Sodium valproate: monotherapy and polytherapy.

abstract：OBJECTIVE:Treatments for convulsive status epilepticus (SE) have a wide range of effectiveness. The estimated effectiveness of non-intravenous benzodiazepines (non-IV BZDs) ranges from approximately 70% to 90% and the estimated effectiveness of non-benzodiazepine antiseizure medications (non-BZD ASMs) ranges from appro...

journal_title：Epilepsia

authors： Sánchez Fernández I,Gaínza-Lein M,Barcia Aguilar C,Amengual-Gual M,Loddenkemper T

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:To study cortical excitability after status epilepticus induced in two age groups of immature rats. METHODS:Lithium-pilocarpine status epilepticus was elicited in 12- (SE12) or 25-day-old (SE25) rats. Control siblings received saline instead of pilocarpine. Interhemispheric responses were elicited by stimulati...

journal_title：Epilepsia

authors： Mares P,Tsenov G,Aleksakhina K,Druga R,Kubová H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The "adenosine hypothesis of SUDEP" (sudden unexpected death in epilepsy) predicts that a seizure-induced adenosine surge combined with impaired metabolic clearance can foster lethal apnea or cardiac arrest. Changes in adenosine receptor density and adenosine kinase (ADK) occur in surgical epilepsy patients. ...

journal_title：Epilepsia

authors： Patodia S,Paradiso B,Garcia M,Ellis M,Diehl B,Thom M,Devinsky O

更新日期：2020-04-01 00:00:00

abstract：:Previous studies have demonstrated that bicuculline-induced seizures of 1-2 h in duration lead to structural, metabolic, and circulatory alterations in the rat brain. Such alterations were observed even though cerebral oxygenation seemed adequate. In the present study, we explored whether pentylenetetrazole, a convuls...

journal_title：Epilepsia

authors： Ingvar M,Söderfeldt B,Folbergrová J,Kalimo H,Olsson Y,Siesjö BK

更新日期：1984-04-01 00:00:00

abstract：:Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study. Twenty-two individuals in a population of 359 persons with neurofibromatos 1 (NF1) had had one or more seizures. Age at first seizure ranged from 4 days to > 20 years. Patients were classified into ...

journal_title：Epilepsia

authors： Korf BR,Carrazana E,Holmes GL

更新日期：1993-07-01 00:00:00

abstract：:The first description of epileptic encephalopathies dates back to Dr. West who, in 1857, described the syndrome that took his name. In addition to West syndrome, in the last century other epileptic syndromes entered into the chapter of epileptic encephalopathies. Henry Gastaut has the virtue of having created the mode...

journal_title：Epilepsia

authors： Capovilla G,Wolf P,Beccaria F,Avanzini G

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:The goal of the study was to assess the health-related quality of life (HRQOL) of persons with epilepsy (PWE) by using the short form survey 36 (SF-36), to compare it with that of a control group and to detect factors influencing it. METHODS:We collected clinical and demographic data and information on health ...

journal_title：Epilepsia

authors： Mrabet H,Mrabet A,Zouari B,Ghachem R

更新日期：2004-07-01 00:00:00

abstract：:The intracarotid amobarbital procedure (IAP) is frequently used to determine hemispheric language dominance and memory competence in individuals with intractable epilepsy before surgical intervention. The present study focused on outcome results concerning use of this technique in children. The IAP was an effective to...

journal_title：Epilepsia

authors： Williams J,Rausch R

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:Psychogenic nonepileptic seizures (PNES) are among the most common clinical manifestations of conversion disorder and consist of paroxysmal behavior that resembles epileptic seizures. Preliminary data from functional neuroimaging studies gave plausible evidence that limbic circuits and sensorimotor cortex might...

journal_title：Epilepsia

authors： Labate A,Cerasa A,Mula M,Mumoli L,Gioia MC,Aguglia U,Quattrone A,Gambardella A

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:To assess the presence, extent, and clinical correlates of quantitative MR volumetric abnormalities in ipsilateral and contralateral hippocampus, and temporal and extratemporal lobe regions in unilateral temporal lobe epilepsy (TLE). METHODS:In total, 34 subjects with unilateral left (n = 15) or right (n = 19)...

