Univerricht-Lundborg disease: underdiagnosed in the Netherlands.

abstract：:The mechanism(s) for sudden death in epilepsy (SUDEP) remain(s) unknown, but seizure spread to brainstem areas serving autonomic and respiratory function is critical. In a rat model, we established a mechanism for SUDEP that involves seizure-induced laryngospasm and obstructive apnea lasting until respiratory arrest. ...

journal_title：Epilepsia

authors： Irizarry R,Sukato D,Kollmar R,Schild S,Silverman J,Sundaram K,Stephenson S,Stewart M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:The Atkins diet may induce ketosis as does the ketogenic diet, without restrictions on calories, fluids, protein, or need for an inpatient fast and admission. Our objective was to evaluate the efficacy and tolerability of a modified Atkins diet for intractable childhood epilepsy. METHODS:Twenty children were t...

journal_title：Epilepsia

authors： Kossoff EH,McGrogan JR,Bluml RM,Pillas DJ,Rubenstein JE,Vining EP

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:The aim of this prospective incident community-based study was to assess the influence of pre- and perinatal risk factors in children in whom an unprovoked afebrile epileptic seizure later developed. METHODS:From November 1, 1985, until June 30, 1987, 75 children aged 0-15 years with a first unprovoked afebril...

journal_title：Epilepsia

authors： Sidenvall R,Heijbel J,Blomquist HK,Nyström L,Forsgren L

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Autoantibodies against glutamic acid decarboxylase (GAD) and the voltage-gated potassium channel (VGKC) complex are associated with distinct subtypes of limbic encephalitis regarding clinical presentation, response to therapy, and outcome. The aim of this study was to investigate white matter changes in these...

journal_title：Epilepsia

authors： Wagner J,Schoene-Bake JC,Witt JA,Helmstaedter C,Malter MP,Stoecker W,Probst C,Weber B,Elger CE

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Few studies have examined the long-term sustainability of complete seizure freedom on the ketogenic diet (KD). The purpose of this study was to describe the risk of seizure recurrence in children who achieved at least 1 month of seizure freedom on the KD, and to assess clinical features associated with sustai...

journal_title：Epilepsia

authors： Taub KS,Kessler SK,Bergqvist AG

更新日期：2014-04-01 00:00:00

abstract：:The results of surgical treatment of intractable epilepsy seizures in a group of patients investigated with the intracarotid amobarbital-pentylenetetrazol EEG test were analyzed. This diagnostic test, originally designed to distinguish a mechanism of primary from that of secondary bilateral synchrony in the EEG was al...

journal_title：Epilepsia

authors： Gloor P,Rasmussen T,Altuzarra A,Garretson H

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:To examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mTLE-HS). METHODS:Activity and levels of antioxidative enzymes-catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), manganese superoxide dismutase (MnSOD), ...

journal_title：Epilepsia

authors： Ristić AJ,Savić D,Sokić D,Bogdanović Pristov J,Nestorov J,Baščarević V,Raičević S,Savić S,Spasojević I

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Decline in verbal memory as a surgical complication remains an unresolved problem in mesial temporal lobe epilepsy. Some areas in the temporal lobe associated with the language function, often including the basal temporal language area, have been removed or transected by conventional surgical procedures. The au...

journal_title：Epilepsia

authors： Mikuni N,Miyamoto S,Ikeda A,Satow T,Taki J,Takahashi J,Ohigashi Y,Hashimoto N

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:Hypothalamic regulation of the reproductive axis in temporal lobe epilepsy (TLE), represented by the ultradian pulsatile secretion of luteinizing hormone (LH), has been shown to be altered interictally and postictally. Our objective is to determine if epilepsy or seizures disrupt normal circadian fluctuations o...

journal_title：Epilepsia

authors： Quigg M,Kiely JM,Johnson ML,Straume M,Bertram EH,Evans WS

更新日期：2006-09-01 00:00:00

abstract：:Epilepsy syndromes occupy an important position in the current nosology of the epilepsies, describing and classifying seizure disorders with shared clinical and EEG features. Increasingly, this schema is being refined as new information becomes available and our understanding of etiology and presentation of each syndr...

