Abstract:
:Postictal refractoriness checked by paired stimulations of the limbic structures was demonstrated to fail in rats<2 weeks old. Cortical epileptic afterdischarges were used in our study to examine if this phenomenon is restricted to old cortical structures or if it is a general one. Rats 12, 15, 18, 25, and 90 days old with implanted electrodes formed the experimental groups. Stimulation was performed by 15-s series of 1-msec pulses with suprathreshold intensity and frequency of 8 Hz. Paired stimulation of the cerebral cortex in 12-day-old rats elicited the second afterdischarge, even if the 30-s interval was used. Refractoriness started to appear in the third postnatal week and developed progressively so that 25-day-old rats did not differ from adult animals, that is, an interval longer than 1 min was necessary for elicitation of the second seizure.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Mareš P,Kubová Hdoi
10.1111/epi.12870subject
Has Abstractpub_date
2015-01-01 00:00:00pages
e10-4issue
1eissn
0013-9580issn
1528-1167journal_volume
56pub_type
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