Functional and morphological changes in the hippocampal neuronal circuits associated with epileptic seizures.

abstract：PURPOSE:Despite the reported diagnostic value of the intracarotid amobarbital procedure (IAP) or "Wada test" for determining hemispheric lateralization and memory functioning, it has never undergone formal reliability testing because a prospective test-retest study design is neither feasible nor ethical. However, some ...

journal_title：Epilepsia

authors： Whitman LA,Morrison CE,Becske T,Barr WB,Carlson C

更新日期：2012-04-01 00:00:00

abstract：:The in vitro effects of four antiepileptic drugs (AEDs) on human sperm motility were studied with a transmembrane migration method. Sperm motility of epileptic patients receiving chronic AED therapy was also investigated. Sperm motility was measured immediately after semen had been mixed with AED and after a 2-h prein...

journal_title：Epilepsia

authors： Chen SS,Shen MR,Chen TJ,Lai SL

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes. METHODS:We retrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analys...

journal_title：Epilepsia

authors： Loesch AM,Steger H,Losher C,Hartl E,Rémi J,Vollmar C,Noachtar S

更新日期：2017-09-01 00:00:00

abstract：:The fragile X mental retardation 1 gene (Fmr1) is polymorphic for CGG trinucleotide repeat number in the 5'-untranslated region, with repeat lengths <45 associated with typical development and repeat lengths >200 resulting in hypermethylation and transcriptional silencing of the gene and mental retardation in the frag...

journal_title：Epilepsia

authors： Berman RF,Murray KD,Arque G,Hunsaker MR,Wenzel HJ

更新日期：2012-06-01 00:00:00

abstract：:Brain magnetic resonance imaging (MRI) was studied in patients with mild-to-moderate temporal lobe epilepsy (TLE), well controlled by pharmacotherapy, and with normal computed tomographic (CT) scans. Magnetic resonance imaging abnormalities were found in 19 patients; of these, nine had abnormalities in temporomesial r...

journal_title：Epilepsia

authors： Franceschi M,Triulzi F,Ferini-Strambi L,Giusti MC,Minicucci F,Fazio F,Smirne S,Del Maschio A

更新日期：1989-09-01 00:00:00

abstract：OBJECTIVE:To identify the timelines of magnetic resonance imaging (MRI) abnormalities and their relationships with the clinical outcomes of patients with new-onset refractory status epilepticus (NORSE). METHODS:This retrospective observational study enrolled patients with NORSE who were admitted from March 2008 to Jul...

journal_title：Epilepsia

authors： Kim HJ,Lee SA,Kim HW,Kim SJ,Jeon SB,Koo YS

更新日期：2020-08-01 00:00:00

abstract：:The purpose of the study was to examine the impact of idiopathic epilepsy on mothers and fathers in terms of strain, burden of care, worries and perception of vulnerability. Data were collected and analyzed shortly after the diagnosis (T0) and 12 months later (T1). The results indicated that at T0 parents of children ...

journal_title：Epilepsia

authors： Ramaglia G,Romeo A,Viri M,Lodi M,Sacchi S,Cioffi G

更新日期：2007-09-01 00:00:00

abstract：:The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...

journal_title：Epilepsia

authors： Fisher RS,Cross JH,French JA,Higurashi N,Hirsch E,Jansen FE,Lagae L,Moshé SL,Peltola J,Roulet Perez E,Scheffer IE,Zuberi SM

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To investigate the risk of illnesses in a cohort of patients with epilepsy and in matched nonepilepsy controls, by type and complications. METHODS:A total of 951 children and adults with idiopathic, cryptogenic, or remote symptomatic epilepsy and 904 matched controls seen in secondary and tertiary centers in e...

journal_title：Epilepsia

authors： van den Broek M,Beghi E,RESt-1 Group.

