Platelet-activating factor receptor antagonism targets neuroinflammation in experimental epilepsy.

abstract：PURPOSE:The present study aimed to clarify the effect of electrical stimulation and lesioning of the anterior nucleus of the thalamus (ANT) on kainic acid (KA)-induced focal cortical seizures in a rat model. To address the mechanism underlying these anticonvulsant actions, cerebral glucose metabolism after ANT electric...

journal_title：Epilepsia

authors： Takebayashi S,Hashizume K,Tanaka T,Hodozuka A

更新日期：2007-02-01 00:00:00

abstract：:We examined the relationship of age of onset of epilepsy, chronological age at time of operation, and adequacy of preoperative memory performance to pre- to postoperative verbal memory decline. Patients who underwent left (n = 50) or right (n = 51) anterior temporal lobectomy (ATL) were administered tests of verbal ep...

journal_title：Epilepsia

authors： Hermann BP,Seidenberg M,Haltiner A,Wyler AR

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:Considering the complexity of neuronal circuits and their epilepsy-associated alterations, epilepsy models cannot be completely replaced by in vitro experimental approaches. Decisions about ethical approval of in vivo studies require a thorough weighing of the animal's burden and the benefit regarding the exp...

journal_title：Epilepsia

authors： Koska I,van Dijk RM,Seiffert I,Di Liberto V,Möller C,Palme R,Hellweg R,Potschka H

更新日期：2019-10-01 00:00:00

abstract：:Neuropsychological evaluation differs from other methods used to localize cerebral lesions in that it analyzes cognitive function. Tests sample widely among cognitive abilities, contrasting language proficiency with visuospatial skills. A thorough assessment of memory is crucial in the investigation because of the pro...

journal_title：Epilepsia

authors： Jones-Gotman M

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with...

journal_title：Epilepsia

authors： King-Stephens D,Mirro E,Weber PB,Laxer KD,Van Ness PC,Salanova V,Spencer DC,Heck CN,Goldman A,Jobst B,Shields DC,Bergey GK,Eisenschenk S,Worrell GA,Rossi MA,Gross RE,Cole AJ,Sperling MR,Nair DR,Gwinn RP,Park YD,

更新日期：2015-06-01 00:00:00

abstract：:The effects of carbamazepine (CBZ) monotherapy on serum sex hormone levels and on pituitary responsiveness to various stimuli were evaluated in a prospective study with 21 male patients with epilepsy. The serum levels of testosterone (T), free testosterone (FT), sex hormone binding globulin (SHBG), estradiol (E2), lut...

journal_title：Epilepsia

authors： Isojärvi JI,Pakarinen AJ,Myllylä VV

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:It remains controversial whether a specific pattern of interictal epileptiform activity exists that may help to differentiate temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) from other forms of TLE. In this study, we characterized the distribution of interictal epileptiform discharges in TLE due ...

journal_title：Epilepsia

authors： Hamer HM,Najm I,Mohamed A,Wyllie E

更新日期：1999-09-01 00:00:00

abstract：:Twenty-three infants and children underwent cortical resection (n = 15) or hemispherectomy (n = 8) for intractable infantile spasms. Infantile spasms were present at the time of surgery in 17 of the 23 patients; in six, spasms had evolved to other seizure types during surgical evaluation. Children with a remote histor...

journal_title：Epilepsia

authors： Chugani HT,Shewmon DA,Shields WD,Sankar R,Comair Y,Vinters HV,Peacock WJ

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:Sudden unexpected death in epilepsy (SUDEP) is a critical issue in epilepsy, and DBA/1 mice are a useful animal model of this devastating epilepsy sequela. The serotonin hypothesis for SUDEP proposes that modifying serotonergic function significantly alters susceptibility to seizure-induced respiratory arrest...

journal_title：Epilepsia

authors： Kommajosyula SP,Faingold CL

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Seizures develop in 80% of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality. Anti-NMDAR antibodies have been linked to memory loss in encephalitis; however, their role in seizures has not been established. We determined whether...

