Valproate treatment and platelet function: the role of arachidonate metabolites.

abstract：PURPOSE:The aim of this study was to characterize the incidence and etiology of temporal lobe epilepsy (TLE) in a community-based cohort of children with new-onset disease. METHODS:A community-based cohort of 30 children with TLE was studied. The patients had new-onset disease before age 14 years between 1995 and 1999...

journal_title：Epilepsia

authors： Sztriha L,Gururaj AK,Bener A,Nork M

更新日期：2002-01-01 00:00:00

abstract：:Approximately three-quarters of epileptic patients seen in consultation by specialists can easily be assigned to one of the diagnostic categories of the International League against Epilepsy. When patient age is taken into account, such a distribution shows that partial epilepsy is more common than generalized epileps...

journal_title：Epilepsia

authors： Gastaut H,Gastaut JL,Gonçalves e Silva GE,Fernandez Sanchez GR

更新日期：1975-09-01 00:00:00

abstract：PURPOSE:Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy. Because the majority of patients continue to receive antiepileptic drugs (AEDs) during KD treatment, interactions between acetone...

journal_title：Epilepsia

authors： Zarnowska I,Luszczki JJ,Zarnowski T,Buszewicz G,Madro R,Czuczwar SJ,Gasior M

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVES:We aimed to determine whether implementation of a structured multidisciplinary electroencephalography (EEG) monitoring pathway improved the timeliness of administration of antiseizure medication in response to electrographic seizures in encephalopathic critically ill children. METHODS:A multidisciplinary te...

journal_title：Epilepsia

authors： Williams RP,Banwell B,Berg RA,Dlugos DJ,Donnelly M,Ichord R,Kessler SK,Lavelle J,Massey SL,Hewlett J,Parker A,Topjian AA,Abend NS

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Zinc is released in synaptic vesicles with glutamate, and modulates glutamatergic neurotransmission. In brain, the highest amount of zinc, detected by Timm staining, is in the mossy fiber (MF) system in the hippocampus. In the intrahippocampal kainate (KA) mouse model of mesial temporal lobe epilepsy, which is ...

journal_title：Epilepsia

authors： Mitsuya K,Nitta N,Suzuki F

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:The Parry-Romberg syndrome is an unusual disorder frequently associated with epilepsy. The origin of this disease, and the cause of epilepsy, are unknown. This study is the first reported case of the Parry-Romberg syndrome, with intractable temporal lobe epilepsy, in which detailed microanatomic analyses have b...

journal_title：Epilepsia

authors： DeFelipe J,Segura T,Arellano JI,Merchán A,DeFelipe-Oroquieta J,Martín P,Maestú F,Ramón y Cajal S,Sánchez A,Sola RG

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:The aim of this prospective incident community-based study was to assess the influence of pre- and perinatal risk factors in children in whom an unprovoked afebrile epileptic seizure later developed. METHODS:From November 1, 1985, until June 30, 1987, 75 children aged 0-15 years with a first unprovoked afebril...

journal_title：Epilepsia

authors： Sidenvall R,Heijbel J,Blomquist HK,Nyström L,Forsgren L

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:Vagus nerve stimulation (VNS) is reported to reduce the frequency of seizures in children and adults without causing serious side effects. However, clinical observation of swallowing difficulties in 2 children treated with VNS made further investigation necessary. METHODS:Seven patients aged 4-18 years and tre...

journal_title：Epilepsia

authors： Lundgren J,Ekberg O,Olsson R

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To evaluate the safety, tolerability, and efficacy of long-term pregabalin as add-on therapy for patients with poorly controlled partial seizures. METHODS:Analysis of data from six long-term clinical trials involving 2,061 patients receiving open-label pregabalin 75-600 mg/day adjunctive therapy for partial on...

journal_title：Epilepsia

authors： Uthman BM,Bazil CW,Beydoun A,Schulze-Bonhage A,Benabou R,Whalen E,Emir B,Griesing T,Leon T

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To describe postoperative outcome in patients with familial mesial temporal lobe epilepsy (FMTLE). METHODS:We studied FMTLE patients who underwent surgical treatment for refractory seizures. FMTLE was defined when at least two individuals in a family had a clinical EEG diagnosis of MTLE. Preoperative investiga...

journal_title：Epilepsia

authors： Kobayashi E,D'Agostino MD,Lopes-Cendes I,Andermann E,Dubeau F,Guerreiro CA,Schenka AA,Queiroz LS,Olivier A,Cendes F,Andermann F

