Cognitive dysfunction associated with antiepileptic drug therapy.

abstract：PURPOSE:Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurologic dysfunction, including seizures. It is known that metabolic crises in affected patients are precipitated by infections. Although growing evidence supports that inflammation facilitates sei...

journal_title：Epilepsia

authors： Salvadori MG,Banderó CR,Jesse AC,Gomes AT,Rambo LM,Bueno LM,Bortoluzzi VT,Oliveira MS,Mello CF

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Exposure to toxic levels of organophosphorus (OP) nerve agents can lead to seizures, respiratory failure, and, if untreated, death. The cholinesterase inhibitor soman belongs to the class of OP nerve agents and can cause status epilepticus (SE) and brain damage due to neuroexcitotoxicity. In the present study, ...

journal_title：Epilepsia

authors： de Araujo Furtado M,Lumley LA,Robison C,Tong LC,Lichtenstein S,Yourick DL

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Potentially pathogenic autoantibodies are found increasingly in adults with seizure disorders, including focal seizures and those of unknown cause. In this study, we investigated a cohort of children with new-onset seizures to see whether there were autoantibodies and the relationship to any specific seizure or...

journal_title：Epilepsia

authors： Suleiman J,Wright S,Gill D,Brilot F,Waters P,Peacock K,Procopis P,Nibber A,Vincent A,Dale RC,Lang B

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Decline in verbal memory as a surgical complication remains an unresolved problem in mesial temporal lobe epilepsy. Some areas in the temporal lobe associated with the language function, often including the basal temporal language area, have been removed or transected by conventional surgical procedures. The au...

journal_title：Epilepsia

authors： Mikuni N,Miyamoto S,Ikeda A,Satow T,Taki J,Takahashi J,Ohigashi Y,Hashimoto N

更新日期：2006-08-01 00:00:00

abstract：:The antiepileptic properties of carbamazepine (Tegretol) and clonazepam (Rivotril) were compared in a double-blind randomized study comprising 36 patients with newly diagnosed, untreated psychomotor epilepsy (partial seizures with complex symptomatology). No significant differences were found between the two drugs dur...

journal_title：Epilepsia

authors： Mikkelsen B,Berggreen P,Joensen P,Kristensen O,Køhler O,Mikkelsen BO

更新日期：1981-08-01 00:00:00

abstract：:The anticonvulsant and motor effects of gabapentin (GBP) were evaluated in rat pups aged 16-17 days. Fourteen-day-old rat pups received an implanted stimulating electrode in the amygdala unilaterally. Kindled seizures were produced on day 16 of life by repeatedly applying an electrical current stimulus to the amygdala...

journal_title：Epilepsia

authors： Lado FA,Sperber EF,Moshé SL

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Uncontrolled epilepsy remains a significant health concern and requires new approaches to therapy. N-methyl-d-aspartate (NMDA) receptor blockade has been considered, but the adverse cognitive and behavioral effects of conventional NMDA-receptor antagonists have prevented the development of clinically useful com...

journal_title：Epilepsia

authors： Zhang DX,Williamson JM,Wu HQ,Schwarcz R,Bertram EH

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:To assess incidence, prevalence, risk factors, and prognosis of peripartum depression and anxiety in a prospective study of women with epilepsy. METHOD:Pregnancies in women with epilepsy (n=706) were compared to pregnancies in all women without epilepsy (n=106,511) including women with specified nonepileptic...

journal_title：Epilepsia

authors： Bjørk MH,Veiby G,Reiter SC,Berle JØ,Daltveit AK,Spigset O,Engelsen BA,Gilhus NE

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to clarify and compare the influence of surgical strategy on relief from seizures in patients with focal cortical dysplasia (FCD) and those with dysembryoplastic neuroepithelial tumor (DNT). METHODS:Six patients with FCD and five patients with DNT, all of whom underwent surgical r...

journal_title：Epilepsia

authors： Kameyama S,Fukuda M,Tomikawa M,Morota N,Oishi M,Wachi M,Kanazawa O,Sasagawa M,Kakita A,Takahashi H

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Upper extremity automatisms are considered to be an ipsilateral seizure lateralizing sign in temporal lobe epilepsy (TLE). Herein we describe different types of contralateral upper extremity automatisms (CUEAs). METHODS:One hundred ninety-three video-(electroencephalography) EEG recordings of 59 patients were ...

journal_title：Epilepsia

authors： Kelemen A,Fogarasi A,Borbély C,Szucs A,Fabó D,Jakus R,Rásonyi G,Halász P

更新日期：2010-02-01 00:00:00

abstract：:Phenytoin is metabolized to its parahydroxylated derivative by hepatic microsomal enzymes. This hydroxylation is a saturable process, that is, the rate of metabolism fails to increase in proportion to the serum concentration. This leads to a nonlinear relationship between the maintenance dose of the drug and the resul...

