Diagnostic utility of invasive EEG for epilepsy surgery: Indications, modalities, and techniques.

abstract：PURPOSE:The main objective of this research is the development of automated video processing and analysis procedures aimed at the recognition and characterization of the types of neonatal seizures. The long-term goal of this research is the integration of these computational procedures into the development of a stand-a...

journal_title：Epilepsia

authors： Karayiannis NB,Tao G,Xiong Y,Sami A,Varughese B,Frost JD Jr,Wise MS,Mizrahi EM

更新日期：2005-06-01 00:00:00

abstract：:Twenty therapy-resistant epileptic patients entered a double-blind, randomized, two-period, cross-over trial comparing progabide (19.3-36 mg/kg/day) and placebo as add-on drugs to standard therapy. Each period lasted 6 weeks with a gradual crossover during 4 days. Five patients were dropped because of reasons unrelate...

journal_title：Epilepsia

authors： Martínez-Lage JM,Bossi L,Morales G,Martínez Vila E,Orofiamma B,Viteri C

更新日期：1984-10-01 00:00:00

abstract：:Since it was originally described nearly 70 years ago, insular epilepsy has been increasingly recognized and may explain failures after apparently well-planned operations. We review the history of awareness of the phenomenon, techniques for its assessment, and its surgical management. Insular epilepsy can mimic featur...

journal_title：Epilepsia

authors： Laoprasert P,Ojemann JG,Handler MH

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To evaluate prospectively patient's aims for epilepsy surgery as previously outlined theoretically by Taylor et al. (Epilepsia 1997;3:625-30). METHODS:Ninety-three consecutive patients were interviewed by a psychiatrist as part of their evaluation for epilepsy surgery. Open-ended questions about the patient we...

journal_title：Epilepsia

authors： Taylor DC,McMacKin D,Staunton H,Delanty N,Phillips J

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:Developmental delay and cognitive impairment are common comorbidities in people with epilepsy associated with malformations of cortical development (MCDs). We studied cognition and behavior in an animal model of diffuse cortical dysplasia (CD), in utero irradiation, using a battery of behavioral tests for neuro...

journal_title：Epilepsia

authors： Zhou FW,Rani A,Martinez-Diaz H,Foster TC,Roper SN

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:Concerns over teratogenicity of antiepileptic drugs (AEDs) during pregnancy must be balanced against the risks of seizures to the mother and developing fetus. Pharmacokinetic changes and vomiting may alter drug levels, but more important may be the patient's decision to stop medication before or during pregnanc...

journal_title：Epilepsia

authors： Williams J,Myson V,Steward S,Jones G,Wilson JF,Kerr MP,Smith PE

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:To describe the developmental trajectories of quality of life (QoL) in a large cohort of children with epilepsy, and to assess the relative contribution of clinical, psychosocial, and sociodemographic variables on QoL trajectories. METHODS:Five assessments during a 28-month prospective cohort study were used...

journal_title：Epilepsia

authors： Ferro MA,Avery L,Fayed N,Streiner DL,Cunningham CE,Boyle MH,Lach L,Glidden G,Rosenbaum PL,Ronen GM,QUALITÉ group.

更新日期：2017-07-01 00:00:00

abstract：:Extracellular field potential recordings were made in CA3 subfield of hippocampal slices from rats aged 11-22 days. In these experiments, we analyzed the effects induced by modifying [Mg2+] in the medium (1 or 2 mM) on (a) 4-aminopyridine (4-AP, 50 microM)-induced synchronous events (including ictal- and interictal-li...

journal_title：Epilepsia

authors： Fueta Y,Siniscalchi A,Tancredi V,Avoli M

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:The posterior cingulate cortex (PCC)/precuneus is a key hub of the default mode network, whose function is known to be altered in epilepsy. Glutamate and γ-aminobutyric acid (GABA) are the main excitatory and inhibitory neurotransmitters in the central nervous system, respectively. Glutathione (GSH) is the mo...

journal_title：Epilepsia

authors： Gonen OM,Moffat BA,Desmond PM,Lui E,Kwan P,O'Brien TJ

更新日期：2020-12-01 00:00:00

abstract：:The use of guidelines to prevent the broadcast of epileptogenic television program content has reduced the incidence of seizures in Britain and Japan. Epileptogenic content includes both flicker and patterns. The guidelines for flicker were developed on the basis of a model that related stimulus parameters to the prop...

