Efficacy of the classic ketogenic and the modified Atkins diets in refractory childhood epilepsy.

abstract：:Clinical trials of antiepileptic drugs (AEDs) are usually performed only in major teaching centers, thus ignoring the very real contribution available from private practice. The relation between the consultant and the referring family physician is often much closer in private practice, allowing much earlier recruitmen...

journal_title：Epilepsia

authors： Beran RG,Tilley M

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To evaluate the safety, tolerability, and efficacy of long-term pregabalin as add-on therapy for patients with poorly controlled partial seizures. METHODS:Analysis of data from six long-term clinical trials involving 2,061 patients receiving open-label pregabalin 75-600 mg/day adjunctive therapy for partial on...

journal_title：Epilepsia

authors： Uthman BM,Bazil CW,Beydoun A,Schulze-Bonhage A,Benabou R,Whalen E,Emir B,Griesing T,Leon T

更新日期：2010-06-01 00:00:00

abstract：:Folic acid deficient diet reduces the duration and severity of intravenous megimide seizures in the rat after 6 months of diet. Plasma and serum folate levels are strongly reduced after that period. The difference between Lactobacillus casei and Streptococcus faecalis activity in brain show a slight, but not significa...

journal_title：Epilepsia

authors： Hommes OR,ten Berge EJ,Jansen MJ,Kok JC

更新日期：1977-12-01 00:00:00

abstract：PURPOSE:  Vagus nerve stimulation (VNS) provides partial relief of medically refractory partial seizures in a subset of patients. The optimal pattern of stimulation and the mechanism of the antiseizure effects are uncertain. Establishing the efficacy of VNS in an animal model of epilepsy would provide an experimental p...

journal_title：Epilepsia

authors： Alexander GM,McNamara JO

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Common data elements (CDEs) are standardized questions and answer choices that allow aggregation, analysis, and comparison of observations from multiple sources. Clinical CDEs are foundational for learning health care systems, a data-driven approach to health care focused on continuous improvement of outcomes...

journal_title：Epilepsia

authors： Grinspan ZM,Patel AD,Shellhaas RA,Berg AT,Axeen ET,Bolton J,Clarke DF,Coryell J,Gaillard WD,Goodkin HP,Koh S,Kukla A,Mbwana JS,Morgan LA,Singhal NS,Storey MM,Yozawitz EG,Abend NS,Fitzgerald MP,Fridinger SE,Helbig

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:In the last decade several studies have been published on incidence, etiology, and prognosis of status epilepticus (SE) with population-based data from the United States and Europe. The aim of this review is to summarize the available information on the epidemiology of SE and to outline the sources of the var...

journal_title：Epilepsia

authors： Logroscino G,Hesdorffer DC,Cascino G,Hauser WA,Coeytaux A,Galobardes B,Morabia A,Jallon P

更新日期：2005-01-01 00:00:00

abstract：:The use of lamotrigine (LTG) can be limited by the occurrence of cutaneous adverse drug reactions (cADRs) that range from maculopapular eruption (MPE) to the more severe Stevens-Johnson syndrome and toxic epidermal necrolysis. A few human leukocyte antigen (HLA)-related genetic risk factors for carbamazepine-induced c...

journal_title：Epilepsia

authors： Moon J,Park HK,Chu K,Sunwoo JS,Byun JI,Lim JA,Kim TJ,Shin JW,Lee ST,Jung KH,Jung KY,Jeon D,Kim DW,Yu KS,Jang IJ,Kang HR,Park HW,Lee SK

更新日期：2015-10-01 00:00:00

abstract：:Phenytoin is metabolized to its parahydroxylated derivative by hepatic microsomal enzymes. This hydroxylation is a saturable process, that is, the rate of metabolism fails to increase in proportion to the serum concentration. This leads to a nonlinear relationship between the maintenance dose of the drug and the resul...

journal_title：Epilepsia

authors： Richens A

更新日期：1975-11-01 00:00:00

abstract：:In the nineteenth and early twentieth centuries, many important discoveries in nervous system structure and function involved the electrical properties of nerve tissue. The application of these advances, as well as those in electronic amplification and recording, led to the discovery of the human electroencephalogram ...

journal_title：Epilepsia

authors： Zifkin BG,Avanzini G

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To determine the influence of valproate (VPA) treatment on acylcarnitines in children with epilepsy. METHODS:Determination of acylcarnitines (including free carnitine and acylcarnitines from C2 to C18) in dried blood spot specimens using tandem-mass spectrometry. Longitudinal study of changes in acylcarnitines...

