Overview: epilepsy surgery in developing countries.

Abstract:

:Epilepsy surgery (ES) is addressed in relation to economic classifications of national resources and welfare in developing countries. A decade ago, ten developing countries conducted ES; now 26 such countries have reported results of ES. A number of international authorities define indicators of national economic welfare. Adopting the economic classification of the International Monetary Fund. we find that ES is nonexistent in 98% of African countries, 76% of Asian countries, 58% of European countries, 82% of Middle East countries, and in 86% of countries of the Western Hemisphere. The 1980-1990 global ES survey conducted by the International League Against Epilepsy identified ten developing countries reporting ES (DCRES): Brazil, China, Czechoslovakia, Hungary, Mexico, Poland, Taiwan, the U.S.S.R., Yugoslavia, and Viet Nam. The present survey based on the proceedings of the 19th-23rd International Epilepsy Congresses and Medline reports from 1991 to November 1999 revealed at least 26 (18.3%) DCRES of 142 developing countries: Argentina, Brazil, Chile, China, Colombia, Czech Republic, Egypt, Estonia, Hungary, India, Iran, Israel, Korea, Lithuania, Mexico, P.R.China, the U.S.S.R., Singapore, Slovenia, South Africa, South Korea, Taiwan, Turkey, Ukraine, Uruguay, and former Yugoslavia. National vital statistics expose the hardships of developing countries. The population ratio of developed countries to developing countries is approximately 1:5. The reverse per capita Gross Domestic Product ratio is 20:1. Great disparities exist in vital statistics, all to the disadvantage of the DCRES. The World Health Organization defines health-related sectors geographically, then divides developing countries into several subgroups. Disability caused by length of disease and years lived with disability can be quantified monetarily for epilepsy, and the total health expenditures of developed and developing countries can be compared. The DCRES are short of technology, and their ES teams must choose from an excess of surgical candidates, investigating with computed tomography, magnetic resonance imaging, noninvasive video-electroencephalography, and neuropsychology. The surgical outcomes achieved are similar to those in the developed world, but at a fractional cost. To internationalize ES, outcome, cost, and savings from care, evolution of assessment methodology is needed. Also needed is general support from the developed world.

journal_name

Epilepsia

journal_title

Epilepsia

authors

Wieser HG,Silfvenius H

doi

10.1111/j.1528-1157.2000.tb01538.x

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

S3-9

eissn

0013-9580

issn

1528-1167

journal_volume

41 Suppl 4

pub_type

杂志文章
  • Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?

    abstract::Neurotrophic factors are involved in the survival of neurons as well as in the proliferation and differentiation of neuronal precursors. Therefore, modulating their levels in lesion areas may exert favorable effects on seizure-induced damage. However, it is unclear if damage limitation or repair may prevent epileptoge...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2010.02609.x

    authors: Simonato M,Zucchini S

    更新日期:2010-07-01 00:00:00

  • Ganglioglioma and intractable epilepsy: clinical and neurophysiologic features and predictors of outcome after surgery.

    abstract:PURPOSE:To review the clinical, neurophysiologic, and radiological data of patients with ganglioglioma who had undergone evaluation and surgery in our Epilepsy Program. METHODS:The medical and neurophysiologic records of 38 patients with intractable epilepsy and ganglioglioma were reviewed. Data underwent statistical ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1998.tb01378.x

    authors: Morris HH,Matkovic Z,Estes ML,Prayson RA,Comair YG,Turnbull J,Najm I,Kotagal P,Wyllie E

    更新日期:1998-03-01 00:00:00

  • Antiepileptic drugs and vitamin D supplementation.

    abstract::The incidence of biochemical signs of vitamin D deficiency and the effects of vitamin D supplementation were investigated in 83 children and 95 adults on chronic antiepileptic therapy and 40 mentally retarded controls living under comparable conditions. Low 25-hydroxyvitamin D and serum calcium, and elevated immunorea...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1979.tb04771.x

    authors: Offermann G,Pinto V,Kruse R

    更新日期:1979-02-01 00:00:00

  • Predictive clinical factors for the differential diagnosis of childhood extratemporal seizures.

    abstract:PURPOSE:To describe predictive clinical factors for the differentiation between childhood frontal lobe epilepsy (FLE) and posterior cortex epilepsy (PCE). METHODS:Two independent, blinded investigators analyzed 177 seizures from 35 children (aged 11 months to 12 years) with extratemporal epilepsy selected by postopera...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2005.06105.x

    authors: Fogarasi A,Tuxhorn I,Hegyi M,Janszky J

    更新日期:2005-08-01 00:00:00

  • Sudden unexplained death among subjects with refractory epilepsy.

