Dilemmas in the interpretation of diagnostic accuracy studies on presurgical workup for epilepsy surgery.

abstract：:Refractory status epilepticus (RSE) is a medical emergency, with significant morbidity and mortality. The use and effectiveness of clobazam, a unique 1,5-benzodiazepine, in the management of RSE has not been reported before. Over the last 24 months, we identified 17 patients with RSE who were treated with clobazam in ...

journal_title：Epilepsia

authors： Sivakumar S,Ibrahim M,Parker D Jr,Norris G,Shah A,Mohamed W

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS). METHODS:In 12 children and adolescents with CPS and 23 age- and gender-matched healthy controls, we ac...

journal_title：Epilepsia

authors： O'Neill J,Seese R,Hudkins M,Siddarth P,Levitt J,Tseng PB,Wu KN,Gurbani S,Shields WD,Caplan R

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Sudden unexpected death in epilepsy (SUDEP) is a critical issue in epilepsy, and DBA/1 mice are a useful animal model of this devastating epilepsy sequela. The serotonin hypothesis for SUDEP proposes that modifying serotonergic function significantly alters susceptibility to seizure-induced respiratory arrest...

journal_title：Epilepsia

authors： Kommajosyula SP,Faingold CL

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:The adenosinergic system is known to exert an inhibitory affect in the brain, and as such adenosine has been considered an endogenous anticonvulsant. Entorhinal cortex (EC) layer II neurons, which serve as the primary input to the hippocampus, are spared in temporal lobe epilepsy (TLE) and become hyperexcitable...

journal_title：Epilepsia

authors： Hargus NJ,Jennings C,Perez-Reyes E,Bertram EH,Patel MK

更新日期：2012-01-01 00:00:00

abstract：:The knowledge of patients with epilepsy about their own condition is poor, and thus the need for educational programs for people with epilepsy has long been recognized. However, no such programs have been established in their routine care. The Modular Service Package Epilepsy (MOSES) now tries to fill this gap for pat...

journal_title：Epilepsia

authors： Ried S,Specht U,Thorbecke R,Goecke K,Wohlfarth R

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:To advance the development of (2S,3S)-sec-butylpropylacetamide (SPD) as a new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in pigs and its PK-pharmacodynamic (PK-PD) correlation in rats. METHODS:Two (2S,3S)-SPD intramuscular formulations (FA and FB ) were administered...

journal_title：Epilepsia

authors： Bibi D,Bialer M

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Although the general utility of voxel-based processing of structural magnetic resonance imaging (MRI) data for detecting occult lesions in focal epilepsy is established, many differences exist among studies, and it is unclear which processing method is preferable. The aim of this study was to compare the abil...

journal_title：Epilepsia

authors： Martin P,Winston GP,Bartlett P,de Tisi J,Duncan JS,Focke NK

更新日期：2017-09-01 00:00:00

abstract：:Posttraumatic epilepsy is a common complication of traumatic brain injury (TBI), occurring in up to 15-20% of patients with severe brain trauma. Trauma accounts for approximately 5% of chronic epilepsy in the community. Because it is a common condition, and because of the relatively short latency period between injury...

journal_title：Epilepsia

authors： Diaz-Arrastia R,Agostini MA,Madden CJ,Van Ness PC

更新日期：2009-02-01 00:00:00

abstract：:The possibility of sudden unexpected death in epilepsy (SUDEP) should affect the management of virtually every patient with proven or suspected epilepsy by (a) underlining the need to make all reasonable efforts to render each patient seizure-free; (b) emphasizing the importance of minimizing avoidable seizures; (c) b...

journal_title：Epilepsia

authors： Fish DR

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:To determine the prevalence, manifestations, lateralizing value, and surgical prognostic value of somatosensory auras (SSAs) in patients with refractory temporal lobe epilepsy (TLE). METHODS:Eighty-one consecutive patients undergoing temporal lobectomy for refractory complex-partial seizures were screened for ...

journal_title：Epilepsia

authors： Erickson JC,Clapp LE,Ford G,Jabbari B

更新日期：2006-01-01 00:00:00

abstract：:Neurogenesis in the adult central nervous system has been well documented in several mammals including humans. By now, a plethora of data has been generated with the aim of understanding the molecular and cellular events governing neurogenesis. This growing comprehension will provide the basis for modulation of neurog...

