Dose-response relationships with nimodipine against electroshock seizures in mice.

abstract：PURPOSE:To evaluate the efficacy and safety of gabapentin (Neurontin; GBP) as add-on therapy for refractory partial seizures in paediatric patients aged 3-12 years. METHODS:After a 6-week baseline period, 247 patients (54 centres) entered a 12-week double-blind phase and were randomized to receive either GBP (t.i.d., ...

journal_title：Epilepsia

authors： Appleton R,Fichtner K,LaMoreaux L,Alexander J,Halsall G,Murray G,Garofalo E

更新日期：1999-08-01 00:00:00

abstract：:Monotherapy is the policy for management of patients with epilepsy. With increasing knowledge of the biology of epilepsy and of the modes of action of antiepileptic drugs (AEDs), this concept must be reevaluated. When monotherapy fails to control seizures, subsequent treatment should be based on "rational pharmacology...

journal_title：Epilepsia

authors： de Bittencourt PR,Mazer S,Marcourakis T,Bigarella MM,Ferreira ZS,Mumford JP

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To evaluate efficacy, tolerability, and safety of adjunctive brivaracetam (BRV) in patients with Unverricht-Lundborg disease (EPM1). METHODS:Two prospective, multicenter, double-blind, phase III trials (N01187/NCT00357669; N01236/NCT00368251) in patients (≥16 years) with genetically ascertained EPM1, showing...

journal_title：Epilepsia

authors： Kälviäinen R,Genton P,Andermann E,Andermann F,Magaudda A,Frucht SJ,Schlit AF,Gerard D,de la Loge C,von Rosenstiel P

更新日期：2016-02-01 00:00:00

abstract：:Postictal refractoriness checked by paired stimulations of the limbic structures was demonstrated to fail in rats<2 weeks old. Cortical epileptic afterdischarges were used in our study to examine if this phenomenon is restricted to old cortical structures or if it is a general one. Rats 12, 15, 18, 25, and 90 days old...

journal_title：Epilepsia

authors： Mareš P,Kubová H

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Ablation surgery has become the first line of treatment for hypothalamic hamartomas (HHs). For effective treatment, optimum targeting of ablation is mandatory. The present study aimed to evaluate the correspondence between the electrophysiological features of HHs and morphological targeting by semimicrorecord...

journal_title：Epilepsia

authors： Shirozu H,Masuda H,Kameyama S

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Patients with medically intractable epilepsy due to brain tumors may undergo resective surgery for treatment of both the tumor and the epilepsy. In this instance, the extent of surgical resection is sometimes guided by spikes recorded on intraoperative electrocorticography (ECoG). Whether spikes recorded by ele...

journal_title：Epilepsia

authors： Tran TA,Spencer SS,Javidan M,Pacia S,Marks D,Spencer DD

更新日期：1997-10-01 00:00:00

abstract：:The pharmacokinetics of antiepileptic drugs have been investigated extensively during the last two decades. It has become evident that the therapeutic management of epileptic patients would be significantly improved with the elimination of the drawbacks associated with existing antiepileptic drugs. Based on the inform...

journal_title：Epilepsia

authors： Levy RH,Kerr BM

更新日期：1989-01-01 00:00:00

abstract：:We report a surgically treated case of early infantile epileptic encephalopathy (EIEE) with suppression-bursts associated with focal cortical dysplasia. Tonic-clonic seizures followed by a series of spasms occurred about a hundred times a day at a few days of age. Interictal electroencephalogram (EEG) revealed a suppr...

journal_title：Epilepsia

authors： Komaki H,Sugai K,Sasaki M,Hashimoto T,Arai N,Takada E,Maehara T,Shimizu H

更新日期：1999-03-01 00:00:00

abstract：:Treatment with sodium valproate (VPA) in association with phenobarbital (PB) is accompanied by a greater systemic hyperammonemia than treatment by VPA alone. The anatomical origins of this difference were studied by injecting a dose of 1,500 mg VPA i.v. into six unmedicated patients and six epileptics chronically trea...

journal_title：Epilepsia

authors： Warter JM,Marescaux C,Brandt C,Rumbach L,Micheletti G,Chabrier G,Imler M,Kurtz D

更新日期：1983-10-01 00:00:00

abstract：PURPOSE:To determine the incidence, duration, risk factors for, and clinical correlates of postictal generalized electroencephalography (EEG) suppression (PGES), and to further delineate the significance of PGES in the pathogenesis of sudden unexpected death in epilepsy (SUDEP). METHODS:We retrospectively reviewed the...

