Eyelid myoclonia with absences (Jeavons syndrome): a well-defined idiopathic generalized epilepsy syndrome or a spectrum of photosensitive conditions?

abstract：:Deletions and duplications/amplifications of the α1-sodium channel subunit (SCN1A) gene occur in about 12% of patients with Dravet syndrome (DS) who are otherwise mutation-negative. Such genomic abnormalities cause loss of function, with severe phenotypes, reproductive disadvantage and, therefore, sporadic occurrence....

journal_title：Epilepsia

authors： Guerrini R,Cellini E,Mei D,Metitieri T,Petrelli C,Pucatti D,Marini C,Zamponi N

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:The use of primary health care personnel to identify cases of epilepsy and initiate simple treatment protocols has been advocated as a solution to the numeric inadequacy and uneven distribution of medical manpower available for the management of epilepsy in developing countries. This study sought to evaluate th...

journal_title：Epilepsia

authors： Adamolekun B,Mielke JK,Ball DE

更新日期：1999-04-01 00:00:00

abstract：:The incidence of epilepsy and of all unprovoked seizures was determined for residents of Rochester, Minnesota U.S.A. from 1935 through 1984. Age-adjusted incidence of epilepsy was 44 per 100,000 person-years. Incidence in males was significantly higher than in females and was high in the first year of life but highest...

journal_title：Epilepsia

authors： Hauser WA,Annegers JF,Kurland LT

更新日期：1993-05-01 00:00:00

abstract：:Clobazam (CLB), a 1,5-benzodiazepine, is a remarkably effective add-on drug for individual patients with refractory partial epilepsy. CLB has an excellent safety record. As with all benzodiazepines used for treating epilepsy, sedation and withdrawal effects, together with the development of tolerance, limit its useful...

journal_title：Epilepsia

authors： Schmidt D

更新日期：1994-01-01 00:00:00

abstract：:The use of rescue benzodiazepines in the management of seizures is widely accepted in emergency pediatric practice. They can, however, cause severe side effects, such as respiratory depression. We describe five patients who presented with severe respiratory depression following benzodiazepine administration for seizur...

journal_title：Epilepsia

authors： Lacroix L,Fluss J,Gervaix A,Korff CM

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Glutamate-gated N-methyl-d-aspartate receptors (NMDARs) are instrumental to brain development and functioning. Defects in the GRIN2A gene, encoding the GluN2A subunit of NMDARs, cause slow-wave sleep (SWS)-related disorders of the epilepsy-aphasia spectrum (EAS). The as-yet poorly understood developmental seq...

journal_title：Epilepsia

authors： Salmi M,Del Gallo F,Minlebaev M,Zakharov A,Pauly V,Perron P,Pons-Bennaceur A,Corby-Pellegrino S,Aniksztejn L,Lenck-Santini PP,Epsztein J,Khazipov R,Burnashev N,Bertini G,Szepetowski P

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Nonconvulsive status epilepticus (NCSE) is an under-recognized cause of altered mental status. There are hardly any reported data on NCSE in developing countries. MATERIAL AND METHODS:Prospectively 210 consecutive patients with altered mental status admitted to neurological intensive care unit (NICU) of a tert...

journal_title：Epilepsia

authors： Narayanan JT,Murthy JM

更新日期：2007-05-01 00:00:00

abstract：:In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome. Among our patients who were prescribed the new cannabidiol formulation, we observed several ca...

journal_title：Epilepsia

authors： McNamara NA,Dang LT,Sturza J,Ziobro JM,Fedak Romanowski EM,Smith GC,Joshi SM,Leber SM,Carlson M,Robertson P,Shellhaas RA

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The substrate of seizure initiation in partial epilepsy is not well understood. Although many studies imply a focus that is will localized to a single structure, some information suggests that seizures arise regionally with simultaneous or near-simultaneous onset at several separate sites. To determine the phys...

journal_title：Epilepsia

authors： Bertram EH

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To determine if seizure frequency differs between anovulatory and ovulatory cycles. METHODS:The data came from the 3-month baseline phase of an investigation of progesterone therapy for intractable focal onset seizures. Of 462 women who enrolled, 281 completed the 3-month baseline phase and 92 had both anovula...

journal_title：Epilepsia

authors： Herzog AG,Fowler KM,Sperling MR,Liporace JD,Kalayjian LA,Heck CN,Krauss GL,Dworetzky BA,Pennell PB,Progesterone Trial Study Group.

