Inhibition of hippocampal excitability by citalopram.

abstract：:The effects of antiepileptic drugs (AEDs) on cognitive function and behavior in children are reviewed on the basis of published studies. Individual AEDs have been shown to differ--the deleterious effects of phenytoin generally contrasting with the relatively minimal effects of valproate and carbamazepine. Some of the ...

journal_title：Epilepsia

authors： Trimble MR

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Little is known about offspring of parents who both have idiopathic generalized epilepsy (IGE). This is of importance for understanding the complex genetic architecture of IGE. METHODS:Families in whom both parents had proven IGE were ascertained through a multiplex families database. Clinical information i...

journal_title：Epilepsia

authors： Marini C,Harvey AS,Pelekanos JT,Berkovic SF

更新日期：2003-09-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a potentially preventable cause of epilepsy. Increasing incidence among army personnel and the high incidence among children and young people raise concern. This article presents a review of selected studies dealing with the risks of TBI and the risk of posttraumatic epilepsy in humans....

journal_title：Epilepsia

authors： Christensen J

更新日期：2012-09-01 00:00:00

abstract：:We sought to determine if there are differences in the incidence of seizure disorders between the children of the indigenous and immigrant (predominantly Pakistani) populations of Bradford, United Kingdom. Annual incidence rates per 100,000 for new onset seizures were calculated along with Townsend deprivation scores....

journal_title：Epilepsia

authors： Hamdy NA,Ginby D,Feltbower R,Ferrie CD

更新日期：2007-05-01 00:00:00

abstract：:We compared zonisamide monotherapy (12 weeks) to carbamazepine monotherapy (12 weeks) after phenytoin baseline monotherapy (8 weeks) in an open crossover pilot study of eight adults with uncontrolled partial seizures. Zonisamide had definite antiepileptic activity in five subjects. In two of these, response to zonisam...

journal_title：Epilepsia

authors： Wilensky AJ,Friel PN,Ojemann LM,Dodrill CB,McCormick KB,Levy RH

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:Genetic testing has become a routine part of the diagnostic workup in children with early onset epilepsies. In the present study, we sought to investigate a cohort of adult patients with epilepsy, to determinate the diagnostic yield and explore the gain of personalized treatment approaches in adult patients. ...

journal_title：Epilepsia

authors： Johannesen KM,Nikanorova N,Marjanovic D,Pavbro A,Larsen LHG,Rubboli G,Møller RS

更新日期：2020-06-01 00:00:00

abstract：:The chronic epileptic syndrome induced by injecting tetanus toxin into rat hippocampus causes functional changes that essentially are permanent, outlasting the period of active seizures by at least 1 year. These long-term changes have been characterized by an impaired performance on a range of behavioral tasks, which ...

journal_title：Epilepsia

authors： Francis PT,Lowe SL,Bowen DM,Jefferys JG

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS:Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizur...

journal_title：Epilepsia

authors： Mares P,Haugvicová R

更新日期：1997-08-01 00:00:00

abstract：:Quantitative evidence of hippocampal atrophy has been correlated with site of seizure onset, hippocampal neuronal loss, and seizure relief after resection. Most studies have quantified hippocampal atrophy using ratios or differences between right and left hippocampal values. However, bilateral hippocampal atrophy may ...

journal_title：Epilepsia

authors： King D,Spencer SS,McCarthy G,Luby M,Spencer DD

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:Low-frequency fiber-tract stimulation has been shown to be effective in treating mesial temporal lobe epilepsies through activation of the hippocampal commissure in rodents and human patients. The corpus callosum is a major pathway connecting the two hemispheres of the brain; however, few experiments have doc...

journal_title：Epilepsia

authors： Couturier NH,Durand DM

更新日期：2018-12-01 00:00:00

abstract：:In developed countries, the incidence of epilepsy is 50-100 cases per 100,000 population per year and the prevalence is approximately 5 to 8 cases per 1,000 population. Epilepsy is by far the most prevalent serious neurologic condition. Mortality rates in epilepsy are two to four times those found in matched nonepilep...

journal_title：Epilepsia

authors： Shorvon SD

更新日期：1996-01-01 00:00:00

abstract：:Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control and subsequent AED changes in women who underwent attempts to withdraw valproic acid (VPA) during the first trimester of pregnancy. Applying Bayesian statistics, we comp...

journal_title：Epilepsia

authors： Tomson T,Battino D,Bonizzoni E,Craig J,Lindhout D,Perucca E,Sabers A,Thomas SV,Vajda F,EURAP Study Group.

