Kindled seizures elevate blood pressure and induce cardiac arrhythmias.

abstract：:Several different types of chemical compounds are useful as antiepileptic drugs. Their mechanisms of action, as well as their physical structures, differ. Compounds such as carbamazepine, phenytoin, and probably valproate act by modifying ionic conductances, particularly sodium and calcium, in excitable membranes, thu...

journal_title：Epilepsia

authors： Ferrendelli JA

更新日期：1987-01-01 00:00:00

abstract：:The effects of 5 alpha-pregnan-3 alpha-ol-20-one (3 alpha-OH-DHP) and phenobarbital (PB) on synaptic excitation and inhibition in rat hippocampal slices in vitro were compared. Stimulations were made orthodromically and antidromically while we recorded extracellularly from the dendritic and the somatic layer of the CA...

journal_title：Epilepsia

authors： Taubøll E,Gjerstad L

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:Recent reports define temporal lobe epilepsy with amygdala enlargement (TLE-AE) as a distinct electroclinical syndrome comparable to TLE with hippocampal sclerosis. In this retrospective observational study, we present the largest consecutive series of patients with new-onset TLE-AE to date and describe clini...

journal_title：Epilepsia

authors： Malter MP,Widman G,Galldiks N,Stoecker W,Helmstaedter C,Elger CE,Wagner J

更新日期：2016-09-01 00:00:00

abstract：:Cardiac changes may occasionally occur during vagus nerve stimulation (VNS) used in epileptic patients. As they can be potentially life-threatening, it is important to detect them, and this is why an intraoperative test is performed during the implantation. Few cases of asystole during this test have been described. O...

journal_title：Epilepsia

authors： Iriarte J,Urrestarazu E,Alegre M,Macías A,Gómez A,Amaro P,Artieda J,Viteri C

更新日期：2009-04-01 00:00:00

abstract：:The authors report the study of a 30-month-old girl with refractory myoclonic epilepsy associated with mental retardation, growth delay, peculiar facial appearance, and minor physical anomalies. Extensive genetic studies were performed, including an array-based comparative genomic hybridization (array-CGH) that showed...

journal_title：Epilepsia

authors： Veredice C,Bianco F,Contaldo I,Orteschi D,Stefanini MC,Battaglia D,Lettori D,Guzzetta F,Zollino M

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate health care expenditures among elderly patients with epilepsy in the United States. METHODS:We performed an analysis of weighted 37 738 607 US participants aged 65 years to estimate health care expenditures in the elderly with and without epilepsy using the Medical E...

journal_title：Epilepsia

authors： Lekoubou A,Bishu KG,Ovbiagele B

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP). METHODS:Male Wistar rats, stereotactically implanted in both ventral hip...

journal_title：Epilepsia

authors： Cuellar-Herrera M,Peña F,Alcantara-Gonzalez D,Neri-Bazan L,Rocha L

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Although levetiracetam undergoes minimum metabolism, B-esterases have been identified in whole blood that are capable of metabolising levetiracetam. The present study was designed to ascertain any variability in levetiracetam blood concentrations that could be attributed to in situ metabolism and which could im...

journal_title：Epilepsia

authors： Patsalos PN,Ghattaura S,Ratnaraj N,Sander JW

更新日期：2006-11-01 00:00:00

abstract：:The feasibility of automated detection of cortical-onset epileptic seizures from subcortical structures such as the thalamus was investigated via simultaneous recording of electroencephalography (EEG) and anterior and centromedian thalamic nuclei electrical signals (electrothalamography) in nine subjects with pharmaco...

journal_title：Epilepsia

authors： Osorio I,Frei MG,Lozano AM,Wennberg R

更新日期：2015-10-01 00:00:00

abstract：:The teratological effect of nicotine has been studied during different trimesters of pregnancy. Three groups of pregnant albino Swiss mice were used for each trimester. The daily doses of nicotine base used were equivalent to 10 (900 micrograms/kg), 20 (1,800 micrograms/kg), or 30 (2,700 micrograms/kg) cigarettes. The...

journal_title：Epilepsia

authors： Al-Hachim GM,Mahmoud FA

更新日期：1985-11-01 00:00:00

abstract：:1-Phenylcyclohexylamine (PCA) and its analogues 1-phenylcyclopentylamine (PPA) and 1-(3-fluorophenyl)cyclohexylamine (3-F-PCA) are potent anticonvulsants in the mouse maximal electroshock (MES) seizure test. Unlike the structurally related dissociative anesthetic phencyclidine (PCP), however, which produces motor toxi...

