Abstract:
:Neurotrophic factors are involved in the survival of neurons as well as in the proliferation and differentiation of neuronal precursors. Therefore, modulating their levels in lesion areas may exert favorable effects on seizure-induced damage. However, it is unclear if damage limitation or repair may prevent epileptogenesis; it is also uncertain which neurotrophic factor should be administered for limiting or repairing damage while avoiding possible proepileptic effects. We used viral vectors to locally supplement fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF), when an epileptogenic damage was already in place. These vectors were tested in the pilocarpine model of status epilepticus-induced neurodegeneration and epileptogenesis. FGF-2/BDNF expressing vectors increased neuronogenesis, limited neuronal damage, and reduced the occurrence of spontaneous seizures. These findings are discussed with consideration of the hurdles that will have to be overcome before clinical application.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Simonato M,Zucchini Sdoi
10.1111/j.1528-1167.2010.02609.xsubject
Has Abstractpub_date
2010-07-01 00:00:00pages
48-51eissn
0013-9580issn
1528-1167pii
EPI2609journal_volume
51 Suppl 3pub_type
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