Audiogenic seizure-induced changes in energy metabolites in cerebral cortical and cerebellar layers.

abstract：:Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviora...

journal_title：Epilepsia

authors： Remler MP,Marcussen WH

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:Previous validation studies assessing the use of administrative data to identify patients with epilepsy have used targeted sampling or have used a reference standard of patients in the neurologist, hospital, or emergency room setting. Therefore, the validity of using administrative data to identify patients w...

journal_title：Epilepsia

authors： Tu K,Wang M,Jaakkimainen RL,Butt D,Ivers NM,Young J,Green D,Jetté N

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:Previous studies of patient-reported seizure precipitants have not evaluated whether different epilepsy syndromes are differentially affected. METHODS:Patients of a tertiary-care epilepsy center were consecutively surveyed with the use of a standardized questionnaire that lists precipitants that might trigger ...

journal_title：Epilepsia

authors： Frucht MM,Quigg M,Schwaner C,Fountain NB

更新日期：2000-12-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of lamotrigine (LTG), a new antiepileptic drug (AED), were studied in healthy volunteers. In an open dose-escalating study, LTG 240 mg produced peak plasma concentrations of around 3 micrograms/mg with no significant adverse events. Subsequent pharmacokinetic studies revealed ...

journal_title：Epilepsia

authors： Peck AW

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To characterize the epileptogenic zone in neocortical epilepsy (NE) by using magnetoencephalography (MEG). METHODS:We defined and compared locations of single and multiple clusters of equivalent current dipoles (ECDs) for interictal spikes with MRI findings, ictal-onset zones (IOZs) from subdural electroenceph...

journal_title：Epilepsia

authors： Oishi M,Kameyama S,Masuda H,Tohyama J,Kanazawa O,Sasagawa M,Otsubo H

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:We used a model of self-staining status epilepticus (SSSE), induced by brief intermittent stimulation of the perforant path in unanesthetized rats, to study the mechanism of initiation and of maintenance of SSSE and the role of neuropeptides in those processes. METHODS:The perforant path was stimulated intermi...

journal_title：Epilepsia

authors： Wasterlain CG,Mazarati AM,Naylor D,Niquet J,Liu H,Suchomelova L,Baldwin R,Katsumori H,Shirasaka Y,Shin D,Sankar R

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To evaluate safety and tolerability of ketogenic diet (KGD) and valproate (VPA) cotherapy in the treatment of intractable seizures. METHODS:The patient records of children who underwent KGD initiation at the Massachusetts General Hospital for Children from February 2002 to September 2004 were retrospectively a...

journal_title：Epilepsia

authors： Lyczkowski DA,Pfeifer HH,Ghosh S,Thiele EA

更新日期：2005-09-01 00:00:00

abstract：:Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study. Twenty-two individuals in a population of 359 persons with neurofibromatos 1 (NF1) had had one or more seizures. Age at first seizure ranged from 4 days to > 20 years. Patients were classified into ...

journal_title：Epilepsia

authors： Korf BR,Carrazana E,Holmes GL

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:To evaluate the changes in serum sex hormones of gonadal or adrenal origin, the gonadotropic hormones, and sex hormone-binding globulin (SHBG) in men and women with chronic temporal lobe epilepsy (TLE), who are undergoing monotherapy with carbamazepine or receiving carbamazepine in combination with other antico...

journal_title：Epilepsia

authors： Stoffel-Wagner B,Bauer J,Flügel D,Brennemann W,Klingmüller D,Elger CE

更新日期：1998-11-01 00:00:00

abstract：:We examined postoperative changes in the memory function of 68 people with unilateral hippocampal sclerosis (HS) who underwent epilepsy surgery and had no previous clinical memory impairments. One in four with right HS (RHS) and one in five with left HS (LHS) in our sample of 323 people with unilateral HS performed wi...

journal_title：Epilepsia

authors： Baxendale S,Thompson PJ,Sander JW

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:The novel antiepileptic drug (AED) levetiracetam (LEV; Keppra) has a wide therapeutic index and pharmacokinetic characteristics predicting limited drug-interaction potential. It is indicated as an add-on treatment in patients with epilepsy, and thus coadministration with valproic acid (VPA) is likely. These stu...