journal_title：Epilepsia

authors： Blake PA,Yamaguchi S,Thurkauf A,Rogawski MA

更新日期：1992-01-01 00:00:00

abstract：:Brain slices incubated with glucose have provided most of our knowledge on cellular, synaptic, and network driven mechanisms. It has been recently suggested that γ-aminobutyric acid (GABA) excites neonatal neurons in conventional glucose-perfused slices but not when ketone bodies metabolites, pyruvate, and/or lactate ...

journal_title：Epilepsia

authors： Ben-Ari Y,Tyzio R,Nehlig A

更新日期：2011-09-01 00:00:00

abstract：:Using transhemispheric transfer and post-transfer interference as specific measures, the relationship between chemical and electrical kindling at the amygdala (AM) in rats was examined. Chemical kindling was accomplished by repeated injections of a subconvulsive dose of combined L-glutamate (GLU) and L-aspartate (ASP)...

journal_title：Epilepsia

authors： Mori N,Wada JA

更新日期：1989-05-01 00:00:00

abstract：:Astrocyte and microglial activation occurs following seizures and plays a role in epileptogenesis. However, the precise temporal and spatial response to seizures has not been fully examined. The pilocarpine model of temporal lobe epilepsy was selected to examine glial changes following seizures because morphological c...

journal_title：Epilepsia

authors： Shapiro LA,Wang L,Ribak CE

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Herein we used electrophysiologic approaches in hippocampal area CA1 to estimate how morphine treatment alters the pentylenetetrazol (PTZ) effects. METHODS:Hippocampal slices taken from either control animals or animals made dependent via chronic morphine administration were examined. Changes in the population...

journal_title：Epilepsia

authors： Jafarzadeh Z,Fathollahi Y,Semnanian S,Omrani A,Salmanzadeh F,Salmani ME

更新日期：2009-04-01 00:00:00

abstract：:Genomic findings are emerging rapidly in 2 large, closely related epilepsy research consortia: the Epilepsy Phenome/Genome Project and Epi4K. Disclosure of individual results to participants in genomic research is increasingly viewed as an ethical obligation, but strategies for return of results were not included in t...

journal_title：Epilepsia

authors： Ottman R,Freyer C,Mefford HC,Poduri A,Lowenstein DH,Epilepsy Return of Results Workshop Participants.

更新日期：2018-09-01 00:00:00

abstract：:Six barbiturates with diverse time-action characteristics--thiopental, pentobarbital, butabarbital, phenobarbital, diphenylbarbiturate, and barbital--were evaluated for "anticonvulsant" and "neurotoxic" effects. For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s.c., and maximal sei...

journal_title：Epilepsia

authors： Raines A,Blake GJ,Richardson B,Gilbert MB

更新日期：1979-04-01 00:00:00

abstract：:The incidence of biochemical signs of vitamin D deficiency and the effects of vitamin D supplementation were investigated in 83 children and 95 adults on chronic antiepileptic therapy and 40 mentally retarded controls living under comparable conditions. Low 25-hydroxyvitamin D and serum calcium, and elevated immunorea...

journal_title：Epilepsia

authors： Offermann G,Pinto V,Kruse R

更新日期：1979-02-01 00:00:00

abstract：:Audiogenic seizure-prone mice (DBA/2J) were exposed to a broad band noise source. A reproducible response consisting of wild run, clonus, and tonic stages resulted in all mice. Layers 1 and pyramidal from the parietal cortex and the molecular and Purkinje cell-rich layers from the cerebellar vermis were separately ana...

journal_title：Epilepsia

authors： McCandless DW,Schwartzenburg FC Jr

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:Eyelid myoclonic jerks have been described in fixation-off-sensitive (FOS) epilepsy, but their relationship to nonconvulsive status epilepticus (NCSE) or to catamenial exacerbations is little reported. METHODS:We describe a woman of normal intelligence with catamenial periods of prolonged NCSE who exhibited va...

journal_title：Epilepsia

authors： Ming X,Kaplan PW

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:The posterior cingulate cortex (PCC)/precuneus is a key hub of the default mode network, whose function is known to be altered in epilepsy. Glutamate and γ-aminobutyric acid (GABA) are the main excitatory and inhibitory neurotransmitters in the central nervous system, respectively. Glutathione (GSH) is the mo...

