Behavioral disorders in pediatric epilepsy: unmet psychiatric need.

abstract：PURPOSE:To investigate whether atypical language dominance in epilepsy patients is related to localization and type of lesions. METHODS:Four hundred and forty-five epilepsy patients received bilateral Wada testing. Language was classified as left (L), right (R), bilateral-dependent (BD, speech arrest after left and ri...

journal_title：Epilepsia

authors： Möddel G,Lineweaver T,Schuele SU,Reinholz J,Loddenkemper T

更新日期：2009-06-01 00:00:00

abstract：:Seizures in the neonate are often considered a form of status epilepticus (SE) because they are relatively prolonged, difficult to control with antiepileptic drugs (AEDs), and may be associated with significant morbidity and mortality. Despite their clinical importance, there is still no clear understanding of how sei...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1999-01-01 00:00:00

abstract：:The neurodegenerative disorders Alzheimer's disease (AD) and Parkinson's disease (PD) share in common the neuropathologic loss of locus coeruleus (LC) noradrenergic neurons. In addition, these two neurodegenerative disorders share two symptoms that define these disorders: cognitive impairment and depression. The hippo...

journal_title：Epilepsia

authors： Szot P

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Epilepsy is common in individuals with mutations in POLG, the gene encoding the catalytic subunit of the mitochondrial DNA polymerase gamma. Early recognition and aggressive seizure management are crucial for patient survival. Disruption of the blood-brain barrier (BBB) is implicated in various neurological d...

journal_title：Epilepsia

authors： Hikmat O,Naess K,Engvall M,Klingenberg C,Rasmussen M,Tallaksen CME,Brodtkorb E,Fiskerstrand T,Isohanni P,Uusimaa J,Darin N,Rahman S,Bindoff LA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:We investigated the incidence of well-directed violent behavior and suicide attempts in patients with temporal lobe epilepsy, with special attention to postictal psychosis. METHODS:We compared 57 episodes of postictal psychosis with 62 episodes of acute interictal (or alternative) psychosis and with 134 comple...

journal_title：Epilepsia

authors： Kanemoto K,Kawasaki J,Mori E

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Posttraumatic epilepsy (PTE) accounts for 20% of acquired epilepsies. Experimental models are important for studying epileptogenesis. We previously reported that repetitive high-frequency oscillations with spikes (rHFOSs) occur early after lateral fluid percussion injury (FPI) and may be a biomarker for PTE. ...

journal_title：Epilepsia

authors： Reid AY,Bragin A,Giza CC,Staba RJ,Engel J Jr

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:We examine improvement and worsening in quality of life (QOL) in terms of proportions achieving minimum clinically important change (MCID), and factors related to MCID, in patients with temporal lobe epilepsy randomized to medical or surgical treatment. METHODS:Eighty patients with temporal lobe epilepsy ran...

journal_title：Epilepsia

authors： Fiest KM,Sajobi TT,Wiebe S

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:Refractory status epilepticus (RSE) is the persistence of seizure activity despite appropriate therapy; it is treated with high-dose suppressive anesthetic agents. We report here the outcome of RSE in a large series of children. METHODS:We retrospectively reviewed cases of RSE treated at Children's Hospital, B...

journal_title：Epilepsia

authors： Sahin M,Menache CC,Holmes GL,Riviello JJ

更新日期：2001-11-01 00:00:00

abstract：:In this article, we review the incidence and significance of seizures in well-established autoimmune disorders, including multiple sclerosis (MS), diabetes mellitus, celiac disease, thyroid disease, and systemic lupus erythematosus (SLE). The five following presentations discuss the incidence and possible pathogenesis...

journal_title：Epilepsia

authors： Vincent A,Crino PB

更新日期：2011-05-01 00:00:00

abstract：:Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100-year period. The side effects, pharmacokinetics, and misuse of barb...

journal_title：Epilepsia

authors： Yasiry Z,Shorvon SD

更新日期：2012-12-01 00:00:00

abstract：:In the first part of this essay, the "common wisdom" about Putnam and Merritt's contributions to the treatment of epilepsy was summarized (Rowland, 1982). Based on the history that has been presented here, how true are these "wisdoms"? Putnam and Merritt did devise "a simple and reliable method to test drugs of antico...

