当前位置： SCI文献检索 > EPILEPSIA期刊下所有文献 > The value of the number-needed-to-treat method in antiepileptic drug trials.

The value of the number-needed-to-treat method in antiepileptic drug trials.

Abstract：

PURPOSE:There is controversy between clinicians and statisticians on the appropriateness of the number needed to treat (NNT) as a summary statistic to report the effectiveness of a treatment. We examine the two viewpoints and make proposals concerning the reporting of clinical trial results. METHODS:In the context of antiepileptic treatments, we explain the two different viewpoints and illustrate the use of the odds ratio, relative risk, absolute difference, and NNT on the results of randomized clinical trials with topiramate (TPM). Special attention is paid to the use of these summary statistics in meta-analyses. Here, the NNT is the expected number of patients one would need to treat to achieve a single occurrence of a specified good outcome (e.g., 50% reduction in seizure rate) in comparison to no (or placebo) treatment. RESULTS:Although the NNT is readily interpretable in some instances, it exhibits undesirable statistical behavior in other cases. In particular, confidence intervals for the NNT may split into two intervals and extend to positive and negative infinity when treatment efficacy is not clearly established by the data. Meta-analyses cannot be sensibly conducted directly on the NNT scale. CONCLUSIONS:Although other measures, such as the odds ratio, have been more commonly used in the context of meta-analyses, clinicians prefer the NNT because it gives them a clearer clinical interpretation of the effectiveness of a (new) treatment. On the other hand, statisticians do not recognize the value of the NNT, as it has undesirable statistical properties. Some reconciliation between the two views could be achieved when the clinicians acknowledge the weak aspects of the NNT and when statisticians realize that statistical appropriateness is not the same as clinical relevance. It is suggested that the NNT be used as a secondary reporting tool not on an equal footing with the classic scales.

journal_name

Epilepsia

journal_title

Epilepsia

authors

Lesaffre E,Boon P,Pledger GW

doi

10.1111/j.1528-1157.2000.tb00186.x

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

440-6

issue

4

eissn

0013-9580

issn

1528-1167

journal_volume

41

pub_type

临床试验,杂志文章,meta分析,随机对照试验

相关文献

EPILEPSIA文献大全
  • Recruitment of families for genetic studies of epilepsy.

    abstract：PURPOSE:Study of families containing multiple affected individuals is essential for genetic research on the epilepsies, yet practically nothing has been published about methods for identification and recruitment of families or expected participation rates. Here we describe the strategy used for data collection in a gen...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.0013-9580.2005.41904.x

    authors： Ottman R,Berenson K,Barker-Cummings C

    更新日期：2005-02-01 00:00:00

  • Public knowledge and attitudes toward epilepsy in Kuwait.

    abstract：PURPOSE:The study was conducted to determine the familiarity with, knowledge of, misunderstandings, and attitudes toward epilepsy among the Kuwaiti population. METHODS:A pretested questionnaire was used to collect data from a sample of 784 Kuwaiti individuals, selected from five governorates in Kuwait using a multista...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1167.2007.01433.x

    authors： Awad A,Sarkhoo F

    更新日期：2008-04-01 00:00:00

  • Association of HLA genotypes with phenobarbital hypersensitivity in children.

    abstract：OBJECTIVE:Phenobarbital hypersensitivity is one of the common drug hypersensitivity syndromes in children. Clinical symptoms of phenobarbital hypersensitivity vary from maculopapular rashes (MPs) to severe cutaneous adverse drug reactions (SCARs) including drug reactions with eosinophilia and systemic symptoms (DRESS),...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/epi.13509

    authors： Manuyakorn W,Mahasirimongkol S,Likkasittipan P,Kamchaisatian W,Wattanapokayakit S,Inunchot W,Visudtibhan A,Wichukchinda N,Benjaponpitak S

    更新日期：2016-10-01 00:00:00

  • The value of EEG-fMRI and EEG source analysis in the presurgical setup of children with refractory focal epilepsy.

    abstract：PURPOSE:In the presurgical evaluation of children and juvenile patients with refractory focal epilepsy, the main challenge is to localize the point of seizure onset as precisely as possible. We compared results of the conventional electroencephalography-functional magnetic resonance imaging (EEG-fMRI) analysis with tho...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1167.2012.03587.x

    authors： Elshoff L,Groening K,Grouiller F,Wiegand G,Wolff S,Michel C,Stephani U,Siniatchkin M

    更新日期：2012-09-01 00:00:00

  • The history of the concept of epileptic encephalopathy.

    abstract：:The first description of epileptic encephalopathies dates back to Dr. West who, in 1857, described the syndrome that took his name. In addition to West syndrome, in the last century other epileptic syndromes entered into the chapter of epileptic encephalopathies. Henry Gastaut has the virtue of having created the mode...

