Abstract:
:Pentylenetetrazol (PTZ) was injected into rats (30 or 35 mg/kg) and guinea pigs (40 or 45 mg/kg) daily or every second day. A progressive development of seizure activity after this treatment was observed. Doses ineffective after the first injection induced tonic seizures after 20 injections. Both kinds of treated animals immediately developed tonic seizures when PTZ was injected after a few months interruption for one time only. The results support the assumption that seizures induced by chronic injection of PTZ are similar to kindled seizures evoked by daily electrical stimulation and can be regarded as a model of epileptogenesis.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Diehl RG,Smialowski A,Gotwo Tdoi
10.1111/j.1528-1157.1984.tb03452.xsubject
Has Abstractpub_date
1984-08-01 00:00:00pages
506-10issue
4eissn
0013-9580issn
1528-1167journal_volume
25pub_type
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