Abstract:
PURPOSE:To evaluate the efficacy of vigabatrin (VGB) in the treatment of infantile spasms (ISs) associated with Down syndrome (DS) and to assess the feasibility of early discontinuation to reduce the possible retinal toxicity. METHODS:Five children with ISs with DS were treated with vigabatrin as first-line monotherapy in an open prospective study. The short-term response was evaluated, and VGB was continued in responders. The treatment was stopped after 6 months in children who were still spasm free. RESULTS:Four children of five became spasm free with VGB, three of them responding within 1 week. This response was maintained during the 6 months of VGB treatment. After VGB discontinuation, and with a follow-up ranging from 2 to 4 years, none of the responders experienced spasm recurrence or other types of seizures. CONCLUSIONS:This study confirms the efficacy of VGB in ISs associated with DS. Moreover, it shows that the duration of VGB treatment can be reduced to 6 months without relapse of ISs. This short treatment might reduce the risk of developing visual field constriction.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Nabbout R,Melki I,Gerbaka B,Dulac O,Akatcherian Cdoi
10.1046/j.1528-1157.2001.13501.xsubject
Has Abstractpub_date
2001-12-01 00:00:00pages
1580-3issue
12eissn
0013-9580issn
1528-1167pii
13501journal_volume
42pub_type
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