Abstract：
:We compared zonisamide monotherapy (12 weeks) to carbamazepine monotherapy (12 weeks) after phenytoin baseline monotherapy (8 weeks) in an open crossover pilot study of eight adults with uncontrolled partial seizures. Zonisamide had definite antiepileptic activity in five subjects. In two of these, response to zonisamide was superior to that to either phenytoin or carbamazepine. A third subject became seizure free on zonisamide, but had to be withdrawn after 18 days because of mild Stevens-Johnson syndrome. The other three subjects were withdrawn from the study because of drug toxicity, manifested mainly by impaired higher mental function and increased seizures. The best response to zonisamide was at doses approximating 6 mg/kg/day, with plasma levels of 20-30 mg/L. Plasma levels of greater than 30 mg/L usually were associated with toxicity. The pharmacokinetics of zonisamide are complex and nonlinear, with steady-state plasma levels being approximately three times higher than those predicted from a single-dose study.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Wilensky AJ,Friel PN,Ojemann LM,Dodrill CB,McCormick KB,Levy RHdoi
10.1111/j.1528-1157.1985.tb05408.xsubject
Has Abstractpub_date
1985-05-01 00:00:00pages
212-20issue
3eissn
0013-9580issn
1528-1167journal_volume
26pub_type
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