A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy.

abstract：OBJECTIVE:Previous studies examining seizures in patients with 22q11.2 deletion syndrome (22q11.2DS) have focused primarily on children and adolescents. In this study we investigated the prevalence and characteristics of seizures and epilepsy in an adult 22q11.2DS population. METHODS:The medical records of 202 adult p...

journal_title：Epilepsia

authors： Wither RG,Borlot F,MacDonald A,Butcher NJ,Chow EWC,Bassett AS,Andrade DM

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:In CSWS (continuous spike waves during sleep) activation of spike waves during slow wave sleep has been causally linked to neuropsychological deficits, but the pathophysiologic mechanisms are still unknown. In healthy subjects, the overnight decrease of the slope of slow waves in NREM (non-rapid eye movement)...

journal_title：Epilepsia

authors： Bölsterli Heinzle BK,Fattinger S,Kurth S,Lebourgeois MK,Ringli M,Bast T,Critelli H,Schmitt B,Huber R

更新日期：2014-04-01 00:00:00

abstract：:Clinical and epidemiological research studies are essential to advancing our understanding of human health conditions such as epilepsy. To be of value, studies must not only address important questions, they must do so in such a way as to contribute usefully to existing knowledge. Comprehensive understanding of the su...

journal_title：Epilepsia

authors： Berg AT

更新日期：2007-12-01 00:00:00

abstract：:Ictal and interictal epileptic activity was recorded for the first time by multichannel magnetoencephalography (MEG) in three patients with partial epilepsy. Pre- and intra-operative localization of the epileptogenic region was compared. The interictal epileptic activity was localized at the same region of the tempora...

journal_title：Epilepsia

authors： Stefan H,Schneider S,Feistel H,Pawlik G,Schüler P,Abraham-Fuchs K,Schlegel T,Neubauer U,Huk WJ

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:To study the neuropsychological status of an epileptic patient presenting with epileptic activity triggered by eye closure in a 14-year follow-up period. METHODS:The patient was studied at 12 and 26 years of age; during this period he underwent periodical clinical evaluations and EEG investigations; brain magn...

journal_title：Epilepsia

authors： Termine C,Rubboli G,Veggiotti P

更新日期：2006-01-01 00:00:00

abstract：:Little is known about what factors predict intractable epilepsy at the time of initial diagnosis. We performed a case-control study to identify early predictors of medically intractable epilepsy in children. Cases were children who had an average of one seizure or more a month over a 2-year period and who, during that...

journal_title：Epilepsia

authors： Berg AT,Levy SR,Novotny EJ,Shinnar S

更新日期：1996-01-01 00:00:00

abstract：:We sought to determine if there are differences in the incidence of seizure disorders between the children of the indigenous and immigrant (predominantly Pakistani) populations of Bradford, United Kingdom. Annual incidence rates per 100,000 for new onset seizures were calculated along with Townsend deprivation scores....

journal_title：Epilepsia

authors： Hamdy NA,Ginby D,Feltbower R,Ferrie CD

更新日期：2007-05-01 00:00:00

abstract：:The randomized, double-blind trial design offers the most accurate data regarding the efficacy of antiepileptic treatments. However, translating the results of a trial into clinical care can be complex due to the intrinsic tension between the requirements for scientific methods that minimize systematic and random erro...

journal_title：Epilepsia

authors： Gilliam F

更新日期：2003-01-01 00:00:00

abstract：:Nocturnal frontal lobe epilepsy (NFLE) is a condition primarily characterized by seizures occurring exclusively or predominantly during sleep, the semiology of which suggest a frontal lobe origin and, more specifically, the involvement of the orbitofrontal or mesial frontal regions. It is usually considered as a relat...

journal_title：Epilepsia

authors： Ryvlin P,Rheims S,Risse G

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:  Memory impairment is a common comorbidity in people with epilepsy-associated malformations of cortical development. We studied spatial memory performance and hippocampal synaptic plasticity in an animal model of cortical dysplasia. METHODS:  Embryonic day 17 rats were exposed to 2.25 Gy external radiation. O...

