Abstract:
PURPOSE:To investigate the self-reported quality of life (QOL) of children and adolescents with new-onset epilepsy and explore parent's perceptions of their child's QOL and the impact of epilepsy on the family. METHODS:As part of the Standard and New Antiepileptic Drug (SANAD) trial, 248 children (aged 8-15 years) with new-onset epilepsy and their parents completed batteries of QOL measures. Children completed the KINDL and subscales of the QOLIE-AD-48. Parental questionnaires included the Rutter Parent Scales, Adverse Events Profile, and subscales of the Child Health Questionnaire. KEY FINDINGS:Compared with published norms, children with epilepsy had significantly poorer QOL across multiple domains compared with healthy children and children with asthma. Parents, particularly of younger children and those with other long-term health problems, were affected by their child's health or behavior, which affected their emotional well-being and time for their own needs. SIGNIFICANCE:Children with new-onset epilepsy, particularly those with comorbid conditions, are at risk of reduced QOL at the time of diagnosis. It is important that children with epilepsy and their families are assessed for psychosocial problems so that early intervention can be undertaken.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Taylor J,Jacoby A,Baker GA,Marson AGdoi
10.1111/j.1528-1167.2011.03094.xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
1489-98issue
8eissn
0013-9580issn
1528-1167journal_volume
52pub_type
杂志文章相关文献
EPILEPSIA文献大全abstract::Valproate (VPA) is an effective, widely used antiepileptic drug. Unfortunately its use in pregnant women is associated with neural tube defects in the offspring. Although the etiology of neural tube defects is multifactorial, there is evidence that underlying genetic susceptibility plays a part. We describe two women ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2001.44300.x
更新日期:2001-06-01 00:00:00
abstract:PURPOSE:We evaluated the role of interictal rhythmical midline theta (RMT) in the identification of frontal lobe epilepsy (FLE) and its differentiation from temporal lobe epilepsy (TLE) and nonepileptic controls. METHODS:We included 162 individuals in the study: 54 FLE patients, 54 TLE patients, and 54 nonepileptic co...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2008.01780.x
更新日期:2009-03-01 00:00:00
abstract::The incidence of biochemical signs of vitamin D deficiency and the effects of vitamin D supplementation were investigated in 83 children and 95 adults on chronic antiepileptic therapy and 40 mentally retarded controls living under comparable conditions. Low 25-hydroxyvitamin D and serum calcium, and elevated immunorea...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1979.tb04771.x
更新日期:1979-02-01 00:00:00
abstract:PURPOSE:To describe the long-term outcome of childhood-onset secondarily generalized epilepsies (SGEs). METHODS:Children were identified from the Nova Scotia population-based epilepsy study (n=692). Onset of epilepsy was between 1977 and 1985, and follow-up was mainly in 2003. SGE was defined as having a mixture of mo...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01072.x
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:To determine the lateralizing value of the clinical manifestations of seizures in patients with temporal lobe epilepsy (TLE), we made a retrospective videotape analysis of complex partial seizures (CPS) in 55 patients who underwent temporal lobectomy and were seizure-free postoperatively for >2 years. METHODS:...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1998.tb01157.x
更新日期:1998-07-01 00:00:00
abstract:PURPOSE:To evaluate the potential pharmacokinetic interactions between topiramate (TPM) and phenytoin (PHT) in patients with epilepsy by studying their pharmacokinetics (PK) after monotherapy and concomitant TPM/PHT treatment. METHODS:Twelve patients with epilepsy stabilized on PHT monotherapy were enrolled in this st...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1046/j.1528-1157.2002.41701.x
更新日期:2002-07-01 00:00:00
abstract::With the launching worldwide of a range of new antiepileptic drugs (AEDs), the prescriber has a much wider choice than ever before. Comparative studies between new and established AEDs are few, and those between new AEDs are rarely performed. This report considers the strengths and weaknesses of nine new and establish...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1157.1994.tb05966.x
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:Appropriate treatment of generalized convulsive refractory status epilepticus (RSE) requires general anesthesia in the intensive care unit (ICU) with continuous electroencephalography (cEEG) monitoring. During out of office hours and weekends, cEEG monitoring is not always available. The Bispectral Index (BIS) ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2009.02514.x
更新日期:2010-08-01 00:00:00
abstract:PURPOSE:Mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) is the most common of the antiepileptic drug (AED)-resistant seizure syndromes that are remediable mostly with surgery, although a small group of patients have benign prognosis with fewer seizures. Material-specific memory impairment ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.0013-9580.2004.23304.x
