The difficulty of diagnosing NCSE in clinical practice; external validation of the Salzburg criteria.


:To improve the diagnostic accuracy of electroencephalography (EEG) criteria for nonconvulsive status epilepticus (NCSE), external validation of the recently proposed Salzburg criteria is paramount. We performed an external, retrospective, diagnostic accuracy study of the Salzburg criteria, using EEG recordings from patients with and without a clinical suspicion of having NCSE. Of the 191 EEG recordings, 12 (12%) was classified as an NCSE according to the reference standard. In the validation cohort, sensitivity was 67% and specificity was 89%. The positive predictive value was 47% and the negative predictive value was 95%. Ten patients in the control group (n = 93) were false positive, resulting in a specificity of 89.2%. The interrater agreement between the reference standards and between the scorers of the Salzburg criteria was moderate; disagreement occurred mainly in patients with an epileptic encephalopathy. The Salzburg criteria showed a lower diagnostic accuracy in our external validation study than in the original design, suggesting that they cannot replace the current practice of careful weighing of both clinical and EEG information on an individual basis.






Goselink RJM,van Dillen JJ,Aerts M,Arends J,van Asch C,van der Linden I,Pasman J,Saris CGJ,Zwarts M,van Alfen N




Has Abstract


2019-08-01 00:00:00












  • Bidirectional transhemispheric interaction between amygdaloid kindling induced by excitatory amino acids and electrical stimulation.

    abstract::Using transhemispheric transfer and post-transfer interference as specific measures, the relationship between chemical and electrical kindling at the amygdala (AM) in rats was examined. Chemical kindling was accomplished by repeated injections of a subconvulsive dose of combined L-glutamate (GLU) and L-aspartate (ASP)...


    pub_type: 杂志文章


    authors: Mori N,Wada JA

    更新日期:1989-05-01 00:00:00

  • Different neurophysiologic patterns of myoclonus characterize Lennox-Gastaut syndrome and myoclonic astatic epilepsy.

    abstract:PURPOSE:To study the neurophysiologic characteristics of epileptic myoclonus in patients with Lennox-Gastaut syndrome (LGS) and myoclonic astatic epilepsy (MAE). METHODS:Three patients with symptomatic LGS (mean age, 15 years +/- 4) and three with cryptogenic MAE (mean age, 9 years +/- 3) were studied. Temporal relati...


    pub_type: 杂志文章


    authors: Bonanni P,Parmeggiani L,Guerrini R

    更新日期:2002-06-01 00:00:00

  • Recruitment of families for genetic studies of epilepsy.

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    pub_type: 杂志文章


    authors: Ottman R,Berenson K,Barker-Cummings C

    更新日期:2005-02-01 00:00:00

  • Distinct white matter integrity in glutamic acid decarboxylase and voltage-gated potassium channel-complex antibody-associated limbic encephalitis.

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    pub_type: 杂志文章


    authors: Wagner J,Schoene-Bake JC,Witt JA,Helmstaedter C,Malter MP,Stoecker W,Probst C,Weber B,Elger CE

    更新日期:2016-03-01 00:00:00

  • Classification of epileptic seizures: a hospital-based study of 1,250 patients in a developing country.

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    pub_type: 杂志文章


    authors: Senanayake N

    更新日期:1993-09-01 00:00:00

  • Progressive myoclonus epilepsies: clinical and genetic aspects.

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    pub_type: 杂志文章,评审


    authors: Berkovic SF,Cochius J,Andermann E,Andermann F

    更新日期:1993-01-01 00:00:00

  • Characterizing the patterned images that precipitate seizures and optimizing guidelines to prevent them.

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    pub_type: 杂志文章


    authors: Wilkins A,Emmett J,Harding G

    更新日期:2005-08-01 00:00:00

  • Neonatal seizures: problems in diagnosis and classification.

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    pub_type: 杂志文章,评审


    authors: Mizrahi EM

    更新日期:1987-01-01 00:00:00

  • Optimal choice of antiseizure medication: Agreement among experts and validation of a web-based decision support application.

