Females, their estrogens, and seizures.

abstract：:Advanced variant detection in genes underlying risk of sudden unexpected death in epilepsy (SUDEP) can uncover extensive epistatic complexity and improve diagnostic accuracy of epilepsy-related mortality. However, the sensitivity and clinical utility of diagnostic panels based solely on established cardiac arrhythmia ...

journal_title：Epilepsia

authors： Klassen TL,Bomben VC,Patel A,Drabek J,Chen TT,Gu W,Zhang F,Chapman K,Lupski JR,Noebels JL,Goldman AM

更新日期：2014-02-01 00:00:00

abstract：:The mean gamma-aminobutyric acid (GABA) level in lumbar CSF of 31 children with epilepsy was not significantly different from that of 41 age-matched controls. However, when the epileptic children were subdivided into untreated patients and patients treated with antiepileptic drugs, the medication-free subgroup had a s...

journal_title：Epilepsia

authors： Löscher W,Siemes H

更新日期：1985-07-01 00:00:00

abstract：:The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact o...

journal_title：Epilepsia

authors： Galanopoulou AS,Kokaia M,Loeb JA,Nehlig A,Pitkänen A,Rogawski MA,Staley KJ,Whittemore VH,Dudek FE

更新日期：2013-08-01 00:00:00

abstract：:We evaluated language functions in 154 patients with left hemisphere speech dominance undergoing anterior temporal lobectomy (ATL). Measures of phonemic and semantic fluency, confrontation naming, repetition, comprehension, and reading were administered before and 3 weeks postoperatively. Patients were grouped by focu...

journal_title：Epilepsia

authors： Saykin AJ,Stafiniak P,Robinson LJ,Flannery KA,Gur RC,O'Connor MJ,Sperling MR

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:The novel antiepileptic drug (AED) levetiracetam (LEV; Keppra) has a wide therapeutic index and pharmacokinetic characteristics predicting limited drug-interaction potential. It is indicated as an add-on treatment in patients with epilepsy, and thus coadministration with valproic acid (VPA) is likely. These stu...

journal_title：Epilepsia

authors： Coupez R,Nicolas JM,Browne TR

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:To estimate the incidence and mortality associated with first unprovoked seizure or newly diagnosed epilepsy in a low-income, predominantly Hispanic community in Northern Manhattan, New York City. METHODS:We performed a population-based study to determine the incidence of first unprovoked seizure or newly diag...

journal_title：Epilepsia

authors： Benn EK,Hauser WA,Shih T,Leary L,Bagiella E,Dayan P,Green R,Andrews H,Thurman DJ,Hesdorffer DC

更新日期：2008-08-01 00:00:00

abstract：:The computed tomography (CT) scans of 132 patients with late onset epilepsy were compared with the CT scans of an age- and sex-matched control group. Patients with neurologic symptoms in addition to epilepsy, patients with a definite antecedent cause for epilepsy, and patients with tumours on CT scanning were excluded...

journal_title：Epilepsia

authors： Roberts RC,Shorvon SD,Cox TC,Gilliatt RW

更新日期：1988-03-01 00:00:00

abstract：:Traditionally, control of seizures in patients with epilepsy is viewed as the most important clinical outcome. Yet, current antiepileptic drugs (AEDs) do not always achieve this. Around 30-40% of patients remain uncontrolled despite pharmacological intervention. Poor tolerability of AEDs is a large part of the problem...

journal_title：Epilepsia

authors： Bazil CW

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS:Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizur...

journal_title：Epilepsia

authors： Mares P,Haugvicová R

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:In 1992, the International Lamotrigine Pregnancy Registry was initiated to enroll prospectively and to monitor pregnancies exposed to lamotrigine (LTG) for the occurrence of major birth defects. This study presents results as of September 2001 on 168 outcomes exposed to LTG monotherapy and 166 outcomes after pr...

journal_title：Epilepsia

authors： Tennis P,Eldridge RR,International Lamotrigine Pregnancy Registry Scientific Advisory Committee.

