Conduct of trials in private clinical practice.

abstract：:Twenty therapy-resistant epileptic patients entered a double-blind, randomized, two-period, cross-over trial comparing progabide (19.3-36 mg/kg/day) and placebo as add-on drugs to standard therapy. Each period lasted 6 weeks with a gradual crossover during 4 days. Five patients were dropped because of reasons unrelate...

journal_title：Epilepsia

authors： Martínez-Lage JM,Bossi L,Morales G,Martínez Vila E,Orofiamma B,Viteri C

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:Unresolved past stressful events can induce a state of vulnerability to epilepsy and comorbidities. Using an experimental model of stress-induced vulnerability to depression, we tested whether an antioxidant treatment applied after the onset of epileptogenesis was disease modifying and could prevent the occur...

journal_title：Epilepsia

authors： Becker C,Mancic A,Ghestem A,Poillerat V,Claverie D,Bartolomei F,Brouillard F,Benoliel JJ,Bernard C

更新日期：2019-04-01 00:00:00

abstract：:Lowering extracellular magnesium induces different patterns of epileptiform activity in rat hippocampus and entorhinal cortex. Short recurrent epileptiform discharges in the hippocampus are stable over time, whereas seizure-like events (SLEs) in the entorhinal cortex, the subiculum, and the neighboring neocortex devel...

journal_title：Epilepsia

authors： Zhang CL,Gloveli T,Heinemann U

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The possibility that a recent seizure or a recent change in antiepileptic medication might produce an occult change in neuropsychological performance is of interest, and especially so in the context of evaluation for epilepsy surgery. Such an evaluation is often done in a setting of video-EEG monitoring where a...

journal_title：Epilepsia

authors： Dodrill CB,Ojemann GA

更新日期：2007-10-01 00:00:00

abstract：:Epilepsy can be a devastating disorder. In addition to debilitating seizures, epilepsy can cause cognitive and emotional problems with reduced quality of life. Therefore, the major aim is to prevent the disorder in the first place: identify, detect, and reverse the processes responsible for its onset, and monitor and ...

journal_title：Epilepsia

authors： Koepp MJ,Årstad E,Bankstahl JP,Dedeurwaerdere S,Friedman A,Potschka H,Ravizza T,Theodore WH,Baram TZ

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:Focal cortical dysplasia type IIb (FCD IIb) lesions are highly epileptogenic and frequently cause pharmacoresistant epilepsy. Complete surgical resection leads to seizure freedom in most cases. However, the term "complete" resection is controversial with regard to the necessity of performing resections of the s...

journal_title：Epilepsia

authors： Wagner J,Urbach H,Niehusmann P,von Lehe M,Elger CE,Wellmer J

更新日期：2011-08-01 00:00:00

abstract：:The success of surgery for seizure focus resection depends on postoperative reduction or disappearance in number of seizures, improvement in psychosocial functioning, and low morbidity and mortality. Permanent neurologic sequelae are most often not discussed in this context. Deficits more than a superior quadrantanops...

journal_title：Epilepsia

authors： Helgason CM,Bergen D,Bleck TP,Morrell F,Whisler W

更新日期：1987-07-01 00:00:00

abstract：:Both early life inflammation and prolonged febrile seizures have been associated with increased excitation in the adult brain. We hypothesized this may be due in part to changes in the cation-chloride cotransporter system. Rat pups received saline or lipopolysaccharide/kainic acid (LPS/KA) resulting in inflammation, f...

journal_title：Epilepsia

authors： Reid AY,Riazi K,Campbell Teskey G,Pittman QJ

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:The astrocytic enzyme glutamine synthetase (GS) is a key regulator of glutamate and γ-aminobutyric acid (GABA) metabolism in the glutamate/glutamine cycle (GGC). Inhibition of GS results in changes of neurotransmitter release and recycling. However, little is known about the influence of GGC on neurotransmitter...

journal_title：Epilepsia

authors： Cremer CM,Bidmon HJ,Görg B,Palomero-Gallagher N,Escobar JL,Speckmann EJ,Zilles K

