An electrophysiological analysis of the anticonvulsant action of cannabidiol on limbic seizures in conscious rats.

abstract：:Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

journal_title：Epilepsia

authors： Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

更新日期：2009-08-01 00:00:00

abstract：:The purpose of this study was to determine whether seizure frequency and cycle days with seizure occurrence vary across the menstrual cycle. The subjects were the first 100 women with intractable focal onset seizures, 13-45 years old, who completed the baseline phase of the National Institutes of Health (NIH) Progeste...

journal_title：Epilepsia

authors： Herzog AG,Fowler KM,Sperling MR,Massaro JM,Progesterone Trial Study Group.

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To investigate brain electrical activity in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene, and to evaluate the efficacy of low frequency deep brain stimulation (DBS) for seizure frequency reduction. METHODS:Electroencephalography (EEG), elect...

journal_title：Epilepsia

authors： Kile KB,Tian N,Durand DM

更新日期：2010-09-01 00:00:00

abstract：:The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In a rat model, we established a mechanism for SUDEP that involves seizure-induced laryngospasm and obstructive apnea lasting until respiratory arrest. ...

journal_title：Epilepsia

authors： Irizarry R,Sukato D,Kollmar R,Schild S,Silverman J,Sundaram K,Stephenson S,Stewart M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:To determine if the clinical characteristics of nonepileptic seizures (NES) are different in children younger than 13 years age as compared to adolescents. METHODS:Retrospective review of medical records and video-EEGs (VEEG) of all patients with NES confirmed on VEEG monitoring was performed. RESULTS:Sixty-e...

journal_title：Epilepsia

authors： Patel H,Scott E,Dunn D,Garg B

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:Patients with medial temporal lobe epilepsy (MTLE) exhibit structural brain damage involving gray matter (GM) and white matter (WM). The mechanisms underlying tissue loss in MTLE are unclear and may be associated with a combination of seizure excitotoxicity and WM vulnerability. The goal of this study was to in...

journal_title：Epilepsia

authors： Lee CY,Tabesh A,Benitez A,Helpern JA,Jensen JH,Bonilha L

更新日期：2013-10-01 00:00:00

abstract：:Differentiation between psychogenic nonepileptic seizures (PNES) and generalized convulsive epileptic seizures (ES) is important for appropriate triaging in the emergency department (ED). This can be difficult in the ED, as the event is often not witnessed by a medical professional. In the current study, we investigat...

journal_title：Epilepsia

authors： Li Y,Matzka L,Maranda L,Weber D

更新日期：2017-09-01 00:00:00

abstract：:Rufinamide (RUF) is a novel antiepileptic drug considered as second-line therapy in the treatment of Lennox-Gastaut syndrome. Treatment-emergent adverse events (AEs) have consisted mainly of drowsiness, irritability, vomiting, and loss of appetite. RUF is considered as a "weight-neutral" drug. We found clinically sign...

journal_title：Epilepsia

authors： Mourand I,Crespel A,Gelisse P

更新日期：2013-01-01 00:00:00

abstract：:Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many of these patients experience significant impairments in quality of life (QOL) in physical, mental, and social dimensions of health. In this study, we measur...

journal_title：Epilepsia

authors： Rosenberg EC,Louik J,Conway E,Devinsky O,Friedman D

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:The posterior cingulate cortex (PCC)/precuneus is a key hub of the default mode network, whose function is known to be altered in epilepsy. Glutamate and γ-aminobutyric acid (GABA) are the main excitatory and inhibitory neurotransmitters in the central nervous system, respectively. Glutathione (GSH) is the mo...

journal_title：Epilepsia

authors： Gonen OM,Moffat BA,Desmond PM,Lui E,Kwan P,O'Brien TJ

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Initial identification of new investigational drugs for the treatment of epilepsy is commonly conducted in well-established mouse acute and chronic seizure models: for example, maximal electroshock (MES), 6 Hz, and corneal kindling. Comparison of the median effective dose (ED50) of approved antiseizure drugs ...

