Epilepsy in offspring of whom both parents have idiopathic generalized epilepsy: biparental inheritance.

abstract：:Differentiation between psychogenic nonepileptic seizures (PNES) and generalized convulsive epileptic seizures (ES) is important for appropriate triaging in the emergency department (ED). This can be difficult in the ED, as the event is often not witnessed by a medical professional. In the current study, we investigat...

journal_title：Epilepsia

authors： Li Y,Matzka L,Maranda L,Weber D

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:The AY-9944 (AY)-treated rat is a reproducible and clinically relevant animal model of atypical absence seizures. AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absence seizures has not been determined. METHODS:Long-Evans hooded rats were treated...

journal_title：Epilepsia

authors： Cortez MA,Cunnane SC,Snead OC 3rd

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:We review what is currently known about functional and morphologic plasticity of hippocampal neuronal circuits in animal epilepsy models. RESULTS:Perforant-path kindling has been shown to enhance excitatory synaptic transmission in the dentate gyrus significantly, and this enhancement has lasted for > or =1 mo...

journal_title：Epilepsia

authors： Maru E,Kanda M,Ashida H

更新日期：2002-01-01 00:00:00

abstract：:The pharmacokinetics of phenylethylmalonamide (PEMA), a major metabolite of primidone, were investigated following administration of single oral doses (400 mg) to six normal subjects and six patients receiving chronic treatment with antiepileptic drugs. Peak serum PEMA levels were usually attained with 2-4 h after int...

journal_title：Epilepsia

authors： Cottrell PR,Streete JM,Berry DJ,Schäfer H,Pisani F,Perucca E,Richens A

更新日期：1982-06-01 00:00:00

abstract：:In 45 patients suffering from secondary generalized epilepsy, we have recorded 239 drop seizures both by radio-telemetered EEG/split-screen video taping and polygraphically. Twenty of these patients had pure tonic drop seizures. Nine patients each had myoclonic-atonic or pure atonic seizures, whereas seven had slow fa...

journal_title：Epilepsia

authors： Egli M,Mothersill I,O'Kane M,O'Kane F

更新日期：1985-09-01 00:00:00

abstract：PURPOSE:Few data describe the sensitivity of a "Seizure Activity Detection Computer" (SzAC) in childhood video/EEG (VEEG) monitoring, especially for very young children. We examined the accuracy of SzAC in childhood VEEG monitoring in different pediatric age groups. METHODS:We visually analyzed VEEG monitoring samples...

journal_title：Epilepsia

authors： Kim HD,Clancy RR

更新日期：1997-11-01 00:00:00

abstract：:Epilepsy syndromes occupy an important position in the current nosology of the epilepsies, describing and classifying seizure disorders with shared clinical and EEG features. Increasingly, this schema is being refined as new information becomes available and our understanding of etiology and presentation of each syndr...

journal_title：Epilepsia

authors： Duchowny M,Harvey AS

更新日期：1996-01-01 00:00:00

abstract：:The duration of epilepsy was evaluated in over 460 previously untreated patients who attended newly established epilepsy clinics in a rural area of Malawi. The mean duration at first attendance was 6.5 years. It was found that as the duration of active epilepsy increased, the number of patients having epilepsy of a gi...

journal_title：Epilepsia

authors： Watts AE

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is a medical emergency associated with a high mortality. Clinical series have suggested that mortality after SE has decreased. No studies have systematically examined trends in incidence, mortality, and case fatality after SE in a well-defined population. METHODS:All first episodes of S...

journal_title：Epilepsia

authors： Logroscino G,Hesdorffer DC,Cascino G,Annegers JF,Hauser WA

更新日期：2001-08-01 00:00:00

abstract：:Mutations of the sodium channel subunit gene SCN2A have been described in families with benign familial neonatal-infantile seizure (BFNIS). We describe two large families with BFNIS and novel SCN2A mutations. The families had 12 and 9 affected individuals, respectively, with phenotypes consistent with BFNIS. Two mutat...

journal_title：Epilepsia

authors： Herlenius E,Heron SE,Grinton BE,Keay D,Scheffer IE,Mulley JC,Berkovic SF

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Low-frequency fiber-tract stimulation has been shown to be effective in treating mesial temporal lobe epilepsies through activation of the hippocampal commissure in rodents and human patients. The corpus callosum is a major pathway connecting the two hemispheres of the brain; however, few experiments have doc...

