Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy.

Abstract:

:Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at efficacy of bumetanide, a specific NKCC1 antagonist, on reduction of seizure frequency in adult patients with temporal lobe epilepsy. According to our results, seizure frequency was reduced considerably in these patients. Furthermore, epileptiform discharges decreased in two of our patients. If the efficacy of bumetanide is proven in large scale studies, it can be used as a supplemental therapy in temporal lobe epilepsy.

journal_name

Epilepsia

journal_title

Epilepsia

authors

Eftekhari S,Mehvari Habibabadi J,Najafi Ziarani M,Hashemi Fesharaki SS,Gharakhani M,Mostafavi H,Joghataei MT,Beladimoghadam N,Rahimian E,Hadjighassem MR

doi

10.1111/j.1528-1167.2012.03654.x

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

e9-12

issue

1

eissn

0013-9580

issn

1528-1167

journal_volume

54

pub_type

临床试验,杂志文章
  • Atrophy of the pedunculopontine nucleus region in patients with sleep-predominant seizures: A voxel-based morphometry study.

    abstract::Non-rapid eye movement (NREM) sleep increases interictal epileptiform discharges and frequency of seizures, whereas REM sleep suppresses them. The pedunculopontine nucleus (PPN), one of the REM sleep-modulating structures, is postulated to have a potent antiepileptogenic role. We asked if patients with sleep-predomina...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13431

    authors: Cho KH,Cho YJ,Lee BI,Heo K

    更新日期:2016-08-01 00:00:00

  • Functional magnetic resonance imaging in partial epilepsy.

    abstract::Functional magnetic resonance imaging (FMRI) detects signal changes in brain that accompany regional changes in neuronal activity. In normal human brain, FMRI shows changes in signal in the postcentral gyrus or superior temporal gyrus that correlate with voluntary motor activity or language processing, respectively. T...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1994.tb01788.x

    authors: Morris GL 3rd,Mueller WM,Yetkin FZ,Haughton VM,Hammeke TA,Swanson S,Rao SM,Jesmanowicz A,Estkowski LD,Bandettini PA

    更新日期:1994-11-01 00:00:00

  • Epileptic seizures in elderly patients with dementia.

    abstract::All inpatients aged greater than 55 years with dementia in the Dundee Psychiatric Service were surveyed for seizure occurrence by interviewing staff and reviewing records. Of 208 patients, 19 (9.1%) were recorded as having seizures. The seizures were major in 92% and occurred at a rate of approximately 2.3 seizures pe...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1992.tb02343.x

    authors: McAreavey MJ,Ballinger BR,Fenton GW

    更新日期:1992-07-01 00:00:00

  • Voltage-sensitive calcium channel development in epileptic DBA/2J mice suggests altered presynaptic function.

    abstract::Aberrant synapse formation has been implicated in development and propagation of epileptic potential. Litzinger et al. (1993a) showed that omega-GVIA conotoxin may be used as a marker for synapse formation in nonepileptic mice. We conducted omega-GVIA binding in synaptosomal preparations from epileptic DBA/2J mice at ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1994.tb02533.x

    authors: Esplin MS,Abbott JR,Smart ML,Burroughs AF,Frandsen TC,Litzinger MJ

    更新日期:1994-09-01 00:00:00

  • Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment.

    abstract::The mean gamma-aminobutyric acid (GABA) level in lumbar CSF of 31 children with epilepsy was not significantly different from that of 41 age-matched controls. However, when the epileptic children were subdivided into untreated patients and patients treated with antiepileptic drugs, the medication-free subgroup had a s...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1985.tb05656.x

    authors: Löscher W,Siemes H

    更新日期:1985-07-01 00:00:00

  • Altered behavior in experimental cortical dysplasia.

    abstract:PURPOSE:Developmental delay and cognitive impairment are common comorbidities in people with epilepsy associated with malformations of cortical development (MCDs). We studied cognition and behavior in an animal model of diffuse cortical dysplasia (CD), in utero irradiation, using a battery of behavioral tests for neuro...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2011.03267.x

    authors: Zhou FW,Rani A,Martinez-Diaz H,Foster TC,Roper SN

    更新日期:2011-12-01 00:00:00

  • Non-monoamine oxidase inhibitor antidepressants and epilepsy: a review.