journal_title：Epilepsia

authors： Koneval Z,Knox KM,Memon A,Zierath DK,White HS,Barker-Haliski M

更新日期：2020-09-01 00:00:00

abstract：:We report the history of a 14-year-old girl with atypical childhood occipital epilepsy "Gastaut type" whose first generalized tonic-clonic seizure was preceded by migraine without aura and followed by a status migrainosus. This status lasted for 3 days despite standard analgesic therapy. An EEG recording revealed an o...

journal_title：Epilepsia

authors： Parisi P,Kasteleijn-Nolst Trenité DG,Piccioli M,Pelliccia A,Luchetti A,Buttinelli C,Villa MP

更新日期：2007-11-01 00:00:00

abstract：:The Epilepsy Association of Maryland, an affiliate of the Epilepsy Foundation of America (EFA), recognized that the Maryland state regulations and laws on driving licensing restricted the rights of individuals with epilepsy. After identifying the problem, the Association determined the needed changes and planned a leg...

journal_title：Epilepsia

authors： Kingham LA

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:We review what is currently known about functional and morphologic plasticity of hippocampal neuronal circuits in animal epilepsy models. RESULTS:Perforant-path kindling has been shown to enhance excitatory synaptic transmission in the dentate gyrus significantly, and this enhancement has lasted for > or =1 mo...

journal_title：Epilepsia

authors： Maru E,Kanda M,Ashida H

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:The interictal and ictal EEG activity in the basal ganglia in patients with temporal lobe epilepsy were studied during invasive EEG monitoring. METHODS:Eight epilepsy surgery candidates, each with a proven mesiotemporal seizure-onset zone, participated in the study. We used two invasive EEG methods to determin...

journal_title：Epilepsia

authors： Rektor I,Kuba R,Brázdil M

更新日期：2002-03-01 00:00:00

abstract：:The Boston Naming Test (BNT) is often used in the evaluation of surgical epilepsy patients to assess left temporal lobe function. In 2005, Busch et al. demonstrated the diagnostic utility of the BNT in predicting ultimate side of surgery in patients with temporal lobe epilepsy. BNT raw score significantly predicted ul...

journal_title：Epilepsia

authors： Busch RM,Frazier TW,Iampietro MC,Chapin JS,Kubu CS

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the efficacy of acute and chronic vagus nerve stimulation (VNS) in genetic absence epilepsy rats from Strasbourg (GAERS). This is a validated model for absence epilepsy, characterized by frequent spontaneous absences concomitant with spike and wave discharges (SWD) on the E...

journal_title：Epilepsia

authors： Dedeurwaerdere S,Vonck K,Van Hese P,Wadman W,Boon P

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS). METHODS:In 12 children and adolescents with CPS and 23 age- and gender-matched healthy controls, we ac...

journal_title：Epilepsia

authors： O'Neill J,Seese R,Hudkins M,Siddarth P,Levitt J,Tseng PB,Wu KN,Gurbani S,Shields WD,Caplan R

更新日期：2011-09-01 00:00:00

abstract：:Two groups of adult outpatients (n = 19 and n = 21) with poorly controlled epilepsy and significant psychological disorder, assessed in terms of rating scales, received two psychological treatments in a balanced cross-over design after stable baseline seizure frequency had been established. A third group (n = 19), who...

journal_title：Epilepsia

authors： Gillham RA

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:In patients with mesial temporal lobe epilepsy (MTLE) it remains an unresolved issue whether the interictal decrease in N-acetyl aspartate (NAA) detected by proton magnetic resonance spectroscopy ((1)H-MRS) reflects the epilepsy-associated loss of hippocampal pyramidal neurons or metabolic dysfunction. METHODS...

journal_title：Epilepsia

authors： Vielhaber S,Niessen HG,Debska-Vielhaber G,Kudin AP,Wellmer J,Kaufmann J,Schönfeld MA,Fendrich R,Willker W,Leibfritz D,Schramm J,Elger CE,Heinze HJ,Kunz WS