更新日期：2010-08-01 00:00:00

abstract：:Twenty-three infants and children underwent cortical resection (n = 15) or hemispherectomy (n = 8) for intractable infantile spasms. Infantile spasms were present at the time of surgery in 17 of the 23 patients; in six, spasms had evolved to other seizure types during surgical evaluation. Children with a remote histor...

journal_title：Epilepsia

authors： Chugani HT,Shewmon DA,Shields WD,Sankar R,Comair Y,Vinters HV,Peacock WJ

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:The aims of the present study were to explore the relation between ictal scalp EEG patterns and ictal hyperperfusion patterns in patients with unilateral hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) by using semiquantitative single-photon emission computed tomography (SPECT) analysis...

journal_title：Epilepsia

authors： Kim JH,Im KC,Kim JS,Lee SA,Lee JK,Khang SK,Kang JK

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in patients with temporal lobe epilepsy (TLE). METHODS:Memory for public and auto...

journal_title：Epilepsia

authors： Lah S,Lee T,Grayson S,Miller L

更新日期：2006-03-01 00:00:00

abstract：:Pinealectomy of the Mongolian gerbil leads to seizure activity. The pineal gland is a major source of malatonin (5-methoxy-N-acetyltryptamine) which may possess a modulatory influence upon neural activity. Melatonin administered in the form of subcutaneous beeswax implants was given to gerbils four days prior to pinea...

journal_title：Epilepsia

authors： Rudeen PK,Philo RC,Symmes SK

更新日期：1980-04-01 00:00:00

abstract：OBJECTIVE:Lowering the length of stay (LOS) is thought to potentially decrease hospital costs and is a metric commonly used to manage capacity. Patients with epilepsy undergoing intracranial electrode monitoring may have longer LOS because the time to seizure is difficult to predict or control. This study investigates ...

journal_title：Epilepsia

authors： Chan AY,Kharrat S,Lundeen K,Mnatsakanyan L,Sazgar M,Sen-Gupta I,Lin JJ,Hsu FPK,Vadera S

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to compare the utility of baseline neuropsychological measures and scores from the intracarotid amobarbital procedure (IAP) in the prediction of postoperative memory decline in temporal lobe epilepsy surgery patients. METHODS:Logistic regression analyses were used to determine the rel...

journal_title：Epilepsia

authors： Baxendale S,Thompson P,Harkness W,Duncan J

更新日期：2007-03-01 00:00:00

abstract：:This study aimed to determine clinical features of adult patients with gelastic seizures recorded on video -electroencephalography (EEG) over a 5-year period. We screened video-EEG telemetry reports for the occurrence of the term "gelastic" seizures, and assessed the semiology, EEG features, and duration of those seiz...

journal_title：Epilepsia

authors： Kovac S,Diehl B,Wehner T,Fois C,Toms N,Walker MC,Duncan JS

更新日期：2015-01-01 00:00:00

abstract：:We studied 36 drop seizures in 5 patients with myoclonic astatic epilepsy of early childhood (MAEE) with simultaneous split-screen video recording and polygraph. Sixteen were falling attacks and 20 were either less severe attacks exhibiting only deep head nodding or seizures equivalent to drop attacks in terms of icta...

journal_title：Epilepsia

authors： Oguni H,Fukuyama Y,Imaizumi Y,Uehara T

更新日期：1992-09-01 00:00:00

abstract：:Infantile spasms begin in a very active phase of brain development. The new neuropathological techniques have shed light on changes in the fine structure of brain in children with infantile spasms. An understanding of the action of adrenocorticotropic hormone on the biochemistry and development of the brain provides, ...

journal_title：Epilepsia

authors： Riikonen R

更新日期：1983-04-01 00:00:00

abstract：PURPOSE:To determine the prevalence, manifestations, lateralizing value, and surgical prognostic value of somatosensory auras (SSAs) in patients with refractory temporal lobe epilepsy (TLE). METHODS:Eighty-one consecutive patients undergoing temporal lobectomy for refractory complex-partial seizures were screened for ...

journal_title：Epilepsia

authors： Erickson JC,Clapp LE,Ford G,Jabbari B

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can ter...

journal_title：Epilepsia

authors： Van Gompel JJ,Bower MR,Worrell GA,Stead M,Chang SY,Goerss SJ,Kim I,Bennet KE,Meyer FB,Marsh WR,Blaha CD,Lee KH

