Abstract:
PURPOSE:To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS:Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizures [minimal (i.e., clonic)] and generalized tonic-clonic (GTCS) were recorded, and seizure severity was scored. RESULTS:GBP suppressed or at least restricted the tonic phase of GTCS at all the developmental stages studied. In addition, minimal seizures were suppressed in 18-day-old rats. Both effects exhibited a tendency to a U-shaped dose-response curve. CONCLUSIONS:Anticonvulsant effects of GBP were demonstrated in immature and in adult rats.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Mares P,Haugvicová Rdoi
10.1111/j.1528-1157.1997.tb01254.xsubject
Has Abstractpub_date
1997-08-01 00:00:00pages
893-6issue
8eissn
0013-9580issn
1528-1167journal_volume
38pub_type
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