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    pub_type: 杂志文章


    authors: Beniczky S,Rampp S,Asadi-Pooya AA,Rubboli G,Perucca E,Sperling MR

    更新日期:2021-01-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Logroscino G,Hesdorffer DC,Cascino G,Hauser WA,Coeytaux A,Galobardes B,Morabia A,Jallon P

    更新日期:2005-01-01 00:00:00

  • Seizure outcome after temporal lobectomy in temporal lobe cortical dysplasia.

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    pub_type: 杂志文章


    authors: Srikijvilaikul T,Najm IM,Hovinga CA,Prayson RA,Gonzalez-Martinez J,Bingaman WE

    更新日期:2003-11-01 00:00:00

  • Role of the sodium channel SCN9A in genetic epilepsy with febrile seizures plus and Dravet syndrome.

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    pub_type: 杂志文章


    authors: Mulley JC,Hodgson B,McMahon JM,Iona X,Bellows S,Mullen SA,Farrell K,Mackay M,Sadleir L,Bleasel A,Gill D,Webster R,Wirrell EC,Harbord M,Sisodiya S,Andermann E,Kivity S,Berkovic SF,Scheffer IE,Dibbens LM

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    pub_type: 杂志文章


    authors: Ogunbodede EO,Adamolekun B,Akintomide AO

    更新日期:1998-06-01 00:00:00

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    pub_type: 杂志文章,多中心研究


    authors: Chhun S,Jullien V,Rey E,Dulac O,Chiron C,Pons G

    更新日期:2009-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Berg AT,Levy SR,Novotny EJ,Shinnar S

    更新日期:1996-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Anhoury S,Brown RJ,Krishnamoorthy ES,Trimble MR

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    pub_type: 杂志文章,评审


    authors: Sills G,Brodie M

    更新日期:2007-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Arpino C,Gattinara GC,Piergili D,Curatolo P

    更新日期:1990-01-01 00:00:00

  • Mechanisms of status epilepticus: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor hypothesis.

    abstract::Prolonged seizures of status epilepticus (SE) result from failure of mechanisms of seizure termination or activation of mechanisms that sustain seizures. Reduced γ-aminobutyric acid type A receptor-mediated synaptic transmission contributes to impairment of seizure termination. However, mechanisms that sustain prolong...


    pub_type: 杂志文章


    authors: Joshi S,Kapur J

    更新日期:2018-10-01 00:00:00

  • Epilepsy in general practice: the Dutch situation.

    abstract::Treatment and supervision of epileptic patients is part of specialist medicine. A possible change in the role of specialists and general practitioners in the care of these patients was explored by a questionnaire mailed to all Dutch neurologists and a random sample of general practitioners. Patients were also asked th...


    pub_type: 杂志文章


    authors: Rutgers MJ

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  • Clinical, functional, and neurophysiologic assessment of dysplastic cortical networks: Implications for cortical functioning and surgical management.

    abstract::Cortical malformations are highly epileptogenic lesions associated with complex, unanticipated, and often aberrant electrophysiologic and functional relationships. These relationships are inextricably linked to widespread cortical networks subserving eloquent functions, particularly language and motor ability. Cytomeg...


    pub_type: 杂志文章,评审


    authors: Duchowny M

    更新日期:2009-10-01 00:00:00

  • Early onset myoclonic epilepsy and 15q26 microdeletion: observation of the first case.

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    pub_type: 古典文章,杂志文章


    authors: Veredice C,Bianco F,Contaldo I,Orteschi D,Stefanini MC,Battaglia D,Lettori D,Guzzetta F,Zollino M

    更新日期:2009-07-01 00:00:00

  • The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy.

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    pub_type: 杂志文章


    authors: Carçak N,Zheng T,Ali I,Abdullah A,French C,Powell KL,Jones NC,van Raay L,Rind G,Onat F,O'Brien TJ

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    pub_type: 杂志文章


    authors: Francis PT,Lowe SL,Bowen DM,Jefferys JG

    更新日期:1990-11-01 00:00:00

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    pub_type: 杂志文章,评审


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    更新日期:2018-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Sankar R,Shin D,Liu H,Katsumori H,Wasterlain CG

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    更新日期:2014-02-01 00:00:00

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    pub_type: 杂志文章


    authors: Bragin A,Wilson CL,Engel J Jr

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    pub_type: 杂志文章


    authors: Lim SH,Pan A

    更新日期:2005-01-01 00:00:00