Pharmacokinetic profile of a 300-mg extended phenytoin sodium capsule (Dilantin) formulation.

Abstract:

:The pharmacokinetic profile of a newly developed Dilantin 300-mg Kapseal formulation was compared with that of currently marketed Dilantin 100-mg Kapseals in both a 300-mg single-dose bioequivalence study in nine healthy volunteers and a once-daily 300-mg multiple-dose study in 18 patients with seizures. Results of these studies indicate the rate and extent of absorption of the 300-mg extended phenytoin (PHT) sodium capsule formulation are similar to that of 100-mg extended PHT sodium capsules based on PHT plasma maximum concentrations and time to achieve them (Cmax, tmax), and area under the curve (AUC) values and the urinary excretion of total hydroxy phenylhydantoin (HPPH) in the single-dose study and steady-state PHT plasma Cmax, tmax, minimum plasma concentrations (Cmin), and AUC values and urinary excretion of total HPPH in the multiple-dose study. Control of seizures in patients was equally maintained on a once-daily 300-mg multiple-dosing regimen administered as either one 300-mg extended PHT sodium capsule daily or three 100-mg extended PHT sodium capsules daily. Therefore, 300-mg extended PHT sodium capsules can be safely and effectively interchanged with three 100-mg extended PHT sodium capsules in patients requiring a once-daily 300-mg PHT sodium dosing regimen.

journal_name

Epilepsia

journal_title

Epilepsia

authors

Randinitis EJ,Buchanan RA,Kinkel AW

doi

10.1111/j.1528-1157.1990.tb05503.x

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

458-64

issue

4

eissn

0013-9580

issn

1528-1167

journal_volume

31

pub_type

杂志文章
  • The intracarotid amobarbital procedure: when is it worth repeating?

    abstract:PURPOSE:Despite the reported diagnostic value of the intracarotid amobarbital procedure (IAP) or "Wada test" for determining hemispheric lateralization and memory functioning, it has never undergone formal reliability testing because a prospective test-retest study design is neither feasible nor ethical. However, some ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2011.03399.x

    authors: Whitman LA,Morrison CE,Becske T,Barr WB,Carlson C

    更新日期:2012-04-01 00:00:00

  • Atrophy of the pedunculopontine nucleus region in patients with sleep-predominant seizures: A voxel-based morphometry study.

    abstract::Non-rapid eye movement (NREM) sleep increases interictal epileptiform discharges and frequency of seizures, whereas REM sleep suppresses them. The pedunculopontine nucleus (PPN), one of the REM sleep-modulating structures, is postulated to have a potent antiepileptogenic role. We asked if patients with sleep-predomina...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13431

    authors: Cho KH,Cho YJ,Lee BI,Heo K

    更新日期:2016-08-01 00:00:00

  • The ketogenic diet: adolescents can do it, too.

    abstract:PURPOSE:To determine both the efficacy of and compliance with the ketogenic diet in the adolescent population. METHODS:A retrospective study of 45 patients, aged 12-19 years, consecutively enrolled in a ketogenic diet program from 1994 to 2002, was performed. Thirty-seven patients were from The Johns Hopkins Medical I...

    journal_title:Epilepsia

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1528-1157.2003.57002.x

    authors: Mady MA,Kossoff EH,McGregor AL,Wheless JW,Pyzik PL,Freeman JM

    更新日期:2003-06-01 00:00:00

  • Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy.

    abstract:OBJECTIVE:We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. METHODS:From March 2011 to March 2014, 104 patients aged 1-18 years who had refractory epilepsy were randomly assigned to each d...

    journal_title:Epilepsia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/epi.13256

    authors: Kim JA,Yoon JR,Lee EJ,Lee JS,Kim JT,Kim HD,Kang HC

    更新日期:2016-01-01 00:00:00

  • Clinical features of patients with posterior cortex epilepsies and predictors of surgical outcome.

    abstract:PURPOSE:Posterior cortex epilepsies (PCEs) encompass a group of epilepsies originating from the occipital, parietal, or occipital border of the temporal lobe, or from any combination of these regions. When their seizures are refractory to pharmacologic treatment, these patients are usually referred for surgery. The aim...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2005.70904.x

    authors: Dalmagro CL,Bianchin MM,Velasco TR,Alexandre V Jr,Walz R,Terra-Bustamante VC,Inuzuka LM,Wichert-Ana L,Araújo D Jr,Serafini LN,Carlotti CG Jr,Assirati JA Jr,Machado HR,Santos AC,Sakamoto AC

