Clinical trials of antiepileptic drugs performed in the private practice setting.

abstract：:Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

journal_title：Epilepsia

authors： Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

更新日期：2009-08-01 00:00:00

abstract：:Some investigators argue that treating epilepsy with several antiepileptic drugs (AEDs) simultaneously (polytherapy) may give rise to more adverse effects than monotherapy, but this argument lacks supporting quantitative data. To reexamine this issue, we recruited a cohort of patients from the outpatients of the Speci...

journal_title：Epilepsia

authors： Lammers MW,Hekster YA,Keyser A,Meinardi H,Renier WO,van Lier H

更新日期：1995-05-01 00:00:00

abstract：:Interictal discharges can occur silently without apparent simultaneous clinical manifestations. Nevertheless, formal testing during electroencephalographic (EEG) recording may demonstrate transitory cognitive impairment (TCI). The probability of demonstrating TCI is related to the nature of the test employed and the t...

journal_title：Epilepsia

authors： Binnie CD,Marston D

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Compare annual direct and indirect costs between privately insured U.S. patients with epileptic partial onset seizures (POS) and matched controls. METHODS:One thousand eight hundred fifty-nine patients (including a subset of 758 employees) with >or=1 (POS) diagnosis (ICD-9-CM: 345.4.x-345.7.x), 1999-2004, ages...

journal_title：Epilepsia

authors： Ivanova JI,Birnbaum HG,Kidolezi Y,Qiu Y,Mallett D,Caleo S

更新日期：2010-05-01 00:00:00

abstract：:This essay explores the usefulness of the concept of consciousness in epileptology and concludes that it does not further the understanding of seizure mechanisms and brain function. The reasons for this are both theoretical and empirical. Consciousness cannot be adequately defined. This may explain why attempts at acc...

journal_title：Epilepsia

authors： Gloor P

更新日期：1986-01-01 00:00:00

abstract：:We performed the blink reflex (BR) in 20 normal volunteers, 13 epileptic patients receiving antiepileptic drug (AED) monotherapy, and 13 epileptic patients receiving AED polytherapy. Comparison of R1, ipsilateral and contralateral R2 and VIIth nerve latencies in the three groups showed no statistically significant dif...

journal_title：Epilepsia

authors： Lancman ME,Cristiano E,Golimstok A,Granillo RJ

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:A large-scale, double-blind trial (SP0993; NCT01243177) demonstrated that lacosamide was noninferior to controlled-release carbamazepine (carbamazepine-CR) in terms of efficacy, and well tolerated as first-line monotherapy in patients (≥16 years of age) with newly diagnosed epilepsy. We report primary safety ...

journal_title：Epilepsia

authors： Ben-Menachem E,Grebe HP,Terada K,Jensen L,Li T,De Backer M,Steiniger-Brach B,Gasalla T,Brock M,Biton V

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To evaluate safety and tolerability of ketogenic diet (KGD) and valproate (VPA) cotherapy in the treatment of intractable seizures. METHODS:The patient records of children who underwent KGD initiation at the Massachusetts General Hospital for Children from February 2002 to September 2004 were retrospectively a...

journal_title：Epilepsia

authors： Lyczkowski DA,Pfeifer HH,Ghosh S,Thiele EA

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate whether the nucleus parafascicularis (Pf) of the thalamus could be a relay of the control of epileptic seizures by the superior colliculus (SC). The Pf is one of the main ascending projections of the SC, the disinhibition of which has been shown to suppress seizures in d...

journal_title：Epilepsia

authors： Nail-Boucherie K,Lê-Pham BT,Gobaille S,Maitre M,Aunis D,Depaulis A

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The presence of specific neurocognitive deficits may help explain why school achievement and psychosocial functioning are often worse in children with epilepsy than would be predicted by their global intellectual functioning. This study compared children with two forms of epilepsy: localization-related epilepsy...

journal_title：Epilepsia

authors： Kernan CL,Asarnow R,Siddarth P,Gurbani S,Lanphier EK,Sankar R,Caplan R

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Under an expanded access investigational new drug (IND) trial, cannabidiol (CBD) is being studied as a possible adjuvant treatment of refractory epilepsy in children. Of the 25 subjects in the trial, 13 were being treated with clobazam (CLB). Because CLB and CBD are both metabolized in the cytochrome P450 (CY...

