First seizure: EEG and neuroimaging following an epileptic seizure.


:An early EEG (within 48 h) and high-resolution magnetic resonance imaging (hr_MRI) are the methods of choice for an accurate diagnosis after a first seizure presentation. Together with a careful history and examination, they will allow definition of the epilepsy syndrome in two-thirds of patients and help assess the individual risk for seizure recurrence, which is determined by the specific syndrome and is highest with focal epileptiform activity on EEG. Despite the heterogeneity of first seizure studies, EEG and etiology are consistently found to be the best predictors for seizure recurrence and prognosis. The additional yield of sleep-deprived EEG and sleep EEG is uncertain; yet MRI is essential for detecting brain tumors and other structural bases for new epilepsy. The rate occurrence of remote symptomatic seizures increases significantly with age and the most common etiology in the elderly with a first seizure is stroke; however, its exact relevance to epileptogenicity is yet to be defined. There is a striking lack of systematic studies using early EEG and hr_MRI in order to better characterize epileptogenic areas and elucidate the mechanisms of seizure provocation.






Pohlmann-Eden B,Newton M




Has Abstract


2008-01-01 00:00:00










49 Suppl 1


  • Neurodevelopment in seizure-prone and seizure-resistant rat strains: recognizing conflicts in management.

    abstract::Cytoarchitectural alterations during central nervous system (CNS) development are believed to underlie aberrations in brain morphology that lead to epilepsy. We have recently reported marked reductions in hippocampal and white matter volumes along with relative ventriculomegaly in a rat strain bred to be seizure-prone...


    pub_type: 杂志文章


    authors: Gilby KL,Crino P,McIntyre DC

    更新日期:2007-01-01 00:00:00

  • Topiramate pharmacokinetics in infants.

    abstract:PURPOSE:This study's goal was to provide preliminary data on the pharmacokinetics of topiramate (TPM) in a cohort of infants (younger than 4 years) participating in an open-label trial of TPM in refractory infantile spasms. METHODS:The pharmacokinetics of TPM were assessed in infants receiving a stable TPM dose for >7...


    pub_type: 临床试验,杂志文章


    authors: Glauser TA,Miles MV,Tang P,Clark P,McGee K,Doose DR

    更新日期:1999-06-01 00:00:00

  • Effects of NMDA- and AMPA-receptor antagonists on different forms of epileptiform activity in rat temporal cortex slices.

    abstract::Lowering extracellular magnesium induces different patterns of epileptiform activity in rat hippocampus and entorhinal cortex. Short recurrent epileptiform discharges in the hippocampus are stable over time, whereas seizure-like events (SLEs) in the entorhinal cortex, the subiculum, and the neighboring neocortex devel...


    pub_type: 杂志文章


    authors: Zhang CL,Gloveli T,Heinemann U

    更新日期:1994-01-01 00:00:00

  • Reliability and validity of a Norwegian version of the quality of life in epilepsy inventory (QOLIE-89).

    abstract:PURPOSE:To develop a Norwegian version of the Quality of Life in Epilepsy Inventory (QOLIE-89) and to confirm its psychometric properties. METHODS:The QOLIE-89 was adapted to Norwegian language through a translation-backtranslation procedure. The assessment included 397 patients with epilepsy. We assessed internal con...


    pub_type: 杂志文章


    authors: Stavem K,Bjørnaes H,Lossius MI

    更新日期:2000-01-01 00:00:00

  • Persistent zinc depletion in the mossy fiber terminals in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy.

    abstract:PURPOSE:Zinc is released in synaptic vesicles with glutamate, and modulates glutamatergic neurotransmission. In brain, the highest amount of zinc, detected by Timm staining, is in the mossy fiber (MF) system in the hippocampus. In the intrahippocampal kainate (KA) mouse model of mesial temporal lobe epilepsy, which is ...


    pub_type: 杂志文章


    authors: Mitsuya K,Nitta N,Suzuki F

    更新日期:2009-08-01 00:00:00

  • Effects of age on seizure susceptibility in genetically epilepsy-prone rats (GEPR-9s).

    abstract::To study the effect of age on seizure latency, intensity, reproducibility, and mortality in genetically epilepsy-prone rats of the severe colony (GEPR-9s), 472 seizure-naive rats, ranging in age from 14 to 65 days, received a series of three audiogenic stimulations. Both the percentage of rats having one or more seizu...


    pub_type: 杂志文章


    authors: Thompson JL,Carl FG,Holmes GL

    更新日期:1991-03-01 00:00:00

  • Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis.