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:High-dose i.v. opioids (e.g., alfentanil, 50 microg/kg bolus) are known to increase the intraoperative reading of epileptiform activity during epilepsy surgery (ES), thereby facilitating localization of the epileptogenic zone (i.e., the site of ictal onset and initial seizure propagation). However, this phenome...

journal_title：Epilepsia

authors： Wass CT,Grady RE,Fessler AJ,Cascino GD,Lozada L,Bechtle PS,Marsh WR,Sharbrough FW,Schroeder DR

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVES:To identify risk and risk factors for developing a subsequent febrile seizure (FS) in children with a first febrile status epilepticus (FSE) compared to a first simple febrile seizure (SFS). To identify home use of rescue medications for subsequent FS. METHODS:Cases included a first FS that was FSE drawn fr...

journal_title：Epilepsia

authors： Hesdorffer DC,Shinnar S,Lax DN,Pellock JM,Nordli DR Jr,Seinfeld S,Gallentine W,Frank LM,Lewis DV,Shinnar RC,Bello JA,Chan S,Epstein LG,Moshé SL,Liu B,Sun S,FEBSTAT study team.

更新日期：2016-07-01 00:00:00

abstract：:To improve the diagnostic accuracy of electroencephalography (EEG) criteria for nonconvulsive status epilepticus (NCSE), external validation of the recently proposed Salzburg criteria is paramount. We performed an external, retrospective, diagnostic accuracy study of the Salzburg criteria, using EEG recordings from pa...

journal_title：Epilepsia

authors： Goselink RJM,van Dillen JJ,Aerts M,Arends J,van Asch C,van der Linden I,Pasman J,Saris CGJ,Zwarts M,van Alfen N

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Most people in the world with epilepsy are untreated with antiepileptic drugs (AEDs). In some developing countries, this is because treatment facilities are unavailable or difficult to access. It has even been suggested that indigenous health systems threaten the prospect of the global control of epilepsy with ...

journal_title：Epilepsia

authors： Pal DK,Das T,Sengupta S,Chaudhury G

更新日期：2002-08-01 00:00:00

abstract：:Infantile spasms begin in a very active phase of brain development. The new neuropathological techniques have shed light on changes in the fine structure of brain in children with infantile spasms. An understanding of the action of adrenocorticotropic hormone on the biochemistry and development of the brain provides, ...

journal_title：Epilepsia

authors： Riikonen R

更新日期：1983-04-01 00:00:00

abstract：PURPOSE:Previous neuroimaging studies provide growing evidence that patients with juvenile myoclonic epilepsy (JME) have both structural and functional abnormalities of the thalamus and frontal lobe gray matter. However, limited data are available regarding the issue of white matter (WM) involvement, making the microst...

journal_title：Epilepsia

authors： Kim JH,Suh SI,Park SY,Seo WK,Koh I,Koh SB,Seol HY

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3-0.9% of the world's population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy. METHODS:We performed literature search...

journal_title：Epilepsia

authors： Johnson EL,Kaplan PW

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To compare the risks of fetal malformation during pregnancy associated with antiepileptic drug (AED) polytherapy and monotherapy. METHODS:Statistical analysis of malformation rate and antiepileptic drug exposure data from the Australian Register of Antiepileptic Drugs in Pregnancy, and from the literature. RE...

journal_title：Epilepsia

authors： Vajda FJ,Hitchcock AA,Graham J,O'Brien TJ,Lander CM,Eadie MJ

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Trials of antiepileptic medications are usually based in tertiary referral centers with teaching hospital resources. Epilepsy Research & Services (ERS) is part of a private outpatient neurological clinic that is involved in research as part of multicenter clinical trials, adhering to Good Clinical Research Prac...

journal_title：Epilepsia

authors： Beran RG,Beran ME

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform ...

journal_title：Epilepsia

authors： Nissen IA,Stam CJ,Reijneveld JC,van Straaten IE,Hendriks EJ,Baayen JC,De Witt Hamer PC,Idema S,Hillebrand A

更新日期：2017-01-01 00:00:00