journal_title：Epilepsia

authors： Gonen OM,Moffat BA,Desmond PM,Lui E,Kwan P,O'Brien TJ

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the influence of prior use of carbamazepine (CBZ) and other antiepileptic drugs (AEDs) with a putatively similar mechanism of action (inhibition of voltage-gated sodium channels; VGSCs) on seizure outcomes and tolerability when converting to eslicarbazepine acetate (ESL), using data pooled from 2 ...

journal_title：Epilepsia

authors： Pazdera L,Sperling MR,Harvey JH,Sam MC,Strom LA,Blum D,Grinnell T,Cheng H

更新日期：2018-03-01 00:00:00

abstract：:The purpose of the study was to examine the impact of idiopathic epilepsy on mothers and fathers in terms of strain, burden of care, worries and perception of vulnerability. Data were collected and analyzed shortly after the diagnosis (T0) and 12 months later (T1). The results indicated that at T0 parents of children ...

journal_title：Epilepsia

authors： Ramaglia G,Romeo A,Viri M,Lodi M,Sacchi S,Cioffi G

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:A large number of studies have highlighted the important role of the gut microbiota in the pathophysiology of neurological disorders, suggesting that its manipulation might serve as a treatment strategy. We hypothesized that the gut microbiota participates in absence seizure development and maintenance in the...

journal_title：Epilepsia

authors： Citraro R,Lembo F,De Caro C,Tallarico M,Coretti L,Iannone LF,Leo A,Palumbo D,Cuomo M,Buommino E,Nesci V,Marascio N,Iannone M,Quirino A,Russo R,Calignano A,Constanti A,Russo E,De Sarro G

更新日期：2021-01-11 00:00:00

abstract：:A 10-year-old boy developed febrile convulsions at age 2 years, and multiple types of nonfebrile generalized seizures over the ensuing months and years. Gestation, birth, and early development were normal, as were initial EEG and brain imaging studies. By age 5 years, he had developed behavioral difficulties, and the ...

journal_title：Epilepsia

authors： Grant AC,Vazquez B

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:We studied temporal changes of brain sodium and apparent diffusion coefficient (ADC) in a temporal lobe epilepsy (TLE) rat model using kainic acid (KA). METHODS:In situ three-dimensional 23Na magnetic resonance imaging (MRI) and proton diffusion-weighted imaging (DWI) were used. KA at a dose of 10 mg/kg body w...

journal_title：Epilepsia

authors： Wang Y,Majors A,Najm I,Xue M,Comair Y,Modic M,Ng TC

更新日期：1996-10-01 00:00:00

abstract：:The Asia-Oceanian region is the most populous region in the world. Although there has been substantial economic development and improvement in health services in recent years, epilepsy remains generally an underrecognized and understudied condition. To help promote research in the region, the Commission on Asian and O...

journal_title：Epilepsia

authors： Kwan P,Cabral-Lim L,D'Souza W,Jain S,Lee BI,Liao W,Lim SH,Otsuki T,Tan CT,Wantanabe M,CAOA Research Task Force.

更新日期：2015-05-01 00:00:00

abstract：:Posttraumatic epilepsy is a common complication of traumatic brain injury (TBI), occurring in up to 15-20% of patients with severe brain trauma. Trauma accounts for approximately 5% of chronic epilepsy in the community. Because it is a common condition, and because of the relatively short latency period between injury...

journal_title：Epilepsia

authors： Diaz-Arrastia R,Agostini MA,Madden CJ,Van Ness PC

更新日期：2009-02-01 00:00:00

abstract：:A 60-year-old patient had a 3-year history of recurrent memory disturbances. The video electroencephalographic (EEG) recording of one attack showed that the amnesic state, which clinically resembled transient global amnesia, was characterized by a normal EEG tracing followed by electroclinical complex partial seizures...

journal_title：Epilepsia

authors： Tassinari CA,Ciarmatori C,Alesi C,Cardinaletti L,Salvi F,Rubboli G,Plasmati R,Forti A,Michelucci R

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:In the last decade several studies have been published on incidence, etiology, and prognosis of status epilepticus (SE) with population-based data from the United States and Europe. The aim of this review is to summarize the available information on the epidemiology of SE and to outline the sources of the var...

journal_title：Epilepsia

authors： Logroscino G,Hesdorffer DC,Cascino G,Hauser WA,Coeytaux A,Galobardes B,Morabia A,Jallon P

更新日期：2005-01-01 00:00:00