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNE...

journal_title：Epilepsia

authors： Kusmakar S,Karmakar C,Yan B,Muthuganapathy R,Kwan P,O'Brien TJ,Palaniswami MS

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:New continuous infusion antiepileptic drugs (cIV-AEDs) offer alternatives to pentobarbital for the treatment of refractory status epilepticus (RSE). However, no prospective randomized studies have evaluated the treatment of RSE. This systematic review compares the efficacy of midazolam (MDL), propofol (PRO),...

journal_title：Epilepsia

authors： Claassen J,Hirsch LJ,Emerson RG,Mayer SA

更新日期：2002-02-01 00:00:00

abstract：:The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact o...

journal_title：Epilepsia

authors： Galanopoulou AS,Kokaia M,Loeb JA,Nehlig A,Pitkänen A,Rogawski MA,Staley KJ,Whittemore VH,Dudek FE

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:To analyze activity of identified dentate gyrus granular cells and interneurons during pathologic high-frequency oscillations (pHFOs). METHODS:Pilocarpine-treated epileptic mice were anesthetized with urethane and ketamine. Their heads were fixed in a stereotaxic frame. Extracellular unit activity was recoded ...

journal_title：Epilepsia

authors： Bragin A,Benassi SK,Kheiri F,Engel J Jr

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:This study evaluated topiramate (TPM) antagonism of glutamate receptors activated by kainate. METHODS:The ability of TPM (3-30 microM) to attenuate kainate (300 microM)-activated cobalt (Co2+) flux through nonselective cation channels permeable to Co2+, Mn2+, and Ca2+ into cultured cerebellar granule neurons [...

journal_title：Epilepsia

authors： Skradski S,White HS

更新日期：2000-01-01 00:00:00

abstract：:Studies from several countries have reported that fewer people with epilepsy marry, but the reasons for this are not clear. In the present investigation, 178 adults with epilepsy were divided into married, separated/divorced, and never married groups. The never married group was subdivided into persons living in depen...

journal_title：Epilepsia

authors： Batzel LW,Dodrill CB

更新日期：1984-10-01 00:00:00

abstract：PURPOSE:Epilepsy is the most common serious neurologic disease, and current treatments are ineffective for

journal_title：Epilepsia

authors： Nilsen KE,Kelso AR,Cock HR

更新日期：2006-07-01 00:00:00

abstract：:The mechanism by which animals develop tolerance to the antiepileptic effects of the carbonic anhydrase (CA) inhibitor, acetazolamide, was explored using a quantitative immunocytochemical method. Cerebral cortex sections of DBA/2J mice susceptible to audiogenic seizures and of C57BL/6J nonsusceptible mice were stained...

journal_title：Epilepsia

authors： Banks DA,Anderson RE,Woodbury DM

更新日期：1986-09-01 00:00:00

abstract：:The chronicity and severity of epilepsy, as well as the presence of temporal lobe toci, appear to correlate with psychopathology. A high prevalence of psychopathology has been reported among patients who are candidates for anterior temporal lobectomy (ATL). A review of the literature indicates that episodic psychosis ...

journal_title：Epilepsia

authors： Matsuura M

更新日期：2000-01-01 00:00:00

abstract：:Many patients with medically refractory epilepsy now undergo successful surgery based on noninvasive diagnostic information, but intracranial electroencephalography (IEEG) continues to be used as increasingly complex cases are considered surgical candidates. The indications for IEEG and the modalities employed vary ac...

journal_title：Epilepsia

authors： Jayakar P,Gotman J,Harvey AS,Palmini A,Tassi L,Schomer D,Dubeau F,Bartolomei F,Yu A,Kršek P,Velis D,Kahane P

更新日期：2016-11-01 00:00:00

abstract：:Ictal and interictal epileptic activity was recorded for the first time by multichannel magnetoencephalography (MEG) in three patients with partial epilepsy. Pre- and intra-operative localization of the epileptogenic region was compared. The interictal epileptic activity was localized at the same region of the tempora...