journal_title：Epilepsia

authors： Couturier NH,Durand DM

更新日期：2018-12-01 00:00:00

abstract：:In 1990, the NIH Consensus Conference Panel on epilepsy surgery called for the development and use of reliable and valid health-related quality-of-life (HRQOL) measures in epilepsy surgery studies. A HRQOL measure for epilepsy surgery patients has been developed and evaluated. The procedure, which could also be used t...

journal_title：Epilepsia

authors： Vickrey BG

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Focal cortical dysplasia type IIb (FCD IIb) lesions are highly epileptogenic and frequently cause pharmacoresistant epilepsy. Complete surgical resection leads to seizure freedom in most cases. However, the term "complete" resection is controversial with regard to the necessity of performing resections of the s...

journal_title：Epilepsia

authors： Wagner J,Urbach H,Niehusmann P,von Lehe M,Elger CE,Wellmer J

更新日期：2011-08-01 00:00:00

abstract：:Severe Myoclonic Epilepsy in infancy (SMEI, or Dravet syndrome) is a drug-resistant epilepsy that occurs in the first year of life of previously healthy children. The main clinical features are prolonged and repeated febrile and afebrile generalized or unilateral convulsive seizures. In the course of the epilepsy, cog...

journal_title：Epilepsia

authors： Wolff M,Cassé-Perrot C,Dravet C

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To evaluate prospectively patient's aims for epilepsy surgery as previously outlined theoretically by Taylor et al. (Epilepsia 1997;3:625-30). METHODS:Ninety-three consecutive patients were interviewed by a psychiatrist as part of their evaluation for epilepsy surgery. Open-ended questions about the patient we...

journal_title：Epilepsia

authors： Taylor DC,McMacKin D,Staunton H,Delanty N,Phillips J

更新日期：2001-05-01 00:00:00

abstract：:Epilepsy-prone and epilepsy-resistant substrains were selectively bred from a strain of BALB/c mice; audiogenic-sensitive epilepsy-prone animals showed enhanced sensitivity to chemical convulsants. Treatment with pyridoxine (100 mg/L in drinking water) initiated at mating and continued throughout pregnancy and the lif...

journal_title：Epilepsia

authors： Dolina S,Peeling J,Sutherland G,Pillay N,Greenberg A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To clarify the role of hippocampal sclerosis (HS) in developing psychiatric and cognitive adverse events during therapy with topiramate (TPM) in patients with temporal lobe epilepsy (TLE). METHODS:We analyzed the data of 70 patients with TLE and HS and 128 patients with cryptogenic TLE matched for age, sex, st...

journal_title：Epilepsia

authors： Mula M,Trimble MR,Sander JW

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:In temporal lobe epilepsy (TLE), the thalamus is well known for its role in the propagation and spread of epileptiform activity. However, the integrity of thalamocortical functional connectivity (FC) in TLE and its relation to specific seizure patterns have not yet been determined. We address these issues wit...

journal_title：Epilepsia

authors： He X,Doucet GE,Sperling M,Sharan A,Tracy JI

更新日期：2015-10-01 00:00:00

abstract：:Brain stimulation is currently used as an experimental treatment for patients with medically refractory epilepsy. However, the results of such stimulation are still less than optimal. A major factor is the lack of understanding of the mechanisms of applied stimuli. Herein we review evidence on the effects of stimulati...

journal_title：Epilepsia

authors： Jiruska P,Powell AD,Deans JK,Jefferys JG

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The Parry-Romberg syndrome is an unusual disorder frequently associated with epilepsy. The origin of this disease, and the cause of epilepsy, are unknown. This study is the first reported case of the Parry-Romberg syndrome, with intractable temporal lobe epilepsy, in which detailed microanatomic analyses have b...

journal_title：Epilepsia

authors： DeFelipe J,Segura T,Arellano JI,Merchán A,DeFelipe-Oroquieta J,Martín P,Maestú F,Ramón y Cajal S,Sánchez A,Sola RG

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:In 2015, the International League Against Epilepsy (ILAE) proposed a new definition of status epilepticus (SE): 5 minutes of ongoing seizure activity to diagnose convulsive SE (CSE, ie, bilateral tonic-clonic SE) and 10 minutes for focal SE and absence SE, rather than the earlier criterion of 30 minutes. Base...