更新日期：2004-01-01 00:00:00

abstract：:Eyelid myoclonia with absences (EMA), or Jeavons syndrome, is a generalized epileptic condition clinically characterized by eyelid myoclonia (EM) with or without absences, eye closure-induced electroencephalography (EEG) paroxysms, and photosensitivity; in addition, rare tonic-clonic seizures may also occur. Although ...

journal_title：Epilepsia

authors： Striano S,Capovilla G,Sofia V,Romeo A,Rubboli G,Striano P,Trenité DK

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:  Models of temporal lobe epilepsy are commonly utilized to study focal epileptogenesis and ictogenesis. The criteria that define animal models representative of human mesial temporal lobe may vary in different laboratories. We describe herein a focal epilepsy model of mesial temporal (hippocampal) origin that ...

journal_title：Epilepsia

authors： Carriero G,Arcieri S,Cattalini A,Corsi L,Gnatkovsky V,de Curtis M

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:The standard practice of switching patients to carbamazepine (CBZ) involves initiating a low dose and raising it by small increments until the desired dose is reached, to avoid intolerable adverse effects (AE). In a pilot study, a protocol using single-dose kinetic studies was developed to switch patients to CB...

journal_title：Epilepsia

authors： Kanner AM,Bourgeois BF,Hasegawa H,Hutson P

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states. METHODS:A single dose of diazepam nasal spray (5, 10, 15, or 20 mg based on weight) was administered during each of two conditions (ictal/peri-ictal ...

journal_title：Epilepsia

authors： Hogan RE,Tarquinio D,Sperling MR,Klein P,Miller I,Segal EB,Rabinowicz AL,Carrazana E

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:The current understanding of epilepsy has changed significantly in the past 2 decades. This report presents a description of newly diagnosed childhood-onset epilepsy, with a special emphasis on epilepsy syndromes, in a large, prospectively ascertained community-based cohort evaluated and diagnosed in the mid-19...

journal_title：Epilepsia

authors： Berg AT,Shinnar S,Levy SR,Testa FM

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:Angelman syndrome (AS) is a neurogenetic disorder characterized by developmental delay and a frequently refractory epileptic condition. Valproate, clonazepam and/or phenytoin are said to be the most effective antiepileptic drugs (AEDs) against the seizures in AS. Experience with the newer AEDs is very limited d...

journal_title：Epilepsia

authors： Dion MH,Novotny EJ Jr,Carmant L,Cossette P,Nguyen DK

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Zinc is released in synaptic vesicles with glutamate, and modulates glutamatergic neurotransmission. In brain, the highest amount of zinc, detected by Timm staining, is in the mossy fiber (MF) system in the hippocampus. In the intrahippocampal kainate (KA) mouse model of mesial temporal lobe epilepsy, which is ...

journal_title：Epilepsia

authors： Mitsuya K,Nitta N,Suzuki F

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To examine which variables available early in the course of childhood epilepsy are associated with a poor short-term outcome and to develop models to predict such an outcome. METHODS:We prospectively followed up 466 children with newly diagnosed epilepsy for 2 years. Variables were collected at intake and afte...

journal_title：Epilepsia

authors： Arts WF,Geerts AT,Brouwer OF,Boudewyn Peters AC,Stroink H,van Donselaar CA

更新日期：1999-06-01 00:00:00

abstract：:Clobazam (CLB), a 1,5-benzodiazepine, is a remarkably effective add-on drug for individual patients with refractory partial epilepsy. CLB has an excellent safety record. As with all benzodiazepines used for treating epilepsy, sedation and withdrawal effects, together with the development of tolerance, limit its useful...

journal_title：Epilepsia

authors： Schmidt D

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3-0.9% of the world's population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy. METHODS:We performed literature search...

journal_title：Epilepsia

authors： Johnson EL,Kaplan PW

更新日期：2017-10-01 00:00:00

abstract：:We conducted a retrospective parallel longitudinal cohort study comparing surgical and medical treatment for epilepsy. The surgical group contained 201 patients treated with resective surgery for epilepsy in Norway since the first operation in 1949 until January 1988. The 185 control group patients treated medically o...

