(1)H-MR spectroscopy indicates prominent cerebellar dysfunction in benign adult familial myoclonic epilepsy.

abstract：OBJECTIVE:The objective was to systematically review studies that have focused on behavioral and emotional functioning before (baseline) and after (follow-up) pediatric epilepsy surgery. METHODS:The systematic review was carried out according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyse...

journal_title：Epilepsia

authors： Reilly C,Baldeweg T,Stewart N,Wadhwani S,Jones C,Helen Cross J,Heyman I

更新日期：2019-05-01 00:00:00

abstract：:Nicotinamide is a ligand of the benzodiazepine receptor and has been reported to have anticonvulsant activity. In addition, our previous clinical experience has raised the possibility that it may also potentiate the action of barbiturates. Therefore, we have examined the anticonvulsant activity and neurotoxicity of ni...

journal_title：Epilepsia

authors： Bourgeois BF,Dodson WE,Ferrendelli JA

更新日期：1983-04-01 00:00:00

abstract：:Neuropsychological evaluation differs from other methods used to localize cerebral lesions in that it analyzes cognitive function. Tests sample widely among cognitive abilities, contrasting language proficiency with visuospatial skills. A thorough assessment of memory is crucial in the investigation because of the pro...

journal_title：Epilepsia

authors： Jones-Gotman M

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Developmental delay and cognitive impairment are common comorbidities in people with epilepsy associated with malformations of cortical development (MCDs). We studied cognition and behavior in an animal model of diffuse cortical dysplasia (CD), in utero irradiation, using a battery of behavioral tests for neuro...

journal_title：Epilepsia

authors： Zhou FW,Rani A,Martinez-Diaz H,Foster TC,Roper SN

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states. METHODS:A single dose of diazepam nasal spray (5, 10, 15, or 20 mg based on weight) was administered during each of two conditions (ictal/peri-ictal ...

journal_title：Epilepsia

authors： Hogan RE,Tarquinio D,Sperling MR,Klein P,Miller I,Segal EB,Rabinowicz AL,Carrazana E

更新日期：2020-05-01 00:00:00

abstract：:Cerebral microbleeds (CMBs) are commonly found in patients with stroke and cerebral amyloid angiopathy. However, there have been no reports of CMBs or their acute appearance in patients with status epilepticus. Herein we describe two patients with refractory status epilepticus of uncertain origin. Both patients were p...

journal_title：Epilepsia

authors： Jeon SB,Parikh G,Choi HA,Lee K,Lee JH,Schmidt JM,Badjatia N,Mayer SA,Claassen J

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:To study prospectively the evolution of visual attention in children with West syndrome to evaluate its development before the onset of spasms, its possible deterioration as a consequence of epileptic disorders, and its outcome at the age of 2 years, and the possible relation between the impairment of visual at...

journal_title：Epilepsia

authors： Guzzetta F,Frisone MF,Ricci D,Randò T,Guzzetta A

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Most people in the world with epilepsy are untreated with antiepileptic drugs (AEDs). In some developing countries, this is because treatment facilities are unavailable or difficult to access. It has even been suggested that indigenous health systems threaten the prospect of the global control of epilepsy with ...

journal_title：Epilepsia

authors： Pal DK,Das T,Sengupta S,Chaudhury G

更新日期：2002-08-01 00:00:00

abstract：:Carbamazepine (CBZ) selectively suppressed kindled convulsions, whereas ethosuximide (ESM) suppressed spike-wave activity accompanying systemic penicillin epilepsy in cats. Evoked potential data indicated that CBZ acted at the thalamic level, whereas ESM acted at cortex. Reduction of seizures and thalamic or cortical ...

journal_title：Epilepsia

authors： Shouse MN,Stroh PJ,Vreeken T

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To identify the short-term outcome of patients who had seizures while watching an animated cartoon TV program, "Pocket Monster," on December 16, 1997. METHODS:One and three years after the incident, questionnaires were sent to physicians of each patient about seizure recurrence, EEGs, and medication. RESULTS:...

