Abstract:
:Visual behavior is frequently impaired at onset of West syndrome (WS). We studied the neuropsychological outcome of eight children who had cryptogenic WS and moderate to severe visual impairment at the onset of epilepsy. At the last examination, a regional cerebral blood flow study using SPECT (single photon emission computed tomography) was performed. The behavior abnormalities observed initially evolved to various defects of cognitive function. Three patients had severe mental retardation with autistic features. Two had marked speech disorders but one had global cognitive impairment. Three patients had specific visual-spatial deficits. SPECT showed perfusion defects involving the parieto-occipital areas in 6 of 8 patients. These abnormalities were restricted to parieto-occipital regions in the three patients with selective visual-spatial deficits, whereas they were associated with other perfusion defects in the three remaining patients. This study demonstrates that the visual inattention observed at the onset of WS is frequently associated with long-term cognitive and/or perfusion defects involving the parieto-occipital regions.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Jambaqué I,Chiron C,Dulac O,Raynaud C,Syrota Pdoi
10.1111/j.1528-1157.1993.tb00448.xsubject
Has Abstractpub_date
1993-07-01 00:00:00pages
692-700issue
4eissn
0013-9580issn
1528-1167journal_volume
34pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract:PURPOSE:To demonstrate the anatomic localization of the cortical sources of the interictal EEG activity in human idiopathic generalized epilepsy (IGE). METHODS:Multiple cortical and hippocampal sources of the interictal spontaneous EEG activity were investigated by low-resolution electromagnetic tomography in 15 untre...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01030.x
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:Our goal was to study the anticonvulsant action of tiagabine (TGB) at different levels of brain maturation in rats. METHODS:Wistar rats in five age groups (7, 12, 18, 25, and 90 days old) were injected intraperitoneally with TGB at doses of 0.5-32 mg/kg. Thirty minutes later, motor seizures were induced by the...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.2000.tb00112.x
更新日期:2000-11-01 00:00:00
abstract::Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interv...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01217.x
更新日期:2007-12-01 00:00:00
abstract:PURPOSE:Epilepsy is the most common serious neurologic disease, and current treatments are ineffective for journal_title:Epilepsia pub_type: 杂志文章 doi:10.1111/j.1528-1167.2006.00540.x 更新日期:2006-07-01 00:00:00
abstract::The purpose of the study was to examine the impact of idiopathic epilepsy on mothers and fathers in terms of strain, burden of care, worries and perception of vulnerability. Data were collected and analyzed shortly after the diagnosis (T0) and 12 months later (T1). The results indicated that at T0 parents of children ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01145.x
更新日期:2007-09-01 00:00:00
abstract::The elderly are the most rapidly growing segment of the population and the incidence of epilepsy is higher in the elderly than in any other age group. They have been subdivided into the "young old," 65-74 years, "middle old" 75-84 years, and the "old old," 85 years or older. But further subdivisions are needed: person...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00664.x
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To describe a previously unreported type of self-induced pattern-sensitive seizures in a child. METHODS:Evaluation of clinical and EEG features. RESULTS:An 18-month-old boy was initially seen with series of short focal tonic seizures self-induced by gazing intermittently at round objects. Self-induction of th...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2005.54004.x
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:The use of primary health care personnel to identify cases of epilepsy and initiate simple treatment protocols has been advocated as a solution to the numeric inadequacy and uneven distribution of medical manpower available for the management of epilepsy in developing countries. This study sought to evaluate th...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb00749.x
更新日期:1999-04-01 00:00:00
abstract::Quality of life (QOL) must be determined from the patients' subjective viewpoint. To determine QOL in epilepsy, it is necessary to use disease-specific scales. We introduced the Side Effects and Life Satisfaction (SEALS) scale to Japan and performed a comparative study on adult patients with epilepsy and normal subjec...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1996.tb01818.x
更新日期:1996-01-01 00:00:00
abstract::Homocysteine thiolactone (HTL) elicits seizures in mice at a dose of 850 mg/kg (95-100% of animals) with an average latency time of 19.5 min. These seizures are reversed by both 5' N-ethylcarboximide adenosine (NECA) and flunitrazepam, with respective ED50 doses of 0.025 and 0.20 mg/kg. NECA was approximately four-fol...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1990.tb05371.x
更新日期:1990-05-01 00:00:00
abstract:PURPOSE:To investigate the self-reported quality of life (QOL) of children and adolescents with new-onset epilepsy and explore parent's perceptions of their child's QOL and the impact of epilepsy on the family. METHODS:As part of the Standard and New Antiepileptic Drug (SANAD) trial, 248 children (aged 8-15 years) wit...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2011.03094.x
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To review the value of experimental models of epilepsy to help us understand the underlying basic neuronal mechanisms. METHODS:The methods addressed here include a variety of acute and chronic experimental epilepsies and their investigation in vitro, in vivo, and in computer simulations. RESULTS:Epileptic dis...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.0013-9580.2003.12004.x
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:The goal of the study was to assess the health-related quality of life (HRQOL) of persons with epilepsy (PWE) by using the short form survey 36 (SF-36), to compare it with that of a control group and to detect factors influencing it. METHODS:We collected clinical and demographic data and information on health ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2004.56903.x
更新日期:2004-07-01 00:00:00