    abstract::The literature dealing with the convulsant effects of the antidepressant drugs of the non-monoamine oxidase inhibitor variety is reviews. It is concluded that most of these drugs do lower the seizure threshold and may precipitate seizures even at normal therapeutic doses. The pathophysiology of antidepressant-induced ...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1157.1978.tb04486.x

    authors: Trimble M

    更新日期:1978-06-01 00:00:00

  • WONOEP appraisal: optogenetic tools to suppress seizures and explore the mechanisms of epileptogenesis.

    abstract::Optogenetics is a novel technology that combines optics and genetics by optical control of microbial opsins, targeted to living cell membranes. The versatility and the electrophysiologic characteristics of the light-sensitive ion-channels channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and the light-sensitive proton ...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/epi.12804

    authors: Mantoan Ritter L,Golshani P,Takahashi K,Dufour S,Valiante T,Kokaia M

    更新日期:2014-11-01 00:00:00

  • Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice.

    abstract:PURPOSE:Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy. Because the majority of patients continue to receive antiepileptic drugs (AEDs) during KD treatment, interactions between acetone...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2008.01864.x

    authors: Zarnowska I,Luszczki JJ,Zarnowski T,Buszewicz G,Madro R,Czuczwar SJ,Gasior M

    更新日期:2009-05-01 00:00:00

  • Low-pressure hydrocephalic state complicating hemispherectomy: a case report.

    abstract:UNLABELLED:Low-pressure hydrocephalic state (LPHS) has only recently been described as a distinct clinical entity occurring in patients with bioatrophic lesions of the brain. We report a patient in whom this syndrome developed after subtotal hemispherectomy for intractable epilepsy. METHODS:A 30-year-old man developed...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2002.46101.x

    authors: Daniel RT,Lee GY,Halcrow SJ

    更新日期:2002-05-01 00:00:00

  • The HLA-A*2402/Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population.

    abstract::The use of lamotrigine (LTG) can be limited by the occurrence of cutaneous adverse drug reactions (cADRs) that range from maculopapular eruption (MPE) to the more severe Stevens-Johnson syndrome and toxic epidermal necrolysis. A few human leukocyte antigen (HLA)-related genetic risk factors for carbamazepine-induced c...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13087

    authors: Moon J,Park HK,Chu K,Sunwoo JS,Byun JI,Lim JA,Kim TJ,Shin JW,Lee ST,Jung KH,Jung KY,Jeon D,Kim DW,Yu KS,Jang IJ,Kang HR,Park HW,Lee SK

    更新日期:2015-10-01 00:00:00

  • Kindled seizures elevate blood pressure and induce cardiac arrhythmias.

    abstract::The effect of kindled seizures on the cardiovascular system was examined in amygdaloid kindled rats. The most prominent cardiovascular response during a generalized kindled seizure was an abrupt 50% increase in mean arterial pressure (MAP) lasting 20-30 s after initiation of the seizure. Superimposed on this change in...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1990.tb06096.x

    authors: Goodman JH,Homan RW,Crawford IL

    更新日期:1990-09-01 00:00:00

  • Serum sex hormones are altered in patients with chronic temporal lobe epilepsy receiving anticonvulsant medication.

    abstract:PURPOSE:To evaluate the changes in serum sex hormones of gonadal or adrenal origin, the gonadotropic hormones, and sex hormone-binding globulin (SHBG) in men and women with chronic temporal lobe epilepsy (TLE), who are undergoing monotherapy with carbamazepine or receiving carbamazepine in combination with other antico...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1998.tb01307.x

    authors: Stoffel-Wagner B,Bauer J,Flügel D,Brennemann W,Klingmüller D,Elger CE

    更新日期:1998-11-01 00:00:00

  • Long-term add-on pregabalin treatment in patients with partial-onset epilepsy: pooled analysis of open-label clinical trials.

    abstract:PURPOSE:To evaluate the safety, tolerability, and efficacy of long-term pregabalin as add-on therapy for patients with poorly controlled partial seizures. METHODS:Analysis of data from six long-term clinical trials involving 2,061 patients receiving open-label pregabalin 75-600 mg/day adjunctive therapy for partial on...

    journal_title:Epilepsia

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1528-1167.2010.02532.x

    authors: Uthman BM,Bazil CW,Beydoun A,Schulze-Bonhage A,Benabou R,Whalen E,Emir B,Griesing T,Leon T

    更新日期:2010-06-01 00:00:00

  • Traumatic brain injury: risks of epilepsy and implications for medicolegal assessment.

    abstract::Traumatic brain injury (TBI) is a potentially preventable cause of epilepsy. Increasing incidence among army personnel and the high incidence among children and young people raise concern. This article presents a review of selected studies dealing with the risks of TBI and the risk of posttraumatic epilepsy in humans....