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of antiepileptic drugs (AEDs; oxcarbazepine [OXC], levetiracetam [LEV], and lamotrigine [LTG]) on semen quality, sexual function, and sex hormones in male adults with epilepsy. METHODS:Individual treatment with OXC, LEV, or LTG was randomly assigned to 38 newly diagnosed male adult...

journal_title：Epilepsia

authors： Wu D,Chen L,Ji F,Si Y,Sun H

更新日期：2018-07-01 00:00:00

abstract：:We determined the incidence of seizures due to acute CNS insults for residents of Rochester, Minnesota, U.S.A., from 1935 through 1984. The age-adjusted incidence rates for 1955-1984, the period of most complete case ascertainment, was 39.0/100,000 person-years (United States 1970 population as standard). The age-adju...

journal_title：Epilepsia

authors： Annegers JF,Hauser WA,Lee JR,Rocca WA

更新日期：1995-04-01 00:00:00

abstract：:Concentrations of prostaglandins (PGs) in the central nervous system are known to increase during and after experimentally induced seizures. In the present study, concentrations of PGE-2 were determined by radioimmunoassay in lumbar cerebrospinal fluid (CSF) of 17 children shortly after a febrile convulsion. PGE-2 dat...

journal_title：Epilepsia

authors： Löscher W,Siemes H

更新日期：1988-05-01 00:00:00

abstract：PURPOSE:Synaptic vesicle protein 2A (SV2A), the binding site for the antiepileptic drug (AED) levetiracetam, has been shown to be involved in the control of neuronal excitability. The aim of the study was to define the expression and cell-specific distribution of SV2A in developmental focal lesions associated with medi...

journal_title：Epilepsia

authors： Toering ST,Boer K,de Groot M,Troost D,Heimans JJ,Spliet WG,van Rijen PC,Jansen FE,Gorter JA,Reijneveld JC,Aronica E

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Seizures are common in individuals with duplications of chromosome 15q11.2-q13 (Dup15q). The goal of this study was to examine the phenotypes and treatments of seizures in Dup15q in a large population. METHODS:A detailed electronic survey was conducted through the Dup15q Alliance containing comprehensive que...

journal_title：Epilepsia

authors： Conant KD,Finucane B,Cleary N,Martin A,Muss C,Delany M,Murphy EK,Rabe O,Luchsinger K,Spence SJ,Schanen C,Devinsky O,Cook EH,LaSalle J,Reiter LT,Thibert RL

更新日期：2014-03-01 00:00:00

abstract：PURPOSE:Previous quantitative trait loci (QTL) mapping studies from our laboratory identified a 6.6 Mb segment of distal chromosome 1 that contains a gene (or genes) having a strong influence on the difference in seizure susceptibility between C57BL/6 (B6) and DBA/2 (D2) mice. A gene transfer strategy involving a bacte...

journal_title：Epilepsia

authors： Ferraro TN,Golden GT,Dahl JP,Smith GG,Schwebel CL,MacDonald R,Lohoff FW,Berrettini WH,Buono RJ

更新日期：2007-09-01 00:00:00

abstract：:Cognitive impairment is the most common comorbidity in children with epilepsy, but its pathophysiology and predisposing conditions remain unknown. Clinical epilepsy characteristics are not conclusive in determining cognitive outcome. Because many children with epilepsy do not have macrostructural magnetic resonance im...

journal_title：Epilepsia

authors： Braakman HM,van der Kruijs SJ,Vaessen MJ,Jansen JF,Debeij-van Hall MH,Vles JS,Aldenkamp AP,Backes WH,Hofman PA

更新日期：2012-10-01 00:00:00

abstract：:We report the clinical presentation, neuroradiologic characteristics, and detailed histopathologic findings in a unique case of drug-resistant focal epilepsy due to sublobar dysplasia (SLD), treated successfully by resection of the malformed cortex. Histopathology with leptomeningeal and subcortical heterotopia, distu...

journal_title：Epilepsia

authors： Tuxhorn I,Woermann FG,Pannek HW,Hans VH

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:To describe the developmental trajectories of quality of life (QoL) in a large cohort of children with epilepsy, and to assess the relative contribution of clinical, psychosocial, and sociodemographic variables on QoL trajectories. METHODS:Five assessments during a 28-month prospective cohort study were used...

journal_title：Epilepsia

authors： Ferro MA,Avery L,Fayed N,Streiner DL,Cunningham CE,Boyle MH,Lach L,Glidden G,Rosenbaum PL,Ronen GM,QUALITÉ group.

