Levetiracetam, a new antiepileptic agent: lack of in vitro and in vivo pharmacokinetic interaction with valproic acid.

abstract：PURPOSE:Eyelid myoclonic jerks have been described in fixation-off-sensitive (FOS) epilepsy, but their relationship to nonconvulsive status epilepticus (NCSE) or to catamenial exacerbations is little reported. METHODS:We describe a woman of normal intelligence with catamenial periods of prolonged NCSE who exhibited va...

journal_title：Epilepsia

authors： Ming X,Kaplan PW

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:The multidrug resistance (mdr) gene family encodes the drug transport macromolecule P-glycoprotein (P-gp), which contributes to the functionality of the blood-brain barrier. Recent evidence suggests that P-gp-mediated drug extrusion may play a facilitatory role in refractory epilepsy. We investigated the region...

journal_title：Epilepsia

authors： Kwan P,Sills GJ,Butler E,Gant TW,Meldrum BS,Brodie MJ

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To examine antiepileptogenic and antiictogenic potential of retigabine (RTG) under conditions of rapid kindling epileptogenesis during different stages of development. METHODS:The experiments were performed in postnatal day 14 (P14), P21, and P35 male Wistar rats. After stereotaxic implantation of hippocampal ...

journal_title：Epilepsia

authors： Mazarati A,Wu J,Shin D,Kwon YS,Sankar R

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Decline in verbal memory as a surgical complication remains an unresolved problem in mesial temporal lobe epilepsy. Some areas in the temporal lobe associated with the language function, often including the basal temporal language area, have been removed or transected by conventional surgical procedures. The au...

journal_title：Epilepsia

authors： Mikuni N,Miyamoto S,Ikeda A,Satow T,Taki J,Takahashi J,Ohigashi Y,Hashimoto N

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:Health-related quality of life (HRQOL) is an important indicator of well-being in patients with epilepsy. When assessing changes in HRQOL over time, some of the changes observed may be due to the patients' change in the internal standards, value, or meaning that they attribute to the HRQOL domain being measu...

journal_title：Epilepsia

authors： Sajobi TT,Fiest KM,Wiebe S

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:To study the mechanisms of startle-induced supplementary sensorimotor area (SSMA) seizures. METHODS:We present a patient investigated with indwelling subdural grid electrodes covering both the SSMA and the dorsolateral frontal lobe. RESULTS:We found a simultaneous seizure onset in the right dorsolateral premo...

journal_title：Epilepsia

authors： Serles W,Leutmezer F,Pataraia E,Olbrich A,Gröppel G,Czech T,Baumgartner C

更新日期：1999-07-01 00:00:00

abstract：:A case of Rasmussen encephalitis with bilateral involvement and onset at age 2 years is reviewed. Rasmussen encephalitis is a rare progressive disease that causes intractable seizures, cognitive decline, and inflammatory changes in the brain. The neurologic involvement is characteristically unilateral. Bilateral invol...

journal_title：Epilepsia

authors： Tobias SM,Robitaille Y,Hickey WF,Rhodes CH,Nordgren R,Andermann F

更新日期：2003-01-01 00:00:00

abstract：:The possibility of sudden unexpected death in epilepsy (SUDEP) should affect the management of virtually every patient with proven or suspected epilepsy by (a) underlining the need to make all reasonable efforts to render each patient seizure-free; (b) emphasizing the importance of minimizing avoidable seizures; (c) b...

journal_title：Epilepsia

authors： Fish DR

更新日期：1997-11-01 00:00:00

abstract：:The teratological effect of nicotine has been studied during different trimesters of pregnancy. Three groups of pregnant albino Swiss mice were used for each trimester. The daily doses of nicotine base used were equivalent to 10 (900 micrograms/kg), 20 (1,800 micrograms/kg), or 30 (2,700 micrograms/kg) cigarettes. The...

journal_title：Epilepsia

authors： Al-Hachim GM,Mahmoud FA

更新日期：1985-11-01 00:00:00

abstract：:The combination of phenobarbital (PB) and phenytoin (PHT) was recommended for many years for treatment of epilepsy in humans. We tested the effectiveness of the combination in a model of hippocampal seizures termed maximal dentate activation (MDA). Two parameters of MDA were measured: duration and time to onset. Neith...