journal_title：Epilepsia

authors： Friedlander WJ

更新日期：1986-01-01 00:00:00

abstract：:We describe the pattern of early childhood seizures within a family with autosomal dominant chondrocalcinosis (CCAL, which causes adult-onset arthritis). All affected family members with CCAL experienced seizures in early childhood, usually, but not always, associated with fever. Similarities exist to the syndrome of ...

journal_title：Epilepsia

authors： McKee S,Pendleton A,Dixey J,Doherty M,Hughes A

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Inhibition of microRNA-134 by an oligonucleotide antagomir (ant-134) has been shown to produce powerful antiseizure effects in multiple models of epilepsy. However, to successfully translate the treatment to the clinic, it is important to assess what potential adverse effects it may have on naive brain tissue...

journal_title：Epilepsia

authors： Morris G,Brennan GP,Reschke CR,Henshall DC,Schorge S

更新日期：2018-08-01 00:00:00

abstract：:The fragile X mental retardation 1 gene (Fmr1) is polymorphic for CGG trinucleotide repeat number in the 5'-untranslated region, with repeat lengths <45 associated with typical development and repeat lengths >200 resulting in hypermethylation and transcriptional silencing of the gene and mental retardation in the frag...

journal_title：Epilepsia

authors： Berman RF,Murray KD,Arque G,Hunsaker MR,Wenzel HJ

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:We report on a quantitative analysis of data from a study that acquired continuous long-term ambulatory human electroencephalography (EEG) data over extended periods. The objectives were to examine the seizure duration and interseizure interval (ISI), their relationship to each other, and the effect of these ...

journal_title：Epilepsia

authors： Cook MJ,Karoly PJ,Freestone DR,Himes D,Leyde K,Berkovic S,O'Brien T,Grayden DB,Boston R

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is a life-threatening medical condition associated with significant morbidity and mortality that requires urgent medical intervention. Although several agents are available to treat SE, they occasionally fail to abort seizure activity. Topiramate (TPM) was anecdotally reported to be effe...

journal_title：Epilepsia

authors： Kahriman M,Minecan D,Kutluay E,Selwa L,Beydoun A

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:To estimate the incidence and mortality associated with first unprovoked seizure or newly diagnosed epilepsy in a low-income, predominantly Hispanic community in Northern Manhattan, New York City. METHODS:We performed a population-based study to determine the incidence of first unprovoked seizure or newly diag...

journal_title：Epilepsia

authors： Benn EK,Hauser WA,Shih T,Leary L,Bagiella E,Dayan P,Green R,Andrews H,Thurman DJ,Hesdorffer DC

更新日期：2008-08-01 00:00:00

abstract：:The awareness, understanding, and attitudes toward epilepsy in 1,278 men and women were surveyed in Henan, China in 1988. Results showed that 93% had read or heard about epilepsy; 77% knew someone who had epilepsy; 72% had seen someone who was having a seizure; 57% would object to having their children associate with ...

journal_title：Epilepsia

authors： Lai CW,Huang XS,Lai YH,Zhang ZQ,Liu GJ,Yang MZ

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3-0.9% of the world's population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy. METHODS:We performed literature search...

journal_title：Epilepsia

authors： Johnson EL,Kaplan PW

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the regional relative interictal and postictal perfusion changes in temporal and parietal lobe epilepsy. METHODS:We investigated interictal and postictal magnet resonance perfusion changes in five patients with temporal lobe epilepsy either with hippocampal sclerosis (n = 3)...

journal_title：Epilepsia

authors： Leonhardt G,de Greiff A,Weber J,Ludwig T,Wiedemayer H,Forsting M,Hufnagel A

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:A large-scale, double-blind trial (SP0993; NCT01243177) demonstrated that lacosamide was noninferior to controlled-release carbamazepine (carbamazepine-CR) in terms of efficacy, and well tolerated as first-line monotherapy in patients (≥16 years of age) with newly diagnosed epilepsy. We report primary safety ...