journal_title：Epilepsia

authors： Werner T,Treiss I,Kohlmueller D,Mehlem P,Teich M,Longin E,Gerstner T,Koenig SA,Schulze A

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To assess the presence, extent, and clinical correlates of quantitative MR volumetric abnormalities in ipsilateral and contralateral hippocampus, and temporal and extratemporal lobe regions in unilateral temporal lobe epilepsy (TLE). METHODS:In total, 34 subjects with unilateral left (n = 15) or right (n = 19)...

journal_title：Epilepsia

authors： Seidenberg M,Kelly KG,Parrish J,Geary E,Dow C,Rutecki P,Hermann B

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Febrile seizures (FS) are the most common type of convulsive events in children. FS are suggested to result from a combination of genetic and environmental factors. However, the pathophysiologic mechanisms underlying FS remain unclear. Using an animal model of experimental FS, it was demonstrated that hyperther...

journal_title：Epilepsia

authors： Schuchmann S,Hauck S,Henning S,Grüters-Kieslich A,Vanhatalo S,Schmitz D,Kaila K

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to characterize the incidence and etiology of temporal lobe epilepsy (TLE) in a community-based cohort of children with new-onset disease. METHODS:A community-based cohort of 30 children with TLE was studied. The patients had new-onset disease before age 14 years between 1995 and 1999...

journal_title：Epilepsia

authors： Sztriha L,Gururaj AK,Bener A,Nork M

更新日期：2002-01-01 00:00:00

abstract：:In a 7-year-old girl with epilepsia partialis continua (EPC) involving the left face, arm, and leg for 1 year, serial neuroimaging studies showed progressive, brain atrophy. Because medical treatment was ineffective, she underwent a large fronto-temporal surgical resection. Neuropathological examination showed loss of...

journal_title：Epilepsia

authors： Yacubian EM,Rosemberg S,Marie SK,Valério RM,Jorge CL,Cukiert A

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:Considering the complexity of neuronal circuits and their epilepsy-associated alterations, epilepsy models cannot be completely replaced by in vitro experimental approaches. Decisions about ethical approval of in vivo studies require a thorough weighing of the animal's burden and the benefit regarding the exp...

journal_title：Epilepsia

authors： Koska I,van Dijk RM,Seiffert I,Di Liberto V,Möller C,Palme R,Hellweg R,Potschka H

更新日期：2019-10-01 00:00:00

abstract：:We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ...

journal_title：Epilepsia

authors： Zumsteg D,Lozano AM,Wennberg RA

更新日期：2006-11-01 00:00:00

abstract：:This paper addresses methodologic issues in studies of mortality, and the impact of these issues in studies of mortality in epilepsy. One important issue is to identify the question: Is it whether epilepsy increases the risk of dying? Or is it whether the underlying condition that led to epilepsy, itself associated wi...

journal_title：Epilepsia

authors： Logroscino G,Hesdorffer DC

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Brivaracetam (BRV), a selective and high-affinity synaptic vesicle protein 2A ligand, is in development as adjunctive treatment for partial-onset (focal) seizures (POS). This phase 3 study (N01358; NCT01261325) aimed to confirm the efficacy and safety/tolerability of BRV in adults (≥ 16-80 years) with POS. M...

journal_title：Epilepsia

authors： Klein P,Schiemann J,Sperling MR,Whitesides J,Liang W,Stalvey T,Brandt C,Kwan P

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To investigate the neurochemical pattern in patients with benign adult familial myoclonic epilepsy (BAFME/FAME), an inherited form of myoclonic epilepsy, by proton magnetic resonance (MR) spectroscopy ((1)H-MRS). METHODS:Eleven BAFME patients from three families showing linkage to 2p11.1-q12.2 were compared wi...

journal_title：Epilepsia

authors： Striano P,Caranci F,Di Benedetto R,Tortora F,Zara F,Striano S

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Seizures are currently defined by their electrographic features. However, neuronal networks are intrinsically dependent on neurotransmitters of which little is known regarding their periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, as its administration can ter...

journal_title：Epilepsia

authors： Van Gompel JJ,Bower MR,Worrell GA,Stead M,Chang SY,Goerss SJ,Kim I,Bennet KE,Meyer FB,Marsh WR,Blaha CD,Lee KH