journal_title：Epilepsia

authors： Seidenberg M,Kelly KG,Parrish J,Geary E,Dow C,Rutecki P,Hermann B

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f) quinoxaline-2,3-dione) and topiramate (TPM) given after hypoxia-induced seizures in preventing the delayed effect of hypoxia on subsequent susceptibility to seizures and neuronal injury. METHODS:We used "two-hit" rodent seizure model t...

journal_title：Epilepsia

authors： Koh S,Tibayan FD,Simpson JN,Jensen FE

更新日期：2004-06-01 00:00:00

abstract：:Eslicarbazepine acetate (ESL) is a novel once-daily antiepileptic drug (AED) approved in Europe since 2009 that was found to be efficacious and well tolerated in a phase III clinical program in adult patients with partial onset seizures previously not controlled with treatment with one to three AEDs, including carbama...

journal_title：Epilepsia

authors： Bialer M,Soares-da-Silva P

更新日期：2012-06-01 00:00:00

abstract：:The Boston Naming Test (BNT) is often used in the evaluation of surgical epilepsy patients to assess left temporal lobe function. In 2005, Busch et al. demonstrated the diagnostic utility of the BNT in predicting ultimate side of surgery in patients with temporal lobe epilepsy. BNT raw score significantly predicted ul...

journal_title：Epilepsia

authors： Busch RM,Frazier TW,Iampietro MC,Chapin JS,Kubu CS

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare the utility of baseline neuropsychological measures and scores from the intracarotid amobarbital procedure (IAP) in the prediction of postoperative memory decline in temporal lobe epilepsy surgery patients. METHODS:Logistic regression analyses were used to determine the rel...

journal_title：Epilepsia

authors： Baxendale S,Thompson P,Harkness W,Duncan J

更新日期：2007-03-01 00:00:00

abstract：:We examined the relationship between clinical characteristics and EEG classification in all children with febrile seizures examined at the University Pediatric Clinic, Skopje, Yugoslavia between 1982 and 1984. This is the only facility in Macedonia providing EEG or neurologic consultation for children. EEGs were class...

journal_title：Epilepsia

authors： Sofijanov N,Emoto S,Kuturec M,Dukovski M,Duma F,Ellenberg JH,Hirtz DG,Nelson KB

更新日期：1992-01-01 00:00:00

abstract：:Cerebral microbleeds (CMBs) are commonly found in patients with stroke and cerebral amyloid angiopathy. However, there have been no reports of CMBs or their acute appearance in patients with status epilepticus. Herein we describe two patients with refractory status epilepticus of uncertain origin. Both patients were p...

journal_title：Epilepsia

authors： Jeon SB,Parikh G,Choi HA,Lee K,Lee JH,Schmidt JM,Badjatia N,Mayer SA,Claassen J

更新日期：2013-05-01 00:00:00

abstract：:A child had two to three generalized tonic-clonic (GTC) seizures per week unresponsive to phenobarbital (PB) and valproate (VPA). Interictal EEG demonstrated left occipital spikes. When carbamazepine (CBZ) therapy was started, he developed very frequent (4-6/day) complex partial seizures (CPS) characterized on ictal E...

journal_title：Epilepsia

authors： Dhuna A,Pascual-Leone A,Talwar D

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To examine which variables available early in the course of childhood epilepsy are associated with a poor short-term outcome and to develop models to predict such an outcome. METHODS:We prospectively followed up 466 children with newly diagnosed epilepsy for 2 years. Variables were collected at intake and afte...

journal_title：Epilepsia

authors： Arts WF,Geerts AT,Brouwer OF,Boudewyn Peters AC,Stroink H,van Donselaar CA

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, and comparative pharmacokinetics (PK) of intravenous and oral carbamazepine. METHODS:In this phase 1, open-label study, adult patients with epilepsy on a stable oral carbamazepine dosage (400-2,000 mg/day) were converted to intravenous carbamazepine (administered at 70% ...

journal_title：Epilepsia

authors： Tolbert D,Cloyd J,Biton V,Bekersky I,Walzer M,Wesche D,Drummond R,Lee D

更新日期：2015-06-01 00:00:00

abstract：:The effect of kindled seizures on the cardiovascular system was examined in amygdaloid kindled rats. The most prominent cardiovascular response during a generalized kindled seizure was an abrupt 50% increase in mean arterial pressure (MAP) lasting 20-30 s after initiation of the seizure. Superimposed on this change in...