journal_title：Epilepsia

authors： Wilkins A,Emmett J,Harding G

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:Validity studies on health-related quality of life (HRQOL) scales for pediatric epilepsy are few, and cross-validation with other samples has not been reported. This study was designed to assess the validity of three parent-rated measures of HRQOL in pediatric epilepsy: (a) the Impact of Childhood Illness Scale...

journal_title：Epilepsia

authors： Sherman EM,Slick DJ,Connolly MB,Steinbok P,Camfield C,Eyrl KL,Massey C,Farrell K

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the regional relative interictal and postictal perfusion changes in temporal and parietal lobe epilepsy. METHODS:We investigated interictal and postictal magnet resonance perfusion changes in five patients with temporal lobe epilepsy either with hippocampal sclerosis (n = 3)...

journal_title：Epilepsia

authors： Leonhardt G,de Greiff A,Weber J,Ludwig T,Wiedemayer H,Forsting M,Hufnagel A

更新日期：2005-12-01 00:00:00

abstract：:The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus ...

journal_title：Epilepsia

authors： McDaniel SS,Rensing NR,Thio LL,Yamada KA,Wong M

更新日期：2011-03-01 00:00:00

abstract：:Refractory status epilepticus (RSE) is a medical emergency, with significant morbidity and mortality. The use and effectiveness of clobazam, a unique 1,5-benzodiazepine, in the management of RSE has not been reported before. Over the last 24 months, we identified 17 patients with RSE who were treated with clobazam in ...

journal_title：Epilepsia

authors： Sivakumar S,Ibrahim M,Parker D Jr,Norris G,Shah A,Mohamed W

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Trials of antiepileptic medications are usually based in tertiary referral centers with teaching hospital resources. Epilepsy Research & Services (ERS) is part of a private outpatient neurological clinic that is involved in research as part of multicenter clinical trials, adhering to Good Clinical Research Prac...

journal_title：Epilepsia

authors： Beran RG,Beran ME

更新日期：2000-07-01 00:00:00

abstract：:Brain stimulation is currently used as an experimental treatment for patients with medically refractory epilepsy. However, the results of such stimulation are still less than optimal. A major factor is the lack of understanding of the mechanisms of applied stimuli. Herein we review evidence on the effects of stimulati...

journal_title：Epilepsia

authors： Jiruska P,Powell AD,Deans JK,Jefferys JG

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the efficacy of acute and chronic vagus nerve stimulation (VNS) in genetic absence epilepsy rats from Strasbourg (GAERS). This is a validated model for absence epilepsy, characterized by frequent spontaneous absences concomitant with spike and wave discharges (SWD) on the E...

journal_title：Epilepsia

authors： Dedeurwaerdere S,Vonck K,Van Hese P,Wadman W,Boon P

更新日期：2005-01-01 00:00:00

abstract：:Felbamate (2-phenyl-1,3-propanediol dicarbamate), phenytoin, phenobarbital, ethosuximide, and valproate were evaluated in mice and rats with a battery of well-standardized anticonvulsant test procedures. The results obtained indicate that felbamate exhibits a wider range of experimental anticonvulsant activity than ei...

journal_title：Epilepsia

authors： Swinyard EA,Sofia RD,Kupferberg HJ

更新日期：1986-01-01 00:00:00

abstract：:The randomized, double-blind trial design offers the most accurate data regarding the efficacy of antiepileptic treatments. However, translating the results of a trial into clinical care can be complex due to the intrinsic tension between the requirements for scientific methods that minimize systematic and random erro...

journal_title：Epilepsia

authors： Gilliam F

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Childhood epilepsy with occipital paroxysms (CEOP) is characterised by ictal visual hallucinations and occipital epileptiform activity on interictal EEG. A variant has been described with nonvisual symptoms including tonic head and eye deviation, vomiting, and episodes of partial status epilepticus. We fully do...

journal_title：Epilepsia

authors： Ferrie CD,Beaumanoir A,Guerrini R,Kivity S,Vigevano F,Takaishi Y,Watanabe K,Mira L,Capizzi G,Costa P,Valseriati D,Grioni D,Lerman P,Ricci S,Vigliano P,Goumas-Kartalas A,Hashimoto K,Robinson RO,Panayiotopoulos CP