更新日期：2003-08-01 00:00:00

abstract：:Ketogenic diets (KDs) are designed to create the metabolic conditions of fasting, which was among the earliest therapies discovered for epilepsy. The major measures used to evaluate dietary effectiveness have been the levels of urinary ketone bodies and the successful reduction of seizure activity. Modifications of th...

journal_title：Epilepsia

authors： Eagles DA

更新日期：2008-11-01 00:00:00

abstract：:Five-hundred twelve epileptic children were followed longitudinally for several years. The 2- and 4-year remission statuses at the latest examination were 50.6 and 44.2%, respectively. Dividing our sample into groups showing onset of seizures in infancy or at 2-3, 4-7, 8-10, or 11-14 years, the remission rates were as...

journal_title：Epilepsia

authors： Sofijanov NG

更新日期：1982-02-01 00:00:00

abstract：PURPOSE:To evaluate the antiepileptic and neuroprotective properties of topiramate (TPM) alone and with coadministration of the N-methyl-D-aspartate (NMDA)-receptor antagonist budipine in a rat model of refractory status epilepticus. METHODS:Male Sprague-Dawley rats had electrodes implanted into the perforant path and...

journal_title：Epilepsia

authors： Fisher A,Wang X,Cock HR,Thom M,Patsalos PN,Walker MC

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:To assess seizure and cognitive outcomes and their predictors in children (<16 years at surgery) and adults undergoing temporal lobe epilepsy (TLE) surgery in eight Italian centers. METHODS:This is a retrospective multicenter study. We performed a descriptive analysis and subsequently carried out multivariab...

journal_title：Epilepsia

authors： Barba C,Cossu M,Guerrini R,Di Gennaro G,Villani F,De Palma L,Grisotto L,Consales A,Battaglia D,Zamponi N,d'Orio P,Revay M,Rizzi M,Casciato S,Esposito V,Quarato PP,Di Giacomo R,Didato G,Pastori C,Pavia GC,Pellacani

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:High-dose i.v. opioids (e.g., alfentanil, 50 microg/kg bolus) are known to increase the intraoperative reading of epileptiform activity during epilepsy surgery (ES), thereby facilitating localization of the epileptogenic zone (i.e., the site of ictal onset and initial seizure propagation). However, this phenome...

journal_title：Epilepsia

authors： Wass CT,Grady RE,Fessler AJ,Cascino GD,Lozada L,Bechtle PS,Marsh WR,Sharbrough FW,Schroeder DR

更新日期：2001-10-01 00:00:00

abstract：:Currently, there are 4 published scales evaluating status epilepticus (SE) prognosis: the Status Epilepticus Severity Score (STESS), the Epidemiology-based Mortality score in Status Epilepticus (EMSE), the modified STESS (mSTESS), and the Encephalitis Nonconvulsive Status Epilepticus Diazepam Resistence Imaging Trache...

journal_title：Epilepsia

authors： Yuan F,Gao Q,Jiang W

更新日期：2018-10-01 00:00:00

abstract：:Monotherapy is the policy for management of patients with epilepsy. With increasing knowledge of the biology of epilepsy and of the modes of action of antiepileptic drugs (AEDs), this concept must be reevaluated. When monotherapy fails to control seizures, subsequent treatment should be based on "rational pharmacology...

journal_title：Epilepsia

authors： de Bittencourt PR,Mazer S,Marcourakis T,Bigarella MM,Ferreira ZS,Mumford JP

更新日期：1994-03-01 00:00:00

abstract：:The ultimate treatment goal in epilepsy therapy is always freedom from seizures with as few treatment adverse effects as possible. If seizures persist with the first monotherapy, alternative monotherapy with another antiepileptic drug (AED) should be considered. Continuing seizures should lead to a reevaluation of dif...

journal_title：Epilepsia

authors： Ben-Menachem E

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The use of primary health care personnel to identify cases of epilepsy and initiate simple treatment protocols has been advocated as a solution to the numeric inadequacy and uneven distribution of medical manpower available for the management of epilepsy in developing countries. This study sought to evaluate th...

journal_title：Epilepsia

authors： Adamolekun B,Mielke JK,Ball DE

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:Management of seizures in learning disabled people is challenging. This prospective study explored the efficacy and tolerability of adjunctive topiramate (TPM) in patients with learning disability and refractory epilepsy attending a single centre. METHODS:Sixty-four patients (36 men, 28 women, aged 16-65 years...