    更新日期:2005-09-01 00:00:00

  • Basal temporal subdural electrodes in the evaluation of patients with intractable epilepsy.

    abstract::In evaluation of patients with complex partial seizures who are candidates for surgical treatment, exact definition of the epileptogenic focus is essential for a good surgical outcome. We report a new technique which permits detailed mapping of the epileptogenic activity in the basal temporal lobe and the convexity of...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1989.tb05445.x

    authors: Lüders H,Hahn J,Lesser RP,Dinner DS,Morris HH 3rd,Wyllie E,Friedman L,Friedman D,Skipper G

    更新日期:1989-03-01 00:00:00

  • Epileptic spikes: magnetoencephalography versus simultaneous electrocorticography.

    abstract:PURPOSE:To test the sensitivity of extracranial magnetoencephalography (MEG) for epileptic spikes in different cerebral sites. METHODS:We simultaneously recorded MEG and electrocorticography (ECoG) by using subdural electrodes with 1-cm interelectrode distances for one patient with lateral frontal epilepsy and one pat...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2002.10702.x

    authors: Oishi M,Otsubo H,Kameyama S,Morota N,Masuda H,Kitayama M,Tanaka R

    更新日期:2002-11-01 00:00:00

  • Genetic attribution and perceived impact of epilepsy in multiplex epilepsy families.

    abstract:OBJECTIVE:Studies have found that affected individuals who believe the cause of their disorder is genetic may react in various ways, including optimism for improved treatments and pessimism due to perceived permanence of the condition. This study assessed the psychosocial impact of genetic attribution among people with...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16352

    authors: Garofalo DC,Sorge ST,Hesdorffer DC,Winawer MR,Phelan JC,Chung WK,Ottman R

    更新日期:2019-11-01 00:00:00

  • Respiratory alkalosis in children with febrile seizures.

    abstract:PURPOSE:Febrile seizures (FS) are the most common type of convulsive events in children. FS are suggested to result from a combination of genetic and environmental factors. However, the pathophysiologic mechanisms underlying FS remain unclear. Using an animal model of experimental FS, it was demonstrated that hyperther...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2011.03259.x

    authors: Schuchmann S,Hauck S,Henning S,Grüters-Kieslich A,Vanhatalo S,Schmitz D,Kaila K

    更新日期:2011-11-01 00:00:00

  • Refractory epilepsy: an evaluation of psychological methods in outpatient management.

    abstract::Two groups of adult outpatients (n = 19 and n = 21) with poorly controlled epilepsy and significant psychological disorder, assessed in terms of rating scales, received two psychological treatments in a balanced cross-over design after stable baseline seizure frequency had been established. A third group (n = 19), who...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1990.tb05498.x

    authors: Gillham RA

    更新日期:1990-07-01 00:00:00

  • Efficacy and safety of eslicarbazepine acetate monotherapy in patients converting from carbamazepine.

    abstract:OBJECTIVE:To evaluate the influence of prior use of carbamazepine (CBZ) and other antiepileptic drugs (AEDs) with a putatively similar mechanism of action (inhibition of voltage-gated sodium channels; VGSCs) on seizure outcomes and tolerability when converting to eslicarbazepine acetate (ESL), using data pooled from 2 ...

    journal_title:Epilepsia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/epi.14014

    authors: Pazdera L,Sperling MR,Harvey JH,Sam MC,Strom LA,Blum D,Grinnell T,Cheng H

    更新日期:2018-03-01 00:00:00

  • Long-term effects of continual intake of phenobarbital on the spontaneously epileptic rat.

    abstract::Spontaneously epileptic rats (SER) are a double mutant (zi/zi, tm/tm) spontaneously exhibiting both tonic and absence-like seizures. We examined the long-term effects of continual intake of phenobarbital (PB) on SER as a method of assessing long-term evaluation of antiepileptic drugs (AEDs). Food pellets containing 0....