journal_title：Epilepsia

authors： Guldvog B,Løyning Y,Hauglie-Hanssen E,Flood S,Bjørnaes H

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:Accurate classification of epileptic seizures, epilepsies, and epilepsy syndromes is mandatory in both clinical practice and epilepsy research. In 2010, the International League Against Epilepsy (ILAE) proposed a new classification scheme. The aim of this study is to determine whether application of this new cl...

journal_title：Epilepsia

authors： van Campen JS,Jansen FE,Brouwer OF,Nicolai J,Braun KP

更新日期：2013-04-01 00:00:00

abstract：:The pharmacokinetic profile of a newly developed Dilantin 300-mg Kapseal formulation was compared with that of currently marketed Dilantin 100-mg Kapseals in both a 300-mg single-dose bioequivalence study in nine healthy volunteers and a once-daily 300-mg multiple-dose study in 18 patients with seizures. Results of th...

journal_title：Epilepsia

authors： Randinitis EJ,Buchanan RA,Kinkel AW

更新日期：1990-07-01 00:00:00

abstract：:To try to identify the critical structures during epileptogenesis, we used the lithium-pilocarpine model that reproduces most clinical and neuropathological features of temporal lobe epilepsy (TLE). We used imaging techniques as well as a disease modifying approach and pharmacological strategy. With [14C]-2-deoxygluco...

journal_title：Epilepsia

authors： André V,Dubé C,François J,Leroy C,Rigoulot MA,Roch C,Namer IJ,Nehlig A

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) is the most common of the antiepileptic drug (AED)-resistant seizure syndromes that are remediable mostly with surgery, although a small group of patients have benign prognosis with fewer seizures. Material-specific memory impairment ...

journal_title：Epilepsia

authors： Ozkara C,Hanoğlu L,Keskinkiliç C,Yeni N,Aysal F,Uzan M,Ozyurt E,Karaağaç N

更新日期：2004-11-01 00:00:00

abstract：:We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ...

journal_title：Epilepsia

authors： Zumsteg D,Lozano AM,Wennberg RA

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases. METHODS:This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected...

journal_title：Epilepsia

authors： Handforth A,DeSalles AA,Krahl SE

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:The pineal hormone melatonin has been shown to enhance hippocampal excitability. We therefore investigated whether inactivation of hippocampal melatonin receptors affects behavioral seizures. METHODS:Intrahippocampal infusions were performed in rats to study the effect of different melatonin receptor antagonis...

journal_title：Epilepsia

authors： Stewart LS,Leung LS

更新日期：2005-04-01 00:00:00

abstract：:Small animal magnetic resonance imaging (MRI) has opened a window through which brain abnormalities can be observed over time in rodents noninvasively. We review MRI studies done during epileptogenesis triggered by status epilepticus in rat. Most of these studies have used quantitative T2, diffusion, and/or volumetric...

journal_title：Epilepsia

authors： Gröhn O,Pitkänen A

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To examine the relationship between seizures and excitatory amino acid transporter (EAAT) activity and whether up-regulation of EAAT activity alters epileptogenicity. METHODS:In this study, we exposed rat hippocampal slices to different convulsants before measuring EAAT activity. Rats were exposed to the EAAT ...

journal_title：Epilepsia

authors： Claudio OI,Ferchmin P,Velísek L,Sperber EF,Moshé SL,Ortiz JG

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Although the general utility of voxel-based processing of structural magnetic resonance imaging (MRI) data for detecting occult lesions in focal epilepsy is established, many differences exist among studies, and it is unclear which processing method is preferable. The aim of this study was to compare the abil...

journal_title：Epilepsia

authors： Martin P,Winston GP,Bartlett P,de Tisi J,Duncan JS,Focke NK

更新日期：2017-09-01 00:00:00