Variability of EEG-fMRI findings in patients with SCN1A-positive Dravet syndrome.

abstract：:Dogs with spontaneous diseases can exhibit a striking similarity in etiology, clinical manifestation, and disease course when compared to human patients. Therefore, dogs are intensely discussed as a translational model of human disease. In particular, genetic studies in selected dog breeds serve as an excellent tool t...

journal_title：Epilepsia

authors： Potschka H,Fischer A,von Rüden EL,Hülsmeyer V,Baumgärtner W

更新日期：2013-04-01 00:00:00

abstract：:The fragile X mental retardation 1 gene (Fmr1) is polymorphic for CGG trinucleotide repeat number in the 5'-untranslated region, with repeat lengths <45 associated with typical development and repeat lengths >200 resulting in hypermethylation and transcriptional silencing of the gene and mental retardation in the frag...

journal_title：Epilepsia

authors： Berman RF,Murray KD,Arque G,Hunsaker MR,Wenzel HJ

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Initial identification of new investigational drugs for the treatment of epilepsy is commonly conducted in well-established mouse acute and chronic seizure models: for example, maximal electroshock (MES), 6 Hz, and corneal kindling. Comparison of the median effective dose (ED50) of approved antiseizure drugs ...

journal_title：Epilepsia

authors： Koneval Z,Knox KM,Memon A,Zierath DK,White HS,Barker-Haliski M

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:The study was conducted to determine the familiarity with, knowledge of, misunderstandings, and attitudes toward epilepsy among the Kuwaiti population. METHODS:A pretested questionnaire was used to collect data from a sample of 784 Kuwaiti individuals, selected from five governorates in Kuwait using a multista...

journal_title：Epilepsia

authors： Awad A,Sarkhoo F

更新日期：2008-04-01 00:00:00

abstract：:Although it is well documented that long-term therapy with older antiepileptic drugs (AEDs) leads to an increase in risk for atherosclerosis, there has been only limited information regarding the vascular risk in patients who are treated with new AEDs. We therefore conducted a prospective longitudinal study to assess ...

journal_title：Epilepsia

authors： Kim DW,Lee SY,Shon YM,Kim JH

更新日期：2013-10-01 00:00:00

abstract：:Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting had been shown to be associated with improved outcomes, but the comparative efficacy and safety of an intramuscular (IM) route, which is faster and consistently achievable, was previously unknown. RA...

journal_title：Epilepsia

authors： Silbergleit R,Lowenstein D,Durkalski V,Conwit R,NETT Investigators.

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:To evaluate reproductive endocrine function in boys and young men with epilepsy taking an antiepileptic drug in a population-based, controlled study. METHODS:Seventy patients and 70 controls matched for age and pubertal stage participated in this study. Twenty-eight patients were taking carbamazepine (CBZ); fi...

journal_title：Epilepsia

authors： Mikkonen K,Tapanainen P,Pakarinen AJ,Päivänsalo M,Isojärvi JI,Vainionpää LK

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:A drug holiday seems to produce seizure interval prolongation (SIP) after reinstitution of antiepileptic drugs (AEDs). This effect was demonstrated mainly with carbamazepine. We evaluated SIP with newer AEDs and tested the relationship of SIP to history of AED tolerance. METHODS:We prospectively studied patien...

journal_title：Epilepsia

authors： Azar NJ,Lagrange AH,Wang L,Song Y,Abou-Khalil BW

更新日期：2010-05-01 00:00:00

abstract：:Early in these proceedings, the origin of the three terms in the title, "idiopathic generalized epilepsy," is discussed with respect to their significance over time, and typical misunderstandings. In the mid-20th century, a rather chaotic use of a multitude of often loosely defined terms had developed, which increasin...

journal_title：Epilepsia

authors： Wolf P

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Effects of pre- and postsynaptic γ-aminobutyric acid B (GABA(B)) receptor activation were characterized in human tissue from epilepsy surgery. METHODS:Slices of human cortical tissue were investigated in a submerged-type chamber with intracellular recordings in layers II/III. Parallel experiments were performe...

journal_title：Epilepsia

authors： Teichgräber LA,Lehmann TN,Meencke HJ,Weiss T,Nitsch R,Deisz RA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP). METHODS:Male Wistar rats, stereotactically implanted in both ventral hip...