journal_title：Epilepsia

authors： Duchowny M,Harvey AS

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:To advance the development of (2S,3S)-sec-butylpropylacetamide (SPD) as a new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in pigs and its PK-pharmacodynamic (PK-PD) correlation in rats. METHODS:Two (2S,3S)-SPD intramuscular formulations (FA and FB ) were administered...

journal_title：Epilepsia

authors： Bibi D,Bialer M

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Previously we demonstrated that L-(+)-beta-hydroxybutyrate (L-BHB), acetoacetate (ACA), acetone, and dibenzylamine (DBA) were anticonvulsant in an audiogenic seizure-susceptible model, and that DBA was a bioactive contaminant identified in commercial lots of L-BHB. In the present study, we asked whether these e...

journal_title：Epilepsia

authors： Donevan SD,White HS,Anderson GD,Rho JM

更新日期：2003-10-01 00:00:00

abstract：:A variety of surgical strategies are available to deal with intractable epilepsy. These are resective operations, consisting of the removal of a focus or a discrete lesion, gross removal of malfunctioning brain, and functional operations consisting of division of the pathways of propagation or of an epileptic neuronal...

journal_title：Epilepsia

authors： Polkey CE,Binnie CD

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP). METHODS:Male Wistar rats, stereotactically implanted in both ventral hip...

journal_title：Epilepsia

authors： Cuellar-Herrera M,Peña F,Alcantara-Gonzalez D,Neri-Bazan L,Rocha L

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:Magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (MRg-LITT) is an alternative to open epilepsy surgery. We assess safety and effectiveness of MRg-LITT for extratemporal lobe epilepsy (ETLE) in patients who are considered less favorable for open resection. METHODS:We retrospectively ...

journal_title：Epilepsia

authors： Gupta K,Cabaniss B,Kheder A,Gedela S,Koch P,Hewitt KC,Alwaki A,Rich C,Ramesha S,Hu R,Drane DL,Gross RE,Willie JT

更新日期：2020-08-01 00:00:00

abstract：:A 73-year-old patient with hyperglycemia and rheumatoid arthritis presented with attacks of involuntary lingual movements that were associated with pain at the base of the tongue, often followed by aversion of head and eyes to the left with clonic contractions of the left corner of the mouth. Seizures could be induced...

journal_title：Epilepsia

authors： Neufeld MY,Blumen SC,Nisipeanu P,Korczyn AD

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:It has been suggested that multilobar epilepsies caused by lesions restricted to the posterior cerebral quadrant (ie, the parietal, temporal, and occipital lobes) can be treated successfully by a procedure termed posterior disconnection. The objective of the present paper was to identify determinants of the e...

journal_title：Epilepsia

authors： Kalbhenn T,Cloppenborg T,Wörmann FG,Blümcke I,Coras R,May TW,Polster T,Simon M,Bien CG

更新日期：2019-09-01 00:00:00

abstract：:Although the technical and human resources for epilepsy care and classification are located largely in high income countries, most people with epilepsy reside in developing regions of the world. Advances over the past two decades in the clinical and basic neurosciences have transformed epilepsy care and largely drive ...

journal_title：Epilepsia

authors： Birbeck GL

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:Occipital lobe epilepsy (OLE) presents in childhood with different manifestations, age of onset and EEG features that form distinct syndromes. The ictal clinical symptoms are difficult to correlate with onset in particular areas in the occipital lobes, and the EEG recordings have not been able to overcome this ...

journal_title：Epilepsia

authors： Leal A,Dias A,Vieira JP,Secca M,Jordão C

更新日期：2006-09-01 00:00:00

abstract：:Tiagabine (TGB) is a recently approved antiepileptic drug (AED) that inhibits y-aminobutyric acid (GABA) reuptake into neurons and glia, a mechanism of action that is specific and unique among the AEDs. TGB is potent and has linear and predictable pharmacokinetics. It has no clinically relevant effects on hepatic meta...

journal_title：Epilepsia

authors： Schachter SC

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:Animal models with spontaneous epileptic seizures may be useful in the discovery of new antiepileptic drugs (AEDs). The purpose of the present study was to evaluate the efficacy of carisbamate on spontaneous motor seizures in rats with kainate-induced epilepsy. METHODS:Repeated, low-dose (5 mg/kg), intraperito...