journal_title：Epilepsia

authors： Goodman JH,Homan RW,Crawford IL

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:To describe the semiological features of auditory aura and to assess their possible lateralizing value in partial epilepsy. METHODS:Out of a series of 8,000 patients with epilepsy, we investigated 121 cases with partial seizures in whom auditory features were the first ictal symptom. According to the dominant ...

journal_title：Epilepsia

authors： Florindo I,Bisulli F,Pittau F,Naldi I,Striano P,Striano S,Michelucci R,Testoni S,Baruzzi A,Tinuper P

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The standard practice of switching patients to carbamazepine (CBZ) involves initiating a low dose and raising it by small increments until the desired dose is reached, to avoid intolerable adverse effects (AE). In a pilot study, a protocol using single-dose kinetic studies was developed to switch patients to CB...

journal_title：Epilepsia

authors： Kanner AM,Bourgeois BF,Hasegawa H,Hutson P

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Nuclear receptors and cytochrome P450 (CYP) regulate hepatic metabolism of several drugs. Nuclear receptors are expressed at the neurovascular unit of patients with drug-resistant epilepsy. We studied whether glucocorticoid receptor (GR) silencing or inhibition in human epileptic brain endothelial cells (EPI-...

journal_title：Epilepsia

authors： Ghosh C,Hossain M,Mishra S,Khan S,Gonzalez-Martinez J,Marchi N,Janigro D,Bingaman W,Najm I

更新日期：2018-11-01 00:00:00

abstract：:The routine EEG study may prove inadequate in selected patients with recurrent and unprovoked seizures. Video-EEG monitoring is an important diagnostic innovation that may be used to confirm the diagnosis of a seizure disorder and classify seizure type. The methodologies and clinical applications of video-EEG monitori...

journal_title：Epilepsia

authors： Cascino GD

更新日期：2002-01-01 00:00:00

abstract：:Status epilepticus (SE) is the most extreme form of epilepsy. It describes a prolonged seizure that may occur in patients with previous epilepsy or in acute disorders of the central nervous system. It is one of the most common neurologic emergencies, with an incidence of up to 41 per 100,000 per year and an estimated ...

journal_title：Epilepsia

authors： Trinka E,Höfler J,Zerbs A

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:Numerous studies have demonstrated changes in cognitive, memory, and language functioning in adults and adolescents after temporal lobectomy, yet little information is available regarding neuropsychological outcome in preadolescent children. METHODS:We studied pre- and postoperative neuropsychological test res...

journal_title：Epilepsia

authors： Szabó CA,Wyllie E,Stanford LD,Geckler C,Kotagal P,Comair YG,Thornton AE

更新日期：1998-08-01 00:00:00

abstract：:We evaluated clinical indicators of genetic susceptibility to epilepsy in the families of 1,957 adults with epilepsy (probands) ascertained from voluntary organizations. Very few of the probands in this series had idiopathic epilepsy syndromes. Among relatives of probands with postnatal CNS insults, risks of epilepsy ...

journal_title：Epilepsia

authors： Ottman R,Lee JH,Risch N,Hauser WA,Susser M

更新日期：1996-04-01 00:00:00

abstract：:Differentiation between psychogenic nonepileptic seizures (PNES) and generalized convulsive epileptic seizures (ES) is important for appropriate triaging in the emergency department (ED). This can be difficult in the ED, as the event is often not witnessed by a medical professional. In the current study, we investigat...

journal_title：Epilepsia

authors： Li Y,Matzka L,Maranda L,Weber D

更新日期：2017-09-01 00:00:00

abstract：:Development of tolerance (i.e., the reduction in response to a drug after repeated administration) is an adaptive response of the body to prolonged exposure to the drug, and tolerance to antiepileptic drugs (AEDs) is no exception. Tolerance develops to some drug effects much more rapidly than to others. The extent of ...

journal_title：Epilepsia

authors： Löscher W,Schmidt D

更新日期：2006-08-01 00:00:00

abstract：:This study sought to determine the frequency and clinical significance of nonhabitual seizures in 101 consecutive patients undergoing presurgical intracranial electroencephalography intracranial (icEEG) recording. We compared clinical data, recording details, and postsurgical outcome in patients with nonhabitual seizu...

journal_title：Epilepsia

authors： Kovac S,Rodionov R,Chinnasami S,Wehner T,Scott CA,McEvoy AW,Miserocchi A,Diehl B

更新日期：2014-01-01 00:00:00