journal_title：Epilepsia

authors： Ben-Menachem E,Grebe HP,Terada K,Jensen L,Li T,De Backer M,Steiniger-Brach B,Gasalla T,Brock M,Biton V

更新日期：2019-12-01 00:00:00

abstract：:Despite over 80 years of use, the ketogenic diet (KD) has never been tested in a blinded manner. Twenty children with intractable Lennox-Gastaut syndrome (LGS) were fasted 36 h and then randomized to receive the classic KD in conjunction with a solution containing either 60 g/day of glucose or saccharin. Parents and p...

journal_title：Epilepsia

authors： Freeman JM,Vining EP,Kossoff EH,Pyzik PL,Ye X,Goodman SN

更新日期：2009-02-01 00:00:00

abstract：:We report identical twins with supernumerary ring chromosome 19 mosaicism, who had severe refractory epilepsy at an early age. The epilepsy was dominated largely by severe life-threatening tonic seizures. Both twins died, likely as a consequence of their severe epilepsy. They displayed no dysmorphic features. Eight ca...

journal_title：Epilepsia

authors： Shahwan A,Green AJ,Carey A,Stallings RL,O'Flaherty OC,King MD

更新日期：2004-08-01 00:00:00

abstract：:Seizure prevalence among school age children residing in a rural western Kentucky area (Hardin County) was determined utilizing a method designed to minimize false positives and to allow estimation of false negatives. The observed prevalence of epilepsy is 5.7/1,000 and of febrile seizures 17/1,000. Because of the hig...

journal_title：Epilepsia

authors： Baumann RJ,Marx MB,Leonidakis MG

更新日期：1978-02-01 00:00:00

abstract：:The clinical identification of neonatal seizures is critical for the recognition of brain dysfunction; however, diagnosis is often difficult because of the poorly organized and varied nature of these behaviors. Current classification systems are limited in their ability to communicate motor, autonomic, and electroence...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Hyperventilation is an activation method that provokes physiological slowing of brain rhythms, interictal discharges, and seizures, especially in generalized idiopathic epilepsies. In this study we assessed its effectiveness in inducing focal seizures during video-EEG monitoring. METHODS:We analyzed the effect...

journal_title：Epilepsia

authors： Guaranha MS,Garzon E,Buchpiguel CA,Tazima S,Yacubian EM,Sakamoto AC

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI), an important research and clinical tool, depends on relatively greater transient increases in (regional cerebral blood flow) rCBF than cerebral metabolic rate for oxygen during neural activity. We investigated whether reduced rest...

journal_title：Epilepsia

authors： Appel S,Duke ES,Martinez AR,Khan OI,Dustin IM,Reeves-Tyer P,Berl MB,Sato S,Gaillard WD,Theodore WH

更新日期：2012-04-01 00:00:00

abstract：:Epilepsy is a disease of complex etiology, and multiple molecular mechanisms contribute to its development. Temporal lobe epilepsy (TLE) may result from an initial precipitating event such as hypoxia, head injury, or prolonged seizure (i.e., status epilepticus [SE]), that is followed by a latent period of months to ye...

journal_title：Epilepsia

authors： Grabenstatter HL,Russek SJ,Brooks-Kayal AR

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:To assess the role of 1H-magnetic resonance spectroscopy (MRS) in detecting biochemical abnormalities in neuronal migration disorders (NMDs). METHODS:We performed 1H-MRS studies on 17 brain NMD areas [five polymicrogyria, eight subcortical heterotopia, and four cortical dysplasia on magnetic resonance imaging ...

journal_title：Epilepsia

authors： Simone IL,Federico F,Tortorella C,De Blasi R,Bellomo R,Lucivero V,Carrara D,Bellacosa A,Livrea P,Carella A

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Study of families containing multiple affected individuals is essential for genetic research on the epilepsies, yet practically nothing has been published about methods for identification and recruitment of families or expected participation rates. Here we describe the strategy used for data collection in a gen...

journal_title：Epilepsia

authors： Ottman R,Berenson K,Barker-Cummings C

更新日期：2005-02-01 00:00:00