Abstract:
:Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at efficacy of bumetanide, a specific NKCC1 antagonist, on reduction of seizure frequency in adult patients with temporal lobe epilepsy. According to our results, seizure frequency was reduced considerably in these patients. Furthermore, epileptiform discharges decreased in two of our patients. If the efficacy of bumetanide is proven in large scale studies, it can be used as a supplemental therapy in temporal lobe epilepsy.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Eftekhari S,Mehvari Habibabadi J,Najafi Ziarani M,Hashemi Fesharaki SS,Gharakhani M,Mostafavi H,Joghataei MT,Beladimoghadam N,Rahimian E,Hadjighassem MRdoi
10.1111/j.1528-1167.2012.03654.xsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
e9-12issue
1eissn
0013-9580issn
1528-1167journal_volume
54pub_type
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