journal_title：Epilepsia

authors： Geffrey AL,Pollack SF,Bruno PL,Thiele EA

更新日期：2015-08-01 00:00:00

abstract：:The availability of generic products of antiepileptic drugs (AEDs) has been increasing in recent years. In view of the importance of the issue, the Italian League against Epilepsy (LICE) set up an ad hoc working group whose task was to assess available evidence on the efficacy and safety of generic AEDs in the treatme...

journal_title：Epilepsia

authors： Perucca E,Albani F,Capovilla G,Bernardina BD,Michelucci R,Zaccara G

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:The objective was to systematically review studies that have focused on behavioral and emotional functioning before (baseline) and after (follow-up) pediatric epilepsy surgery. METHODS:The systematic review was carried out according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyse...

journal_title：Epilepsia

authors： Reilly C,Baldeweg T,Stewart N,Wadhwani S,Jones C,Helen Cross J,Heyman I

更新日期：2019-05-01 00:00:00

abstract：:Clinical course and long-term seizure prognosis were studied in 155 patients with complex-partial seizures during a follow-up of 10.1 +/- 1 (SD) years. In 79% of the patients generalized tonic-clonic seizures were recorded, mostly within the first 3 years of epilepsy but occurring as late as 20 years after the onset o...

journal_title：Epilepsia

authors： Schmidt D,Tsai JJ,Janz D

更新日期：1983-02-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of lamotrigine (LTG), a new antiepileptic drug (AED), were studied in healthy volunteers. In an open dose-escalating study, LTG 240 mg produced peak plasma concentrations of around 3 micrograms/mg with no significant adverse events. Subsequent pharmacokinetic studies revealed ...

journal_title：Epilepsia

authors： Peck AW

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Fluorodeoxyglucose positron emission computed tomography (FDG-PET) hypometabolism is important for surgical planning in patients with temporal lobe epilepsy (TLE), but its significance remains unclear in patients who do not have evidence of mesial temporal sclerosis (MTS) on magnetic resonance imaging (MRI). We...

journal_title：Epilepsia

authors： LoPinto-Khoury C,Sperling MR,Skidmore C,Nei M,Evans J,Sharan A,Mintzer S

更新日期：2012-02-01 00:00:00

abstract：:Symptomatic occipital lobe epilepsy is increasingly recognized among patients with partial-onset seizures. Although traditional clinical and electroencephalographic criteria had defined occipital lobe epilepsy in the past, new neuroimaging techniques and the recognition of specific syndromes associated with occipital ...

journal_title：Epilepsia

authors： Kuzniecky R

更新日期：1998-01-01 00:00:00

abstract：:The objectives of this study were to investigate the lifetime prevalence of epileptic seizures in a population with acute intermittent porphyria (AIP) and to characterize the seizures and the seizure-triggering factors. A letter was sent to all patients with known AIP in Sweden registered at the National Porphyria Cen...

journal_title：Epilepsia

authors： Bylesjö I,Forsgren L,Lithner F,Boman K

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease. METHODS:A retrospective chart review of all patients with TSC seen between January 2002 and October 2008. Charts were reviewed for a history of infant...

journal_title：Epilepsia

authors： Chu-Shore CJ,Major P,Camposano S,Muzykewicz D,Thiele EA

更新日期：2010-07-01 00:00:00

abstract：:Status epilepticus (SE) is a major neurological and medical emergency associated with a high morbidity and mortality. Retrospective and prospective studies from the Medical College of Virginia Epilepsy Research Center have been utilized to investigate several clinical and epidemiological factors associated with SE. Un...

journal_title：Epilepsia

authors： DeLorenzo RJ,Towne AR,Pellock JM,Ko D

更新日期：1992-01-01 00:00:00

abstract：:Nicotinic acetylcholine receptor genes are involved mainly in nocturnal frontal epilepsy. Despite extensive studies, to date, the α2 subunit did not show a strong association with this peculiar epileptic phenotype. We report CHRNA2 missense mutation in a family with benign familial infantile seizures (BFIS). TrueSeq C...

journal_title：Epilepsia

authors： Trivisano M,Terracciano A,Milano T,Cappelletti S,Pietrafusa N,Bertini ES,Vigevano F,Specchio N