journal_title：Epilepsia

authors： Ishiguro Y,Takada H,Watanabe K,Okumura A,Aso K,Ishikawa T

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Five to 20% of patients discontinue antiepileptic drug (AED) therapy because of adverse reactions. Careful reintroduction, however, may be considered if true drug allergy can be ruled out. Definitive assessment of such immunologically mediated reactions requires demonstration of either specific antibodies or se...

journal_title：Epilepsia

authors： Troost RJ,Van Parys JA,Hooijkaas H,van Joost T,Benner R,Prens EP

更新日期：1996-11-01 00:00:00

abstract：:Before a health education program can be established, one must first know what the target population believes and does with respect to the disease in question. Therefore, we performed a study among Tanzanian rural inhabitants to identify their knowledge, attitude, and practice (KAP) toward epilepsy: 3,256 heads of hou...

journal_title：Epilepsia

authors： Rwiza HT,Matuja WB,Kilonzo GP,Haule J,Mbena P,Mwang'ombola R,Jilek-Aall L

更新日期：1993-11-01 00:00:00

abstract：:Epilepsy-prone and epilepsy-resistant substrains were selectively bred from a strain of BALB/c mice; audiogenic-sensitive epilepsy-prone animals showed enhanced sensitivity to chemical convulsants. Treatment with pyridoxine (100 mg/L in drinking water) initiated at mating and continued throughout pregnancy and the lif...

journal_title：Epilepsia

authors： Dolina S,Peeling J,Sutherland G,Pillay N,Greenberg A

更新日期：1993-01-01 00:00:00

abstract：:Vagus nerve stimulation (VNS) has demonstrated a significant anticonvulsant effect in preclinical studies, in pilot studies in humans, and in the acute phase of a multicenter, double-blinded, randomized study. After completion of a 14-week, blinded, randomized study, with 31 receiving high (therapeutic) VNS and 36 rec...

journal_title：Epilepsia

authors： George R,Salinsky M,Kuzniecky R,Rosenfeld W,Bergen D,Tarver WB,Wernicke JF

更新日期：1994-05-01 00:00:00

abstract：:The in vitro effects of four antiepileptic drugs (AEDs) on human sperm motility were studied with a transmembrane migration method. Sperm motility of epileptic patients receiving chronic AED therapy was also investigated. Sperm motility was measured immediately after semen had been mixed with AED and after a 2-h prein...

journal_title：Epilepsia

authors： Chen SS,Shen MR,Chen TJ,Lai SL

更新日期：1992-01-01 00:00:00

abstract：:Electrical stimulation of the visual cortex evoked the cortical focal seizure restricted in the neighbor cortex of the stimulated area in gallamine-immobilized cats. The present experiment was performed to clarify the participation of anticonvulsants in the cortex itself. Phenytoin and carbamazepine depressed the foca...

journal_title：Epilepsia

authors： Ito T,Hori M,Yoshida K,Shimizu M

更新日期：1977-03-01 00:00:00

abstract：:Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100-year period. The side effects, pharmacokinetics, and misuse of barb...

journal_title：Epilepsia

authors： Yasiry Z,Shorvon SD

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to characterize the incidence and etiology of temporal lobe epilepsy (TLE) in a community-based cohort of children with new-onset disease. METHODS:A community-based cohort of 30 children with TLE was studied. The patients had new-onset disease before age 14 years between 1995 and 1999...

journal_title：Epilepsia

authors： Sztriha L,Gururaj AK,Bener A,Nork M

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Univerricht-Lundborg disease (ULD), with its major symptom of action myoclonus, is supposed to be very rare in the Netherlands and western Europe. We hypothesized that the syndrome may be underdiagnosed in patients with myoclonus epilepsy. METHODS:Mutation analysis of the cystatin B gene was performed in 21 ca...

journal_title：Epilepsia

authors： de Haan GJ,Halley DJ,Doelman JC,Geesink HH,Augustijn PB,Jager-Jongkind AD,Majoie M,Bader AJ,Leliefeld-Ten Doeschate LA,Deelen WH,Bertram E,Lehesjoki AE,Lindhout D

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in patients with temporal lobe epilepsy (TLE). METHODS:Memory for public and auto...

journal_title：Epilepsia

authors： Lah S,Lee T,Grayson S,Miller L

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Epileptic spasms are seizures that occur predominantly in children and are characterized by clusters of brief axial movements. Epileptic spasms may occur in the context of a variety of syndromes. Previous research has found that epileptic spasms occur in a sleep/wake and diurnal rhythm. The purpose of this stud...

