Subtle microscopic abnormalities in hippocampal sclerosis do not predict clinical features of temporal lobe epilepsy.

abstract：OBJECTIVE:Organophosphates (OPs) are commonly used insecticides for agriculture and domestic purposes, but may also serve as nerve agents. Exposure to OPs result in overstimulation of the cholinergic system and lead to status epilepticus (SE), a life-threatening condition that is often resistant to treatment. SE is ass...

journal_title：Epilepsia

authors： Bar-Klein G,Swissa E,Kamintsky L,Shekh-Ahmad T,Saar-Ashkenazy R,Hubary Y,Shrot S,Stetlander L,Eisenkraft A,Friedman A,Bialer M

更新日期：2014-12-01 00:00:00

abstract：:The randomized, double-blind trial design offers the most accurate data regarding the efficacy of antiepileptic treatments. However, translating the results of a trial into clinical care can be complex due to the intrinsic tension between the requirements for scientific methods that minimize systematic and random erro...

journal_title：Epilepsia

authors： Gilliam F

更新日期：2003-01-01 00:00:00

abstract：:A variety of experimental paradigms have been utilized to study verbal learning and memory ability in patients with epilepsy. One commonly used paradigm, the free recall of a list(s) of related or unrelated words, has revealed a variety of performance anomalies in patients with complex partial seizures (CPS) of tempor...

journal_title：Epilepsia

authors： Hermann BP,Wyler AR,Richey ET,Rea JM

更新日期：1987-09-01 00:00:00

abstract：PURPOSE:The main objective of this research is the development of automated video processing and analysis procedures aimed at the recognition and characterization of the types of neonatal seizures. The long-term goal of this research is the integration of these computational procedures into the development of a stand-a...

journal_title：Epilepsia

authors： Karayiannis NB,Tao G,Xiong Y,Sami A,Varughese B,Frost JD Jr,Wise MS,Mizrahi EM

更新日期：2005-06-01 00:00:00

abstract：:We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ...

journal_title：Epilepsia

authors： Zumsteg D,Lozano AM,Wennberg RA

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Acetone is the principal ketone body elevated in the ketogenic diet (KD), with demonstrated robust anticonvulsant properties across a variety of seizure tests and models of epilepsy. Because the majority of patients continue to receive antiepileptic drugs (AEDs) during KD treatment, interactions between acetone...

journal_title：Epilepsia

authors： Zarnowska I,Luszczki JJ,Zarnowski T,Buszewicz G,Madro R,Czuczwar SJ,Gasior M

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:We studied the effect of vagus nerve stimulation (VNS) on seizure reduction in patients with intractable epilepsy with bilateral independent temporal lobe foci. METHODS:Ten patients who met the criterion of the presence of two distinctive clinical and ictal EEG seizure patterns were identified and followed up ...

journal_title：Epilepsia

authors： Alsaadi TM,Laxer KD,Barbaro NM,Marks WJ Jr,Garcia PA

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS:Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizur...

journal_title：Epilepsia

authors： Mares P,Haugvicová R

更新日期：1997-08-01 00:00:00

abstract：:A 28-year-old man with regularly occurring clusters of complex partial seizures was studied over a total of 224 days. His seizure periods lasted 2-4 days and occurred at intervals of 5-6 weeks. Several parameters were studied. The most striking finding was an increase in the serum concentration of thyroxine prior to a...

journal_title：Epilepsia

authors： Taubøll E,Stokke KT,Gjerstad L,Løyning Y,Johannessen SI

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in patients with temporal lobe epilepsy (TLE). METHODS:Memory for public and auto...

journal_title：Epilepsia

authors： Lah S,Lee T,Grayson S,Miller L

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Although anterior temporal lobectomy (ATL) is an effective treatment for many patients with medically refractory temporal lobe epilepsy (TLE), one risk associated with this procedure is postsurgical decline in memory. A substantial number of past studies examined factors that predict memory decline after surger...

journal_title：Epilepsia

authors： Lineweaver TT,Morris HH,Naugle RI,Najm IM,Diehl B,Bingaman W

更新日期：2006-11-01 00:00:00

abstract：:Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

journal_title：Epilepsia

authors： Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) and to suggest recommended doses of LEV in children. METHODS:LEV PK were investigated in a prospective open trial of LEV as adjunctive therapy using a population a...

journal_title：Epilepsia

authors： Chhun S,Jullien V,Rey E,Dulac O,Chiron C,Pons G

更新日期：2009-05-01 00:00:00

abstract：:The authors report the study of a 30-month-old girl with refractory myoclonic epilepsy associated with mental retardation, growth delay, peculiar facial appearance, and minor physical anomalies. Extensive genetic studies were performed, including an array-based comparative genomic hybridization (array-CGH) that showed...

journal_title：Epilepsia

authors： Veredice C,Bianco F,Contaldo I,Orteschi D,Stefanini MC,Battaglia D,Lettori D,Guzzetta F,Zollino M

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:Depression is a common comorbidity of epilepsy, and its timely identification in persons with epilepsy is essential. The use of screening tools to detect depression is common in epilepsy, but some scales in current use have not been validated using a gold standard in this population. The present study aims to...

journal_title：Epilepsia

authors： Fiest KM,Patten SB,Wiebe S,Bulloch AG,Maxwell CJ,Jetté N

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:To demonstrate the anatomic localization of the cortical sources of the interictal EEG activity in human idiopathic generalized epilepsy (IGE). METHODS:Multiple cortical and hippocampal sources of the interictal spontaneous EEG activity were investigated by low-resolution electromagnetic tomography in 15 untre...

