Abstract:
:Pinealectomy of the Mongolian gerbil leads to seizure activity. The pineal gland is a major source of malatonin (5-methoxy-N-acetyltryptamine) which may possess a modulatory influence upon neural activity. Melatonin administered in the form of subcutaneous beeswax implants was given to gerbils four days prior to pinealectomy or sham pinealectomy. Beeswax pellets were implanted as the vehicle agent in respective groups. Melatonin-treated pinealectomized animals exhibited fewer seizures than did pinealectomized animals that did not receive melatonin. The results indicate that melatonin has an ameliorative effect upon pinealectomy-induced seizures, but the mechanism by which pinealectomy induced the seizures, and the etiology in which melatonin reduces the seizure activity is unknown.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Rudeen PK,Philo RC,Symmes SKdoi
10.1111/j.1528-1157.1980.tb04056.xsubject
Has Abstractpub_date
1980-04-01 00:00:00pages
149-54issue
2eissn
0013-9580issn
1528-1167journal_volume
21pub_type
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