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1990.tb05353.x

    authors: Serikawa T,Kogishi K,Yamada J,Ohno Y,Ujihara H,Fujita Y,Sasa M,Takaori S

    更新日期:1990-01-01 00:00:00

  • The management of refractory idiopathic epilepsies.

    abstract::Idiopathic epilepsies comprise a wide variety of partial and generalized syndromes that have in common a known or presumed genetic etiology and the lack of overt abnormalities other than the epilepsy itself. Most of these epilepsies have a benign natural history and/or show a favorable response to antiepileptic drug (...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1046/j.1528-1157.2001.042suppl.3031.x

    authors: Perucca E

    更新日期:2001-01-01 00:00:00

  • Pattern-sensitive epilepsy. I: A demonstration of a spatial frequency selective epileptic response to gratings.

    abstract::Rare individuals suffer epileptic seizures when they view certain images, particularly stripes. Contrast-threshold functions (the ability to see faint stripes of various widths) were determined for two pattern-sensitive brothers, and the epileptogenicity of various patterns was assessed for one of them. Sine wave grat...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1980.tb04075.x

    authors: Soso MJ,Lettich E,Belgum JH

    更新日期:1980-06-01 00:00:00

  • Ictal brain hyperperfusion contralateral to seizure onset: the SPECT mirror image.

    abstract:PURPOSE:Ictal single-photon emission computed tomography (SPECT) may help localize the seizure-onset zone (SOZ) by detecting changes in regional cerebral blood flow induced by epileptic discharges. This imaging method also reveals hyperperfusions in areas of seizure propagation, including the hemisphere contralateral t...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00378.x

    authors: Huberfeld G,Habert MO,Clemenceau S,Maksud P,Baulac M,Adam C

    更新日期:2006-01-01 00:00:00

  • Caring for transgender patients with epilepsy.

    abstract:OBJECTIVE:Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3-0.9% of the world's population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy. METHODS:We performed literature search...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/epi.13864

    authors: Johnson EL,Kaplan PW

    更新日期:2017-10-01 00:00:00

  • Provocation of nonepileptic seizures by suggestion in a general seizure population.

    abstract::Nonepileptic seizures (NES) are common and are often diagnosed at epilepsy centers by video-EEG recording of both spontaneous and suggestion-induced episodes, but no study has evaluated provocative testing in a general seizure population. We studied consecutive patients with a tentative diagnosis of epilepsy using sal...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1994.tb02509.x

    authors: Bazil CW,Kothari M,Luciano D,Moroney J,Song S,Vasquez B,Weinreb HJ,Devinsky O

    更新日期:1994-07-01 00:00:00

  • Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions.

    abstract:PURPOSE:Intracerebral vascular malformations including cavernous angiomas (CAs) and arteriovenous malformations (AVMs) are an important cause of chronic pharmacoresistant epilepsies. Little is known about the pathogenetic basis of epilepsy in patients with vascular malformations. Intracerebral deposits of iron-containi...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2012.03405.x

    authors: Raabe A,Schmitz AK,Pernhorst K,Grote A,von der Brelie C,Urbach H,Friedman A,Becker AJ,Elger CE,Niehusmann P

    更新日期:2012-03-01 00:00:00

  • Which anesthetic should be used in the treatment of refractory status epilepticus?

    abstract::While the treatment of refractory status epilepticus (SE) relies on the use of anesthetic agents, mostly barbiturates, propofol, or midazolam, the study of the available literature discloses that the evidence level is low. Therapeutic coma induction appears straightforward for generalized convulsive or subtle SE, but ...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2007.01350.x

    authors: Rossetti AO

    更新日期:2007-01-01 00:00:00

  • Defective visual inhibition in photosensitive idiopathic generalized epilepsy.

    abstract:PURPOSE:To assess the visual system excitability of photosensitive patients with idiopathic generalized epilepsy (IGE) with the paired-pulse flash-evoked potential (paired F-VEP) technique. METHODS:We studied 19 photosensitive patients with IGE (16 women) showing a photoparoxysmal electroencephalographic (EEG) respons...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2012.03411.x

    authors: Strigaro G,Prandi P,Varrasi C,Monaco F,Cantello R

    更新日期:2012-04-01 00:00:00

  • Neuropsychological effect of temporal lobe resection in preadolescent children with epilepsy.

