Nonepileptic seizure outcome varies by type of spell and duration of illness.

abstract：PURPOSE:The substrate of seizure initiation in partial epilepsy is not well understood. Although many studies imply a focus that is will localized to a single structure, some information suggests that seizures arise regionally with simultaneous or near-simultaneous onset at several separate sites. To determine the phys...

journal_title：Epilepsia

authors： Bertram EH

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Electrical stimulation (ES) is used during intracranial electroencephalography (EEG) investigations to delineate epileptogenic areas and seizure-onset zones (SOZs) by provoking afterdischarges (ADs) or patients' typical seizure. High frequency oscillations (HFOs--ripples, 80-250 Hz; fast ripples, 250-500 Hz) ar...

journal_title：Epilepsia

authors： Jacobs J,Zijlmans M,Zelmann R,Olivier A,Hall J,Gotman J,Dubeau F

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:To conduct the first randomized trial on classical and medium-chain triglyceride (MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 months. METHODS:One hundred forty-five children with intractable epilepsy were randomized to receive a classical or an MCT diet. Seizure ...

journal_title：Epilepsia

authors： Neal EG,Chaffe H,Schwartz RH,Lawson MS,Edwards N,Fitzsimmons G,Whitney A,Cross JH

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To determine the cerebral electroencephalography (EEG) substrates of scalp EEG seizure patterns, such as source area and synchrony, and in so doing assess the limitations of scalp seizure recording in the localization of seizure onset zones in patients with temporal lobe epilepsy. METHODS:We recorded simultane...

journal_title：Epilepsia

authors： Tao JX,Baldwin M,Ray A,Hawes-Ebersole S,Ebersole JS

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To evaluate relationships between self-report measures of seizure severity and health-related quality of life (HRQOL) in people with refractory localization-related epilepsy. METHODS:A sample of 340 adults enrolled in a seven-center, prospective study of resective epilepsy surgery completed baseline questionna...

journal_title：Epilepsia

authors： Vickrey BG,Berg AT,Sperling MR,Shinnar S,Langfitt JT,Bazil CW,Walczak TS,Pacia S,Kim S,Spencer SS

更新日期：2000-06-01 00:00:00

abstract：:Epilepsy is a disease of recurrent seizures that can be associated with a wide variety of acquired and developmental brain lesions. Current medications for patients with epilepsy can suppress seizures; they do not cure or modify the underlying disease process. On the other hand, surgical removal of focal brain regions...

journal_title：Epilepsia

authors： Mittal S,Shah AK,Barkmeier DT,Loeb JA

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:The selection of a minimal active sequence of erythropoietin allowed the design of peptide mimetics that exert beneficial effects in the central nervous system but lack an erythropoietic effect. Erythropoietin has been suggested as a promising therapeutic and prophylactic for epilepsies based on its neuroprotec...

journal_title：Epilepsia

authors： Seeger N,Zellinger C,Rode A,Roloff F,Bicker G,Russmann V,Fischborn S,Wendt H,Potschka H

更新日期：2011-12-01 00:00:00

abstract：:Cardiac changes may occasionally occur during vagus nerve stimulation (VNS) used in epileptic patients. As they can be potentially life-threatening, it is important to detect them, and this is why an intraoperative test is performed during the implantation. Few cases of asystole during this test have been described. O...

journal_title：Epilepsia

authors： Iriarte J,Urrestarazu E,Alegre M,Macías A,Gómez A,Amaro P,Artieda J,Viteri C

更新日期：2009-04-01 00:00:00

abstract：:Brain stimulation is currently used as an experimental treatment for patients with medically refractory epilepsy. However, the results of such stimulation are still less than optimal. A major factor is the lack of understanding of the mechanisms of applied stimuli. Herein we review evidence on the effects of stimulati...

journal_title：Epilepsia

authors： Jiruska P,Powell AD,Deans JK,Jefferys JG

更新日期：2010-07-01 00:00:00

abstract：:A 30-year-old man with long-standing localization-related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic low-grade hemolytic anemia. Pertinent laboratory result...

journal_title：Epilepsia

authors： Asconapé JJ,Manning KR,Lancman ME

更新日期：1994-01-01 00:00:00

abstract：:We set out to review the extent to which molecular karyotyping has overtaken conventional cytogenetics in applications related to epilepsy. Multiplex ligase-dependent probe amplification (MLPA) targeted to predetermined regions such as SCN1A and KCNQ2 has been effectively applied over the last half a decade, and oligo...

