Abstract：
PURPOSE:This study investigated the impact of a treatment information package on patients being monitored for possible surgical treatment for temporal lobe epilepsy. METHODS:One hundred patients were randomly assigned to either a high- or low-information preparation condition. Levels of anxiety were tested soon after admission by using the Hospital Anxiety and Depression Scale (HADS), The State-Trait Anxiety Inventory (STAI), and a newly devised questionnaire to assess specific concerns and anxieties of epilepsy patients presenting for monitoring and surgery, the Concerns About Epilepsy Monitoring Questionnaire (CAEMQ). Dispositional desire for information was assessed by the Miller Behavioural Style Scale (MBSS) to investigate whether coping disposition affected coping styles in the hospital setting. Patients assigned to the high-information condition were exposed to an intervention package, which included viewing a video depicting two separate interviews with patients who had undergone surgery as well as an information package, which described the various tests that the patient would undergo in the course of the monitoring procedure. Patients assigned to the low-information group were given information that the hospital provided to all patients in their care. All subjects were then retested on anxiety levels a few days later. RESULTS:Those in the high-information group showed a significant decrease in anxiety and depression levels compared with those in the low-information group. CONCLUSIONS:Within the main findings, an effect of dispositional style was found. Identification as either a monitor or blunter on the MBSS showed different coping strategies on arrival in hospital as measured by the CAEMQ, indicating that the level of information given to patients with epilepsy on arrival needs to be mediated by awareness of these two dispositional styles so that they obtain maximal benefit from the information to which patients with epilepsy are exposed.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Andrewes D,Camp K,Kilpatrick C,Cook Mdoi
10.1111/j.1528-1157.1999.tb02037.xsubject
Has Abstractpub_date
1999-11-01 00:00:00pages
1535-42issue
11eissn
0013-9580issn
1528-1167journal_volume
40pub_type
临床试验,杂志文章,随机对照试验相关文献
EPILEPSIA文献大全abstract：:Concentrations of prostaglandins (PGs) in the central nervous system are known to increase during and after experimentally induced seizures. In the present study, concentrations of PGE-2 were determined by radioimmunoassay in lumbar cerebrospinal fluid (CSF) of 17 children shortly after a febrile convulsion. PGE-2 dat...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1988.tb03724.x
更新日期：1988-05-01 00:00:00
abstract：PURPOSE:We evaluated the role of interictal rhythmical midline theta (RMT) in the identification of frontal lobe epilepsy (FLE) and its differentiation from temporal lobe epilepsy (TLE) and nonepileptic controls. METHODS:We included 162 individuals in the study: 54 FLE patients, 54 TLE patients, and 54 nonepileptic co...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2008.01780.x
更新日期：2009-03-01 00:00:00
abstract：:Tiagabine (TGB) is a recently approved antiepileptic drug (AED) that inhibits y-aminobutyric acid (GABA) reuptake into neurons and glia, a mechanism of action that is specific and unique among the AEDs. TGB is potent and has linear and predictable pharmacokinetics. It has no clinically relevant effects on hepatic meta...
journal_title：Epilepsia
pub_type： 杂志文章,评审
doi：10.1111/j.1528-1157.1999.tb00915.x
更新日期：1999-01-01 00:00:00
abstract：:In the nineteenth and early twentieth centuries, many important discoveries in nervous system structure and function involved the electrical properties of nerve tissue. The application of these advances, as well as those in electronic amplification and recording, led to the discovery of the human electroencephalogram ...
journal_title：Epilepsia
pub_type： 历史文章,杂志文章
doi：10.1111/j.1528-1167.2009.02037.x
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut-1 DS). METHODS:Twenty children with clinical and laboratory features of Glut-1 DS were evaluated. Age at seizure diagnosis, seizure classification, and response to treatment were determine...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1046/j.1528-1157.2003.05302.x
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:Most people in the world with epilepsy are untreated with antiepileptic drugs (AEDs). In some developing countries, this is because treatment facilities are unavailable or difficult to access. It has even been suggested that indigenous health systems threaten the prospect of the global control of epilepsy with ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1046/j.1528-1157.2002.47601.x
更新日期：2002-08-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the regional relative interictal and postictal perfusion changes in temporal and parietal lobe epilepsy. METHODS:We investigated interictal and postictal magnet resonance perfusion changes in five patients with temporal lobe epilepsy either with hippocampal sclerosis (n = 3)...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2005.00336.x
更新日期：2005-12-01 00:00:00
abstract：:The randomized, double-blind trial design offers the most accurate data regarding the efficacy of antiepileptic treatments. However, translating the results of a trial into clinical care can be complex due to the intrinsic tension between the requirements for scientific methods that minimize systematic and random erro...