更新日期：2002-10-01 00:00:00

abstract：:Epilepsy is frequently associated with cognitive dysfunction. However, the reasons for this correlation are unclear. Possible influential factors include patient age; duration, frequency, etiology, and type of seizures; hereditary factors; psychosocial issues; and antiepileptic drug (AED) therapy. Whereas many of thes...

journal_title：Epilepsia

authors： Vining EP

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Substantia nigra (SN) and locus coeruleus (LC) neurons are implicated in the propagation and suppression of amygdaloid seizures. Both structures are activated concomitant with amygdaloid seizure discharges. Their mechanisms of activation, however, remain to be elucidated. SN firing is not associated with the in...

journal_title：Epilepsia

authors： Silveira DC,Liu Z,de LaCalle S,Lu J,Klein P,Holmes GL,Herzog AG

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:Acute encephalopathy is the most serious complication of pediatric viral infections, such as influenza and exanthema subitum. It occurs worldwide, but is most prevalent in East Asia. Recently, there have been sporadic case reports of epilepsy/febrile seizure and acute encephalopathy with a neuronal sodium chann...

journal_title：Epilepsia

authors： Saitoh M,Shinohara M,Hoshino H,Kubota M,Amemiya K,Takanashi JL,Hwang SK,Hirose S,Mizuguchi M

更新日期：2012-03-01 00:00:00

abstract：:A transient functional depression of thalamic activity (TFDTA) was induced in acute experiments in cats by the microinjection of 25% KCl into the thalamus. Spontaneous and evoked thalamic electrical activity was markedly depressed at the site of KCl microinjection. Spread of this depression to other thalamic areas oft...

journal_title：Epilepsia

authors： Avoli M,Gloor P

更新日期：1981-08-01 00:00:00

abstract：:Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing response...

journal_title：Epilepsia

authors： Eftekhari S,Mehvari Habibabadi J,Najafi Ziarani M,Hashemi Fesharaki SS,Gharakhani M,Mostafavi H,Joghataei MT,Beladimoghadam N,Rahimian E,Hadjighassem MR

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:We evaluated the role of interictal rhythmical midline theta (RMT) in the identification of frontal lobe epilepsy (FLE) and its differentiation from temporal lobe epilepsy (TLE) and nonepileptic controls. METHODS:We included 162 individuals in the study: 54 FLE patients, 54 TLE patients, and 54 nonepileptic co...

journal_title：Epilepsia

authors： Beleza P,Bilgin O,Noachtar S

更新日期：2009-03-01 00:00:00

abstract：:Using transhemispheric transfer and post-transfer interference as specific measures, the relationship between chemical and electrical kindling at the amygdala (AM) in rats was examined. Chemical kindling was accomplished by repeated injections of a subconvulsive dose of combined L-glutamate (GLU) and L-aspartate (ASP)...

journal_title：Epilepsia

authors： Mori N,Wada JA

更新日期：1989-05-01 00:00:00

abstract：:Clinical course and long-term seizure prognosis were studied in 155 patients with complex-partial seizures during a follow-up of 10.1 +/- 1 (SD) years. In 79% of the patients generalized tonic-clonic seizures were recorded, mostly within the first 3 years of epilepsy but occurring as late as 20 years after the onset o...

journal_title：Epilepsia

authors： Schmidt D,Tsai JJ,Janz D

更新日期：1983-02-01 00:00:00

abstract：PURPOSE:Few reports detailing late-onset epileptic spasms have been published. To determine whether this condition merely represents a late variant of classic West syndrome or exhibits specific features distinct from the latter and related to a later stage of brain maturation, we analyzed the whole population with this...

journal_title：Epilepsia

authors： Eisermann MM,Ville D,Soufflet C,Plouin P,Chiron C,Dulac O,Kaminska A

更新日期：2006-06-01 00:00:00

abstract：:The epilepsy community increasingly recognizes the need for a modern classification system that can also be easily integrated with effective informatics tools. The 2010 reports by the United States President's Council of Advisors on Science and Technology (PCAST) identified informatics as a critical resource to improv...