journal_title：Epilepsia

authors： Mulley JC,Mefford HC

更新日期：2011-03-01 00:00:00

abstract：:Epilepsy syndromes occupy an important position in the current nosology of the epilepsies, describing and classifying seizure disorders with shared clinical and EEG features. Increasingly, this schema is being refined as new information becomes available and our understanding of etiology and presentation of each syndr...

journal_title：Epilepsia

authors： Duchowny M,Harvey AS

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To test the sensitivity of extracranial magnetoencephalography (MEG) for epileptic spikes in different cerebral sites. METHODS:We simultaneously recorded MEG and electrocorticography (ECoG) by using subdural electrodes with 1-cm interelectrode distances for one patient with lateral frontal epilepsy and one pat...

journal_title：Epilepsia

authors： Oishi M,Otsubo H,Kameyama S,Morota N,Masuda H,Kitayama M,Tanaka R

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:To advance the development of (2S,3S)-sec-butylpropylacetamide (SPD) as a new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in pigs and its PK-pharmacodynamic (PK-PD) correlation in rats. METHODS:Two (2S,3S)-SPD intramuscular formulations (FA and FB ) were administered...

journal_title：Epilepsia

authors： Bibi D,Bialer M

更新日期：2020-01-01 00:00:00

abstract：:Seizures cannot be medically controlled in approximately 40% of people with epilepsy. Although we are beginning to understand how to better treat certain seizure types, we still do not know the regulatory events that determine antiepileptic drug resistance. Proposed pathoetiologic mechanisms include altered expression...

journal_title：Epilepsia

authors： Kobow K,El-Osta A,Blümcke I

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:Corpus callosotomy is an effective palliative treatment for drug-resistant Lennox-Gastaut syndrome (LGS). Laser interstitial thermal therapy has been increasingly used in the treatment of epilepsy. Here, we assess the safety and effectiveness of minimally invasive stereotactic laser anterior corpus callosotom...

journal_title：Epilepsia

authors： Tao JX,Satzer D,Issa NP,Collins J,Wu S,Rose S,Henry J,Santos de Lima F,Nordli D,Warnke PC

更新日期：2020-06-01 00:00:00

abstract：:Ictal and interictal epileptic activity was recorded for the first time by multichannel magnetoencephalography (MEG) in three patients with partial epilepsy. Pre- and intra-operative localization of the epileptogenic region was compared. The interictal epileptic activity was localized at the same region of the tempora...

journal_title：Epilepsia

authors： Stefan H,Schneider S,Feistel H,Pawlik G,Schüler P,Abraham-Fuchs K,Schlegel T,Neubauer U,Huk WJ

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:Decline in verbal memory as a surgical complication remains an unresolved problem in mesial temporal lobe epilepsy. Some areas in the temporal lobe associated with the language function, often including the basal temporal language area, have been removed or transected by conventional surgical procedures. The au...

journal_title：Epilepsia

authors： Mikuni N,Miyamoto S,Ikeda A,Satow T,Taki J,Takahashi J,Ohigashi Y,Hashimoto N

更新日期：2006-08-01 00:00:00

abstract：:Currently, there are 4 published scales evaluating status epilepticus (SE) prognosis: the Status Epilepticus Severity Score (STESS), the Epidemiology-based Mortality score in Status Epilepticus (EMSE), the modified STESS (mSTESS), and the Encephalitis Nonconvulsive Status Epilepticus Diazepam Resistence Imaging Trache...

journal_title：Epilepsia

authors： Yuan F,Gao Q,Jiang W

更新日期：2018-10-01 00:00:00

abstract：:Rare individuals suffer epileptic seizures when they view certain images, particularly stripes. Contrast-threshold functions (the ability to see faint stripes of various widths) were determined for two pattern-sensitive brothers, and the epileptogenicity of various patterns was assessed for one of them. Sine wave grat...

journal_title：Epilepsia

authors： Soso MJ,Lettich E,Belgum JH

更新日期：1980-06-01 00:00:00

abstract：PURPOSE:To determine if seizure frequency differs between anovulatory and ovulatory cycles. METHODS:The data came from the 3-month baseline phase of an investigation of progesterone therapy for intractable focal onset seizures. Of 462 women who enrolled, 281 completed the 3-month baseline phase and 92 had both anovula...

journal_title：Epilepsia

authors： Herzog AG,Fowler KM,Sperling MR,Liporace JD,Kalayjian LA,Heck CN,Krauss GL,Dworetzky BA,Pennell PB,Progesterone Trial Study Group.