journal_title：Epilepsia

authors： Rotheneichner P,Marschallinger J,Couillard-Despres S,Aigner L

更新日期：2013-09-01 00:00:00

abstract：:Transient epileptic amnesia (TEA) is a distinct neurologic condition occurring in late-middle/old age and presenting with amnesic attacks of epileptic nature and interictal memory disturbances. For many years this condition has been associated with the nonepileptic condition of transient global amnesia (TGA) and still...

journal_title：Epilepsia

authors： Bilo L,Meo R,Ruosi P,de Leva MF,Striano S

更新日期：2009-05-01 00:00:00

abstract：:Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton ...

journal_title：Epilepsia

authors： Mantoan Ritter L,Golshani P,Takahashi K,Dufour S,Valiante T,Kokaia M

更新日期：2014-11-01 00:00:00

abstract：:Although it is well documented that long-term therapy with older antiepileptic drugs (AEDs) leads to an increase in risk for atherosclerosis, there has been only limited information regarding the vascular risk in patients who are treated with new AEDs. We therefore conducted a prospective longitudinal study to assess ...

journal_title：Epilepsia

authors： Kim DW,Lee SY,Shon YM,Kim JH

更新日期：2013-10-01 00:00:00

abstract：:Of the 605 patients seen since 1973, 336 patients have been treated with sodium valproate (VPA) alone or in combination with drugs other than carbamazepine (CBZ). Of these 336, 240 have been on monotherapy, of whom 200 are seizure-free. Follow up has been longer than 3 years in 78%. Complete control of seizures has be...

journal_title：Epilepsia

authors： Covanis A,Gupta AK,Jeavons PM

更新日期：1982-12-01 00:00:00

abstract：:A recent systematic synthesis of qualitative research demonstrated that patients with psychogenic nonepileptic seizures (PNES) often experience unsatisfactory encounters with health care practitioners (HCPs). It is important to understand such interactions from the perspective of those responsible for delivering care....

journal_title：Epilepsia

authors： Rawlings GH,Reuber M

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To determine the cerebral electroencephalography (EEG) substrates of scalp EEG seizure patterns, such as source area and synchrony, and in so doing assess the limitations of scalp seizure recording in the localization of seizure onset zones in patients with temporal lobe epilepsy. METHODS:We recorded simultane...

journal_title：Epilepsia

authors： Tao JX,Baldwin M,Ray A,Hawes-Ebersole S,Ebersole JS

更新日期：2007-11-01 00:00:00

abstract：AIM:To trace the concept that the cerebral cortex is the site of epileptogenesis before Hughlings Jackson published the idea in 1870 in the paper "A study of convulsions" which marks the beginning of modern epileptology. METHOD:Perusal of 19th century English language medical literature. RESULT:The existence of corti...

journal_title：Epilepsia

authors： Eadie MJ

更新日期：2007-11-01 00:00:00

abstract：:The possible effect of in utero antiepileptic drug (AED) exposure on the incidence of spontaneous abortion was evaluated among pregnancies of women with epilepsy and the wives of men with epilepsy. The proportion of pregnancy outcomes terminating in spontaneous abortion, the gestational age-specific rates of spontaneo...

journal_title：Epilepsia

authors： Annegers JF,Baumgartner KB,Hauser WA,Kurland LT

更新日期：1988-07-01 00:00:00

abstract：PURPOSE:Higher homocysteine levels were found in actively drinking patients with alcohol dependence. Recent studies have shown that high homocysteine levels are associated with alcohol-withdrawal seizures. The aim of the present study was to calculate the best predictive cutoff value of plasma homocysteine levels in ac...

journal_title：Epilepsia

authors： Bleich S,Bayerlein K,Hillemacher T,Degner D,Kornhuber J,Frieling H

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:To compare surgical outcome in mesial temporal lobe epilepsy (MTLE) patients with unilateral hippocampal sclerosis (MTLE-HS) who had or did not have preoperative video-electroencephalographic monitoring (VEEG). METHODS:A prospective study was undertaken with 166 consecutive pharmacoresistant unilateral MTLE-...