更新日期：2014-02-01 00:00:00

abstract：:Idiopathic epilepsies comprise a wide variety of partial and generalized syndromes that have in common a known or presumed genetic etiology and the lack of overt abnormalities other than the epilepsy itself. Most of these epilepsies have a benign natural history and/or show a favorable response to antiepileptic drug (...

journal_title：Epilepsia

authors： Perucca E

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:The objective of this study was the isobolographic evaluation of the interactions between the novel antiepileptic drug (AED) gabapentin (GBP) and a number of other AEDs against electroconvulsion-induced convulsions in mice. METHODS:Electroconvulsions were produced by means of an alternating current (ear-clip e...

journal_title：Epilepsia

authors： Borowicz KK,Swiader M,Luszczki J,Czuczwar SJ

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Accurate classification of epileptic seizures, epilepsies, and epilepsy syndromes is mandatory in both clinical practice and epilepsy research. In 2010, the International League Against Epilepsy (ILAE) proposed a new classification scheme. The aim of this study is to determine whether application of this new cl...

journal_title：Epilepsia

authors： van Campen JS,Jansen FE,Brouwer OF,Nicolai J,Braun KP

更新日期：2013-04-01 00:00:00

abstract：:Drug-resistant epilepsy poses a challenge in neonatal patients, especially those in the neonatal intensive care unit (NICU), who have various secondary comorbidities. We present results of four children with a history of drug-resistant epilepsy for whom a ketogenic diet was initiated and used in the NICU. A nonfasting...

journal_title：Epilepsia

authors： Thompson L,Fecske E,Salim M,Hall A

更新日期：2017-02-01 00:00:00

abstract：:As a young man, Graham Greene (1904-1991) experienced several episodes of loss of consciousness, which were confidently diagnosed as epilepsy by a Harley Street specialist who saw him on two occasions during the 1920s. The diagnosis was initially concealed from him by his family and the specialist, but when it was rev...

journal_title：Epilepsia

authors： Reynolds EH

更新日期：2001-08-01 00:00:00

abstract：:We aimed to determine whether analysis of EEG envelope trend aids bedside detection of neonatal seizures. Five neonatal EEGs with multiple seizures were used to determine optimal trend parameters for seizure detection. Using these parameters, envelope trends were generated on eight additional EEGs, evaluated by experi...

journal_title：Epilepsia

authors： Abend NS,Dlugos D,Herman S

更新日期：2008-02-01 00:00:00

abstract：:Children with epilepsy often grow into adults with significant social problems including decreased employment, marriage, social relationships, and independent living arrangements. These problems are noted in population-based longitudinal and cross-sectional studies from many countries. Learning disorder and mental han...

journal_title：Epilepsia

authors： Camfield CS,Camfield PR

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To assess the presence, extent, and clinical correlates of quantitative MR volumetric abnormalities in ipsilateral and contralateral hippocampus, and temporal and extratemporal lobe regions in unilateral temporal lobe epilepsy (TLE). METHODS:In total, 34 subjects with unilateral left (n = 15) or right (n = 19)...

journal_title：Epilepsia

authors： Seidenberg M,Kelly KG,Parrish J,Geary E,Dow C,Rutecki P,Hermann B

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Chronic cellular inflammation closely associated with epilepsy without an active infection is a hallmark of Rasmussen encephalitis (RE). RE has typical and defining features lacking in other rare epilepsy patients who also have neocortical lymphocytes without an identifiable cause. A patient with malformations ...

journal_title：Epilepsia

authors： Rhodes RH,Lehman RM,Wu BY,Roychowdhury S

更新日期：2007-06-01 00:00:00

abstract：:Study of patients with temporal lobe epilepsy and generalized epilepsy revealed no overall seizure type differences, nor overall age-at-onset effects, on MMPI measures of psychopathology. However, statistically significant interactions between seizure type and age at onset were obtained on several MMPI measures, and s...

journal_title：Epilepsia

authors： Hermann BP,Schwartz MS,Karnes WE,Vahdat P

更新日期：1980-02-01 00:00:00