journal_title：Epilepsia

authors： Clemens B,Bessenyei M,Piros P,Tóth M,Seress L,Kondákor I

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Five to 20% of patients discontinue antiepileptic drug (AED) therapy because of adverse reactions. Careful reintroduction, however, may be considered if true drug allergy can be ruled out. Definitive assessment of such immunologically mediated reactions requires demonstration of either specific antibodies or se...

journal_title：Epilepsia

authors： Troost RJ,Van Parys JA,Hooijkaas H,van Joost T,Benner R,Prens EP

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:Brivaracetam (BRV), a selective and high-affinity synaptic vesicle protein 2A ligand, is in development as adjunctive treatment for partial-onset (focal) seizures (POS). This phase 3 study (N01358; NCT01261325) aimed to confirm the efficacy and safety/tolerability of BRV in adults (≥ 16-80 years) with POS. M...

journal_title：Epilepsia

authors： Klein P,Schiemann J,Sperling MR,Whitesides J,Liang W,Stalvey T,Brandt C,Kwan P

更新日期：2015-12-01 00:00:00

abstract：:Carbamazepine (CBZ) selectively suppressed kindled convulsions, whereas ethosuximide (ESM) suppressed spike-wave activity accompanying systemic penicillin epilepsy in cats. Evoked potential data indicated that CBZ acted at the thalamic level, whereas ESM acted at cortex. Reduction of seizures and thalamic or cortical ...

journal_title：Epilepsia

authors： Shouse MN,Stroh PJ,Vreeken T

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Hypothalamic regulation of the reproductive axis in temporal lobe epilepsy (TLE), represented by the ultradian pulsatile secretion of luteinizing hormone (LH), has been shown to be altered interictally and postictally. Our objective is to determine if epilepsy or seizures disrupt normal circadian fluctuations o...

journal_title：Epilepsia

authors： Quigg M,Kiely JM,Johnson ML,Straume M,Bertram EH,Evans WS

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:Phenobarbital hypersensitivity is one of the common drug hypersensitivity syndromes in children. Clinical symptoms of phenobarbital hypersensitivity vary from maculopapular rashes (MPs) to severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS),...

journal_title：Epilepsia

authors： Manuyakorn W,Mahasirimongkol S,Likkasittipan P,Kamchaisatian W,Wattanapokayakit S,Inunchot W,Visudtibhan A,Wichukchinda N,Benjaponpitak S

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...

journal_title：Epilepsia

authors： Labiner DM,Ettinger AB,Fakhoury TA,Chung SS,Shneker B,Tatum Iv WO,Mitchell Miller J,Vuong A,Hammer AE,Messenheimer JA

更新日期：2009-03-01 00:00:00

abstract：:Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study. Twenty-two individuals in a population of 359 persons with neurofibromatos 1 (NF1) had had one or more seizures. Age at first seizure ranged from 4 days to > 20 years. Patients were classified into ...

journal_title：Epilepsia

authors： Korf BR,Carrazana E,Holmes GL

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:This study examined the influence of two psychosocial variables mediating between disease severity and quality of life (QoL) in epilepsy; social support and mastery (measured by locus of control and self-efficacy). A model placing these two variables as mediators between disease severity and QoL was tested with...

journal_title：Epilepsia

authors： Amir M,Roziner I,Knoll A,Neufeld MY

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:This study was designed to measure the brain penetration of phenytoin (PHT) after intravenous (i.v.) administration of either standard PHT or fosphenytoin (FPHT), a PHT prodrug. The study was formulated to answer the question whether the time required for FPHT to be converted to PHT in the bloodstream would del...

journal_title：Epilepsia

authors： Walton NY,Uthman BM,El Yafi K,Kim JM,Treiman DM

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:This report concerns the 2-year extension of the study of mortality and sudden, unexpected, unexplained death in epilepsy (SUDEP) in the cohort of patients receiving vagal nerve stimulation by the NCP System for the treatment of epilepsy. METHODS:A cohort of 1,819 individuals was followed 3,176.3 person-years ...

journal_title：Epilepsia

authors： Annegers JF,Coan SP,Hauser WA,Leestma J

更新日期：2000-05-01 00:00:00

abstract：:Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interv...

journal_title：Epilepsia

authors： Jones JE,Bell B,Fine J,Rutecki P,Seidenberg M,Hermann B

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To investigate brain electrical activity in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene, and to evaluate the efficacy of low frequency deep brain stimulation (DBS) for seizure frequency reduction. METHODS:Electroencephalography (EEG), elect...

journal_title：Epilepsia

authors： Kile KB,Tian N,Durand DM

更新日期：2010-09-01 00:00:00

abstract：:Forty-five outpatients with chronic epilepsy with complex partial seizures (CPS) alone or associated with secondarily generalized tonic-clonic seizures (SGTCS) were treated with carbamazepine (CBZ) monotherapy. All patients had only a unilateral scalp electroencephalographic (EEG) focus. Left- (n = 29) and right- (n =...

journal_title：Epilepsia

authors： Defazio G,Lepore V,Specchio LM,Pisani F,Livrea P

更新日期：1991-09-01 00:00:00

abstract：:This article explores the historic underpinnings of the exclusion of women from clinical drug trials, identifies recent developments, and examines legal implications for women with epilepsy and for others. Distinguishing stakeholders and their interests may lead to policies that better serve all. Past and present stat...

journal_title：Epilepsia

authors： Herz SE

更新日期：1997-01-01 00:00:00