journal_title：Epilepsia

authors： Alvim MKM,Morita ME,Yasuda CL,Damasceno BP,Lopes TM,Coan AC,Ghizoni E,Tedeschi H,Cendes F

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:This study's goal was to provide preliminary data on the pharmacokinetics of topiramate (TPM) in a cohort of infants (younger than 4 years) participating in an open-label trial of TPM in refractory infantile spasms. METHODS:The pharmacokinetics of TPM were assessed in infants receiving a stable TPM dose for >7...

journal_title：Epilepsia

authors： Glauser TA,Miles MV,Tang P,Clark P,McGee K,Doose DR

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To describe the semiologic features of aggressive behaviors observed in human epileptic seizures with particular reference to the act of biting a conspecific. METHODS:We analyzed the biting behavior (BB) and other aggressive gestures occurring in a group of 11 patients retrospectively selected from >1,000 pati...

journal_title：Epilepsia

authors： Tassinari CA,Tassi L,Calandra-Buonaura G,Stanzani-Maserati M,Fini N,Pizza F,Sartori I,Michelucci R,Lo Russo G,Meletti S

更新日期：2005-05-01 00:00:00

abstract：:Pinealectomy of the Mongolian gerbil leads to seizure activity. The pineal gland is a major source of malatonin (5-methoxy-N-acetyltryptamine) which may possess a modulatory influence upon neural activity. Melatonin administered in the form of subcutaneous beeswax implants was given to gerbils four days prior to pinea...

journal_title：Epilepsia

authors： Rudeen PK,Philo RC,Symmes SK

更新日期：1980-04-01 00:00:00

abstract：:Perampanel is an adjunctive treatment for epilepsy that works through the direct inhibition of AMPA receptors. The same molecular mechanism has recently been shown for a fatty acid, decanoic acid, prescribed in the medium chain triglyceride ketogenic diet for the treatment of patients with drug-resistant epilepsy. Bec...

journal_title：Epilepsia

authors： Augustin K,Williams S,Cunningham M,Devlin AM,Friedrich M,Jayasekera A,Hussain MA,Holliman D,Mitchell P,Jenkins A,Chen PE,Walker MC,Williams RSB

更新日期：2018-11-01 00:00:00

abstract：:The literature dealing with the convulsant effects of the antidepressant drugs of the non-monoamine oxidase inhibitor variety is reviews. It is concluded that most of these drugs do lower the seizure threshold and may precipitate seizures even at normal therapeutic doses. The pathophysiology of antidepressant-induced ...

journal_title：Epilepsia

authors： Trimble M

更新日期：1978-06-01 00:00:00

abstract：:We report the case of a 3-year-old boy with status gelasticus symptomatic to a giant hypothalamic hamartoma despite two previous hypothalamic hamartoma surgeries using pterional approaches from each side. Following his third resection employing an endoscopic, transventricular approach, he has been seizure free for 6 m...

journal_title：Epilepsia

authors： Ng YT,Rekate HL

更新日期：2011-01-01 00:00:00

abstract：:The combination of phenobarbital (PB) and phenytoin (PHT) was recommended for many years for treatment of epilepsy in humans. We tested the effectiveness of the combination in a model of hippocampal seizures termed maximal dentate activation (MDA). Two parameters of MDA were measured: duration and time to onset. Neith...

journal_title：Epilepsia

authors： Stringer JL,Higgins MG

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To examine the relationship between seizures and excitatory amino acid transporter (EAAT) activity and whether up-regulation of EAAT activity alters epileptogenicity. METHODS:In this study, we exposed rat hippocampal slices to different convulsants before measuring EAAT activity. Rats were exposed to the EAAT ...

journal_title：Epilepsia

authors： Claudio OI,Ferchmin P,Velísek L,Sperber EF,Moshé SL,Ortiz JG

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:New continuous infusion antiepileptic drugs (cIV-AEDs) offer alternatives to pentobarbital for the treatment of refractory status epilepticus (RSE). However, no prospective randomized studies have evaluated the treatment of RSE. This systematic review compares the efficacy of midazolam (MDL), propofol (PRO),...

journal_title：Epilepsia

authors： Claassen J,Hirsch LJ,Emerson RG,Mayer SA

更新日期：2002-02-01 00:00:00