    abstract:PURPOSE:The objective of this study was the isobolographic evaluation of the interactions between the novel antiepileptic drug (AED) gabapentin (GBP) and a number of other AEDs against electroconvulsion-induced convulsions in mice. METHODS:Electroconvulsions were produced by means of an alternating current (ear-clip e...


    pub_type: 杂志文章


    authors: Borowicz KK,Swiader M,Luszczki J,Czuczwar SJ

    更新日期:2002-09-01 00:00:00

  • Development of intelligence and neuropsychological impairment scales for the Washington Psychosocial Seizure Inventory.

    abstract::The Washington Psychosocial Seizure Inventory (WPSI) was used to evaluate the relative extent of psychosocial problems in 379 adults with epilepsy, having differing levels of intelligence and neuropsychological impairment. In general, there were more psychosocial problems when abilities were decreased. Two new scales ...


    pub_type: 杂志文章


    authors: Dodrill CB

    更新日期:1983-02-01 00:00:00

  • Tiagabine.

    abstract::Tiagabine (TGB) is a recently approved antiepileptic drug (AED) that inhibits y-aminobutyric acid (GABA) reuptake into neurons and glia, a mechanism of action that is specific and unique among the AEDs. TGB is potent and has linear and predictable pharmacokinetics. It has no clinically relevant effects on hepatic meta...


    pub_type: 杂志文章,评审


    authors: Schachter SC

    更新日期:1999-01-01 00:00:00

  • Clinical pharmacology of lamotrigine.

    abstract::The pharmacokinetics and pharmacodynamics of lamotrigine (LTG), a new antiepileptic drug (AED), were studied in healthy volunteers. In an open dose-escalating study, LTG 240 mg produced peak plasma concentrations of around 3 micrograms/mg with no significant adverse events. Subsequent pharmacokinetic studies revealed ...


    pub_type: 临床试验,杂志文章,评审


    authors: Peck AW

    更新日期:1991-01-01 00:00:00

  • Operative posterior disconnection in epilepsy surgery: Experience with 29 patients.

    abstract:OBJECTIVE:It has been suggested that multilobar epilepsies caused by lesions restricted to the posterior cerebral quadrant (ie, the parietal, temporal, and occipital lobes) can be treated successfully by a procedure termed posterior disconnection. The objective of the present paper was to identify determinants of the e...


    pub_type: 杂志文章


    authors: Kalbhenn T,Cloppenborg T,Wörmann FG,Blümcke I,Coras R,May TW,Polster T,Simon M,Bien CG

    更新日期:2019-09-01 00:00:00

  • Double pathology in Rasmussen's encephalitis: etiologic considerations.

    abstract::In a 7-year-old girl with epilepsia partialis continua (EPC) involving the left face, arm, and leg for 1 year, serial neuroimaging studies showed progressive, brain atrophy. Because medical treatment was ineffective, she underwent a large fronto-temporal surgical resection. Neuropathological examination showed loss of...


    pub_type: 杂志文章


    authors: Yacubian EM,Rosemberg S,Marie SK,Valério RM,Jorge CL,Cukiert A

    更新日期:1996-05-01 00:00:00

  • Whole-exome sequencing in an individual with severe global developmental delay and intractable epilepsy identifies a novel, de novo GRIN2A mutation.

    abstract::We present a 4-year-old girl with profound global developmental delay and refractory epilepsy characterized by multiple seizure types (partial complex with secondary generalization, tonic, myoclonic, and atypical absence). Her seizure semiology did not fit within a specific epileptic syndrome. Despite a broad metaboli...


    pub_type: 杂志文章


    authors: Venkateswaran S,Myers KA,Smith AC,Beaulieu CL,Schwartzentruber JA,FORGE Canada Consortium.,Majewski J,Bulman D,Boycott KM,Dyment DA

    更新日期:2014-07-01 00:00:00

  • Quinolinic-phosphoribosyl transferase activity is decreased in epileptic human brain tissue.

    abstract::The presence of the excitotoxic and convulsant agent quinolinic acid (QUIN) in human brain has led to the hypothesis that an increase of this tryptophan metabolite could serve as an endogenous epileptogen. A possible mechanism for a pathological accumulation of QUIN being a deficiency in its degradation, we have measu...


    pub_type: 杂志文章


    authors: Feldblum S,Rougier A,Loiseau H,Loiseau P,Cohadon F,Morselli PL,Lloyd KG

    更新日期:1988-09-01 00:00:00

  • An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group.