journal_title：Epilepsia

authors： Leitinger M,Trinka E,Giovannini G,Zimmermann G,Florea C,Rohracher A,Kalss G,Neuray C,Kreidenhuber R,Höfler J,Kuchukhidze G,Granbichler C,Dobesberger J,Novak HF,Pilz G,Meletti S,Siebert U

更新日期：2019-01-01 00:00:00

abstract：:Folic acid deficient diet reduces the duration and severity of intravenous megimide seizures in the rat after 6 months of diet. Plasma and serum folate levels are strongly reduced after that period. The difference between Lactobacillus casei and Streptococcus faecalis activity in brain show a slight, but not significa...

journal_title：Epilepsia

authors： Hommes OR,ten Berge EJ,Jansen MJ,Kok JC

更新日期：1977-12-01 00:00:00

abstract：PURPOSE:  Models of temporal lobe epilepsy are commonly utilized to study focal epileptogenesis and ictogenesis. The criteria that define animal models representative of human mesial temporal lobe may vary in different laboratories. We describe herein a focal epilepsy model of mesial temporal (hippocampal) origin that ...

journal_title：Epilepsia

authors： Carriero G,Arcieri S,Cattalini A,Corsi L,Gnatkovsky V,de Curtis M

更新日期：2012-11-01 00:00:00

abstract：:The pathogenesis of neurogenic pulmonary edema has been debated for many years. Whether cardiogenic mechanisms and increased pulmonary vascular pressures are primary or even necessary for the production of pulmonary edema has been argued. We used postictal pulmonary edema to study this problem in a sheep model of neur...

journal_title：Epilepsia

authors： Johnston SC,Darragh TM,Simon RP

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:To identify the short-term outcome of patients who had seizures while watching an animated cartoon TV program, "Pocket Monster," on December 16, 1997. METHODS:One and three years after the incident, questionnaires were sent to physicians of each patient about seizure recurrence, EEGs, and medication. RESULTS:...

journal_title：Epilepsia

authors： Ishiguro Y,Takada H,Watanabe K,Okumura A,Aso K,Ishikawa T

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic in...

journal_title：Epilepsia

authors： Ung H,Davis KA,Wulsin D,Wagenaar J,Fox E,McDonnell JJ,Patterson N,Vite CH,Worrell G,Litt B

更新日期：2016-12-01 00:00:00

abstract：:A prospective study of the children in 12 families examined the impact of and adjustments to epilepsy in one of the parents. Young children allowed to see the parent's seizures and the treatment for those seizures adapted to the threat of illness in a parent by becoming involved in the care and supervision of the affe...

journal_title：Epilepsia

authors： Lechtenberg R,Akner L

更新日期：1984-02-01 00:00:00

abstract：:ACC-9653, the disodium phosphate ester of 3-hydroxymethyl-5,5-diphenylhydantoin, is a prodrug of phenytoin with advantageous physicochemical properties. ACC-9653 is rapidly converted enzymatically to phenytoin in vivo. ACC-9653 and phenytoin sodium have equivalent anticonvulsant activity against seizures induced by ma...

journal_title：Epilepsia

authors： Smith RD,Brown BS,Maher RW,Matier WL

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Genetic testing has become a routine part of the diagnostic workup in children with early onset epilepsies. In the present study, we sought to investigate a cohort of adult patients with epilepsy, to determinate the diagnostic yield and explore the gain of personalized treatment approaches in adult patients. ...

journal_title：Epilepsia

authors： Johannesen KM,Nikanorova N,Marjanovic D,Pavbro A,Larsen LHG,Rubboli G,Møller RS

更新日期：2020-06-01 00:00:00

abstract：:Six barbiturates with diverse time-action characteristics--thiopental, pentobarbital, butabarbital, phenobarbital, diphenylbarbiturate, and barbital--were evaluated for "anticonvulsant" and "neurotoxic" effects. For the former, the MES test, clonic seizures induced by pentylenetetrazol, 90 mg/kg, s.c., and maximal sei...

journal_title：Epilepsia

authors： Raines A,Blake GJ,Richardson B,Gilbert MB

更新日期：1979-04-01 00:00:00