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2012.03612.x

    authors: Christensen J

    更新日期:2012-09-01 00:00:00

  • In situ metabolism of levetiracetam in blood of patients with epilepsy.

    abstract:PURPOSE:Although levetiracetam undergoes minimum metabolism, B-esterases have been identified in whole blood that are capable of metabolising levetiracetam. The present study was designed to ascertain any variability in levetiracetam blood concentrations that could be attributed to in situ metabolism and which could im...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2006.00819.x

    authors: Patsalos PN,Ghattaura S,Ratnaraj N,Sander JW

    更新日期:2006-11-01 00:00:00

  • Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities.

    abstract:PURPOSE:Evidence for a poor psychiatric, social, and vocational adult outcome in childhood absence epilepsy (CAE) suggests long-term unmet mental health, social, and vocational needs. This cross-sectional study examined behavioral/emotional, cognitive, and linguistic comorbidities as well as their correlates in childre...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2008.01680.x

    authors: Caplan R,Siddarth P,Stahl L,Lanphier E,Vona P,Gurbani S,Koh S,Sankar R,Shields WD

    更新日期:2008-11-01 00:00:00

  • The ketogenic diet in a pill: is this possible?

    abstract::Over the past decade, much progress has been made in understanding the mechanisms of ketogenic diet (KD) action. From the complex systemic and metabolic changes induced by the KD have emerged innovative hypotheses attempting to link biochemical adaptations to its clinical effects. Despite such developments, the fundam...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2008.01857.x

    authors: Rho JM,Sankar R

    更新日期:2008-11-01 00:00:00

  • Levetiracetam, a new antiepileptic agent: lack of in vitro and in vivo pharmacokinetic interaction with valproic acid.

    abstract:PURPOSE:The novel antiepileptic drug (AED) levetiracetam (LEV; Keppra) has a wide therapeutic index and pharmacokinetic characteristics predicting limited drug-interaction potential. It is indicated as an add-on treatment in patients with epilepsy, and thus coadministration with valproic acid (VPA) is likely. These stu...

    journal_title:Epilepsia

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1528-1157.2003.25302.x

    authors: Coupez R,Nicolas JM,Browne TR

    更新日期:2003-02-01 00:00:00

  • Bicuculline methiodide in the blood-brain barrier-epileptogen model of epilepsy.

    abstract::Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviora...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1985.tb05189.x

    authors: Remler MP,Marcussen WH

    更新日期:1985-01-01 00:00:00

  • Double-blind, placebo-controlled trial of topiramate as add-on therapy in patients with refractory partial seizures.

    abstract::In a double-blind, randomized, parallel-group trial, we compared topiramate (TPM) with placebo as add-on therapy in patients with refractory partial epilepsy. TPM was titrated either to the target dosage of 800 mg/ day [400 mg twice daily (b.i.d)] or to the maximal tolerated dose if lower. Twenty-eight (28) patients w...

    journal_title:Epilepsia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1528-1157.1996.tb00606.x

    authors: Ben-Menachem E,Henriksen O,Dam M,Mikkelsen M,Schmidt D,Reid S,Reife R,Kramer L,Pledger G,Karim R

    更新日期:1996-06-01 00:00:00

  • Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid.

    abstract::In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome. Among our patients who were prescribed the new cannabidiol formulation, we observed several ca...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16596

    authors: McNamara NA,Dang LT,Sturza J,Ziobro JM,Fedak Romanowski EM,Smith GC,Joshi SM,Leber SM,Carlson M,Robertson P,Shellhaas RA

    更新日期:2020-08-01 00:00:00

  • Trends in lobectomy/amygdalohippocampectomy over time and the impact of hospital surgical volume on hospitalization outcomes: A population-based study.

    abstract:OBJECTIVE:Despite national guidelines supporting surgical referral in drug-resistant epilepsy, it is hypothesized that surgery is underutilized. We investigated the volumes of lobectomy/amygdalohippocampectomy surgeries over time and examined differences in outcomes between (1) high-volume (HV), middle-volume (MV), and...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16664

    authors: Kwon CS,Blank L,Mu L,Jetté N

    更新日期:2020-10-01 00:00:00

  • Early-onset benign occipital seizure susceptibility syndrome.