    journal_title：Epilepsia

    pub_type： 历史文章,杂志文章,评审

    doi：10.1111/epi.12416

    authors： Capovilla G,Wolf P,Beccaria F,Avanzini G

    更新日期：2013-11-01 00:00:00

  • Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy.

    abstract：:Nicotinic acetylcholine receptor genes are involved mainly in nocturnal frontal epilepsy. Despite extensive studies, to date, the α2 subunit did not show a strong association with this peculiar epileptic phenotype. We report CHRNA2 missense mutation in a family with benign familial infantile seizures (BFIS). TrueSeq C...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/epi.12967

    authors： Trivisano M,Terracciano A,Milano T,Cappelletti S,Pietrafusa N,Bertini ES,Vigevano F,Specchio N

    更新日期：2015-05-01 00:00:00

  • Antiepileptic drugs and vitamin D supplementation.

    abstract：:The incidence of biochemical signs of vitamin D deficiency and the effects of vitamin D supplementation were investigated in 83 children and 95 adults on chronic antiepileptic therapy and 40 mentally retarded controls living under comparable conditions. Low 25-hydroxyvitamin D and serum calcium, and elevated immunorea...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1157.1979.tb04771.x

    authors： Offermann G,Pinto V,Kruse R

    更新日期：1979-02-01 00:00:00

  • Hippocampal antioxidative system in mesial temporal lobe epilepsy.

    abstract：OBJECTIVE:To examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mTLE-HS). METHODS:Activity and levels of antioxidative enzymes-catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), manganese superoxide dismutase (MnSOD), ...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/epi.12981

    authors： Ristić AJ,Savić D,Sokić D,Bogdanović Pristov J,Nestorov J,Baščarević V,Raičević S,Savić S,Spasojević I

    更新日期：2015-05-01 00:00:00

  • Developmental patterns of postictal refractoriness and potentiation akin to cortical stimulation.

    abstract：:Postictal refractoriness checked by paired stimulations of the limbic structures was demonstrated to fail in rats<2 weeks old. Cortical epileptic afterdischarges were used in our study to examine if this phenomenon is restricted to old cortical structures or if it is a general one. Rats 12, 15, 18, 25, and 90 days old...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/epi.12870

    authors： Mareš P,Kubová H

    更新日期：2015-01-01 00:00:00

  • In situ metabolism of levetiracetam in blood of patients with epilepsy.

    abstract：PURPOSE:Although levetiracetam undergoes minimum metabolism, B-esterases have been identified in whole blood that are capable of metabolising levetiracetam. The present study was designed to ascertain any variability in levetiracetam blood concentrations that could be attributed to in situ metabolism and which could im...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1167.2006.00819.x

    authors： Patsalos PN,Ghattaura S,Ratnaraj N,Sander JW

    更新日期：2006-11-01 00:00:00

  • A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsy.

    abstract：:Temporal lobe epilepsy patients (n = 48) and healthy controls (n = 69) underwent structured psychiatric interview at baseline and 4 years later to characterize the course of DSM-IV Axis I disorders. Adjusting for the influence of prior psychiatric history, epilepsy subjects exhibit significantly greater risk of interv...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1167.2007.01217.x

    authors： Jones JE,Bell B,Fine J,Rutecki P,Seidenberg M,Hermann B

    更新日期：2007-12-01 00:00:00

  • The epidemiology of the comorbidity of epilepsy in the general population.

    abstract：PURPOSE:To describe the epidemiology of somatic and psychiatric conditions in adults with epilepsy in the community and compare it to that of people without epilepsy. METHODS:A cross-sectional population-based study extracting data from the UK General Practice Research Database for the period 1995-1998. Age- and sex-s...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.0013-9580.2004.17504.x

    authors： Gaitatzis A,Carroll K,Majeed A,W Sander J

    更新日期：2004-12-01 00:00:00

  • Effects of temporal lobe epilepsy on retrograde memory.

    abstract：PURPOSE:In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in patients with temporal lobe epilepsy (TLE). METHODS:Memory for public and auto...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1167.2006.00476.x

    authors： Lah S,Lee T,Grayson S,Miller L

    更新日期：2006-03-01 00:00:00

  • The HLA-A*2402/Cw*0102 haplotype is associated with lamotrigine-induced maculopapular eruption in the Korean population.

    abstract：:The use of lamotrigine (LTG) can be limited by the occurrence of cutaneous adverse drug reactions (cADRs) that range from maculopapular eruption (MPE) to the more severe Stevens-Johnson syndrome and toxic epidermal necrolysis. A few human leukocyte antigen (HLA)-related genetic risk factors for carbamazepine-induced c...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/epi.13087

    authors： Moon J,Park HK,Chu K,Sunwoo JS,Byun JI,Lim JA,Kim TJ,Shin JW,Lee ST,Jung KH,Jung KY,Jeon D,Kim DW,Yu KS,Jang IJ,Kang HR,Park HW,Lee SK