journal_title：Epilepsia

authors： Cuellar-Herrera M,Peña F,Alcantara-Gonzalez D,Neri-Bazan L,Rocha L

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To investigate the neurochemical pattern in patients with benign adult familial myoclonic epilepsy (BAFME/FAME), an inherited form of myoclonic epilepsy, by proton magnetic resonance (MR) spectroscopy ((1)H-MRS). METHODS:Eleven BAFME patients from three families showing linkage to 2p11.1-q12.2 were compared wi...

journal_title：Epilepsia

authors： Striano P,Caranci F,Di Benedetto R,Tortora F,Zara F,Striano S

更新日期：2009-06-01 00:00:00

abstract：:Ten infantile spasms (IS) patients had single photon emission computed tomography (SPECT) with [99mTc]HMPAO, EEG, and magnetic resonance imaging (MRI) studies. SPECT showed localized cerebral hypoperfusion in 7 infants (4 unifocal; 3 multifocal) always involving the temporal regions either unilaterally or bilaterally....

journal_title：Epilepsia

authors： Miyazaki M,Hashimoto T,Fujii E,Tayama M,Kuroda Y

更新日期：1994-09-01 00:00:00

abstract：:Epilepsy is a disease of complex etiology, and multiple molecular mechanisms contribute to its development. Temporal lobe epilepsy (TLE) may result from an initial precipitating event such as hypoxia, head injury, or prolonged seizure (i.e., status epilepticus [SE]), that is followed by a latent period of months to ye...

journal_title：Epilepsia

authors： Grabenstatter HL,Russek SJ,Brooks-Kayal AR

更新日期：2012-12-01 00:00:00

abstract：:Over the past decade, much progress has been made in understanding the mechanisms of ketogenic diet (KD) action. From the complex systemic and metabolic changes induced by the KD have emerged innovative hypotheses attempting to link biochemical adaptations to its clinical effects. Despite such developments, the fundam...

journal_title：Epilepsia

authors： Rho JM,Sankar R

更新日期：2008-11-01 00:00:00

abstract：:The neurodegenerative disorders Alzheimer's disease (AD) and Parkinson's disease (PD) share in common the neuropathologic loss of locus coeruleus (LC) noradrenergic neurons. In addition, these two neurodegenerative disorders share two symptoms that define these disorders: cognitive impairment and depression. The hippo...

journal_title：Epilepsia

authors： Szot P

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:In patients with mesial temporal lobe epilepsy (MTLE) it remains an unresolved issue whether the interictal decrease in N-acetyl aspartate (NAA) detected by proton magnetic resonance spectroscopy ((1)H-MRS) reflects the epilepsy-associated loss of hippocampal pyramidal neurons or metabolic dysfunction. METHODS...

journal_title：Epilepsia

authors： Vielhaber S,Niessen HG,Debska-Vielhaber G,Kudin AP,Wellmer J,Kaufmann J,Schönfeld MA,Fendrich R,Willker W,Leibfritz D,Schramm J,Elger CE,Heinze HJ,Kunz WS

更新日期：2008-01-01 00:00:00

abstract：AIM:Dedicated magnetic resonance imaging (MRI) protocol can diagnose epileptogenic abnormalities in patients with intractable epilepsy. However, it is not sufficiently sensitive to detect small calcified lesions that may result from infections, tumors, or vascular malformations. This study aims to study the impact of t...

journal_title：Epilepsia

authors： Saini J,Kesavadas C,Thomas B,Kapilamoorthy TR,Gupta AK,Radhakrishnan A,Radhakrishnan K

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:The role of alpha 1b-adrenergic receptor (alpha 1b-AR) in relation with neuronal degeneration, drug addiction, and seizure susceptibility has recently emerged. In particular, mice that overexpress alpha 1b-AR undergo spontaneous epileptic seizures and progressive neuronal loss in a variety of brain areas. There...

journal_title：Epilepsia

authors： Pizzanelli C,Lazzeri G,Fulceri F,Giorgi FS,Pasquali L,Cifelli G,Murri L,Fornai F

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:In vitro brain preparations have been used extensively to study the generation and propagation of epileptiform activity. Transverse and longitudinal slices of the rodent hippocampus have revealed various patterns of propagation. Yet intact connections between the transverse and longitudinal pathways should gene...

journal_title：Epilepsia

authors： Kibler AB,Durand DM

更新日期：2011-09-01 00:00:00

abstract：:The incidence of biochemical signs of vitamin D deficiency and the effects of vitamin D supplementation were investigated in 83 children and 95 adults on chronic antiepileptic therapy and 40 mentally retarded controls living under comparable conditions. Low 25-hydroxyvitamin D and serum calcium, and elevated immunorea...