journal_title：Epilepsia

authors： Kelly K,Stephen LJ,Sills GJ,Brodie MJ

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To identify the timelines of magnetic resonance imaging (MRI) abnormalities and their relationships with the clinical outcomes of patients with new-onset refractory status epilepticus (NORSE). METHODS:This retrospective observational study enrolled patients with NORSE who were admitted from March 2008 to Jul...

journal_title：Epilepsia

authors： Kim HJ,Lee SA,Kim HW,Kim SJ,Jeon SB,Koo YS

更新日期：2020-08-01 00:00:00

abstract：UNLABELLED:Low-pressure hydrocephalic state (LPHS) has only recently been described as a distinct clinical entity occurring in patients with bioatrophic lesions of the brain. We report a patient in whom this syndrome developed after subtotal hemispherectomy for intractable epilepsy. METHODS:A 30-year-old man developed...

journal_title：Epilepsia

authors： Daniel RT,Lee GY,Halcrow SJ

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:Single photon emission computed tomography (SPECT) is widely used to evaluate functional abnormalities during the epileptic event. Changes in regional cerebral blood flow (rCBF) are well defined in patients with temporal lobe epilepsy (TLE) undergoing surgical resection. Nonetheless, the interpretation of ictal...

journal_title：Epilepsia

authors： Rabinowicz AL,Salas E,Beserra F,Leiguarda RC,Vazquez SE

更新日期：1997-09-01 00:00:00

abstract：:Status epilepticus (SE) is typically defined as a prolonged self-sustaining seizure or repeated seizures showing an incomplete recovery between them. SE represents a medical emergency often associated with significant disability, morbidity, and mortality. Despite the clinical impact, the mechanisms underlying the tran...

journal_title：Epilepsia

authors： Leo A,Giovannini G,Russo E,Meletti S

更新日期：2018-06-01 00:00:00

abstract：:We studied a 41-year-old woman who had nocturnal somatosensory seizures followed by orgasm. The interictal EEG showed discrete left central parietal region paroxysmal activity that markedly increased during sleep. Eight electroclinical seizures were recorded during sleep polygraphic recording. Orgasms occurred coincid...

journal_title：Epilepsia

authors： Calleja J,Carpizo R,Berciano J

更新日期：1988-09-01 00:00:00

abstract：:We review information from large studies of defined populations, examining the role of known factors and especially of prenatal and perinatal factors in contributing to nonfebrile seizure disorders of early childhood. We depend especially, but not exclusively, on the recently completed analyses from the Collaborative ...

journal_title：Epilepsia

authors： Nelson KB,Ellenberg JH

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Patients with tuberous sclerosis complex (TSC) often have severe epilepsy that is intractable to available therapies. The development of novel treatments for epilepsy in TSC would benefit greatly from a suitable animal model, but most animal models of TSC to date have few reported neurological abnormalities, su...

journal_title：Epilepsia

authors： Erbayat-Altay E,Zeng LH,Xu L,Gutmann DH,Wong M

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To describe seizure control, complications, adaptive function and language skills following hemispheric surgery for epilepsy. METHODS:Retrospective chart review of patients who underwent hemispheric surgery from July 1993 to June 2004 with a minimum follow-up of 12 months. RESULTS:The study population compris...

journal_title：Epilepsia

authors： Basheer SN,Connolly MB,Lautzenhiser A,Sherman EM,Hendson G,Steinbok P

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The objective of this study was the isobolographic evaluation of the interactions between the novel antiepileptic drug (AED) gabapentin (GBP) and a number of other AEDs against electroconvulsion-induced convulsions in mice. METHODS:Electroconvulsions were produced by means of an alternating current (ear-clip e...

journal_title：Epilepsia

authors： Borowicz KK,Swiader M,Luszczki J,Czuczwar SJ

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:Precipitants of seizures are often reported by patients and carers, but the accuracy of these claims remains unknown. Focusing on epilepsy in people with intellectual disability (ID), the aims of this work were to (1) identify a set of methods for assessing the validity of reported seizure triggers in indivi...

journal_title：Epilepsia

authors： Illingworth JL,Watson P,Xu S,Manford M,Ring H

更新日期：2015-11-01 00:00:00