journal_title：Epilepsia

authors： Zhou FW,Roper SN

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:To determine whether differences in clinical manifestations of psychogenic nonepileptic events are associated with differences in outcome and whether the length of illness before diagnosis correlates with outcome. METHODS:We reviewed ictal videotapes and EEGs in 85 patients diagnosed with exclusively nonepilep...

journal_title：Epilepsia

authors： Selwa LM,Geyer J,Nikakhtar N,Brown MB,Schuh LA,Drury I

更新日期：2000-10-01 00:00:00

abstract：:We examined the seizure records of 13 patients (nine men and four women, ages 27-50 years) with intractable partial epilepsy, maintained with steady anti-epileptic drug dosages. Patients recorded daily seizure frequency on calendars. Periods of outpatient observation ranged from 99 to 1,710 days and the number of obse...

journal_title：Epilepsia

authors： Balish M,Albert PS,Theodore WH

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:This study aims to map the temporal and extratemporal 18-fluorodeoxyglucose positron emission tomography (FDG-PET)-defined hypometabolism in mesial temporal lobe epilepsy (MTLE). We hypothesize that quantitative analysis will reveal extensive extratemporal glucose hypometabolism (EH), that the EH is related to ...

journal_title：Epilepsia

authors： Wong CH,Bleasel A,Wen L,Eberl S,Byth K,Fulham M,Somerville E,Mohamed A

更新日期：2010-08-01 00:00:00

abstract：:Medically intractable tonic and atonic seizures may be responsive to either vagus nerve stimulation (VNS) or corpus callosum section. VNS has been shown to be effective and is associated with very low morbidity. Callosotomy is a more ambitious procedure, with a higher risk of complications but greater likelihood of se...

journal_title：Epilepsia

authors： Rosenfeld WE,Roberts DW

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and tolerability of antiepileptic drugs (AEDs) in elderly individuals with epilepsy. METHODS:We searched four electronic databases as well as bibliographies and conference abstracts. Published and unpublished, randomized, or quasirandomized trials reporting the use of AEDs in people ...

journal_title：Epilepsia

authors： Lezaic N,Gore G,Josephson CB,Wiebe S,Jetté N,Keezer MR

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Patients with medically intractable epilepsy due to brain tumors may undergo resective surgery for treatment of both the tumor and the epilepsy. In this instance, the extent of surgical resection is sometimes guided by spikes recorded on intraoperative electrocorticography (ECoG). Whether spikes recorded by ele...

journal_title：Epilepsia

authors： Tran TA,Spencer SS,Javidan M,Pacia S,Marks D,Spencer DD

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:Diacylglycerol kinase epsilon (DGKepsilon) regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid signaling. We studied the significance of arachidonoyl-diacylglycerol (20:4 DAG) in epileptogenesis in DGKepsilon-deficient mice undergoing rapid kindling epileptogenesis. ...

journal_title：Epilepsia

authors： Musto A,Bazan NG

更新日期：2006-02-01 00:00:00

abstract：:The computed tomography (CT) scans of 132 patients with late onset epilepsy were compared with the CT scans of an age- and sex-matched control group. Patients with neurologic symptoms in addition to epilepsy, patients with a definite antecedent cause for epilepsy, and patients with tumours on CT scanning were excluded...

journal_title：Epilepsia

authors： Roberts RC,Shorvon SD,Cox TC,Gilliatt RW

更新日期：1988-03-01 00:00:00

abstract：PURPOSE:To characterize patterns and determinants of normal and abnormal cognitive development in children with new onset epilepsy compared to healthy controls. METHODS:Longitudinal (2-year) cognitive growth was examined in 100 children, age 8-18 years, including healthy controls (n = 48) and children with new onset e...

journal_title：Epilepsia

authors： Hermann BP,Jones JE,Sheth R,Koehn M,Becker T,Fine J,Allen CA,Seidenberg M

更新日期：2008-11-01 00:00:00

abstract：:Since the clinical data have been equivocal in regard to the effects of clonazepam (CZP) in focal-motor seizures, an alumina gel monkey model was used to evaluate quantitatively its efficacy with respect to this seizure category. The insolubility of CZP and its short biological half-life in monkey necessitated its eva...