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:In temporal lobe epilepsy (TLE), the thalamus is well known for its role in the propagation and spread of epileptiform activity. However, the integrity of thalamocortical functional connectivity (FC) in TLE and its relation to specific seizure patterns have not yet been determined. We address these issues wit...

journal_title：Epilepsia

authors： He X,Doucet GE,Sperling M,Sharan A,Tracy JI

更新日期：2015-10-01 00:00:00

abstract：:Recent clinical trials indicate that cannabidiol (CBD) may reduce seizure frequency in pediatric patients with certain forms of treatment-resistant epilepsy. Many of these patients experience significant impairments in quality of life (QOL) in physical, mental, and social dimensions of health. In this study, we measur...

journal_title：Epilepsia

authors： Rosenberg EC,Louik J,Conway E,Devinsky O,Friedman D

更新日期：2017-08-01 00:00:00

abstract：:Ten regularly menstruating women with epilepsy were studied in a 12-month prospective follow-up study to evaluate the short-term effects of carbamazepine (CBZ) on serum sex hormone balance and pituitary function. Thirteen female epilepsy patients receiving long-term CBZ monotherapy (mean medication duration 5.3 years)...

journal_title：Epilepsia

authors： Isojärvi JI

更新日期：1990-07-01 00:00:00

abstract：:Cognitive impairment is the most common comorbidity in children with epilepsy, but its pathophysiology and predisposing conditions remain unknown. Clinical epilepsy characteristics are not conclusive in determining cognitive outcome. Because many children with epilepsy do not have macrostructural magnetic resonance im...

journal_title：Epilepsia

authors： Braakman HM,van der Kruijs SJ,Vaessen MJ,Jansen JF,Debeij-van Hall MH,Vles JS,Aldenkamp AP,Backes WH,Hofman PA

更新日期：2012-10-01 00:00:00

abstract：:Studies from several countries have reported that fewer people with epilepsy marry, but the reasons for this are not clear. In the present investigation, 178 adults with epilepsy were divided into married, separated/divorced, and never married groups. The never married group was subdivided into persons living in depen...

journal_title：Epilepsia

authors： Batzel LW,Dodrill CB

更新日期：1984-10-01 00:00:00

abstract：:DBA/2J (DBA) mice are susceptible to audiogenic seizures (AGSs) in an age-dependent manner, susceptibility being maximal at 21 days and absent at 110 days of age. Previous studies have demonstrated that there is a decrease in anion transport and an increase in carbonic anhydrase (CA) activity in brain from DBA mice as...

journal_title：Epilepsia

authors： Engstrom FL,Kemp JW,Chow SY,Woodbury DM

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVES:We aimed to determine whether implementation of a structured multidisciplinary electroencephalography (EEG) monitoring pathway improved the timeliness of administration of antiseizure medication in response to electrographic seizures in encephalopathic critically ill children. METHODS:A multidisciplinary te...

journal_title：Epilepsia

authors： Williams RP,Banwell B,Berg RA,Dlugos DJ,Donnelly M,Ichord R,Kessler SK,Lavelle J,Massey SL,Hewlett J,Parker A,Topjian AA,Abend NS

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:In 1992, the International Lamotrigine Pregnancy Registry was initiated to enroll prospectively and to monitor pregnancies exposed to lamotrigine (LTG) for the occurrence of major birth defects. This study presents results as of September 2001 on 168 outcomes exposed to LTG monotherapy and 166 outcomes after pr...

journal_title：Epilepsia

authors： Tennis P,Eldridge RR,International Lamotrigine Pregnancy Registry Scientific Advisory Committee.

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:There is controversy between clinicians and statisticians on the appropriateness of the number needed to treat (NNT) as a summary statistic to report the effectiveness of a treatment. We examine the two viewpoints and make proposals concerning the reporting of clinical trial results. METHODS:In the context of ...

journal_title：Epilepsia

authors： Lesaffre E,Boon P,Pledger GW

更新日期：2000-04-01 00:00:00

abstract：SUMMARY:First-time seizure and status epilepticus during pregnancy have been previously reported as the initial manifestation of intracranial cavernous hemangioma. We report a woman with no history of seizures who presented with refractory status epilepticus at 10 weeks gestation. Cranial MRI revealed a right frontal c...

journal_title：Epilepsia

authors： Aladdin Y,Gross DW

更新日期：2008-09-01 00:00:00