journal_title：Epilepsia
pub_type： 杂志文章,评审
doi：10.1046/j.1528-1157.44.s7.2.x
更新日期：2003-01-01 00:00:00
abstract：:The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact o...
journal_title：Epilepsia
pub_type： 杂志文章,评审
doi：10.1111/epi.12295
更新日期：2013-08-01 00:00:00
abstract：:Many patients with medically refractory epilepsy now undergo successful surgery based on noninvasive diagnostic information, but intracranial electroencephalography (IEEG) continues to be used as increasingly complex cases are considered surgical candidates. The indications for IEEG and the modalities employed vary ac...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/epi.13515
更新日期：2016-11-01 00:00:00
abstract：:We examined auto-correlation and interval distribution characteristics of neuronal discharge from patients with complex partial seizures. The objective was to compare the interictal firing patterns of neurons in mesial temporal structures ipsilateral to the site of seizure onset with firing patterns of neurons in homo...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1996.tb00001.x
更新日期：1996-02-01 00:00:00
abstract：PURPOSE:Absence epilepsies are common, with a major genetic contribution to etiology. Certain environmental factors can influence absence occurrence but a complete understanding of absence precipitation is lacking. Herein we investigate if lowering blood glucose increases spike-wave activity in mouse models with varyin...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2010.02911.x
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:The use of primary health care personnel to identify cases of epilepsy and initiate simple treatment protocols has been advocated as a solution to the numeric inadequacy and uneven distribution of medical manpower available for the management of epilepsy in developing countries. This study sought to evaluate th...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1999.tb00749.x
更新日期：1999-04-01 00:00:00
abstract：:Between 1929 and 1980, 284 patients with refractory nontumoral frontal lobe epilepsy (FLE) underwent operation at the Montreal Neurological Institute (MNI). We studied 39 patients (14%) who required reoperation. Mean age at the time of first operation was 18 years and at reoperation was 22 years. Clinical manifestatio...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1994.tb02914.x
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVE:We examine improvement and worsening in quality of life (QOL) in terms of proportions achieving minimum clinically important change (MCID), and factors related to MCID, in patients with temporal lobe epilepsy randomized to medical or surgical treatment. METHODS:Eighty patients with temporal lobe epilepsy ran...
journal_title：Epilepsia
pub_type： 杂志文章,随机对照试验
doi：10.1111/epi.12625
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:To develop a Norwegian version of the Quality of Life in Epilepsy Inventory (QOLIE-89) and to confirm its psychometric properties. METHODS:The QOLIE-89 was adapted to Norwegian language through a translation-backtranslation procedure. The assessment included 397 patients with epilepsy. We assessed internal con...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.2000.tb01511.x
更新日期：2000-01-01 00:00:00
abstract：:Multiple studies have highlighted how seizures induce different molecular, cellular, and physiologic consequences in an immature brain as compared to a mature brain. In keeping with these studies, seizures early in life alter dentate granule cell birth in different, and even opposing, fashion to adult seizure models (...