journal_title：Epilepsia

authors： Coupez R,Nicolas JM,Browne TR

更新日期：2003-02-01 00:00:00

abstract：:The mechanism by which animals develop tolerance to the antiepileptic effects of the carbonic anhydrase (CA) inhibitor, acetazolamide, was explored using a quantitative immunocytochemical method. Cerebral cortex sections of DBA/2J mice susceptible to audiogenic seizures and of C57BL/6J nonsusceptible mice were stained...

journal_title：Epilepsia

authors： Banks DA,Anderson RE,Woodbury DM

更新日期：1986-09-01 00:00:00

abstract：:Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed before 1980 appear to act on sodium channels, gamma-aminobutyric acid type A (GABAA) receptors, or calcium channels. Benzodiazepines and barbiturates enhance GABAA recept...

journal_title：Epilepsia

authors： Macdonald RL,Kelly KM

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Nonconvulsive status epilepticus (NCSE) is an under-recognized cause of altered mental status. There are hardly any reported data on NCSE in developing countries. MATERIAL AND METHODS:Prospectively 210 consecutive patients with altered mental status admitted to neurological intensive care unit (NICU) of a tert...

journal_title：Epilepsia

authors： Narayanan JT,Murthy JM

更新日期：2007-05-01 00:00:00

abstract：:Severe Myoclonic Epilepsy in infancy (SMEI, or Dravet syndrome) is a drug-resistant epilepsy that occurs in the first year of life of previously healthy children. The main clinical features are prolonged and repeated febrile and afebrile generalized or unilateral convulsive seizures. In the course of the epilepsy, cog...

journal_title：Epilepsia

authors： Wolff M,Cassé-Perrot C,Dravet C

更新日期：2006-01-01 00:00:00

abstract：:We examined auto-correlation and interval distribution characteristics of neuronal discharge from patients with complex partial seizures. The objective was to compare the interictal firing patterns of neurons in mesial temporal structures ipsilateral to the site of seizure onset with firing patterns of neurons in homo...

journal_title：Epilepsia

authors： Colder BW,Frysinger RC,Wilson CL,Harper RM,Engel J Jr

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVES:To identify risk and risk factors for developing a subsequent febrile seizure (FS) in children with a first febrile status epilepticus (FSE) compared to a first simple febrile seizure (SFS). To identify home use of rescue medications for subsequent FS. METHODS:Cases included a first FS that was FSE drawn fr...

journal_title：Epilepsia

authors： Hesdorffer DC,Shinnar S,Lax DN,Pellock JM,Nordli DR Jr,Seinfeld S,Gallentine W,Frank LM,Lewis DV,Shinnar RC,Bello JA,Chan S,Epstein LG,Moshé SL,Liu B,Sun S,FEBSTAT study team.

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To induce status epilepticus (SE) followed by the subsequent onset of spontaneous recurrent seizures, thus characterizing a new model of temporal lobe epilepsy in a nonhuman primate. METHODS:Male and female marmosets (Callithrix jacchus) (n = 18), ages between 2 and 8 years, were injected with domoic acid (0.5...

journal_title：Epilepsia

authors： Perez-Mendes P,Cinini SM,Medeiros MA,Tufik S,Mello LE

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Nitric oxide (NO), a short-lived radical synthesized from L-arginine by activation of the enzyme nitric oxide synthase (NOS), has been implicated in the pathophysiology of epilepsy by some investigators. However, the current data about NO and NOS in epilepsy are controversial and are derived only from animal mo...

journal_title：Epilepsia

authors： González-Hernández T,García-Marín V,Pérez-Delgado MM,González-González ML,Rancel-Torres N,González-Feria L

更新日期：2000-10-01 00:00:00

abstract：:Autoantibodies to surface proteins that influence neuronal excitability are increasingly found in different forms of epilepsy or encephalitis in adults, and are also beginning to be identified in children. The conditions are often refractory to traditional antiepileptic drugs. Detection of these antibodies can help to...