    abstract:PURPOSE:Childhood epilepsy with occipital paroxysms (CEOP) is characterised by ictal visual hallucinations and occipital epileptiform activity on interictal EEG. A variant has been described with nonvisual symptoms including tonic head and eye deviation, vomiting, and episodes of partial status epilepticus. We fully do...

    journal_title:Epilepsia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1528-1157.1997.tb01119.x

    authors: Ferrie CD,Beaumanoir A,Guerrini R,Kivity S,Vigevano F,Takaishi Y,Watanabe K,Mira L,Capizzi G,Costa P,Valseriati D,Grioni D,Lerman P,Ricci S,Vigliano P,Goumas-Kartalas A,Hashimoto K,Robinson RO,Panayiotopoulos CP

    更新日期:1997-03-01 00:00:00

  • Late-onset epilepsy and 25-year cognitive change: The Atherosclerosis Risk in Communities (ARIC) study.

    abstract:OBJECTIVE:To define the association between late-onset epilepsy (LOE) and 25-year change in cognitive performance. METHODS:The Atherosclerosis Risk in Communities (ARIC) study is a multicenter longitudinal cohort study with participants from four U.S. communities. From linked Medicare claims, we identified cases of LO...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16616

    authors: Johnson EL,Krauss GL,Walker KA,Brandt J,Kucharska-Newton A,Mosley TH Jr,Yasar S,Gottesman RF

    更新日期:2020-08-01 00:00:00

  • Hippocampal antioxidative system in mesial temporal lobe epilepsy.

    abstract:OBJECTIVE:To examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mTLE-HS). METHODS:Activity and levels of antioxidative enzymes-catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), manganese superoxide dismutase (MnSOD), ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.12981

    authors: Ristić AJ,Savić D,Sokić D,Bogdanović Pristov J,Nestorov J,Baščarević V,Raičević S,Savić S,Spasojević I

    更新日期:2015-05-01 00:00:00

  • The early prognosis of epilepsy in childhood: the prediction of a poor outcome. The Dutch study of epilepsy in childhood.

    abstract:PURPOSE:To examine which variables available early in the course of childhood epilepsy are associated with a poor short-term outcome and to develop models to predict such an outcome. METHODS:We prospectively followed up 466 children with newly diagnosed epilepsy for 2 years. Variables were collected at intake and afte...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1999.tb00770.x

    authors: Arts WF,Geerts AT,Brouwer OF,Boudewyn Peters AC,Stroink H,van Donselaar CA

    更新日期:1999-06-01 00:00:00

  • Patterns of altered functional connectivity in mesial temporal lobe epilepsy.

    abstract:PURPOSE:In mesial temporal lobe epilepsy (MTLE) the epileptogenic area is confined to the mesial temporal lobe, but other cortical and subcortical areas are also affected and cognitive and psychiatric impairments are usually documented. Functional connectivity methods are based on the correlation of the blood oxygen le...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2012.03464.x

    authors: Pittau F,Grova C,Moeller F,Dubeau F,Gotman J

    更新日期:2012-06-01 00:00:00

  • Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy.

    abstract:PURPOSE:A pilot study of the safety, tolerability, dose range and potential efficacy of ganaxolone for the treatment of refractory epilepsy in pediatric and adolescent subjects. METHODS:We report the results of a nonrandomized, nonblinded, open-label, dose-escalation trial of ganaxolone in pediatric subjects (5-15 yea...

    journal_title:Epilepsia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1528-1167.2007.01182.x

    authors: Pieribone VA,Tsai J,Soufflet C,Rey E,Shaw K,Giller E,Dulac O

    更新日期:2007-10-01 00:00:00

  • Temporal lobe epilepsy surgery in children and adults: A multicenter study.

    abstract:OBJECTIVE:To assess seizure and cognitive outcomes and their predictors in children (<16 years at surgery) and adults undergoing temporal lobe epilepsy (TLE) surgery in eight Italian centers. METHODS:This is a retrospective multicenter study. We performed a descriptive analysis and subsequently carried out multivariab...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16772

    authors: Barba C,Cossu M,Guerrini R,Di Gennaro G,Villani F,De Palma L,Grisotto L,Consales A,Battaglia D,Zamponi N,d'Orio P,Revay M,Rizzi M,Casciato S,Esposito V,Quarato PP,Di Giacomo R,Didato G,Pastori C,Pavia GC,Pellacani

    更新日期:2021-01-01 00:00:00