    abstract:PURPOSE:To address concerns about possible increases in rates of sudden unexplained death (SUD) after use of new anticonvulsants, more information on the rate of SUD among subjects with refractory epilepsy is needed to provide a comparison. METHODS:We conducted a study to estimate the incidence of SUD among subjects y...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1996.tb00529.x

    authors: Derby LE,Tennis P,Jick H

    更新日期:1996-10-01 00:00:00

  • Hippocampal sclerosis and a second focal lesion--how often is it ipsilateral?

    abstract:PURPOSE:Hippocampal sclerosis (HS) is the most common pathologic finding in intractable temporal lobe epilepsy (TLE). In many patients, HS is accompanied by an extrahippocampal lesion (EHL). We sought to assess the lobar distribution and side of EHLs in relation to HS in a large consecutive series of patients presentin...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2011.03021.x

    authors: Hofman PA,Fitt G,Mitchell LA,Jackson GD

    更新日期:2011-04-01 00:00:00

  • Generalized convulsive status epilepticus management in adults: a cohort study with evaluation of professional practice.

    abstract:PURPOSE:Generalized convulsive status epilepticus (GCSE) needs immediate management. Despite guidelines, adherence to management protocols is often poor, this contributing to poor outcome. We aimed to evaluate the usefulness of a management protocol in GCSE. METHODS:This is a prospective population-based study of cons...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2010.02688.x

    authors: Aranda A,Foucart G,Ducassé JL,Grolleau S,McGonigal A,Valton L

    更新日期:2010-10-01 00:00:00

  • Clues to the genetic influences of drug responsiveness in epilepsy.

    abstract::Despite the introduction of newer antiepileptic drugs (AEDs), nonresponsiveness to AEDs remains a common problem in epilepsy clinics. There may be important genetic determinants for responsiveness, and this discussion focused on some potential areas: drug transporters; drug-metabolizing enzymes, and ion channels. We r...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1046/j.1528-1157.44.s.1.13.x

    authors: Ramachandran V,Shorvon SD

    更新日期:2003-01-01 00:00:00

  • Differences between patients with temporal lobe seizures and those with other forms of epileptic attacks.

    abstract::Seventy-eight patients with temporal lobe type seizures were precisely matched for age, sex, and Wechsler I.Q. levels with patients suffering from other seizure types. Statistically significant differences were established between the groups in regard to treatment response, etiologies, and behavioral variables. Furthe...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1976.tb03409.x

    authors: Rodin EA,Katz M,Lennox K

    更新日期:1976-09-01 00:00:00

  • Can BIS monitoring be used to assess the depth of propofol anesthesia in the treatment of refractory status epilepticus?

    abstract:PURPOSE:Appropriate treatment of generalized convulsive refractory status epilepticus (RSE) requires general anesthesia in the intensive care unit (ICU) with continuous electroencephalography (cEEG) monitoring. During out of office hours and weekends, cEEG monitoring is not always available. The Bispectral Index (BIS) ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2009.02514.x

    authors: Musialowicz T,Mervaala E,Kälviäinen R,Uusaro A,Ruokonen E,Parviainen I

    更新日期:2010-08-01 00:00:00

  • Increased cortical extracellular adenosine correlates with seizure termination.

    abstract:OBJECTIVE:Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can ter...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.12511

    authors: Van Gompel JJ,Bower MR,Worrell GA,Stead M,Chang SY,Goerss SJ,Kim I,Bennet KE,Meyer FB,Marsh WR,Blaha CD,Lee KH

    更新日期:2014-02-01 00:00:00

  • The effects of remifentanil on epileptiform discharges during intraoperative electrocorticography in patients undergoing epilepsy surgery.

    abstract:PURPOSE:High-dose i.v. opioids (e.g., alfentanil, 50 microg/kg bolus) are known to increase the intraoperative reading of epileptiform activity during epilepsy surgery (ES), thereby facilitating localization of the epileptogenic zone (i.e., the site of ictal onset and initial seizure propagation). However, this phenome...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1046/j.1528-1157.2001.05901.x

    authors: Wass CT,Grady RE,Fessler AJ,Cascino GD,Lozada L,Bechtle PS,Marsh WR,Sharbrough FW,Schroeder DR

    更新日期:2001-10-01 00:00:00

  • The treatment of nonepileptic seizures: historical perspectives and future directions.