更新日期:2004-11-01 00:00:00
abstract::Amygdala kindling, the progressive development of seizures following repeated electrical stimulation, has been used as a model of epileptogenesis, neural memory, and the development of behavioral alterations. In an attempt to interfere with the kindling process, electroconvulsive seizures (ECS) were administered 6 h p...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1984.tb04181.x
更新日期:1984-04-01 00:00:00
abstract:PURPOSE:To demonstrate the anatomic localization of the cortical sources of the interictal EEG activity in human idiopathic generalized epilepsy (IGE). METHODS:Multiple cortical and hippocampal sources of the interictal spontaneous EEG activity were investigated by low-resolution electromagnetic tomography in 15 untre...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01030.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:Few studies have examined the long-term sustainability of complete seizure freedom on the ketogenic diet (KD). The purpose of this study was to describe the risk of seizure recurrence in children who achieved at least 1 month of seizure freedom on the KD, and to assess clinical features associated with sustai...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/epi.12583
更新日期:2014-04-01 00:00:00
abstract::Why some patients with seizures are successfully treated with antiepileptic drugs (AEDs) and others prove medically intractable is not known. Inadequate intraparenchymal drug concentration is a possible mechanism of resistance to AEDs. The multiple drug resistance gene (MDR1) encodes P-glycoprotein, an energy-dependen...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1995.tb01657.x
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The incidence of status epilepticus (SE) in Asian children, including Japanese, has not been reported. METHODS:In 2003, we performed an epidemiological study of SE on Japanese children (31 days or older to <15 years of age) in Okayama City by ascertaining all lifetime first episodes of SE. RESULTS:Thirty-s...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01106.x
更新日期:2007-06-01 00:00:00
abstract::Before a health education program can be established, one must first know what the target population believes and does with respect to the disease in question. Therefore, we performed a study among Tanzanian rural inhabitants to identify their knowledge, attitude, and practice (KAP) toward epilepsy: 3,256 heads of hou...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1993.tb02127.x
更新日期:1993-11-01 00:00:00
abstract::Forty-eight patients with complex partial and/or tonic-clonic seizures were treated with an 8 p.m. single dose of carbamazepine slow release (CBZ-SR) monotherapy. The steady-state serum level profiles of carbamazepine (CBZ) and its metabolites CBZ-10,11-epoxide (CBZE) and 10,11-dihydro-CBZ-10,11-diole (CBZD) during 24...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1988.tb03763.x
更新日期:1988-09-01 00:00:00
abstract::Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2009.02218.x
更新日期:2009-08-01 00:00:00
abstract:PURPOSE:Doublecortin (DCX) is a microtubule-associated protein with regulatory roles in radial and tangential migration of neurons during cortical development. In normal adult cortex there is restricted expression, and DCX is widely used as a marker of neurogenesis. Imperfect corticogenesis is thought to underpin many ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2009.02194.x
更新日期:2009-12-01 00:00:00
abstract::The Washington Psychosocial Seizure Inventory (WPSI) was used to evaluate the relative extent of psychosocial problems in 379 adults with epilepsy, having differing levels of intelligence and neuropsychological impairment. In general, there were more psychosocial problems when abilities were decreased. Two new scales ...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1983.tb04859.x
更新日期:1983-02-01 00:00:00
abstract:PURPOSE:Myoclonic astatic epilepsy (MAE) is a generalized epilepsy of early childhood. Little is known about the use of newer antiepileptic treatments (AET) in MAE. The purpose of this study was to describe the characteristics, treatment, and outcome of a contemporary MAE cohort exposed to the new generation AET. METH...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2007.01186.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Recent evidence suggests a metabolic contribution of cytochrome P450 enzymes (CYPs) to the drug-resistant phenotype in human epilepsy. However, the upstream molecular regulators of CYP in the epileptic brain remain understudied. We therefore investigated the expression and function of pregnane xenobiotic (PXR...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.13703
更新日期:2017-04-01 00:00:00
abstract::Despite over 80 years of use, the ketogenic diet (KD) has never been tested in a blinded manner. Twenty children with intractable Lennox-Gastaut syndrome (LGS) were fasted 36 h and then randomized to receive the classic KD in conjunction with a solution containing either 60 g/day of glucose or saccharin. Parents and p...
