What we don't learn from clinical trials in epilepsy.

abstract：OBJECTIVE:We conducted clinical testing of an automated Bayesian machine learning algorithm (Epilepsy Seizure Assessment Tool [EpiSAT]) for outpatient seizure risk assessment using seizure counting data, and validated performance against specialized epilepsy clinician experts. METHODS:We conducted a prospective longit...

journal_title：Epilepsia

authors： Chiang S,Goldenholz DM,Moss R,Rao VR,Haneef Z,Theodore WH,Kleen JK,Gavvala J,Vannucci M,Stern JM

更新日期：2020-01-01 00:00:00

abstract：:Although it is well documented that long-term therapy with older antiepileptic drugs (AEDs) leads to an increase in risk for atherosclerosis, there has been only limited information regarding the vascular risk in patients who are treated with new AEDs. We therefore conducted a prospective longitudinal study to assess ...

journal_title：Epilepsia

authors： Kim DW,Lee SY,Shon YM,Kim JH

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:Hemispherectomy is an established surgical treatment for carefully selected pediatric patients with intractable epilepsy. Published perioperative data report low mortality rates and seizure reduction rates of 50-89%. This study investigates trends in the demographics, hospital utilization, and in-hospital com...

journal_title：Epilepsia

authors： Lin Y,Harris DA,Curry DJ,Lam S

更新日期：2015-01-01 00:00:00

abstract：:Seizures in the neonate are often considered a form of status epilepticus (SE) because they are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be associated with significant morbidity and mortality. Despite their clinical importance, there is still no clear understanding of how sei...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1999-01-01 00:00:00

abstract：:Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interv...

journal_title：Epilepsia

authors： Jones JE,Bell B,Fine J,Rutecki P,Seidenberg M,Hermann B

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Temporal lobe epilepsy is associated with the inflammatory process related to the basic mechanisms that lead to seizure susceptibility and brain damage. Platelet-activating factor (PAF), a potent, short-lived phospholipid mediator of inflammation, participates in physiologic signaling in the brain. However, aft...

journal_title：Epilepsia

authors： Musto AE,Samii M

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Organophosphates (OPs) are commonly used insecticides for agriculture and domestic purposes, but may also serve as nerve agents. Exposure to OPs result in overstimulation of the cholinergic system and lead to status epilepticus (SE), a life-threatening condition that is often resistant to treatment. SE is ass...

journal_title：Epilepsia

authors： Bar-Klein G,Swissa E,Kamintsky L,Shekh-Ahmad T,Saar-Ashkenazy R,Hubary Y,Shrot S,Stetlander L,Eisenkraft A,Friedman A,Bialer M

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:In mesial temporal lobe epilepsy (MTLE) the epileptogenic area is confined to the mesial temporal lobe, but other cortical and subcortical areas are also affected and cognitive and psychiatric impairments are usually documented. Functional connectivity methods are based on the correlation of the blood oxygen le...

journal_title：Epilepsia

authors： Pittau F,Grova C,Moeller F,Dubeau F,Gotman J

更新日期：2012-06-01 00:00:00

abstract：:This study evaluated ictal stereotaxic electroencephalogram (SEEG) records in 75 patients with complex partial seizures who later received anterior temporal lobectomy and were evaluated for long-term seizure relief. The time required for seizures to propagate from the putatively epileptogenic hippocampal formation to ...

journal_title：Epilepsia

authors： Lieb JP,Engel J Jr,Babb TL

更新日期：1986-05-01 00:00:00

abstract：:The suppressive effect of sunglasses upon photoparoxysmal responses (PPRs) elicited by 15-Hz flicker stimuli with a low luminance of nearly 10 nits was studied in eight patients with photosensitive epilepsy. Using three commercially available sunglasses of neutral density (ND), blue, and brown, the influence upon gene...

journal_title：Epilepsia

authors： Takahashi T,Tsukahara Y

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:To evaluate relationships between self-report measures of seizure severity and health-related quality of life (HRQOL) in people with refractory localization-related epilepsy. METHODS:A sample of 340 adults enrolled in a seven-center, prospective study of resective epilepsy surgery completed baseline questionna...

journal_title：Epilepsia

authors： Vickrey BG,Berg AT,Sperling MR,Shinnar S,Langfitt JT,Bazil CW,Walczak TS,Pacia S,Kim S,Spencer SS