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:Univerricht-Lundborg disease (ULD), with its major symptom of action myoclonus, is supposed to be very rare in the Netherlands and western Europe. We hypothesized that the syndrome may be underdiagnosed in patients with myoclonus epilepsy. METHODS:Mutation analysis of the cystatin B gene was performed in 21 ca...

journal_title：Epilepsia

authors： de Haan GJ,Halley DJ,Doelman JC,Geesink HH,Augustijn PB,Jager-Jongkind AD,Majoie M,Bader AJ,Leliefeld-Ten Doeschate LA,Deelen WH,Bertram E,Lehesjoki AE,Lindhout D

更新日期：2004-09-01 00:00:00

abstract：:This article reviews the potential interactions of antiepileptic drugs (AEDs) and the pharmacokinetic and pharmacodynamic principles involved. It describes the absorptive and distributive properties of AEDs and the effects on protein binding, hepatic metabolism, and elimination resulting from co-administration of AEDs...

journal_title：Epilepsia

authors： French JA,Gidal BE

更新日期：2000-01-01 00:00:00

abstract：:Forebrain seizures were kindled in rats by daily electrical stimulation of the amygdala. Genetically epilepsy-prone rats scoring 9 (GEPR-9s) on the seizure severity scale during audiogenic seizure (AGS) screening ("brainstem seizure-experienced") required fewer stimulations to achieve fully kindled seizures (forelimb ...

journal_title：Epilepsia

authors： Coffey LL,Reith ME,Chen NH,Mishra PK,Jobe PC

更新日期：1996-02-01 00:00:00

abstract：:Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilep...

journal_title：Epilepsia

authors： Middleton O,Atherton D,Bundock E,Donner E,Friedman D,Hesdorffer D,Jarrell H,McCrillis A,Mena OJ,Morey M,Thurman D,Tian N,Tomson T,Tseng Z,White S,Wright C,Devinsky O

更新日期：2018-03-01 00:00:00

abstract：:Both early life inflammation and prolonged febrile seizures have been associated with increased excitation in the adult brain. We hypothesized this may be due in part to changes in the cation-chloride cotransporter system. Rat pups received saline or lipopolysaccharide/kainic acid (LPS/KA) resulting in inflammation, f...

journal_title：Epilepsia

authors： Reid AY,Riazi K,Campbell Teskey G,Pittman QJ

更新日期：2013-04-01 00:00:00

abstract：:Androgen deficiency is unusually common among men with epilepsy. It may contribute to reproductive and sexual dysfunction and possibly exacerbate seizure frequency. The most important androgen is testosterone. it exists in the serum in a free form or bound to albumin or sex hormone-binding globulin (SHBG). Free testos...

journal_title：Epilepsia

authors： Herzog AG

更新日期：1991-01-01 00:00:00

abstract：:The effects of seizures on the hypocretin/orexin system have not yet been investigated in epileptic patients. The present study aimed to assay hypocretin-1 in the cerebrospinal fluid (CSF) of patients after generalized tonic-clonic (GTC) seizures. Study groups consisted of 21 patients after GTC seizures and 19 control...

journal_title：Epilepsia

authors： Rejdak K,Papuć E,Grieb P,Stelmasiak Z

更新日期：2009-06-01 00:00:00

abstract：:The management of epilepsy is an essential clinical issue in many patients with brain tumors. Tumoral epilepsy is often drug resistant and is associated with poor quality of life. Surgery represents a key therapeutic option in the management of patients with refractory tumoral epilepsy, with high rates of postoperativ...

journal_title：Epilepsia

authors： Rheims S,Ducray F,Ryvlin P

更新日期：2013-12-01 00:00:00

abstract：:Epileptic seizures and pseudoseizures in temporal lobe epilepsies were studied from the viewpoint of the hierarchy of consciousness. Twenty-two patients with temporal lobe epilepsies (TLE) who showed true amnesia or impairment of consciousness developing from the dreamy state, even though their actions and movement co...

journal_title：Epilepsia

authors： Oana Y

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs). We evaluated the possible anticonvulsant effect and interaction of Flut with BZD receptors in common seizure models. METHODS:(a) Different groups of mice each were pretreated i.p. with Flu...

journal_title：Epilepsia

authors： Ahmadiani A,Mandgary A,Sayyah M

更新日期：2003-05-01 00:00:00