abstract::Felbamate (2-phenyl-1,3-propanediol dicarbamate), phenytoin, phenobarbital, ethosuximide, and valproate were evaluated in mice and rats with a battery of well-standardized anticonvulsant test procedures. The results obtained indicate that felbamate exhibits a wider range of experimental anticonvulsant activity than ei...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1986.tb03497.x
更新日期:1986-01-01 00:00:00
abstract::Seventy-eight patients with temporal lobe type seizures were precisely matched for age, sex, and Wechsler I.Q. levels with patients suffering from other seizure types. Statistically significant differences were established between the groups in regard to treatment response, etiologies, and behavioral variables. Furthe...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1976.tb03409.x
更新日期:1976-09-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of vigabatrin (VGB) in the treatment of infantile spasms (ISs) associated with Down syndrome (DS) and to assess the feasibility of early discontinuation to reduce the possible retinal toxicity. METHODS:Five children with ISs with DS were treated with vigabatrin as first-line monotherap...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章
doi:10.1046/j.1528-1157.2001.13501.x
更新日期:2001-12-01 00:00:00
abstract::Multiple studies have highlighted how seizures induce different molecular, cellular, and physiologic consequences in an immature brain as compared to a mature brain. In keeping with these studies, seizures early in life alter dentate granule cell birth in different, and even opposing, fashion to adult seizure models (...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2008.01637.x
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:The antiepileptic effects of clobazam, a 1,5-benzodiazepine, have been well documented in animal experiments and clinical trials. However, the drug's mechanisms of antiepileptic actions are still undetermined. The purpose of this study was to learn how clobazam and its active metabolite modulate gamma-aminobuty...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1996.tb00643.x
更新日期:1996-08-01 00:00:00
abstract::The antiepileptic drug sodium valproate (VPA) can provoke a thrombocytopenia or platelet dysfunction, with or without hemorrhages. These unwanted side effects are probably infrequent or, at least, have little clinical importance except in patients undergoing surgery. Thromboelastography appears to be a reliable screen...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1157.1981.tb04094.x
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVE:Benzodiazepines (BZD) are recommended as first-line treatment for status epilepticus (SE), with lorazepam (LZP) and midazolam (MDZ) being the most widely used drugs and part of current treatment guidelines. Clonazepam (CLZ) is also utilized in many countries; however, there is no systematic comparison of thes...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/epi.13056
更新日期:2015-08-01 00:00:00
abstract::Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing response...
journal_title:Epilepsia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1528-1167.2012.03654.x
更新日期:2013-01-01 00:00:00
abstract::The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13670
更新日期:2017-04-01 00:00:00
abstract::A 30-year-old man with long-standing localization-related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic low-grade hemolytic anemia. Pertinent laboratory result...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1994.tb02927.x
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Our objective was to identify whether the whole-brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic-clonic seizures (FBTCS) differ from alterations in patients without FBTCS. METHODS:We dichotomized a cohort of 83 drug-resistant patients with TLE in...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16819
更新日期:2021-01-21 00:00:00
abstract:PURPOSE:To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut-1 DS). METHODS:Twenty children with clinical and laboratory features of Glut-1 DS were evaluated. Age at seizure diagnosis, seizure classification, and response to treatment were determine...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2003.05302.x
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To identify the short-term outcome of patients who had seizures while watching an animated cartoon TV program, "Pocket Monster," on December 16, 1997. METHODS:One and three years after the incident, questionnaires were sent to physicians of each patient about seizure recurrence, EEGs, and medication. RESULTS:...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2004.18903.x
更新日期:2004-04-01 00:00:00
abstract::Continuous, generalized 2.5 to 3.5-Hz spike-wave (SW) discharges were evident in an EEG performed 13 h after a first seizure associated with a viral illness, in an 8-year-old girl. On eye opening, the EEG abnormality was suppressed and replaced by delta activity and brief spike-wave paroxysms. No alteration in conscio...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1995.tb00982.x
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:We evaluated the anticonvulsant efficacy of topiramate (TPM), a structurally novel antiepileptic drug (AED), in amygdala kindled rats that had been preselected with respect to their response to phenytoin (PHT). METHODS:Anticonvulsant response was tested by determining the afterdischarge threshold (ADT; i.e., a...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.2000.tb00176.x
更新日期:2000-04-01 00:00:00
abstract::We report three cases of reflex epilepsy with myoclonic jerks of the right arm and fingers precipitated by calculation using a Soroban. An EEG spike-wave complex with left central prevalence was induced. Various types of stimulation were used to induce epileptic discharges, and a simultaneous mental task requiring a h...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1991.tb05608.x
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:Ictal asystole (IA) and ictal bradycardia (IB) are rare autonomic symptoms during epileptic seizures and may be potentially life-threatening. Guidelines for the care of these patients are missing. The aim of this multicenter study was to evaluate the management and long-term outcome in patients with IA and IB. ...
journal_title:Epilepsia
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1528-1167.2010.02961.x
更新日期:2011-06-01 00:00:00