journal_title：Epilepsia

authors： Taraschenko O,Fox HS,Pittock SJ,Zekeridou A,Gafurova M,Eldridge E,Liu J,Dravid SM,Dingledine R

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS:Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizur...

journal_title：Epilepsia

authors： Mares P,Haugvicová R

更新日期：1997-08-01 00:00:00

abstract：:Visual behavior is frequently impaired at onset of West syndrome (WS). We studied the neuropsychological outcome of eight children who had cryptogenic WS and moderate to severe visual impairment at the onset of epilepsy. At the last examination, a regional cerebral blood flow study using SPECT (single photon emission ...

journal_title：Epilepsia

authors： Jambaqué I,Chiron C,Dulac O,Raynaud C,Syrota P

更新日期：1993-07-01 00:00:00

abstract：:A group of patients with benign epilepsy of children with centrotemporal EEG foci, consisting of 40 patients reported 10 years ago, has been reinvestigated. Thirty-seven of these patients were reinvestigated. They were 26-34 years old (mean, 29 years). The observation time from the first seizure was 13-27 years (mean,...

journal_title：Epilepsia

authors： Blom S,Heijbel J

更新日期：1982-12-01 00:00:00

abstract：OBJECTIVE:Automatic detection of generalized tonic-clonic seizures (GTCS) will facilitate patient monitoring and early intervention to prevent comorbidities, recurrent seizures, or death. Brain Sentinel (San Antonio, Texas, USA) developed a seizure-detection algorithm evaluating surface electromyography (sEMG) signals ...

journal_title：Epilepsia

authors： Szabó CÁ,Morgan LC,Karkar KM,Leary LD,Lie OV,Girouard M,Cavazos JE

更新日期：2015-09-01 00:00:00

abstract：:Medically intractable tonic and atonic seizures may be responsive to either vagus nerve stimulation (VNS) or corpus callosum section. VNS has been shown to be effective and is associated with very low morbidity. Callosotomy is a more ambitious procedure, with a higher risk of complications but greater likelihood of se...

journal_title：Epilepsia

authors： Rosenfeld WE,Roberts DW

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Mesial temporal sclerosis (MTS) is characterized by neuronal loss in the hippocampus. Studies on experimental models and patients with intractable epilepsy suggest that apoptosis may be involved in neuronal death induced by recurrent seizures. METHODS:We searched evidence for apoptotic cell death in temporal l...

journal_title：Epilepsia

authors： Uysal H,Cevik IU,Soylemezoglu F,Elibol B,Ozdemir YG,Evrenkaya T,Saygi S,Dalkara T

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:Hemispherectomy is an established surgical treatment for carefully selected pediatric patients with intractable epilepsy. Published perioperative data report low mortality rates and seizure reduction rates of 50-89%. This study investigates trends in the demographics, hospital utilization, and in-hospital com...

journal_title：Epilepsia

authors： Lin Y,Harris DA,Curry DJ,Lam S

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the interaction of the preferential brain nitric oxide synthase (NOS) inhibitor, 7-nitroindazole (7-NI), with conventional antiepileptic drugs (AEDs) against amygdala-kindled seizures in rats. METHODS:Experiments were performed on fully kindled rats. Adverse effects ...

journal_title：Epilepsia

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To confirm the efficacy and to clarify the problems of clobazam (CLB) as a new antiepileptic drug (AED) and clorazepate (CLP) as an alternative AED in Japan. METHODS:CLB and CLP were added on or replaced with conventional AEDs in 55 and 170 patients with refractory epilepsies, respectively. Short-term efficacy...

journal_title：Epilepsia

authors： Sugai K

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To determine the incidence, duration, risk factors for, and clinical correlates of postictal generalized electroencephalography (EEG) suppression (PGES), and to further delineate the significance of PGES in the pathogenesis of sudden unexpected death in epilepsy (SUDEP). METHODS:We retrospectively reviewed the...