更新日期：2000-06-01 00:00:00

abstract：:Five-hundred twelve epileptic children were followed longitudinally for several years. The 2- and 4-year remission statuses at the latest examination were 50.6 and 44.2%, respectively. Dividing our sample into groups showing onset of seizures in infancy or at 2-3, 4-7, 8-10, or 11-14 years, the remission rates were as...

journal_title：Epilepsia

authors： Sofijanov NG

更新日期：1982-02-01 00:00:00

abstract：PURPOSE:Felbamate (FBM) is a new antiepileptic drug (AED) that is often effective in seizure disorders refractory to other treatments; its use has been greatly restricted after cases of aplastic anemia were reported. To elucidate the putative association between FBM and aplastic anemia, we made a detailed evaluation of...

journal_title：Epilepsia

authors： Kaufman DW,Kelly JP,Anderson T,Harmon DC,Shapiro S

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:We investigated the incidence of well-directed violent behavior and suicide attempts in patients with temporal lobe epilepsy, with special attention to postictal psychosis. METHODS:We compared 57 episodes of postictal psychosis with 62 episodes of acute interictal (or alternative) psychosis and with 134 comple...

journal_title：Epilepsia

authors： Kanemoto K,Kawasaki J,Mori E

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Although anterior temporal lobectomy (ATL) is an effective treatment for many patients with medically refractory temporal lobe epilepsy (TLE), one risk associated with this procedure is postsurgical decline in memory. A substantial number of past studies examined factors that predict memory decline after surger...

journal_title：Epilepsia

authors： Lineweaver TT,Morris HH,Naugle RI,Najm IM,Diehl B,Bingaman W

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:The acute, subacute, and chronic effects of vigabatrin (VGB) were studied in patients with refractory complex partial seizures. VGB increases human brain gamma-aminobutyric acid (GABA) and the related metabolites, homocarnosine and 2-pyrrolidinone. METHODS:In vivo measurements of GABA and homocarnosine were ma...

journal_title：Epilepsia

authors： Petroff OA,Hyder F,Collins T,Mattson RH,Rothman DL

更新日期：1999-07-01 00:00:00

abstract：:The anticonvulsant effect of the dihydropyridine calcium channel blocker, nimodipine (NMD) was evaluated against electroshock-induced seizures in mice. At 1 h postdosing, NMD elicited a dose-dependent reduction in the occurrence of tonic hindlimb extension (THE) after maximal electroshock (MES). The calculated ED50 fo...

journal_title：Epilepsia

authors： Sills GJ,Carswell A,Brodie MJ

更新日期：1994-03-01 00:00:00

abstract：:We performed positron emission tomography (PET) with [11C]deuterium-deprenyl in 9 patients with temporal lobe epilepsy (TLE) undergoing evaluation for possible epilepsy surgery. Seven patients had unilateral and 2 had bilateral mesiotemporal epileptic foci based on the preoperative investigation including ictal EEG di...

journal_title：Epilepsia

authors： Kumlien E,Bergström M,Lilja A,Andersson J,Szekeres V,Westerberg CE,Westerberg G,Antoni G,Långström B

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:Studies have found that affected individuals who believe the cause of their disorder is genetic may react in various ways, including optimism for improved treatments and pessimism due to perceived permanence of the condition. This study assessed the psychosocial impact of genetic attribution among people with...

journal_title：Epilepsia

authors： Garofalo DC,Sorge ST,Hesdorffer DC,Winawer MR,Phelan JC,Chung WK,Ottman R

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Single photon emission computed tomography (SPECT) is widely used to evaluate functional abnormalities during the epileptic event. Changes in regional cerebral blood flow (rCBF) are well defined in patients with temporal lobe epilepsy (TLE) undergoing surgical resection. Nonetheless, the interpretation of ictal...

journal_title：Epilepsia

authors： Rabinowicz AL,Salas E,Beserra F,Leiguarda RC,Vazquez SE

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:To compare the risks of fetal malformation during pregnancy associated with antiepileptic drug (AED) polytherapy and monotherapy. METHODS:Statistical analysis of malformation rate and antiepileptic drug exposure data from the Australian Register of Antiepileptic Drugs in Pregnancy, and from the literature. RE...