    abstract::Nonepileptic seizures (NES) are neuropsychiatric disorders presenting with a combination of neurologic signs and underlying psychological conflicts. For more than a century, the medical community has accumulated data and insights about the phenomenology, epidemiology, risks, comorbidities, and prognosis of NES. Howeve...

    journal_title:Epilepsia

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.0013-9580.2004.452002.x

    authors: LaFrance WC Jr,Devinsky O

    更新日期:2004-01-01 00:00:00

  • Role of the superior colliculus in the expression of acute and kindled audiogenic seizures in Wistar audiogenic rats.

    abstract:PURPOSE:The role of the superior colliculus (SC) in seizure expression is controversial and appears to be dependent upon the epilepsy model. This study shows the effect of disconnection between SC deep layers and adjacent tissues in the expression of acute and kindling seizures. METHODS:Subcollicular transections, abl...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2009.02164.x

    authors: Doretto MC,Cortes-de-Oliveira JA,Rossetti F,Garcia-Cairasco N

    更新日期:2009-12-01 00:00:00

  • Ex vivo characterization of neuroinflammatory and neuroreceptor changes during epileptogenesis using candidate positron emission tomography biomarkers.

    abstract:OBJECTIVE:Identification of patients at risk of developing epilepsy before the first spontaneous seizure may promote the development of preventive treatment providing opportunity to stop or slow down the disease. METHODS:As development of novel radiotracers and on-site setup of existing radiotracers is highly time-con...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.16353

    authors: Bascuñana P,Gendron T,Sander K,Jahreis I,Polyak A,Ross TL,Bankstahl M,Arstad E,Bankstahl JP

    更新日期:2019-11-01 00:00:00

  • Distribution of seizure precipitants among epilepsy syndromes.

    abstract:PURPOSE:Previous studies of patient-reported seizure precipitants have not evaluated whether different epilepsy syndromes are differentially affected. METHODS:Patients of a tertiary-care epilepsy center were consecutively surveyed with the use of a standardized questionnaire that lists precipitants that might trigger ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1499-1654.2000.001534.x

    authors: Frucht MM,Quigg M,Schwaner C,Fountain NB

    更新日期:2000-12-01 00:00:00

  • MRS metabolic markers of seizures and seizure-induced neuronal damage.

    abstract:PURPOSE:Proton magnetic resonance spectroscopy (MRS) was used to identify specific in situ metabolic markers for seizures and seizure-induced neuronal damage. Kainic acid (KA)-induced seizures lead to histopathologic changes in rat brain. The protective effect of cycloheximide treatment against neuronal damage caused b...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1998.tb01368.x

    authors: Najm IM,Wang Y,Shedid D,Lüders HO,Ng TC,Comair YG

    更新日期:1998-03-01 00:00:00

  • Identification and preclinical testing of novel antiepileptic compounds.

    abstract::Procedures for identifying novel antiepileptic drugs (AEDs) are changing and need to change more. Widespread reliance on two primary screens has led to the identification of novel compounds that resemble either phenytoin (suppressing high-frequency repetitive firing in cultured neurons and prolonging inactivation of v...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1157.1997.tb05204.x

    authors: Meldrum BS

    更新日期:1997-01-01 00:00:00

  • Temporal lobe epilepsy surgery and the quest for optimal extent of resection: a review.

    abstract::The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial. It remains controversial which resection method gives best results for seizure freedom and neuropsychological function. This review of 53 studies addressing extent of resection in surge...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2008.01604.x

    authors: Schramm J

    更新日期:2008-08-01 00:00:00

  • Changes in quality of life after epilepsy surgery: the role of reprioritization response shift.

    abstract:OBJECTIVES:Health-related quality of life (HRQOL) is an important indicator of well-being in patients with epilepsy. When assessing changes in HRQOL over time, some of the changes observed may be due to the patients' change in the internal standards, value, or meaning that they attribute to the HRQOL domain being measu...

    journal_title:Epilepsia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/epi.12697

    authors: Sajobi TT,Fiest KM,Wiebe S

    更新日期:2014-09-01 00:00:00

  • Computerized motion analysis of videotaped neonatal seizures of epileptic origin.

    abstract:PURPOSE:The main objective of this research is the development of automated video processing and analysis procedures aimed at the recognition and characterization of the types of neonatal seizures. The long-term goal of this research is the integration of these computational procedures into the development of a stand-a...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1167.2005.56504.x

    authors: Karayiannis NB,Tao G,Xiong Y,Sami A,Varughese B,Frost JD Jr,Wise MS,Mizrahi EM

    更新日期:2005-06-01 00:00:00

  • From clinical observation to long-term monitoring: diagnostic developments in conservative epileptology.