journal_title:Epilepsia
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1528-1167.2008.01740.x
更新日期:2009-02-01 00:00:00
abstract::We present a review of phenotype-genotype correlation and the genetics of photosensitivity. The photoparoxysmal response in EEG (PPR) is still one of the best paradigms for exogenously triggered brain responses based on a genetic predisposition. The definition of the PPR phenotype requires multiple, precise methodolog...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.0013-9580.2004.451008.x
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:We investigated the incidence of well-directed violent behavior and suicide attempts in patients with temporal lobe epilepsy, with special attention to postictal psychosis. METHODS:We compared 57 episodes of postictal psychosis with 62 episodes of acute interictal (or alternative) psychosis and with 134 comple...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1999.tb01996.x
更新日期:1999-01-01 00:00:00
abstract::Pentylenetetrazol (PTZ) was injected into rats (30 or 35 mg/kg) and guinea pigs (40 or 45 mg/kg) daily or every second day. A progressive development of seizure activity after this treatment was observed. Doses ineffective after the first injection induced tonic seizures after 20 injections. Both kinds of treated anim...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1157.1984.tb03452.x
更新日期:1984-08-01 00:00:00
abstract:PURPOSE:To study the neuropsychological status of an epileptic patient presenting with epileptic activity triggered by eye closure in a 14-year follow-up period. METHODS:The patient was studied at 12 and 26 years of age; during this period he underwent periodical clinical evaluations and EEG investigations; brain magn...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00708.x
更新日期:2006-01-01 00:00:00
abstract::Children with epilepsy often grow into adults with significant social problems including decreased employment, marriage, social relationships, and independent living arrangements. These problems are noted in population-based longitudinal and cross-sectional studies from many countries. Learning disorder and mental han...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2007.01390.x
更新日期:2007-01-01 00:00:00
abstract::To improve the diagnostic accuracy of electroencephalography (EEG) criteria for nonconvulsive status epilepticus (NCSE), external validation of the recently proposed Salzburg criteria is paramount. We performed an external, retrospective, diagnostic accuracy study of the Salzburg criteria, using EEG recordings from pa...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/epi.16289
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:Although levetiracetam undergoes minimum metabolism, B-esterases have been identified in whole blood that are capable of metabolising levetiracetam. The present study was designed to ascertain any variability in levetiracetam blood concentrations that could be attributed to in situ metabolism and which could im...
journal_title:Epilepsia
pub_type: 杂志文章
doi:10.1111/j.1528-1167.2006.00819.x
更新日期:2006-11-01 00:00:00
abstract::The interictal EEG provides information that aids in diagnosis and management of epilepsy. One must remember that the EEG is merely a tool, and its usefulness depends largely upon the skill of the individual who wields it. Like all diagnostic tests, it has significant limitations and cannot substitute for a careful hi...
journal_title:Epilepsia
pub_type: 杂志文章,评审
doi:10.1111/j.1528-1167.2006.00654.x
更新日期:2006-01-01 00:00:00