journal_title：Epilepsia

authors： Tao JX,Yung I,Lee A,Rose S,Jacobsen J,Ebersole JS

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Nonconvulsive status epilepticus (NCSE) is an under-recognized cause of altered mental status. There are hardly any reported data on NCSE in developing countries. MATERIAL AND METHODS:Prospectively 210 consecutive patients with altered mental status admitted to neurological intensive care unit (NICU) of a tert...

journal_title：Epilepsia

authors： Narayanan JT,Murthy JM

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Traumatic brain injury has long been known to be a cause of epilepsy. Most information on risk factors for developing posttraumatic seizures is from before computed tomography (CT) scanning became universal. This article looks at factors about the injury or individual that put people at especially high risk of ...

journal_title：Epilepsia

authors： Temkin NR

更新日期：2003-01-01 00:00:00

abstract：:The in vitro effects of four antiepileptic drugs (AEDs) on human sperm motility were studied with a transmembrane migration method. Sperm motility of epileptic patients receiving chronic AED therapy was also investigated. Sperm motility was measured immediately after semen had been mixed with AED and after a 2-h prein...

journal_title：Epilepsia

authors： Chen SS,Shen MR,Chen TJ,Lai SL

更新日期：1992-01-01 00:00:00

abstract：:The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...

journal_title：Epilepsia

authors： Fisher RS,Cross JH,French JA,Higurashi N,Hirsch E,Jansen FE,Lagae L,Moshé SL,Peltola J,Roulet Perez E,Scheffer IE,Zuberi SM

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To develop an epilepsy-specific comorbidity risk adjustment index for mortality outcomes research. METHODS:Data were extracted from five linked administrative databases in Calgary, Canada from April 1, 1996 to March 31, 2004. Epilepsy patients were defined using a validated ICD-9-CM- and ICD-10-CA-based case d...

journal_title：Epilepsia

authors： St Germaine-Smith C,Liu M,Quan H,Wiebe S,Jette N

更新日期：2011-12-01 00:00:00

abstract：:Epileptogenic networks are defined by the brain regions involved in the production and propagation of epileptic activities. In this review we describe the historical, methodologic, and conceptual bases of this model in the analysis of electrophysiologic intracerebral recordings. In the context of epilepsy surgery, the...

journal_title：Epilepsia

authors： Bartolomei F,Lagarde S,Wendling F,McGonigal A,Jirsa V,Guye M,Bénar C

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Children with rolandic spikes may or may not have seizures, ranging from benign rolandic epilepsy to severe atypical rolandic epilepsy. We investigated whether ripples (80-250 Hz), superimposed on rolandic spikes in surface electroencephalography (EEG), can differentiate between different entities. METHODS:I...

journal_title：Epilepsia

authors： van Klink NE,van 't Klooster MA,Leijten FS,Jacobs J,Braun KP,Zijlmans M

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in patients with temporal lobe epilepsy (TLE). METHODS:Memory for public and auto...

journal_title：Epilepsia

authors： Lah S,Lee T,Grayson S,Miller L

更新日期：2006-03-01 00:00:00

abstract：:Electrical stimulation of the visual cortex evoked the cortical focal seizure restricted in the neighbor cortex of the stimulated area in gallamine-immobilized cats. The present experiment was performed to clarify the participation of anticonvulsants in the cortex itself. Phenytoin and carbamazepine depressed the foca...

journal_title：Epilepsia

authors： Ito T,Hori M,Yoshida K,Shimizu M

更新日期：1977-03-01 00:00:00

abstract：:We present a 4-year-old girl with profound global developmental delay and refractory epilepsy characterized by multiple seizure types (partial complex with secondary generalization, tonic, myoclonic, and atypical absence). Her seizure semiology did not fit within a specific epileptic syndrome. Despite a broad metaboli...

journal_title：Epilepsia

authors： Venkateswaran S,Myers KA,Smith AC,Beaulieu CL,Schwartzentruber JA,FORGE Canada Consortium.,Majewski J,Bulman D,Boycott KM,Dyment DA

更新日期：2014-07-01 00:00:00