更新日期：2011-10-01 00:00:00

abstract：:The anticonvulsant effect of the dihydropyridine calcium channel blocker, nimodipine (NMD) was evaluated against electroshock-induced seizures in mice. At 1 h postdosing, NMD elicited a dose-dependent reduction in the occurrence of tonic hindlimb extension (THE) after maximal electroshock (MES). The calculated ED50 fo...

journal_title：Epilepsia

authors： Sills GJ,Carswell A,Brodie MJ

更新日期：1994-03-01 00:00:00

abstract：:[3H]Nimodipine and high-affinity [125I]omega-conotoxin GVIA (CgTX) binding were investigated in membranes from rat cerebral cortex, cerebellum, and hippocampus after electrically and chemically induced seizures. Animals were decapitated 30 min after a single electroconvulsive shock (ECS) or lidocaine-induced seizure a...

journal_title：Epilepsia

authors： Gleiter CH,Cain CJ,Weiss SR,Post RM,Marangos PJ

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:Subtle microdysplastic features are found in some patients with hippocampal sclerosis (HS) and refractory temporal lobe epilepsy. The significance of these findings is unknown. We investigated their frequency, relation to the pattern of HS, and clinical associations. METHODS:One-hundred forty patients with his...

journal_title：Epilepsia

authors： Kalnins RM,McIntosh A,Saling MM,Berkovic SF,Jackson GD,Briellmann RS

更新日期：2004-08-01 00:00:00

abstract：:In this article, we review the incidence and significance of seizures in well-established autoimmune disorders, including multiple sclerosis (MS), diabetes mellitus, celiac disease, thyroid disease, and systemic lupus erythematosus (SLE). The five following presentations discuss the incidence and possible pathogenesis...

journal_title：Epilepsia

authors： Vincent A,Crino PB

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS). METHODS:In 12 children and adolescents with CPS and 23 age- and gender-matched healthy controls, we ac...

journal_title：Epilepsia

authors： O'Neill J,Seese R,Hudkins M,Siddarth P,Levitt J,Tseng PB,Wu KN,Gurbani S,Shields WD,Caplan R

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:Standard mortality ratio for suicide in patients with epilepsy is three times higher than in the general population, and such a risk remains high even after adjusting for clinical and socioeconomic factors. It is thus important to have suitable screening instruments and to implement care pathways for suicide ...

journal_title：Epilepsia

authors： Mula M,McGonigal A,Micoulaud-Franchi JA,May TW,Labudda K,Brandt C

更新日期：2016-06-01 00:00:00

abstract：SUMMARY:Phenobarbital (PB) is the most widely used antiepileptic drug (AED) in the developing world and remains a popular choice in many industrialized countries. Meta-analyses of randomized controlled trials suggest that few differences in efficacy exist between PB and other established AEDs, but its possible deleteri...

journal_title：Epilepsia

authors： Kwan P,Brodie MJ

更新日期：2004-09-01 00:00:00

abstract：:The practice of epileptology at a molecular level, where gene products are identified by gene mapping, will soon be possible for a growing number of epilepsies. Juvenile myoclonic epilepsy (JME) is the first of such epilepsies to be mapped to a chromosome, namely chromosome 6p21.3. Family studies of 68 JME probands fr...

journal_title：Epilepsia

authors： Delgado-Escueta AV,Greenberg DA,Treiman L,Liu A,Sparkes RS,Barbetti A,Park MS,Terasaki PI

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Both clinical genomics and e-Health technology are changing the way medicine is being practiced. Although the basic clinical methodology of good medical care will remain unchanged, the combined power of genomics and electronic health records has the capability of enhancing, and in some cases transforming, th...

journal_title：Epilepsia

authors： Delanty N,White M,Benson K,McCormack M,Heavin S,Comerford E,Gangadharan N,Power K,Dunleavey B,El-Naggar H,Doherty C,Greally M,Cavalleri G,Fitzsimons M

更新日期：2019-08-01 00:00:00