    abstract:PURPOSE:Numerous studies have demonstrated changes in cognitive, memory, and language functioning in adults and adolescents after temporal lobectomy, yet little information is available regarding neuropsychological outcome in preadolescent children. METHODS:We studied pre- and postoperative neuropsychological test res...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1998.tb01174.x

    authors: Szabó CA,Wyllie E,Stanford LD,Geckler C,Kotagal P,Comair YG,Thornton AE

    更新日期:1998-08-01 00:00:00

  • Circadian/multidien Molecular Oscillations and Rhythmicity of Epilepsy (MORE).

    abstract::The occurrence of seizures at specific times of the day has been consistently observed for centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that seizures have a higher probability of occurring at a given time during the night and day cycle in individuals with epilepsy here refer...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16716

    authors: Bernard C

    更新日期:2020-10-16 00:00:00

  • Gender and drug effects on neuroimaging in epilepsy.

    abstract::Men are different from women, and patients with epilepsy are different in many aspects from healthy control subjects. Quantitative or semiquantitative analysis of neuroimaging data depends on the comparison between either a single patient against a group of healthy or unaffected controls, or comparisons between groups...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2011.03150.x

    authors: Koepp MJ

    更新日期:2011-07-01 00:00:00

  • Cerebral and cerebellar volume reduction in children with intractable epilepsy.

    abstract:PURPOSE:Adult epilepsy studies have demonstrated cerebral and cerebellar volume reduction beyond the epileptogenic zone, correlating this with an inferior surgical outcome. We determined whether brain volumes were reduced in childhood epilepsy and the significance of this. METHODS:Cerebral, cerebellar, and hippocampal...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.2000.tb00122.x

    authors: Lawson JA,Vogrin S,Bleasel AF,Cook MJ,Bye AM

    更新日期:2000-11-01 00:00:00

  • Deep brain stimulation of the subthalamic nucleus as adjunct treatment for refractory epilepsy.

    abstract:PURPOSE:We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases. METHODS:This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00563.x

    authors: Handforth A,DeSalles AA,Krahl SE

    更新日期:2006-07-01 00:00:00

  • Mesial temporal inhibition in a patient with deep brain stimulation of the anterior thalamus for epilepsy.

    abstract::We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00824.x

    authors: Zumsteg D,Lozano AM,Wennberg RA

    更新日期:2006-11-01 00:00:00

  • The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsy.

    abstract:PURPOSE:To clarify the role of hippocampal sclerosis (HS) in developing psychiatric and cognitive adverse events during therapy with topiramate (TPM) in patients with temporal lobe epilepsy (TLE). METHODS:We analyzed the data of 70 patients with TLE and HS and 128 patients with cryptogenic TLE matched for age, sex, st...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.0013-9580.2003.19103.x

    authors: Mula M,Trimble MR,Sander JW

    更新日期:2003-12-01 00:00:00

  • First epileptic seizure induced by occupational nickel poisoning.

    abstract::Toxic causes of seizures are numerous: alcohol and other substances of abuse, drugs, and industrial and household products. However, in the absence of a clearly suggestive history and/or associated symptoms and signs, identification of the toxic origin of new-onset seizures may be extremely difficult. We report here t...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2005.70004.x

    authors: Denays R,Kumba C,Lison D,De Bels D

    更新日期:2005-06-01 00:00:00

  • Nocturnal seizures are associated with more severe hypoxemia and increased risk of postictal generalized EEG suppression.

    abstract::Patients with epilepsy have 20-fold risk of sudden death when compared to the general population. Uncontrolled seizures is the most consistent risk factor, and death often occurs at night or in relation to sleep. We examined seizure-related respiratory disturbances in sleep versus wakefulness, focusing on periictal ox...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13841

    authors: Latreille V,Abdennadher M,Dworetzky BA,Ramel J,White D,Katz E,Zarowski M,Kothare S,Pavlova M

    更新日期:2017-09-01 00:00:00

  • Decreased cerebrospinal fluid hypocretin-1 (orexin A) in patients after repetitive generalized tonic-clonic seizures.

    abstract::The effects of seizures on the hypocretin/orexin system have not yet been investigated in epileptic patients. The present study aimed to assay hypocretin-1 in the cerebrospinal fluid (CSF) of patients after generalized tonic-clonic (GTC) seizures. Study groups consisted of 21 patients after GTC seizures and 19 control...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2008.01990.x

    authors: Rejdak K,Papuć E,Grieb P,Stelmasiak Z

    更新日期:2009-06-01 00:00:00