    abstract:PURPOSE:To assess safety of diazepam rectal gel (DZPRG) for control of acute seizures in epilepsy patients and to evaluate tolerance with repeated use of DZPRG at intervals of > or =5 days. METHODS:Subjects were persons with epilepsy, age 2 years or older, with seizure clusters or prolonged seizures. Onset of a treata...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Mitchell WG,Conry JA,Crumrine PK,Kriel RL,Cereghino JJ,Groves L,Rosenfeld WE

    更新日期:1999-11-01 00:00:00

  • Alteration of cardiac function in patients with temporal lobe epilepsy: different roles of EEG-ECG monitoring and spectral analysis of RR variability.

    abstract:PURPOSE:Because several reports have described the relation between epilepsy and cardiac arrhythmias and suggest that changes in autonomic neural control of the heart could be involved in the pathogenesis of sudden unexplained death in patients with epilepsy, the aim of this study was to evaluate cardiac function in pa...


    pub_type: 杂志文章


    authors: Massetani R,Strata G,Galli R,Gori S,Gneri C,Limbruno U,Di Santo D,Mariani M,Murri L

    更新日期:1997-03-01 00:00:00

  • Epileptic seizures and pseudoseizures from the viewpoint of the hierarchy of consciousness.

    abstract::Epileptic seizures and pseudoseizures in temporal lobe epilepsies were studied from the viewpoint of the hierarchy of consciousness. Twenty-two patients with temporal lobe epilepsies (TLE) who showed true amnesia or impairment of consciousness developing from the dreamy state, even though their actions and movement co...


    pub_type: 杂志文章


    authors: Oana Y

    更新日期:1998-01-01 00:00:00

  • Elevated cerebrospinal fluid protein in POLG-related epilepsy: Diagnostic and prognostic implications.

    abstract:OBJECTIVE:Epilepsy is common in individuals with mutations in POLG, the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma. Early recognition and aggressive seizure management are crucial for patient survival. Disruption of the blood-brain barrier (BBB) is implicated in various neurological d...


    pub_type: 杂志文章,多中心研究


    authors: Hikmat O,Naess K,Engvall M,Klingenberg C,Rasmussen M,Tallaksen CME,Brodtkorb E,Fiskerstrand T,Isohanni P,Uusimaa J,Darin N,Rahman S,Bindoff LA

    更新日期:2018-08-01 00:00:00

  • Quality of life in psychogenic nonepileptic seizures.

    abstract:PURPOSE:Psychogenic nonepileptic seizures (PNESs) are events that alter or seem to alter the neurologic function and, in their appearance, resemble epileptic seizures (ESs). In patients with ESs the psychological and medical aspects of epilepsy greatly influence the health-related quality of life (HRQOL). The relation ...


    pub_type: 杂志文章


    authors: Szaflarski JP,Hughes C,Szaflarski M,Ficker DM,Cahill WT,Li M,Privitera MD

    更新日期:2003-02-01 00:00:00

  • Pharmacokinetic considerations in prescribing antiepileptic drugs.

    abstract::Each antiepileptic drug has a characteristic pharmacokinetic profile, and the unique properties of each must be considered when selecting the optimal agent for a particular patient. Detailed pharmacologic data are obtained during the preapproval evaluation of a drug, particularly in early phase studies in healthy volu...


    pub_type: 杂志文章,评审


    authors: Faught E

    更新日期:2001-01-01 00:00:00

  • Differential selectivity of several barbiturates on experimental seizures and neurotoxicity in the mouse.

    abstract::Six barbiturates with diverse time-action characteristics--thiopental, pentobarbital, butabarbital, phenobarbital, diphenylbarbiturate, and barbital--were evaluated for "anticonvulsant" and "neurotoxic" effects. For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s.c., and maximal sei...


    pub_type: 杂志文章


    authors: Raines A,Blake GJ,Richardson B,Gilbert MB

    更新日期:1979-04-01 00:00:00

  • Bioequivalence of oral and intravenous carbamazepine formulations in adult patients with epilepsy.

    abstract:OBJECTIVE:To evaluate the safety, tolerability, and comparative pharmacokinetics (PK) of intravenous and oral carbamazepine. METHODS:In this phase 1, open-label study, adult patients with epilepsy on a stable oral carbamazepine dosage (400-2,000 mg/day) were converted to intravenous carbamazepine (administered at 70% ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Tolbert D,Cloyd J,Biton V,Bekersky I,Walzer M,Wesche D,Drummond R,Lee D