journal_title：Epilepsia

authors： Offermann G,Pinto V,Kruse R

更新日期：1979-02-01 00:00:00

abstract：:Patients with epilepsy have 20-fold risk of sudden death when compared to the general population. Uncontrolled seizures is the most consistent risk factor, and death often occurs at night or in relation to sleep. We examined seizure-related respiratory disturbances in sleep versus wakefulness, focusing on periictal ox...

journal_title：Epilepsia

authors： Latreille V,Abdennadher M,Dworetzky BA,Ramel J,White D,Katz E,Zarowski M,Kothare S,Pavlova M

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:We analyzed a large group of patients investigated for suspected seizures to test whether gender or side are important factors in the origins of hippocampal sclerosis (HS). METHODS:We studied 996 consecutive patients (48% men, 52% women) by using standard hippocampal T2-relaxometry methods. RESULTS:HS was ass...

journal_title：Epilepsia

authors： Briellmann RS,Jackson GD,Mitchell LA,Fitt GJ,Kim SE,Berkovic SF

更新日期：1999-12-01 00:00:00

abstract：PURPOSE:This study was designed to measure the brain penetration of phenytoin (PHT) after intravenous (i.v.) administration of either standard PHT or fosphenytoin (FPHT), a PHT prodrug. The study was formulated to answer the question whether the time required for FPHT to be converted to PHT in the bloodstream would del...

journal_title：Epilepsia

authors： Walton NY,Uthman BM,El Yafi K,Kim JM,Treiman DM

更新日期：1999-02-01 00:00:00

abstract：:Nicotinic acetylcholine receptor genes are involved mainly in nocturnal frontal epilepsy. Despite extensive studies, to date, the α2 subunit did not show a strong association with this peculiar epileptic phenotype. We report CHRNA2 missense mutation in a family with benign familial infantile seizures (BFIS). TrueSeq C...

journal_title：Epilepsia

authors： Trivisano M,Terracciano A,Milano T,Cappelletti S,Pietrafusa N,Bertini ES,Vigevano F,Specchio N

更新日期：2015-05-01 00:00:00

abstract：:A child had two to three generalized tonic-clonic (GTC) seizures per week unresponsive to phenobarbital (PB) and valproate (VPA). Interictal EEG demonstrated left occipital spikes. When carbamazepine (CBZ) therapy was started, he developed very frequent (4-6/day) complex partial seizures (CPS) characterized on ictal E...

journal_title：Epilepsia

authors： Dhuna A,Pascual-Leone A,Talwar D

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:We review what is currently known about functional and morphologic plasticity of hippocampal neuronal circuits in animal epilepsy models. RESULTS:Perforant-path kindling has been shown to enhance excitatory synaptic transmission in the dentate gyrus significantly, and this enhancement has lasted for > or =1 mo...

journal_title：Epilepsia

authors： Maru E,Kanda M,Ashida H

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To explore the structure-function relation of the temporal lobe in newly diagnosed West syndrome of unknown cause (uWS). METHODS:Quantitative magnetic resonance imaging (three-dimensional [3D] structural MRI and diffusion tensor imaging [DTI]) was analyzed using voxel-based morphometry (VBM) and tract-based ...

journal_title：Epilepsia

authors： Fosi T,Chu C,Chong WK,Clark C,Scott RC,Boyd S,De Haan M,Neville B

更新日期：2015-04-01 00:00:00

abstract：:This study evaluated ictal stereotaxic electroencephalogram (SEEG) records in 75 patients with complex partial seizures who later received anterior temporal lobectomy and were evaluated for long-term seizure relief. The time required for seizures to propagate from the putatively epileptogenic hippocampal formation to ...

journal_title：Epilepsia

authors： Lieb JP,Engel J Jr,Babb TL

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:Previous studies have shown that the immunosuppressant cyclosporin A (CsA), a specific blocker of the mitochondrial permeability transition (MPT) pore, can dramatically ameliorate the selective neuronal necrosis resulting from ischemia-reperfusion, traumatic brain injury, and N-methyl-d-aspartate (NMDA)-evoked ...

journal_title：Epilepsia

authors： Santos JB,Schauwecker PE

更新日期：2003-08-01 00:00:00