    更新日期：2015-10-01 00:00:00

  • Facial asymmetry in partial epilepsies.

    abstract：:Fifty-six consecutive epileptic patients with partial seizures (30 temporal, 26 extratemporal) and facial asymmetry were studied. Facial asymmetry was compared with EEG, radiologic, and other clinical findings. Thirty patients had a lesional epilepsy whereas 26 were considered cryptogenic. In lesional epilepsies, 60% ...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1157.1992.tb01765.x

    authors： Tinuper P,Plazzi G,Provini F,Cerullo A,Leonardi M,Agati R,Righini A,Montagna P

    更新日期：1992-11-01 00:00:00

  • Abnormal dendrite and spine morphology in primary visual cortex in the CGG knock-in mouse model of the fragile X premutation.

    abstract：:The fragile X mental retardation 1 gene (Fmr1) is polymorphic for CGG trinucleotide repeat number in the 5'-untranslated region, with repeat lengths <45 associated with typical development and repeat lengths >200 resulting in hypermethylation and transcriptional silencing of the gene and mental retardation in the frag...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1167.2012.03486.x

    authors： Berman RF,Murray KD,Arque G,Hunsaker MR,Wenzel HJ

    更新日期：2012-06-01 00:00:00

  • On seeing the trees and the forest: single-signal and multisignal analysis of periictal intracranial EEG.

    abstract：PURPOSE:Epileptic seizures are associated with a dysregulation of electrical brain activity on many different spatial scales. To better understand the dynamics of epileptic seizures, that is, how the seizures initiate, propagate, and terminate, it is important to consider changes of electrical brain activity on differe...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1167.2012.03588.x

    authors： Schindler K,Gast H,Goodfellow M,Rummel C

    更新日期：2012-09-01 00:00:00

  • Genomics of brain and blood: progress and pitfalls.

    abstract：:Gene expression profiles in brain and blood of animals and humans can be useful for diagnosis, prognosis, and treatment of epilepsy. This article reviews recent progress and prospects for the future. ...

    journal_title：Epilepsia

    pub_type： 杂志文章,评审

    doi：10.1111/j.1528-1167.2006.00809.x

    authors： Sharp FR,Lit L,Xu H,Apperson M,Walker W,Wong B,Gilbert DL,Hershey A,Glauser TA

    更新日期：2006-10-01 00:00:00

  • Quality of life in adult patients with epilepsy.

    abstract：:Quality of life (QOL) must be determined from the patients' subjective viewpoint. To determine QOL in epilepsy, it is necessary to use disease-specific scales. We introduced the Side Effects and Life Satisfaction (SEALS) scale to Japan and performed a comparative study on adult patients with epilepsy and normal subjec...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1157.1996.tb01818.x

    authors： Kugoh T

    更新日期：1996-01-01 00:00:00

  • Clinical utility of the Boston Naming Test in predicting ultimate side of surgery in patients with medically intractable temporal lobe epilepsy: A double cross-validation study.

    abstract：:The Boston Naming Test (BNT) is often used in the evaluation of surgical epilepsy patients to assess left temporal lobe function. In 2005, Busch et al. demonstrated the diagnostic utility of the BNT in predicting ultimate side of surgery in patients with temporal lobe epilepsy. BNT raw score significantly predicted ul...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1167.2008.01865.x

    authors： Busch RM,Frazier TW,Iampietro MC,Chapin JS,Kubu CS

    更新日期：2009-05-01 00:00:00

  • Temporal lobe epilepsy subtypes: differential patterns of cerebral perfusion on ictal SPECT.

    abstract：PURPOSE:We studied cerebral perfusion patterns in the various subtypes of TLE, as determined by pathology and good outcome after temporal lobectomy (as confirmation of temporal origin). METHODS:We studied clinical features and ictal technetium 99m hexamethyl-propyleneamineoxime (99mTc-HM-PAO) single-photon emission-co...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1157.1996.tb00653.x

    authors： Ho SS,Berkovic SF,McKay WJ,Kalnins RM,Bladin PF

    更新日期：1996-08-01 00:00:00

  • Behavioral disorders in pediatric epilepsy: unmet psychiatric need.

    abstract：PURPOSE:This study examined the relation between psychiatric diagnosis and mental health services in children with epilepsy and the associated demographic, cognitive, linguistic, behavioral, and seizure-related variables. METHODS:The Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), the Child Behavio...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1046/j.1528-1157.2003.25002.x

    authors： Ott D,Siddarth P,Gurbani S,Koh S,Tournay A,Shields WD,Caplan R

    更新日期：2003-04-01 00:00:00

  • sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats.