journal_title：Epilepsia

authors： Vajda FJ,Hitchcock AA,Graham J,O'Brien TJ,Lander CM,Eadie MJ

更新日期：2010-05-01 00:00:00

abstract：:The use of rescue benzodiazepines in the management of seizures is widely accepted in emergency pediatric practice. They can, however, cause severe side effects, such as respiratory depression. We describe five patients who presented with severe respiratory depression following benzodiazepine administration for seizur...

journal_title：Epilepsia

authors： Lacroix L,Fluss J,Gervaix A,Korff CM

更新日期：2011-10-01 00:00:00

abstract：:Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usually practically applied as having two unprovoked seizures >24 h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a t...

journal_title：Epilepsia

authors： Fisher RS,Acevedo C,Arzimanoglou A,Bogacz A,Cross JH,Elger CE,Engel J Jr,Forsgren L,French JA,Glynn M,Hesdorffer DC,Lee BI,Mathern GW,Moshé SL,Perucca E,Scheffer IE,Tomson T,Watanabe M,Wiebe S

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:A pilot study of the safety, tolerability, dose range and potential efficacy of ganaxolone for the treatment of refractory epilepsy in pediatric and adolescent subjects. METHODS:We report the results of a nonrandomized, nonblinded, open-label, dose-escalation trial of ganaxolone in pediatric subjects (5-15 yea...

journal_title：Epilepsia

authors： Pieribone VA,Tsai J,Soufflet C,Rey E,Shaw K,Giller E,Dulac O

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Patients with temporal lobe epilepsy (TLE) experience significant deficits in category-related object recognition and naming following standard surgical approaches. These deficits may result from a decoupling of core processing modules (e.g., language, visual processing, and semantic memory), due to "collate...

journal_title：Epilepsia

authors： Drane DL,Loring DW,Voets NL,Price M,Ojemann JG,Willie JT,Saindane AM,Phatak V,Ivanisevic M,Millis S,Helmers SL,Miller JW,Meador KJ,Gross RE

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Synaptic vesicle protein 2A (SV2A), the binding site for the antiepileptic drug (AED) levetiracetam, has been shown to be involved in the control of neuronal excitability. The aim of the study was to define the expression and cell-specific distribution of SV2A in developmental focal lesions associated with medi...

journal_title：Epilepsia

authors： Toering ST,Boer K,de Groot M,Troost D,Heimans JJ,Spliet WG,van Rijen PC,Jansen FE,Gorter JA,Reijneveld JC,Aronica E

更新日期：2009-06-01 00:00:00

abstract：:Androgen deficiency is unusually common among men with epilepsy. It may contribute to reproductive and sexual dysfunction and possibly exacerbate seizure frequency. The most important androgen is testosterone. it exists in the serum in a free form or bound to albumin or sex hormone-binding globulin (SHBG). Free testos...

journal_title：Epilepsia

authors： Herzog AG

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To compare surgical outcome in mesial temporal lobe epilepsy (MTLE) patients with unilateral hippocampal sclerosis (MTLE-HS) who had or did not have preoperative video-electroencephalographic monitoring (VEEG). METHODS:A prospective study was undertaken with 166 consecutive pharmacoresistant unilateral MTLE-...

journal_title：Epilepsia

authors： Alvim MKM,Morita ME,Yasuda CL,Damasceno BP,Lopes TM,Coan AC,Ghizoni E,Tedeschi H,Cendes F

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:Common data elements (CDEs) are standardized questions and answer choices that allow aggregation, analysis, and comparison of observations from multiple sources. Clinical CDEs are foundational for learning health care systems, a data-driven approach to health care focused on continuous improvement of outcomes...

journal_title：Epilepsia

authors： Grinspan ZM,Patel AD,Shellhaas RA,Berg AT,Axeen ET,Bolton J,Clarke DF,Coryell J,Gaillard WD,Goodkin HP,Koh S,Kukla A,Mbwana JS,Morgan LA,Singhal NS,Storey MM,Yozawitz EG,Abend NS,Fitzgerald MP,Fridinger SE,Helbig

更新日期：2021-01-01 00:00:00

abstract：:The presence of the excitotoxic and convulsant agent quinolinic acid (QUIN) in human brain has led to the hypothesis that an increase of this tryptophan metabolite could serve as an endogenous epileptogen. A possible mechanism for a pathological accumulation of QUIN being a deficiency in its degradation, we have measu...

journal_title：Epilepsia

authors： Feldblum S,Rougier A,Loiseau H,Loiseau P,Cohadon F,Morselli PL,Lloyd KG

更新日期：1988-09-01 00:00:00