Abstract:
:The chronic epileptic syndrome induced by injecting tetanus toxin into rat hippocampus causes functional changes that essentially are permanent, outlasting the period of active seizures by at least 1 year. These long-term changes have been characterized by an impaired performance on a range of behavioral tasks, which in turn have been associated with a physiologic depression of hippocampal evoked responses but not with any discernible histopathology. In the present study, we examined the hippocampi of rats in the postseizure phase of the tetanus toxin model and observed no significant changes in the concentration of neurochemical markers for six neurotransmitters. Therefore, the long-term reduction in hippocampal excitability cannot be attributed to any major loss of afferents or hippocampal neurons using aspartate, acetylcholine, gamma-aminobutyric acid (GABA), glutamate, norepinephrine (NE), or serotonin as their transmitters.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Francis PT,Lowe SL,Bowen DM,Jefferys JGdoi
10.1111/j.1528-1157.1990.tb05508.xsubject
Has Abstractpub_date
1990-11-01 00:00:00pages
697-701issue
6eissn
0013-9580issn
1528-1167journal_volume
31pub_type
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