journal_title：Epilepsia

authors： Lockard JS,Levy RH,Congdon WC,DuCharme LL,Salonen LD

更新日期：1979-12-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is more common in children than adults and has a high mortality and morbidity rate. SE in adult rats results in long-term disturbances in learning and memory, as well as an enhanced seizure susceptibility to further seizures. In contrast, a number of studies suggest that the immature bra...

journal_title：Epilepsia

authors： Cilio MR,Sogawa Y,Cha BH,Liu X,Huang LT,Holmes GL

更新日期：2003-04-01 00:00:00

abstract：:A child had two to three generalized tonic-clonic (GTC) seizures per week unresponsive to phenobarbital (PB) and valproate (VPA). Interictal EEG demonstrated left occipital spikes. When carbamazepine (CBZ) therapy was started, he developed very frequent (4-6/day) complex partial seizures (CPS) characterized on ictal E...

journal_title：Epilepsia

authors： Dhuna A,Pascual-Leone A,Talwar D

更新日期：1991-03-01 00:00:00

abstract：:This paper addresses methodologic issues in studies of mortality, and the impact of these issues in studies of mortality in epilepsy. One important issue is to identify the question: Is it whether epilepsy increases the risk of dying? Or is it whether the underlying condition that led to epilepsy, itself associated wi...

journal_title：Epilepsia

authors： Logroscino G,Hesdorffer DC

更新日期：2005-01-01 00:00:00

abstract：:Treatment and supervision of epileptic patients is part of specialist medicine. A possible change in the role of specialists and general practitioners in the care of these patients was explored by a questionnaire mailed to all Dutch neurologists and a random sample of general practitioners. Patients were also asked th...

journal_title：Epilepsia

authors： Rutgers MJ

更新日期：1986-11-01 00:00:00

abstract：:The occurrence of seizures at specific times of the day has been consistently observed for centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that seizures have a higher probability of occurring at a given time during the night and day cycle in individuals with epilepsy here refer...

journal_title：Epilepsia

authors： Bernard C

更新日期：2020-10-16 00:00:00

abstract：PURPOSE:Temporal lobe epilepsy is associated with the inflammatory process related to the basic mechanisms that lead to seizure susceptibility and brain damage. Platelet-activating factor (PAF), a potent, short-lived phospholipid mediator of inflammation, participates in physiologic signaling in the brain. However, aft...

journal_title：Epilepsia

authors： Musto AE,Samii M

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:In mesial temporal lobe epilepsy (MTLE) the epileptogenic area is confined to the mesial temporal lobe, but other cortical and subcortical areas are also affected and cognitive and psychiatric impairments are usually documented. Functional connectivity methods are based on the correlation of the blood oxygen le...

journal_title：Epilepsia

authors： Pittau F,Grova C,Moeller F,Dubeau F,Gotman J

更新日期：2012-06-01 00:00:00

abstract：:In the nineteenth and early twentieth centuries, many important discoveries in nervous system structure and function involved the electrical properties of nerve tissue. The application of these advances, as well as those in electronic amplification and recording, led to the discovery of the human electroencephalogram ...

journal_title：Epilepsia

authors： Zifkin BG,Avanzini G

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Occipital lobe epilepsy (OLE) presents in childhood with different manifestations, age of onset and EEG features that form distinct syndromes. The ictal clinical symptoms are difficult to correlate with onset in particular areas in the occipital lobes, and the EEG recordings have not been able to overcome this ...

journal_title：Epilepsia

authors： Leal A,Dias A,Vieira JP,Secca M,Jordão C

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:The AY-9944 (AY)-treated rat is a reproducible and clinically relevant animal model of atypical absence seizures. AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absence seizures has not been determined. METHODS:Long-Evans hooded rats were treated...

journal_title：Epilepsia

authors： Cortez MA,Cunnane SC,Snead OC 3rd

更新日期：2002-01-01 00:00:00