journal_title：Epilepsia

authors： Tao JX,Yung I,Lee A,Rose S,Jacobsen J,Ebersole JS

更新日期：2013-05-01 00:00:00

abstract：:Genetic factors play a major role in the etiology of juvenile myoclonic epilepsy (JME), a common form of idiopathic generalized epilepsy, but so far, genes related to JME remain largely unknown. JME shares electroclinical features with Unverricht-Lundborg disease (progressive myoclonic epilepsy type 1; EPM1), a form o...

journal_title：Epilepsia

authors： Mumoli L,Tarantino P,Michelucci R,Bianchi A,Labate A,Franceschetti S,Marini C,Striano P,Gagliardi M,Ferlazzo E,Sofia V,Pennese L,Annesi G,Aguglia U,Guerrini R,Zara F,Gambardella A,Genetic Commission, Italian League Agai

更新日期：2015-04-01 00:00:00

abstract：:Currently, there are 4 published scales evaluating status epilepticus (SE) prognosis: the Status Epilepticus Severity Score (STESS), the Epidemiology-based Mortality score in Status Epilepticus (EMSE), the modified STESS (mSTESS), and the Encephalitis Nonconvulsive Status Epilepticus Diazepam Resistence Imaging Trache...

journal_title：Epilepsia

authors： Yuan F,Gao Q,Jiang W

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Benign epilepsy with centrotemporal spikes (BECTS) is associated with mild cognitive deficits, especially language impairment. This study aimed to clarify whether children with BECTS with left- or right-hemispheric, or bilateral focus have specific neuropsychological language deficits when compared to healthy c...

journal_title：Epilepsia

authors： Datta AN,Oser N,Bauder F,Maier O,Martin F,Ramelli GP,Steinlin M,Weber P,Penner IK

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate health care expenditures among elderly patients with epilepsy in the United States. METHODS:We performed an analysis of weighted 37 738 607 US participants aged 65 years to estimate health care expenditures in the elderly with and without epilepsy using the Medical E...

journal_title：Epilepsia

authors： Lekoubou A,Bishu KG,Ovbiagele B

更新日期：2018-07-01 00:00:00

abstract：:Nicotinamide is a ligand of the benzodiazepine receptor and has been reported to have anticonvulsant activity. In addition, our previous clinical experience has raised the possibility that it may also potentiate the action of barbiturates. Therefore, we have examined the anticonvulsant activity and neurotoxicity of ni...

journal_title：Epilepsia

authors： Bourgeois BF,Dodson WE,Ferrendelli JA

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVES:We aimed to determine whether implementation of a structured multidisciplinary electroencephalography (EEG) monitoring pathway improved the timeliness of administration of antiseizure medication in response to electrographic seizures in encephalopathic critically ill children. METHODS:A multidisciplinary te...

journal_title：Epilepsia

authors： Williams RP,Banwell B,Berg RA,Dlugos DJ,Donnelly M,Ichord R,Kessler SK,Lavelle J,Massey SL,Hewlett J,Parker A,Topjian AA,Abend NS

更新日期：2016-05-01 00:00:00

abstract：:The pathogenesis of neurogenic pulmonary edema has been debated for many years. Whether cardiogenic mechanisms and increased pulmonary vascular pressures are primary or even necessary for the production of pulmonary edema has been argued. We used postictal pulmonary edema to study this problem in a sheep model of neur...

journal_title：Epilepsia

authors： Johnston SC,Darragh TM,Simon RP

更新日期：1996-05-01 00:00:00

abstract：:The Epilepsy Association of Maryland, an affiliate of the Epilepsy Foundation of America (EFA), recognized that the Maryland state regulations and laws on driving licensing restricted the rights of individuals with epilepsy. After identifying the problem, the Association determined the needed changes and planned a leg...

journal_title：Epilepsia

authors： Kingham LA

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:To test the sensitivity of extracranial magnetoencephalography (MEG) for epileptic spikes in different cerebral sites. METHODS:We simultaneously recorded MEG and electrocorticography (ECoG) by using subdural electrodes with 1-cm interelectrode distances for one patient with lateral frontal epilepsy and one pat...