journal_title：Epilepsia

authors： Stringer JL,Higgins MG

更新日期：1994-01-01 00:00:00

abstract：:The 1981 International Classification of Epileptic Seizures (ICES) was used to study the distribution of seizure types in 1,250 patients attending an Epilepsy Clinic in Sri Lanka. Based on seizure symptomatology 94.6% of the cases could be classified, and by adding the routine interictal EEG findings the percentage of...

journal_title：Epilepsia

authors： Senanayake N

更新日期：1993-09-01 00:00:00

abstract：:Fifteen children (7 boys and 8 girls) with generalized tonic-clonic seizures (GTCS) and partial seizures with elementary or complex symptomatology, treated with carbamazepine (CBZ) alone (n = 7) or in combination with either phenobarbital (PB, n = 6) or clobazam (CLB, n = 2) given for at least 3 months at stable indiv...

journal_title：Epilepsia

authors： Cornaggia C,Gianetti S,Battino D,Granata T,Romeo A,Viani F,Limido G

更新日期：1993-01-01 00:00:00

abstract：:Two healthy male volunteers received 10 mg carbamazepine (CBZ) as a 2-h constant-rate intravenous (i.v.) infusion and 100 mg 15N-labeled CBZ as a 2% oral suspension, concomitantly. The two compounds have identical pharmacokinetics. Their respective concentrations in plasma were determined by gas chromatography-mass sp...

journal_title：Epilepsia

authors： Gérardin A,Dubois JP,Moppert J,Geller L

更新日期：1990-05-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults. TLE has a high chance of becoming medically refractory, and as such, is frequently considered for further evaluation and surgical intervention. Up to 30% of TLE cases, however, can have normal ("nonlesional" or negative) magnetic resonance imagi...

journal_title：Epilepsia

authors： Muhlhofer W,Tan YL,Mueller SG,Knowlton R

更新日期：2017-05-01 00:00:00

abstract：:Two patients developed clinical and laboratory evidence of systemic lupus erythematosus (SLE) during treatment with valproate (VPA) preparations. The first patient, a 47-year-old man, had fever, malaise, and thrombocytopenia 1 month after VPA was added to phenytoin (PHT) and primidone (PRM). He developed high titers o...

journal_title：Epilepsia

authors： Bleck TP,Smith MC

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To investigate brain electrical activity in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene, and to evaluate the efficacy of low frequency deep brain stimulation (DBS) for seizure frequency reduction. METHODS:Electroencephalography (EEG), elect...

journal_title：Epilepsia

authors： Kile KB,Tian N,Durand DM

更新日期：2010-09-01 00:00:00

abstract：:In 45 patients suffering from secondary generalized epilepsy, we have recorded 239 drop seizures both by radio-telemetered EEG/split-screen video taping and polygraphically. Twenty of these patients had pure tonic drop seizures. Nine patients each had myoclonic-atonic or pure atonic seizures, whereas seven had slow fa...

journal_title：Epilepsia

authors： Egli M,Mothersill I,O'Kane M,O'Kane F

更新日期：1985-09-01 00:00:00

abstract：:Brain stimulation is currently used as an experimental treatment for patients with medically refractory epilepsy. However, the results of such stimulation are still less than optimal. A major factor is the lack of understanding of the mechanisms of applied stimuli. Herein we review evidence on the effects of stimulati...

journal_title：Epilepsia

authors： Jiruska P,Powell AD,Deans JK,Jefferys JG

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The antiepileptic drug (AED) vigabatrin (VGB), which exerts its pharmacologic effects on the gamma-aminobutyric acid (GABA) system, causes concentric visual field constriction in >40% of exposed adults. This may be a class effect of all agents with GABA-related mechanisms of action. We compared the concentratio...

journal_title：Epilepsia

authors： Sills GJ,Butler E,Forrest G,Ratnaraj N,Patsalos PN,Brodie MJ

更新日期：2003-07-01 00:00:00

abstract：:Cortical dysplasia (CD, also known as malformations of cortical development) are the pathological substrates in a large percentage of patients with pharmacoresistant epilepsy who may be amenable to surgical treatment. Therefore, research on the mechanisms of dysplastic lesion formation and epileptogenicity is of param...

journal_title：Epilepsia

authors： Najm IM,Tilelli CQ,Oghlakian R

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The medical benefits of epilepsy surgery are well documented, but the psychosocial consequences of surgery have received less attention. This is especially true of the roles of expectations and satisfaction in postsurgery functioning. The present study was designed to examine the relationships between expectati...