journal_title：Epilepsia
pub_type： 杂志文章,评审
doi：10.1111/j.1528-1167.2008.01637.x
更新日期：2008-06-01 00:00:00
abstract：PURPOSE:In refractory temporal lobe epilepsy (rTLE), gray matter (GM) abnormalities are not confined to the hippocampus but also are found in extrahippocampal structures. Very recently we observed in mild TLE (mTLE) with or without mesiotemporal sclerosis (MTS), GM reductions in regions outside the presumed epileptogen...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2009.02310.x
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:Patients with medial temporal lobe epilepsy (MTLE) exhibit structural brain damage involving gray matter (GM) and white matter (WM). The mechanisms underlying tissue loss in MTLE are unclear and may be associated with a combination of seizure excitotoxicity and WM vulnerability. The goal of this study was to in...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/epi.12353
更新日期：2013-10-01 00:00:00
abstract：:Previous studies have demonstrated that bicuculline-induced seizures of 1-2 h in duration lead to structural, metabolic, and circulatory alterations in the rat brain. Such alterations were observed even though cerebral oxygenation seemed adequate. In the present study, we explored whether pentylenetetrazole, a convuls...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1984.tb04176.x
更新日期：1984-04-01 00:00:00
abstract：OBJECTIVE:Genetic testing has become a routine part of the diagnostic workup in children with early onset epilepsies. In the present study, we sought to investigate a cohort of adult patients with epilepsy, to determinate the diagnostic yield and explore the gain of personalized treatment approaches in adult patients. ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/epi.16533
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Bone disease and fractures are common with chronic antiepileptic drug (AED) therapy, but the underlying mechanisms are poorly understood. This study aimed to characterize adverse bone effects of valproate and to identify mouse strains either resistant or sensitive to these effects. METHODS:Seven mouse strains ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1167.2009.02516.x
更新日期：2010-06-01 00:00:00
abstract：:There is little evidence to guide the choice of intravenous anesthetic agent to treat refractory status epilepticus but midazolam, propofol, and barbiturates are widely used. It is impractical to use inhalational anesthetic agents in most circumstances and there is little experience with non-GABA-ergic agents such as ...
journal_title：Epilepsia
pub_type： 杂志文章,评审
doi：10.1111/j.1528-1167.2011.03234.x
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:Concerns over teratogenicity of antiepileptic drugs (AEDs) during pregnancy must be balanced against the risks of seizures to the mother and developing fetus. Pharmacokinetic changes and vomiting may alter drug levels, but more important may be the patient's decision to stop medication before or during pregnanc...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1046/j.1528-1157.2002.38601.x
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVE:To evaluate efficacy, tolerability, and safety of adjunctive brivaracetam (BRV) in patients with Unverricht-Lundborg disease (EPM1). METHODS:Two prospective, multicenter, double-blind, phase III trials (N01187/NCT00357669; N01236/NCT00368251) in patients (≥16 years) with genetically ascertained EPM1, showing...
journal_title：Epilepsia
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/epi.13275
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:There is controversy between clinicians and statisticians on the appropriateness of the number needed to treat (NNT) as a summary statistic to report the effectiveness of a treatment. We examine the two viewpoints and make proposals concerning the reporting of clinical trial results. METHODS:In the context of ...
journal_title：Epilepsia
pub_type： 临床试验,杂志文章,meta分析,随机对照试验
doi：10.1111/j.1528-1157.2000.tb00186.x
更新日期：2000-04-01 00:00:00
abstract：:The incidence of idiopathic/cryptogenic epilepsy and isolated unprovoked seizures has been relatively stable in the population of Rochester, Minnesota, for the 50-year period 1935 through 1984. In each decade, the age-specific rates exhibited a consistent U-shaped pattern of decreasing rates from infancy to age 40-49 ...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1995.tb02570.x
更新日期：1995-06-01 00:00:00
abstract：:A group of patients with benign epilepsy of children with centrotemporal EEG foci, consisting of 40 patients reported 10 years ago, has been reinvestigated. Thirty-seven of these patients were reinvestigated. They were 26-34 years old (mean, 29 years). The observation time from the first seizure was 13-27 years (mean,...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1982.tb05078.x
更新日期：1982-12-01 00:00:00
abstract：:The combination of phenobarbital (PB) and phenytoin (PHT) was recommended for many years for treatment of epilepsy in humans. We tested the effectiveness of the combination in a model of hippocampal seizures termed maximal dentate activation (MDA). Two parameters of MDA were measured: duration and time to onset. Neith...
journal_title：Epilepsia
pub_type： 杂志文章
doi：10.1111/j.1528-1157.1994.tb02936.x
更新日期：1994-01-01 00:00:00
abstract：:From the earliest days of neurology, the classification of epileptic seizures into those generalized from the beginning and those with a definable localization in the cortex from the onset has added to knowledge about the function of the nervous system. Further elaboration of the classification of seizures into those ...
journal_title：Epilepsia
pub_type： 杂志文章,评审
doi：10.1111/j.1528-1157.1990.tb05856.x
更新日期：1990-01-01 00:00:00
