobe epilepsy and generalized epilepsy revealed no overall seizure type differences, nor overall age-at-onset effects, on MMPI measures of psychopathology. However, statistically significant interactions between seizure type and age at onset were obtained on several MMPI measures, and s...

journal_title：Epilepsia

authors： Hermann BP,Schwartz MS,Karnes WE,Vahdat P

更新日期：1980-02-01 00:00:00

abstract：:The effect of kindled seizures on the cardiovascular system was examined in amygdaloid kindled rats. The most prominent cardiovascular response during a generalized kindled seizure was an abrupt 50% increase in mean arterial pressure (MAP) lasting 20-30 s after initiation of the seizure. Superimposed on this change in...

journal_title：Epilepsia

authors： Goodman JH,Homan RW,Crawford IL

更新日期：1990-09-01 00:00:00

abstract：:Felbamate (2-phenyl-1,3-propanediol dicarbamate), phenytoin, phenobarbital, ethosuximide, and valproate were evaluated in mice and rats with a battery of well-standardized anticonvulsant test procedures. The results obtained indicate that felbamate exhibits a wider range of experimental anticonvulsant activity than ei...

journal_title：Epilepsia

authors： Swinyard EA,Sofia RD,Kupferberg HJ

更新日期：1986-01-01 00:00:00

abstract：:Immune abnormalities have been found in epileptic patients receiving antiepileptic drugs (AEDs). Phenytoin (PHT) produces a decrease in serum IgA and IgM levels and a decrease in blastic transformation of circulating lymphocytes stimulated with phytohemoagglutinin (PHA). The effects of carbamazepine (CBZ) on the immun...

journal_title：Epilepsia

authors： Pacifici R,Paris L,Di Carlo S,Pichini S,Zuccaro P

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Brivaracetam (BRV) is a new anticonvulsant under development. Although BRV is an analog of levetiracetam (LEV), in addition to being an SV2A ligand, it also inhibits sodium channels in a voltage-dependent manner. The cognitive effects of BRV are uncertain. METHODS:A randomized, double-blind, placebo-controlled...

journal_title：Epilepsia

authors： Meador KJ,Gevins A,Leese PT,Otoul C,Loring DW

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Schizophrenia and epilepsy may share a mutual susceptibility. This study examined the bidirectional relation between the two disorders. METHODS:We used claims data obtained from the Taiwan National Health Insurance database to conduct retrospective cohort analyses. Analysis 1 compared 5,195 patients with incid...

journal_title：Epilepsia

authors： Chang YT,Chen PC,Tsai IJ,Sung FC,Chin ZN,Kuo HT,Tsai CH,Chou IC

更新日期：2011-11-01 00:00:00

abstract：:An early EEG (within 48 h) and high-resolution magnetic resonance imaging (hr_MRI) are the methods of choice for an accurate diagnosis after a first seizure presentation. Together with a careful history and examination, they will allow definition of the epilepsy syndrome in two-thirds of patients and help assess the i...

journal_title：Epilepsia

authors： Pohlmann-Eden B,Newton M

更新日期：2008-01-01 00:00:00

abstract：:Phenytoin is metabolized to its parahydroxylated derivative by hepatic microsomal enzymes. This hydroxylation is a saturable process, that is, the rate of metabolism fails to increase in proportion to the serum concentration. This leads to a nonlinear relationship between the maintenance dose of the drug and the resul...

journal_title：Epilepsia

authors： Richens A

更新日期：1975-11-01 00:00:00

abstract：:Twenty-one cases (12 males, 9 females) of Lafora's disease in 16 families were studied at the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India, from 1982 to 1990. Mean age of onset was 13.5 years (range 9.5-18 years). First symptom was generalized tonic-clonic seizure (17), myoclonus ...

journal_title：Epilepsia

authors： Acharya JN,Satishchandra P,Asha T,Shankar SK

更新日期：1993-05-01 00:00:00

abstract：:The antiepileptic drug sodium valproate (VPA) can provoke a thrombocytopenia or platelet dysfunction, with or without hemorrhages. These unwanted side effects are probably infrequent or, at least, have little clinical importance except in patients undergoing surgery. Thromboelastography appears to be a reliable screen...

journal_title：Epilepsia

authors： Loiseau P

更新日期：1981-04-01 00:00:00

abstract：:ACC-9653, the disodium phosphate ester of 3-hydroxymethyl-5,5-diphenylhydantoin, is a prodrug of phenytoin with advantageous physicochemical properties. ACC-9653 is rapidly converted enzymatically to phenytoin in vivo. ACC-9653 and phenytoin sodium have equivalent anticonvulsant activity against seizures induced by ma...

journal_title：Epilepsia

authors： Smith RD,Brown BS,Maher RW,Matier WL

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:The current understanding of epilepsy has changed significantly in the past 2 decades. This report presents a description of newly diagnosed childhood-onset epilepsy, with a special emphasis on epilepsy syndromes, in a large, prospectively ascertained community-based cohort evaluated and diagnosed in the mid-19...

journal_title：Epilepsia

authors： Berg AT,Shinnar S,Levy SR,Testa FM

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:To report our evaluation of interictal two epileptic spike fields on magnetoencephalography (MEG) by using invasive intracranial monitoring in a patient without lesion on magnetic resonance imaging (MRI). METHODS:A 15-year-old left-handed boy with a 9-year history of refractory simple partial seizures, seconda...

journal_title：Epilepsia

authors： Otsubo H,Sharma R,Elliott I,Holowka S,Rutka JT,Snead OC 3rd

更新日期：1999-05-01 00:00:00