    abstract：OBJECTIVE:Organophosphates (OPs) are commonly used insecticides for agriculture and domestic purposes, but may also serve as nerve agents. Exposure to OPs result in overstimulation of the cholinergic system and lead to status epilepticus (SE), a life-threatening condition that is often resistant to treatment. SE is ass...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/epi.12838

    authors： Bar-Klein G,Swissa E,Kamintsky L,Shekh-Ahmad T,Saar-Ashkenazy R,Hubary Y,Shrot S,Stetlander L,Eisenkraft A,Friedman A,Bialer M

    更新日期：2014-12-01 00:00:00

  • Increased deposition of cholesterol in brain after electroconvulsive seizure.

    abstract：:Rats injected intracranially with cholesterol precursors and subjected to electroconvulsive seizures showed significantly higher levels of deposition of [4-14C]cholesterol into brain cholesterol than controls. The degree of incorporation was cholesterol greater than mevalonic acid greater than sodium acetate; in each ...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1157.1983.tb03424.x

    authors： Colannino NM,Lipke H

    更新日期：1983-10-01 00:00:00

  • Nonconvulsive status epilepticus: high incidence of complex partial status.

    abstract：:Nonconvulsive status epilepticus may be subdivided into generalized (absence) status and complex partial status. The latter is regarded as a rarity, whereas the former constitutes the dominant part of the hitherto reported cases. We report 10 consecutive cases of adult patients with nonconvulsive status epilepticus, a...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1157.1986.tb03540.x

    authors： Tomson T,Svanborg E,Wedlund JE

    更新日期：1986-05-01 00:00:00

  • Atrophy of the pedunculopontine nucleus region in patients with sleep-predominant seizures: A voxel-based morphometry study.

    abstract：:Non-rapid eye movement (NREM) sleep increases interictal epileptiform discharges and frequency of seizures, whereas REM sleep suppresses them. The pedunculopontine nucleus (PPN), one of the REM sleep-modulating structures, is postulated to have a potent antiepileptogenic role. We asked if patients with sleep-predomina...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/epi.13431

    authors： Cho KH,Cho YJ,Lee BI,Heo K

    更新日期：2016-08-01 00:00:00

  • Quality of life in psychogenic nonepileptic seizures.

    abstract：PURPOSE:Psychogenic nonepileptic seizures (PNESs) are events that alter or seem to alter the neurologic function and, in their appearance, resemble epileptic seizures (ESs). In patients with ESs the psychological and medical aspects of epilepsy greatly influence the health-related quality of life (HRQOL). The relation ...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1046/j.1528-1157.2003.35302.x

    authors： Szaflarski JP,Hughes C,Szaflarski M,Ficker DM,Cahill WT,Li M,Privitera MD

    更新日期：2003-02-01 00:00:00

  • Epilepsy and deprivation, a data linkage study.

    abstract：OBJECTIVE:To investigate whether the link between epilepsy and deprivation is due to factors associated with deprivation (social causation) or factors associated with a diagnosis of epilepsy (social drift). METHODS:We reviewed electronic primary health care records from 2004 to 2010, identifying prevalent and incident...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/epi.12942

    authors： Pickrell WO,Lacey AS,Bodger OG,Demmler JC,Thomas RH,Lyons RA,Smith PE,Rees MI,Kerr MP

    更新日期：2015-04-01 00:00:00

  • Epidemiology and clinical characteristics of seizures in patients with acute intermittent porphyria.

    abstract：:The objectives of this study were to investigate the lifetime prevalence of epileptic seizures in a population with acute intermittent porphyria (AIP) and to characterize the seizures and the seizure-triggering factors. A letter was sent to all patients with known AIP in Sweden registered at the National Porphyria Cen...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1157.1996.tb00018.x

    authors： Bylesjö I,Forsgren L,Lithner F,Boman K

    更新日期：1996-03-01 00:00:00

  • MR spectroscopy shows reduced frontal lobe concentrations of N-acetyl aspartate in patients with juvenile myoclonic epilepsy.

    abstract：PURPOSE:Neuropsychological studies suggest frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy (JME). In this study we investigated whether an underlying mechanism could be a regional neuronal damage not visible with structural magnetic resonance (MR), but detectable with magnetic resonance spectrosc...

    journal_title：Epilepsia

    pub_type： 杂志文章

    doi：10.1111/j.1528-1157.2000.tb00158.x

    authors： Savic I,Lekvall A,Greitz D,Helms G

    更新日期：2000-03-01 00:00:00