journal_title：Epilepsia

authors： Oishi M,Otsubo H,Kameyama S,Morota N,Masuda H,Kitayama M,Tanaka R

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:Angelman syndrome (AS) is a neurogenetic disorder characterized by developmental delay and a frequently refractory epileptic condition. Valproate, clonazepam and/or phenytoin are said to be the most effective antiepileptic drugs (AEDs) against the seizures in AS. Experience with the newer AEDs is very limited d...

journal_title：Epilepsia

authors： Dion MH,Novotny EJ Jr,Carmant L,Cossette P,Nguyen DK

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:Both clinical genomics and e-Health technology are changing the way medicine is being practiced. Although the basic clinical methodology of good medical care will remain unchanged, the combined power of genomics and electronic health records has the capability of enhancing, and in some cases transforming, th...

journal_title：Epilepsia

authors： Delanty N,White M,Benson K,McCormack M,Heavin S,Comerford E,Gangadharan N,Power K,Dunleavey B,El-Naggar H,Doherty C,Greally M,Cavalleri G,Fitzsimons M

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI), an important research and clinical tool, depends on relatively greater transient increases in (regional cerebral blood flow) rCBF than cerebral metabolic rate for oxygen during neural activity. We investigated whether reduced rest...

journal_title：Epilepsia

authors： Appel S,Duke ES,Martinez AR,Khan OI,Dustin IM,Reeves-Tyer P,Berl MB,Sato S,Gaillard WD,Theodore WH

更新日期：2012-04-01 00:00:00

abstract：:The 1981 International Classification of Epileptic Seizures (ICES) was used to study the distribution of seizure types in 1,250 patients attending an Epilepsy Clinic in Sri Lanka. Based on seizure symptomatology 94.6% of the cases could be classified, and by adding the routine interictal EEG findings the percentage of...

journal_title：Epilepsia

authors： Senanayake N

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:To confirm the efficacy and to clarify the problems of clobazam (CLB) as a new antiepileptic drug (AED) and clorazepate (CLP) as an alternative AED in Japan. METHODS:CLB and CLP were added on or replaced with conventional AEDs in 55 and 170 patients with refractory epilepsies, respectively. Short-term efficacy...

journal_title：Epilepsia

authors： Sugai K

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Valproate (VPA) is an extensively used drug in the therapy of epilepsies. One of the most frequently reported side effects of VPA is hemorrhagic diathesis. Some authors emphasized the decreased platelet count as the basis of VPA-induced hemorrhagic diathesis, but some reports suggested that a significant propor...

journal_title：Epilepsia

authors： Kis B,Szupera Z,Mezei Z,Gecse A,Telegdy G,Vécsei L

更新日期：1999-03-01 00:00:00

abstract：:We present a technique for automatic detection of epileptic spikes in electroencephalogram (EEG) recordings. We used a nonlinear modeling method that enables us to detect rapidly and accurately epileptic behavior in the EEG signal. Our approach is illustrated by an application to interictal activity from a patient wit...

journal_title：Epilepsia

authors： Diambra L

更新日期：2002-01-01 00:00:00

abstract：:The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial. It remains controversial which resection method gives best results for seizure freedom and neuropsychological function. This review of 53 studies addressing extent of resection in surge...

journal_title：Epilepsia

authors： Schramm J

更新日期：2008-08-01 00:00:00

abstract：:Two groups of adult outpatients (n = 19 and n = 21) with poorly controlled epilepsy and significant psychological disorder, assessed in terms of rating scales, received two psychological treatments in a balanced cross-over design after stable baseline seizure frequency had been established. A third group (n = 19), who...

journal_title：Epilepsia

authors： Gillham RA

更新日期：1990-07-01 00:00:00

abstract：:Sleep is a modulator of seizure activity, and many antiepileptic drugs are modulators of sleep. Can influences on sleep organization be involved in antiepileptic drug action, and can these partly account for differences in drug response of various epileptic syndromes? Much more exact data must be collected before thes...

journal_title：Epilepsia

authors： Wolf P,Röder-Wanner UU,Brede M

更新日期：1984-08-01 00:00:00

abstract：:Infantile spasms begin in a very active phase of brain development. The new neuropathological techniques have shed light on changes in the fine structure of brain in children with infantile spasms. An understanding of the action of adrenocorticotropic hormone on the biochemistry and development of the brain provides, ...

journal_title：Epilepsia

authors： Riikonen R

更新日期：1983-04-01 00:00:00