journal_title：Epilepsia

authors： Wheelock I,Peterson C,Buchtel HA

更新日期：1998-05-01 00:00:00

abstract：:Fibroblast growth-factor homologous factor (FHF1) gene variants have recently been associated with developmental and epileptic encephalopathy (DEE). FHF1 encodes a cytosolic protein that modulates neuronal sodium channel gating. We aim to refine the electroclinical phenotypic spectrum of patients with pathogenic FHF1 ...

journal_title：Epilepsia

authors： Trivisano M,Ferretti A,Bebin E,Huh L,Lesca G,Siekierska A,Takeguchi R,Carneiro M,De Palma L,Guella I,Haginoya K,Shi RM,Kikuchi A,Kobayashi T,Jung J,Lagae L,Milh M,Mathieu ML,Minassian BA,Novelli A,Pietrafusa N,T

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Through international collaboration, we evaluated the phenotypic aspects of a multiethnic cohort of KCNT1-related epilepsy and explored genotype-phenotype correlations associated with frequently encountered variants. METHODS:A cross-sectional analysis of children harboring pathogenic or likely pathogenic KCN...

journal_title：Epilepsia

authors： Borlot F,Abushama A,Morrison-Levy N,Jain P,Puthenveettil Vinayan K,Abukhalid M,Aldhalaan HM,Almuzaini HS,Gulati S,Hershkovitz T,Konanki R,Lingappa L,Luat AF,Shafi S,Tabarki B,Thomas M,Yoganathan S,Alfadhel M,Arya R,

更新日期：2020-04-01 00:00:00

abstract：:The feasibility of automated detection of cortical-onset epileptic seizures from subcortical structures such as the thalamus was investigated via simultaneous recording of electroencephalography (EEG) and anterior and centromedian thalamic nuclei electrical signals (electrothalamography) in nine subjects with pharmaco...

journal_title：Epilepsia

authors： Osorio I,Frei MG,Lozano AM,Wennberg R

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:The AY-9944 (AY)-treated rat is a reproducible and clinically relevant animal model of atypical absence seizures. AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absence seizures has not been determined. METHODS:Long-Evans hooded rats were treated...

journal_title：Epilepsia

authors： Cortez MA,Cunnane SC,Snead OC 3rd

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Diacylglycerol kinase epsilon (DGKepsilon) regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis. ...

journal_title：Epilepsia

authors： Musto A,Bazan NG

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:The hippocampus is one of the principal target areas for neurosteroidal action, and the major neuroendocrine conversion of progesterone appears to be 5alpha-reduction and 3alpha-hydroxysteroid oxidoreduction, leading to the potent neurosteroid 3alpha,5alpha-tetrahydroxyprogesterone. To investigate whether the h...

journal_title：Epilepsia

authors： Stoffel-Wagner B,Beyenburg S,Watzka M,Blümcke I,Bauer J,Schramm J,Bidlingmaier F,Elger CE

更新日期：2000-02-01 00:00:00

abstract：:The effects of cannabidiol (CBD) on electrically evoked kindled seizures were studied in conscious, unrestrained rats with chronically implanted cortical and limbic electrodes, and the results were compared with those of delta 9-tetrahydrocannabinol (delta 9-THC), phenytoin (PHT), and ethosuximide (ESM). All drugs wer...

journal_title：Epilepsia

authors： Turkanis SA,Smiley KA,Borys HK,Olsen DM,Karler R

更新日期：1979-08-01 00:00:00

abstract：PURPOSE:Effects of pre- and postsynaptic γ-aminobutyric acid B (GABA(B)) receptor activation were characterized in human tissue from epilepsy surgery. METHODS:Slices of human cortical tissue were investigated in a submerged-type chamber with intracellular recordings in layers II/III. Parallel experiments were performe...

journal_title：Epilepsia

authors： Teichgräber LA,Lehmann TN,Meencke HJ,Weiss T,Nitsch R,Deisz RA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:With intraperitoneal N-methyl-D-aspartate (NMDA; 15-200 mg/kg) administration, we attempted to develop an animal model of age-specific West syndrome to serve for testing of putative anticonvulsant drugs and to determine the mechanisms of this disorder. METHODS:Experiments were performed in 12-, 18-, and 60-day...

journal_title：Epilepsia

authors： Kábová R,Liptáková S,Slamberová R,Pometlová M,Velísek L

更新日期：1999-10-01 00:00:00