journal_title：Epilepsia

authors： Ramgopal S,Shah A,Zarowski M,Vendrame M,Gregas M,Alexopoulos AV,Loddenkemper T,Kothare SV

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:Quantitative measurement of hippocampal volume using structural magnetic resonance imaging (MRI) is a valuable tool for detection and lateralization of mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE). We compare two automated hippocampal volume methodologies and manual hippocampal volumetry to d...

journal_title：Epilepsia

authors： Pardoe HR,Pell GS,Abbott DF,Jackson GD

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Cortical stimulation to abort seizures is under human investigation. Ideal electrode placement and stimulating parameters are unknown with poor understanding of tissue volume affected by stimulation or duration and nature of its effect on cortical activity. To help characterize this effect, we analyzed electroc...

journal_title：Epilepsia

authors： Gwinn RP,Spencer DD,Spencer SS,Duckrow RB,Vives K,Wu K,Tkeshelashvili D,Zaveri HP

更新日期：2008-09-01 00:00:00

abstract：:In patients with pharmacoresistant focal epilepsy,we demonstrate that magnetoencephalography (MEG) detects spike-locked and spike-independent epileptic high gamma oscillations (HGOs) using combined MEG and invasive electroencephalography (iEEG) from subdural macroelectrodes. Six patients, who underwent presurgical wor...

journal_title：Epilepsia

authors： Rampp S,Kaltenhäuser M,Weigel D,Buchfelder M,Ingmar Blümcke I,Dörfler A,Stefan H

更新日期：2010-08-01 00:00:00

abstract：:Many patients with medically refractory epilepsy now undergo successful surgery based on noninvasive diagnostic information, but intracranial electroencephalography (IEEG) continues to be used as increasingly complex cases are considered surgical candidates. The indications for IEEG and the modalities employed vary ac...

journal_title：Epilepsia

authors： Jayakar P,Gotman J,Harvey AS,Palmini A,Tassi L,Schomer D,Dubeau F,Bartolomei F,Yu A,Kršek P,Velis D,Kahane P

更新日期：2016-11-01 00:00:00

abstract：:The clinical presentation of 366 children with rolandic spikes was examined to determine whether the presence of a temporal-frontal dipole field is associated with a lower incidence of clinical abnormality. Comparisons were made between the clinical presentation of 99 children with temporal-frontal dipole discharges v...

journal_title：Epilepsia

authors： Gregory DL,Wong PK

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the long-term seizure outcome and potential factors associated with seizure outcome in patients with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. METHODS:In the setting of a prospective, single-center, longitudinal cohort study, 109 patients were evaluated with ongoing follow-up....

journal_title：Epilepsia

authors： Liu X,Yan B,Wang R,Li C,Chen C,Zhou D,Hong Z

更新日期：2017-12-01 00:00:00

abstract：:Audiogenic seizure-prone mice (DBA/2J) were exposed to a broad band noise source. A reproducible response consisting of wild run, clonus, and tonic stages resulted in all mice. Layers 1 and pyramidal from the parietal cortex and the molecular and Purkinje cell-rich layers from the cerebellar vermis were separately ana...

journal_title：Epilepsia

authors： McCandless DW,Schwartzenburg FC Jr

更新日期：1982-10-01 00:00:00

abstract：:The pathogenesis of neurogenic pulmonary edema has been debated for many years. Whether cardiogenic mechanisms and increased pulmonary vascular pressures are primary or even necessary for the production of pulmonary edema has been argued. We used postictal pulmonary edema to study this problem in a sheep model of neur...

journal_title：Epilepsia

authors： Johnston SC,Darragh TM,Simon RP

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:To investigate the self-reported quality of life (QOL) of children and adolescents with new-onset epilepsy and explore parent's perceptions of their child's QOL and the impact of epilepsy on the family. METHODS:As part of the Standard and New Antiepileptic Drug (SANAD) trial, 248 children (aged 8-15 years) wit...

journal_title：Epilepsia

authors： Taylor J,Jacoby A,Baker GA,Marson AG

更新日期：2011-08-01 00:00:00