journal_title：Epilepsia

authors： Grabenstatter HL,Dudek FE

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Electroencephalographic seizures (ESs) are common in encephalopathic critically ill children, but identification requires extensive resources for continuous electroencephalographic monitoring (CEEG). In a previous study, we developed a clinical prediction rule using three clinical variables (age, acute enceph...

journal_title：Epilepsia

authors： Fung FW,Parikh DS,Jacobwitz M,Vala L,Donnelly M,Wang Z,Xiao R,Topjian AA,Abend NS

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:It remains controversial whether a specific pattern of interictal epileptiform activity exists that may help to differentiate temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) from other forms of TLE. In this study, we characterized the distribution of interictal epileptiform discharges in TLE due ...

journal_title：Epilepsia

authors： Hamer HM,Najm I,Mohamed A,Wyllie E

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:Our goal was to study the anticonvulsant action of tiagabine (TGB) at different levels of brain maturation in rats. METHODS:Wistar rats in five age groups (7, 12, 18, 25, and 90 days old) were injected intraperitoneally with TGB at doses of 0.5-32 mg/kg. Thirty minutes later, motor seizures were induced by the...

journal_title：Epilepsia

authors： Haugvicová R,Skutová M,Kubová H,Suchomelová L,Mares P

更新日期：2000-11-01 00:00:00

abstract：:Visual behavior is frequently impaired at onset of West syndrome (WS). We studied the neuropsychological outcome of eight children who had cryptogenic WS and moderate to severe visual impairment at the onset of epilepsy. At the last examination, a regional cerebral blood flow study using SPECT (single photon emission ...

journal_title：Epilepsia

authors： Jambaqué I,Chiron C,Dulac O,Raynaud C,Syrota P

更新日期：1993-07-01 00:00:00

abstract：:Differentiation between psychogenic nonepileptic seizures (PNES) and generalized convulsive epileptic seizures (ES) is important for appropriate triaging in the emergency department (ED). This can be difficult in the ED, as the event is often not witnessed by a medical professional. In the current study, we investigat...

journal_title：Epilepsia

authors： Li Y,Matzka L,Maranda L,Weber D

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:Mutations involving the cyclin-dependent kinase-like 5 (CDKL5) gene cause an early onset epileptic encephalopathy (EE) with severe neurologic impairment and a skewed 12:1 female-to-male ratio. To date, 18 mutations have been described in boys. We analyzed our cohort of boys with early onset EE to assess the d...

journal_title：Epilepsia

authors： Mei D,Darra F,Barba C,Marini C,Fontana E,Chiti L,Parrini E,Dalla Bernardina B,Guerrini R

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:The purpose of this study is to determine the sensibility of each imaging tool in identifying focal cortical dysplasia (FCD) in children and adolescents with epilepsy and to define the prognostic factors of pediatric and adolescent epilepsy surgery. METHODS:We identified 48 children with FCD who underwent rese...

journal_title：Epilepsia

authors： Kim YH,Kang HC,Kim DS,Kim SH,Shim KW,Kim HD,Lee JS

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Benign rolandic epilepsy (BRE) is considered a genetically determined idiopathic partial epilepsy. We analyzed a large sample of twins from four international twin registers to probe the genetics of BRE. We also aim to synthesize the apparently conflicting family and twin data into a model of BRE etiology. MET...

journal_title：Epilepsia

authors： Vadlamudi L,Kjeldsen MJ,Corey LA,Solaas MH,Friis ML,Pellock JM,Nakken KO,Milne RL,Scheffer IE,Harvey AS,Hopper JL,Berkovic SF

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:The present study aimed to clarify the effect of electrical stimulation and lesioning of the anterior nucleus of the thalamus (ANT) on kainic acid (KA)-induced focal cortical seizures in a rat model. To address the mechanism underlying these anticonvulsant actions, cerebral glucose metabolism after ANT electric...

journal_title：Epilepsia

authors： Takebayashi S,Hashizume K,Tanaka T,Hodozuka A

更新日期：2007-02-01 00:00:00