journal_title：Epilepsia

authors： Stefan H,Schneider S,Feistel H,Pawlik G,Schüler P,Abraham-Fuchs K,Schlegel T,Neubauer U,Huk WJ

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:Organophosphates (OPs) are commonly used insecticides for agriculture and domestic purposes, but may also serve as nerve agents. Exposure to OPs result in overstimulation of the cholinergic system and lead to status epilepticus (SE), a life-threatening condition that is often resistant to treatment. SE is ass...

journal_title：Epilepsia

authors： Bar-Klein G,Swissa E,Kamintsky L,Shekh-Ahmad T,Saar-Ashkenazy R,Hubary Y,Shrot S,Stetlander L,Eisenkraft A,Friedman A,Bialer M

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The aim of this work is to study, by means of computational simulations, the induction and sustaining of nonsynaptic epileptiform activity. METHODS:The computational model consists of a network of cellular bodies of neurons and glial cells connected to a three-dimensional (3D) network of juxtaposed extracellul...

journal_title：Epilepsia

authors： de Almeida AC,Rodrigues AM,Scorza FA,Cavalheiro EA,Teixeira HZ,Duarte MA,Silveira GA,Arruda EZ

更新日期：2008-11-01 00:00:00

abstract：:No reports of the Washington Psychosocial Seizure Inventory (WPSI) have yet been presented from Asian countries in detail. We performed a multiinstitutional study of this test in 652 Japanese subjects. The mean value of the Lie Scale was high, and only one third of our subjects were under the limit of the original cri...

journal_title：Epilepsia

authors： Hosokawa K,Kugoh T,Mino S

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:We evaluated the anticonvulsant efficacy of topiramate (TPM), a structurally novel antiepileptic drug (AED), in amygdala kindled rats that had been preselected with respect to their response to phenytoin (PHT). METHODS:Anticonvulsant response was tested by determining the afterdischarge threshold (ADT; i.e., a...

journal_title：Epilepsia

authors： Reissmüller E,Ebert U,Löscher W

更新日期：2000-04-01 00:00:00

abstract：PURPOSE:Effects of pre- and postsynaptic γ-aminobutyric acid B (GABA(B)) receptor activation were characterized in human tissue from epilepsy surgery. METHODS:Slices of human cortical tissue were investigated in a submerged-type chamber with intracellular recordings in layers II/III. Parallel experiments were performe...

journal_title：Epilepsia

authors： Teichgräber LA,Lehmann TN,Meencke HJ,Weiss T,Nitsch R,Deisz RA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Previous studies of patient-reported seizure precipitants have not evaluated whether different epilepsy syndromes are differentially affected. METHODS:Patients of a tertiary-care epilepsy center were consecutively surveyed with the use of a standardized questionnaire that lists precipitants that might trigger ...

journal_title：Epilepsia

authors： Frucht MM,Quigg M,Schwaner C,Fountain NB

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:Nitric oxide (NO), a short-lived radical synthesized from L-arginine by activation of the enzyme nitric oxide synthase (NOS), has been implicated in the pathophysiology of epilepsy by some investigators. However, the current data about NO and NOS in epilepsy are controversial and are derived only from animal mo...

journal_title：Epilepsia

authors： González-Hernández T,García-Marín V,Pérez-Delgado MM,González-González ML,Rancel-Torres N,González-Feria L

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:Whether magnetic resonance imaging (MRI) is informative in febrile seizures (FS) is unknown. We undertook a study to determine the frequency of MRI-detected brain abnormalities and to evaluate their association with FS type and with specific features of complex FS. METHODS:A prospective cohort study, from 19...

journal_title：Epilepsia

authors： Hesdorffer DC,Chan S,Tian H,Allen Hauser W,Dayan P,Leary LD,Hinton VJ

更新日期：2008-05-01 00:00:00

abstract：:It is unclear whether the outcome of status epilepticus (SE), a neurological emergency associated with high mortality and morbidity, has changed over the past decade. We investigated the difference in prognosis (mortality, functional status at discharge) after adult SE episodes in a large registry between 2 time point...

journal_title：Epilepsia

authors： Fatuzzo D,Novy J,Rossetti AO

更新日期：2018-07-01 00:00:00