    更新日期:2015-06-01 00:00:00

  • Behavioral and histopathological analysis of domoic Acid administration in marmosets.

    abstract:PURPOSE:To induce status epilepticus (SE) followed by the subsequent onset of spontaneous recurrent seizures, thus characterizing a new model of temporal lobe epilepsy in a nonhuman primate. METHODS:Male and female marmosets (Callithrix jacchus) (n = 18), ages between 2 and 8 years, were injected with domoic acid (0.5...


    pub_type: 杂志文章


    authors: Perez-Mendes P,Cinini SM,Medeiros MA,Tufik S,Mello LE

    更新日期:2005-01-01 00:00:00

  • Consciousness as a neurological concept in epileptology: a critical review.

    abstract::This essay explores the usefulness of the concept of consciousness in epileptology and concludes that it does not further the understanding of seizure mechanisms and brain function. The reasons for this are both theoretical and empirical. Consciousness cannot be adequately defined. This may explain why attempts at acc...


    pub_type: 杂志文章


    authors: Gloor P

    更新日期:1986-01-01 00:00:00

  • Anticonvulsant hypersensitivity syndrome: is there a role for immunomodulation?

    abstract::The anticonvulsant hypersensitivity syndrome (AHS) is an idiosyncratic immunologic reaction to certain anticonvulsant medications, in which internal organ involvement may lead to fatal multisystemic failure. This syndrome has been associated with the use of aromatic ring-containing agents such as phenytoin, carbamazep...


    pub_type: 杂志文章


    authors: Cumbo-Nacheli G,Weinberger J,Alkhalil M,Thati N,Baptist AP

    更新日期:2008-12-01 00:00:00

  • Confirmation of two magnetoencephalographic epileptic foci by invasive monitoring from subdural electrodes in an adolescent with right frontocentral epilepsy.

    abstract:PURPOSE:To report our evaluation of interictal two epileptic spike fields on magnetoencephalography (MEG) by using invasive intracranial monitoring in a patient without lesion on magnetic resonance imaging (MRI). METHODS:A 15-year-old left-handed boy with a 9-year history of refractory simple partial seizures, seconda...


    pub_type: 杂志文章


    authors: Otsubo H,Sharma R,Elliott I,Holowka S,Rutka JT,Snead OC 3rd

    更新日期:1999-05-01 00:00:00

  • The management of refractory idiopathic epilepsies.

    abstract::Idiopathic epilepsies comprise a wide variety of partial and generalized syndromes that have in common a known or presumed genetic etiology and the lack of overt abnormalities other than the epilepsy itself. Most of these epilepsies have a benign natural history and/or show a favorable response to antiepileptic drug (...


    pub_type: 杂志文章,评审


    authors: Perucca E

    更新日期:2001-01-01 00:00:00

  • Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality.

    abstract::Valproate (VPA) is an effective, widely used antiepileptic drug. Unfortunately its use in pregnant women is associated with neural tube defects in the offspring. Although the etiology of neural tube defects is multifactorial, there is evidence that underlying genetic susceptibility plays a part. We describe two women ...


    pub_type: 杂志文章


    authors: Duncan S,Mercho S,Lopes-Cendes I,Seni MH,Benjamin A,Dubeau F,Andermann F,Andermann E

    更新日期:2001-06-01 00:00:00

  • The development of intellectual abilities in pediatric temporal lobe epilepsy.

    abstract:PURPOSE:The aim of this study was to examine the impact of clinical variables, particularly age at onset of epilepsy, on intellectual function in a group of children with temporal lobe epilepsy (TLE). METHODS:We reviewed the preoperative neuropsychological test results of 79 children with unilateral TLE who subsequent...


    pub_type: 杂志文章


    authors: Cormack F,Cross JH,Isaacs E,Harkness W,Wright I,Vargha-Khadem F,Baldeweg T

    更新日期:2007-01-01 00:00:00

  • Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina.

    abstract:PURPOSE:The antiepileptic drug (AED) vigabatrin (VGB), which exerts its pharmacologic effects on the gamma-aminobutyric acid (GABA) system, causes concentric visual field constriction in >40% of exposed adults. This may be a class effect of all agents with GABA-related mechanisms of action. We compared the concentratio...


    pub_type: 杂志文章


    authors: Sills GJ,Butler E,Forrest G,Ratnaraj N,Patsalos PN,Brodie MJ

    更新日期:2003-07-01 00:00:00