Abstract:
:Despite over 80 years of use, the ketogenic diet (KD) has never been tested in a blinded manner. Twenty children with intractable Lennox-Gastaut syndrome (LGS) were fasted 36 h and then randomized to receive the classic KD in conjunction with a solution containing either 60 g/day of glucose or saccharin. Parents and physicians were blinded to both the solution composition and level of ketosis. A crossover to the KD with the alternate solution occurred following the sixth day and a repeat fast. A 24-h electroencephalography (EEG) was obtained at baseline and after each arm. After administration of the solution, there was moderate evidence of a reduction in parent-reported seizures between the glucose and saccharin arms, with a median difference of 1.5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Freeman JM,Vining EP,Kossoff EH,Pyzik PL,Ye X,Goodman SNdoi
10.1111/j.1528-1167.2008.01740.xsubject
Has Abstractpub_date
2009-02-01 00:00:00pages
322-5issue
2eissn
0013-9580issn
1528-1167pii
EPI1740journal_volume
50pub_type
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