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:Concerns over teratogenicity of antiepileptic drugs (AEDs) during pregnancy must be balanced against the risks of seizures to the mother and developing fetus. Pharmacokinetic changes and vomiting may alter drug levels, but more important may be the patient's decision to stop medication before or during pregnanc...

journal_title：Epilepsia

authors： Williams J,Myson V,Steward S,Jones G,Wilson JF,Kerr MP,Smith PE

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:Corpus callosotomy is an effective palliative treatment for drug-resistant Lennox-Gastaut syndrome (LGS). Laser interstitial thermal therapy has been increasingly used in the treatment of epilepsy. Here, we assess the safety and effectiveness of minimally invasive stereotactic laser anterior corpus callosotom...

journal_title：Epilepsia

authors： Tao JX,Satzer D,Issa NP,Collins J,Wu S,Rose S,Henry J,Santos de Lima F,Nordli D,Warnke PC

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:A large number of studies have highlighted the important role of the gut microbiota in the pathophysiology of neurological disorders, suggesting that its manipulation might serve as a treatment strategy. We hypothesized that the gut microbiota participates in absence seizure development and maintenance in the...

journal_title：Epilepsia

authors： Citraro R,Lembo F,De Caro C,Tallarico M,Coretti L,Iannone LF,Leo A,Palumbo D,Cuomo M,Buommino E,Nesci V,Marascio N,Iannone M,Quirino A,Russo R,Calignano A,Constanti A,Russo E,De Sarro G

更新日期：2021-01-11 00:00:00

abstract：OBJECTIVE:Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can ter...

journal_title：Epilepsia

authors： Van Gompel JJ,Bower MR,Worrell GA,Stead M,Chang SY,Goerss SJ,Kim I,Bennet KE,Meyer FB,Marsh WR,Blaha CD,Lee KH

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:We analyzed sequential changes in the localization of EEG foci along with age to identify a specific EEG pattern, and the relation between the clinical manifestations and the EEG pattern in patients with Panayiotopoulos syndrome (PS). METHODS:The subjects were 76 children, who had been followed up >2 years wit...

journal_title：Epilepsia

authors： Ohtsu M,Oguni H,Hayashi K,Funatsuka M,Imai K,Osawa M

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:To identify the temporal lobe cortical dysplasia (CD) histopathology classification subtype and determine the seizure outcome of patients who underwent temporal lobectomy with coincident CD. METHODS:We reviewed the data of 28 patients with temporal lobe epilepsy who underwent surgery with pathologically verifi...

journal_title：Epilepsia

authors： Srikijvilaikul T,Najm IM,Hovinga CA,Prayson RA,Gonzalez-Martinez J,Bingaman WE

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:In patients with tuberous sclerosis complex (TSC), a wide range of neurologic abnormalities develop, including mental retardation and seizures. Brains from TSC patients are characterized by the presence of cortical tubers, large dysmorphic neurons, and abnormal cytomegalic cells. Although analysis of human TSC ...

journal_title：Epilepsia

authors： Takahashi DK,Dinday MT,Barbaro NM,Baraban SC

更新日期：2004-12-01 00:00:00

abstract：:Epilepsy can be a devastating disorder. In addition to debilitating seizures, epilepsy can cause cognitive and emotional problems with reduced quality of life. Therefore, the major aim is to prevent the disorder in the first place: identify, detect, and reverse the processes responsible for its onset, and monitor and ...

journal_title：Epilepsia

authors： Koepp MJ,Årstad E,Bankstahl JP,Dedeurwaerdere S,Friedman A,Potschka H,Ravizza T,Theodore WH,Baram TZ

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:The rat electrical amygdala kindling model is one of the most widely studied animal models of temporal lobe epilepsy (TLE); however, the processes underlying epileptogenesis in this model remain incompletely understood. Magnetic resonance imaging (MRI) is a powerful method to investigate epileptogenesis, allowi...

journal_title：Epilepsia

authors： Jupp B,Williams JP,Tesiram YA,Vosmansky M,O'Brien TJ

更新日期：2006-01-01 00:00:00