journal_title：Epilepsia

authors： Sahoo SS,Zhang GQ,Lhatoo SD

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. METHODS:From March 2011 to March 2014, 104 patients aged 1-18 years who had refractory epilepsy were randomly assigned to each d...

journal_title：Epilepsia

authors： Kim JA,Yoon JR,Lee EJ,Lee JS,Kim JT,Kim HD,Kang HC

更新日期：2016-01-01 00:00:00

abstract：:The clinical identification of neonatal seizures is critical for the recognition of brain dysfunction; however, diagnosis is often difficult because of the poorly organized and varied nature of these behaviors. Current classification systems are limited in their ability to communicate motor, autonomic, and electroence...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1987-01-01 00:00:00

abstract：:The knowledge of patients with epilepsy about their own condition is poor, and thus the need for educational programs for people with epilepsy has long been recognized. However, no such programs have been established in their routine care. The Modular Service Package Epilepsy (MOSES) now tries to fill this gap for pat...

journal_title：Epilepsia

authors： Ried S,Specht U,Thorbecke R,Goecke K,Wohlfarth R

更新日期：2001-01-01 00:00:00

abstract：:Twenty-seven epileptic patients, most from low socioeconomic groups and aged 15-54 years, were studied for effects of prolonged anticonvulsant medication. They had received the usual doses of phenobarbitone and diphenylhydantoin (PHT) regularly for 3-32 years, with control of seizures, and had not taken any B-vitamins...

journal_title：Epilepsia

authors： Dastur DK,Dave UP

更新日期：1987-03-01 00:00:00

abstract：:Eyelid myoclonia with absences (EMA), or Jeavons syndrome, is a generalized epileptic condition clinically characterized by eyelid myoclonia (EM) with or without absences, eye closure-induced electroencephalography (EEG) paroxysms, and photosensitivity; in addition, rare tonic-clonic seizures may also occur. Although ...

journal_title：Epilepsia

authors： Striano S,Capovilla G,Sofia V,Romeo A,Rubboli G,Striano P,Trenité DK

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To investigate in vitro, the cellular network activity of the hippocampus in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene. METHODS:Extacellular recordings were obtained from CA1 and CA3 pyramidal neurons in hippocampal slices prepared from Q...

journal_title：Epilepsia

authors： Kile KB,Tian N,Durand DM

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:The main objective of this research is the development of automated video processing and analysis procedures aimed at the recognition and characterization of the types of neonatal seizures. The long-term goal of this research is the integration of these computational procedures into the development of a stand-a...

journal_title：Epilepsia

authors： Karayiannis NB,Tao G,Xiong Y,Sami A,Varughese B,Frost JD Jr,Wise MS,Mizrahi EM

更新日期：2005-06-01 00:00:00

abstract：:A case-control study of 305 children was done to evaluate the relationship between toxocariasis and seizures and risk factors associated with toxocariasis transmission and seizure onset. A significant association existed between seropositivity for anti-Toxocara canis and seizures (p less than 0.05); the correlation wa...

journal_title：Epilepsia

authors： Arpino C,Gattinara GC,Piergili D,Curatolo P

更新日期：1990-01-01 00:00:00

abstract：:There has been a recent surge of interest in chronic animal models of epilepsy. Proper assessment of these models requires documentation of spontaneous seizures by EEG, observation, or both in each individual animal to confirm the presumed epileptic condition. We used the same automatic seizure detection system as tha...

journal_title：Epilepsia

authors： Mascott CR,Gotman J,Beaudet A

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:Dravet syndrome (DS) or severe myoclonic epilepsy of infancy is an intractable epileptic encephalopathy of early childhood that is caused by a mutation in the SCN1A gene in most patients. The aim of this study was to identify a syndrome-specific epileptic network underlying interictal epileptiform discharges (I...

journal_title：Epilepsia

authors： Moehring J,von Spiczak S,Moeller F,Helbig I,Wolff S,Jansen O,Muhle H,Boor R,Stephani U,Siniatchkin M

更新日期：2013-05-01 00:00:00