更新日期：2015-05-01 00:00:00

abstract：:We present a technique for automatic detection of epileptic spikes in electroencephalogram (EEG) recordings. We used a nonlinear modeling method that enables us to detect rapidly and accurately epileptic behavior in the EEG signal. Our approach is illustrated by an application to interictal activity from a patient wit...

journal_title：Epilepsia

authors： Diambra L

更新日期：2002-01-01 00:00:00

abstract：:5-Hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured by high-performance liquid chromatography (HPLC) in lumbar cerebrospinal fluid (CSF) obtained from febrile children subdivided according to the presence or absence of convulsions. Lumbar puncture was made either early (mean time 2 h) or late...

journal_title：Epilepsia

authors： Giroud M,Dumas R,Dauvergne M,D'Athis P,Rochette L,Beley A,Bralet J

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Common data elements (CDEs) are currently unavailable for mobile health (mHealth) in epilepsy devices and related applications. As a result, despite expansive growth of new digital services for people with epilepsy, information collected is often not interoperable or directly comparable. We aim to correct thi...

journal_title：Epilepsia

authors： Goldenholz DM,Moss R,Jost DA,Crone NE,Krauss G,Picard R,Caborni C,Cavazos JE,Hixson J,Loddenkemper T,Salazar TD,Lubbers L,Harte-Hargrove LC,Whittemore V,Duun-Henriksen J,Dolan E,Kasturia N,Oberemk M,Cook MJ,Lehmkuhl

更新日期：2018-05-01 00:00:00

abstract：:Medically intractable tonic and atonic seizures may be responsive to either vagus nerve stimulation (VNS) or corpus callosum section. VNS has been shown to be effective and is associated with very low morbidity. Callosotomy is a more ambitious procedure, with a higher risk of complications but greater likelihood of se...

journal_title：Epilepsia

authors： Rosenfeld WE,Roberts DW

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To describe the correlations between spiking pattern and EEG power spectrum frequency in DBA/2J mice, a model for murine absence seizures, after gamma-aminobutyric acid (GABA)(B) modulation. METHODS:The animals were first tested with the GABA(B) agonist l-baclofen followed by the GABA(B) antagonist SCH 50911. ...

journal_title：Epilepsia

authors： Marrosu F,Santoni F,Fà M,Puligheddu M,Barberini L,Genugu F,Frau R,Manunta M,Mereu G

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To clarify the differences between postictal mania (PIM) and postictal psychosis (PIP). METHODS:Five patients with PIM were compared to 17 patients with PIP, with respect to clinical, epileptological, electrophysiological, and neuroimaging features. PIM was distinguished from PIP by the symptoms observed in th...

journal_title：Epilepsia

authors： Nishida T,Kudo T,Inoue Y,Nakamura F,Yoshimura M,Matsuda K,Yagi K,Fujiwara T

更新日期：2006-12-01 00:00:00

abstract：:The hypothesis was tested that epileptiform alterations of brain excitability may be elicited by a conditioning stimulus (CS) in a classical conditioning paradigm. Fifteen male albino rats were chronically implanted with electrodes in the amygdala and over the visual cortex. A train of six stroboscopic flashes served ...

journal_title：Epilepsia

authors： Myslobodsky MS,Mintz M,Lerner T,Mostofsky DI

更新日期：1983-06-01 00:00:00

abstract：PURPOSE:The role of the superior colliculus (SC) in seizure expression is controversial and appears to be dependent upon the epilepsy model. This study shows the effect of disconnection between SC deep layers and adjacent tissues in the expression of acute and kindling seizures. METHODS:Subcollicular transections, abl...

journal_title：Epilepsia

authors： Doretto MC,Cortes-de-Oliveira JA,Rossetti F,Garcia-Cairasco N

更新日期：2009-12-01 00:00:00

abstract：:A child had two to three generalized tonic-clonic (GTC) seizures per week unresponsive to phenobarbital (PB) and valproate (VPA). Interictal EEG demonstrated left occipital spikes. When carbamazepine (CBZ) therapy was started, he developed very frequent (4-6/day) complex partial seizures (CPS) characterized on ictal E...

journal_title：Epilepsia

authors： Dhuna A,Pascual-Leone A,Talwar D

更新日期：1991-03-01 00:00:00