    abstract::The diagnostic goals in nonsurgical (conservative) epileptology differ from presurgical diagnostic aims. The resulting development of diagnostic methods in a tertiary-level epilepsy center is shown and the major technical and organizational consequences of this difference for diagnostic long-term monitoring (LTM) as o...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.2000.tb01528.x

    authors: Ried S,Hilfiker P,Mothersill IW,Krämer G

    更新日期:2000-01-01 00:00:00

  • Psychologic adaptation of children to epilepsy in a parent.

    abstract::A prospective study of the children in 12 families examined the impact of and adjustments to epilepsy in one of the parents. Young children allowed to see the parent's seizures and the treatment for those seizures adapted to the threat of illness in a parent by becoming involved in the care and supervision of the affe...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1984.tb04153.x

    authors: Lechtenberg R,Akner L

    更新日期:1984-02-01 00:00:00

  • Effect of systemic estrogen on seizure susceptibility in the immature animal.

    abstract::Estrogens have previously been reported to be proconvulsants in adult animals. This study evaluated the effects of acute, high-dose estrogen administration on rate of kindling in immature rats. No significant differences in rate of kindling between the estrogen-treated rats and controls were noted. This study, using t...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1986.tb03580.x

    authors: Schultz-Krohn WA,Thompson J,Holmes GL

    更新日期:1986-09-01 00:00:00

  • First seizure: EEG and neuroimaging following an epileptic seizure.

    abstract::An early EEG (within 48 h) and high-resolution magnetic resonance imaging (hr_MRI) are the methods of choice for an accurate diagnosis after a first seizure presentation. Together with a careful history and examination, they will allow definition of the epilepsy syndrome in two-thirds of patients and help assess the i...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1528-1167.2008.01445.x

    authors: Pohlmann-Eden B,Newton M

    更新日期:2008-01-01 00:00:00

  • Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy.

    abstract:OBJECTIVE:Under an expanded access investigational new drug (IND) trial, cannabidiol (CBD) is being studied as a possible adjuvant treatment of refractory epilepsy in children. Of the 25 subjects in the trial, 13 were being treated with clobazam (CLB). Because CLB and CBD are both metabolized in the cytochrome P450 (CY...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13060

    authors: Geffrey AL,Pollack SF,Bruno PL,Thiele EA

    更新日期:2015-08-01 00:00:00

  • Clinical relevance of a dipole field in rolandic spikes.

    abstract::The clinical presentation of 366 children with rolandic spikes was examined to determine whether the presence of a temporal-frontal dipole field is associated with a lower incidence of clinical abnormality. Comparisons were made between the clinical presentation of 99 children with temporal-frontal dipole discharges v...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1992.tb02280.x

    authors: Gregory DL,Wong PK

    更新日期:1992-01-01 00:00:00

  • Reduction of duration and severity of megimide seizures in rats on a folic acid deficient diet.

    abstract::Folic acid deficient diet reduces the duration and severity of intravenous megimide seizures in the rat after 6 months of diet. Plasma and serum folate levels are strongly reduced after that period. The difference between Lactobacillus casei and Streptococcus faecalis activity in brain show a slight, but not significa...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/j.1528-1157.1977.tb04987.x

    authors: Hommes OR,ten Berge EJ,Jansen MJ,Kok JC

    更新日期:1977-12-01 00:00:00

  • Comprehensive care of the epilepsy patient--control, comorbidity, and cost.

    abstract::Traditionally, control of seizures in patients with epilepsy is viewed as the most important clinical outcome. Yet, current antiepileptic drugs (AEDs) do not always achieve this. Around 30-40% of patients remain uncontrolled despite pharmacological intervention. Poor tolerability of AEDs is a large part of the problem...

    journal_title:Epilepsia

    pub_type: 杂志文章,评审

    doi:10.1111/j.0013-9580.2004.455002.x

    authors: Bazil CW

    更新日期:2004-01-01 00:00:00

  • Ictal onset on intracranial EEG: Do we know it when we see it? State of the evidence.

    abstract:OBJECTIVE:A major limitation of intracranial electroencephalography (iEEG) is recording from a confined region. This may falsely localize seizure onset if the distinction between ictal onset zone, proximity, and spread is unclear, or if the ictal rhythm is not clearly identified. Delineation of the ictal onset zone is ...

    journal_title:Epilepsia

    pub_type: 杂志文章

    doi:10.1111/epi.13120

    authors: Singh S,Sandy S,Wiebe S

    更新日期:2015-10-01 00:00:00