journal_title：Epilepsia

authors： Vincent A,Irani SR,Lang B

更新日期：2011-10-01 00:00:00

abstract：:Twenty-seven patients with medically refractory paroxysmal disorders underwent EEG-video-audio (EVA) monitoring in an inpatient neurology-neurosurgery unit over 1-15 (mean 8.9) days. Fast visual review of all EEG records (5,784 h) and subsequent analysis of synchronized EVA patterns demonstrated a total of 208 partial...

journal_title：Epilepsia

authors： Pierelli F,Chatrian GE,Erdly WW,Swanson PD

更新日期：1989-09-01 00:00:00

abstract：:We report three cases of reflex epilepsy with myoclonic jerks of the right arm and fingers precipitated by calculation using a Soroban. An EEG spike-wave complex with left central prevalence was induced. Various types of stimulation were used to induce epileptic discharges, and a simultaneous mental task requiring a h...

journal_title：Epilepsia

authors： Yamamoto J,Egawa I,Yamamoto S,Shimizu A

更新日期：1991-01-01 00:00:00

abstract：:Seizures cannot be medically controlled in approximately 40% of people with epilepsy. Although we are beginning to understand how to better treat certain seizure types, we still do not know the regulatory events that determine antiepileptic drug resistance. Proposed pathoetiologic mechanisms include altered expression...

journal_title：Epilepsia

authors： Kobow K,El-Osta A,Blümcke I

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:To evaluate the pharmacokinetics and safety of multiple oral doses of tiagabine HCl in subjects with different degrees of hepatic impairment. METHODS:Four subjects with mild hepatic impairment, three subjects with moderate hepatic impairment, and six matched normal subjects received twice daily oral tiagabine ...

journal_title：Epilepsia

authors： Lau AH,Gustavson LE,Sperelakis R,Lam NP,El-Shourbagy T,Qian JX,Layden T

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:The rat electrical amygdala kindling model is one of the most widely studied animal models of temporal lobe epilepsy (TLE); however, the processes underlying epileptogenesis in this model remain incompletely understood. Magnetic resonance imaging (MRI) is a powerful method to investigate epileptogenesis, allowi...

journal_title：Epilepsia

authors： Jupp B,Williams JP,Tesiram YA,Vosmansky M,O'Brien TJ

更新日期：2006-01-01 00:00:00

abstract：:Homocysteine thiolactone (HTL) elicits seizures in mice at a dose of 850 mg/kg (95-100% of animals) with an average latency time of 19.5 min. These seizures are reversed by both 5' N-ethylcarboximide adenosine (NECA) and flunitrazepam, with respective ED50 doses of 0.025 and 0.20 mg/kg. NECA was approximately four-fol...

journal_title：Epilepsia

authors： Marangos PJ,Loftus T,Wiesner J,Lowe T,Rossi E,Browne CE,Gruber HE

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients. METHODS:In this prospective case series, 17 patients with drug-resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 wi...

journal_title：Epilepsia

authors： Rolinski R,Austermuehle A,Wiggs E,Agrawal S,Sepeta LN,Gaillard WD,Zaghloul KA,Inati SK,Theodore WH

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Identifying adverse outcomes and examining trends and causes of nonelective admissions among persons with epilepsy would be beneficial to optimize patient care and reduce health services utilization. We examined the association of epilepsy with discharge status, in-hospital mortality, length-of-stay, and char...

journal_title：Epilepsia

authors： Kwon CS,Wong B,Agarwal P,Lin JY,Mazumdar M,Dhamoon M,Jetté N

更新日期：2020-09-01 00:00:00

abstract：:Epileptic seizures and pseudoseizures in temporal lobe epilepsies were studied from the viewpoint of the hierarchy of consciousness. Twenty-two patients with temporal lobe epilepsies (TLE) who showed true amnesia or impairment of consciousness developing from the dreamy state, even though their actions and movement co...

journal_title：Epilepsia

authors： Oana Y

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:We report on a quantitative analysis of data from a study that acquired continuous long-term ambulatory human electroencephalography (EEG) data over extended periods. The objectives were to examine the seizure duration and interseizure interval (ISI), their relationship to each other, and the effect of these ...

journal_title：Epilepsia

authors： Cook MJ,Karoly PJ,Freestone DR,Himes D,Leyde K,Berkovic S,O'Brien T,Grayden DB,Boston R

更新日期：2016-03-01 00:00:00