journal_title：Epilepsia

authors： Richens A

更新日期：1975-11-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of vigabatrin (VGB) in the treatment of infantile spasms (ISs) associated with Down syndrome (DS) and to assess the feasibility of early discontinuation to reduce the possible retinal toxicity. METHODS:Five children with ISs with DS were treated with vigabatrin as first-line monotherap...

journal_title：Epilepsia

authors： Nabbout R,Melki I,Gerbaka B,Dulac O,Akatcherian C

更新日期：2001-12-01 00:00:00

abstract：:Takotsubo cardiomyopathy is characterized by chest pain, dyspnea, electrocardiographic changes resembling an acute coronary syndrome, and transient wall-motion abnormalities without identifiable coronary culprit lesion explaining the wall-motion abnormality. Takotsubo cardiomyopathy occurs frequently after emotional o...

journal_title：Epilepsia

authors： Stöllberger C,Wegner C,Finsterer J

更新日期：2011-11-01 00:00:00

abstract：:The management of epilepsy is an essential clinical issue in many patients with brain tumors. Tumoral epilepsy is often drug resistant and is associated with poor quality of life. Surgery represents a key therapeutic option in the management of patients with refractory tumoral epilepsy, with high rates of postoperativ...

journal_title：Epilepsia

authors： Rheims S,Ducray F,Ryvlin P

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:To compare surgical outcome in mesial temporal lobe epilepsy (MTLE) patients with unilateral hippocampal sclerosis (MTLE-HS) who had or did not have preoperative video-electroencephalographic monitoring (VEEG). METHODS:A prospective study was undertaken with 166 consecutive pharmacoresistant unilateral MTLE-...

journal_title：Epilepsia

authors： Alvim MKM,Morita ME,Yasuda CL,Damasceno BP,Lopes TM,Coan AC,Ghizoni E,Tedeschi H,Cendes F

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:We wished to determine the effects of seizure type, age at onset, and family history of epilepsy on risk of spontaneous abortion in the pregnancies of adults with idiopathic/cryptogenic epilepsy. METHODS:We examined pregnancy outcomes in 812 adults with idiopathic/cryptogenic epilepsy who had ever had or fathe...

journal_title：Epilepsia

authors： Schupf N,Ottman R

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVE:Electroencephalographic seizures (ESs) are common in encephalopathic critically ill children, but identification requires extensive resources for continuous electroencephalographic monitoring (CEEG). In a previous study, we developed a clinical prediction rule using three clinical variables (age, acute enceph...

journal_title：Epilepsia

authors： Fung FW,Parikh DS,Jacobwitz M,Vala L,Donnelly M,Wang Z,Xiao R,Topjian AA,Abend NS

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to clarify functional c...

journal_title：Epilepsia

authors： Kanyo R,Wang CK,Locskai LF,Li J,Allison WT,Kurata HT

更新日期：2020-08-01 00:00:00

abstract：:An understanding of the basic principles of human inheritance patterns is necessary to appreciate the variety and complexity of genetic influences in the epilepsies. The various modes of human inheritance include single gene (mendelian), chromosomal, mitochondrial, and multifactorial/polygenic. Recent insights regardi...

journal_title：Epilepsia

authors： Bird TD

更新日期：1994-01-01 00:00:00

abstract：:Convulsive epilepsies are generally unmistakable. Absence epilepsies, which are easily recognized by the provocation of an episode during hyperventilation and by the typical features of the EEG, can be overdiagnosed, especially in the child who daydreams in class and has scattered, asymptomatic, epileptogenic EEG chan...

journal_title：Epilepsia

authors： Murphy JV,Dehkharghani F

更新日期：1994-01-01 00:00:00

abstract：:Clinical features of seizures occurring in a neurofibromatosis clinic population were examined in a retrospective study. Twenty-two individuals in a population of 359 persons with neurofibromatos 1 (NF1) had had one or more seizures. Age at first seizure ranged from 4 days to > 20 years. Patients were classified into ...

journal_title：Epilepsia

authors： Korf BR,Carrazana E,Holmes GL

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:Clobazam (CLB) has an important antiepileptic effect and is less expensive than the new antiepileptic drugs (AEDs), but still has not been considered as first-line drug in the treatment of epilepsy. We evaluated the efficacy of CLB as add-on therapy in patients with refractory partial epilepsy. METHODS:This wa...

journal_title：Epilepsia

authors： Montenegro MA,Cendes F,Noronha AL,Mory SB,Carvalho MI,Marques LH,Guerreiro CA

更新日期：2001-04-01 00:00:00

abstract：:In this study, we aimed to investigate the types of seizures and epilepsy associated with systemic lupus erythematosus (SLE). We searched the medical records at a tertiary referral center to identify a cohort of epilepsy patients with SLE who were treated between January 2000 and August 2011. We analyzed the clinical ...

journal_title：Epilepsia

authors： Toyota T,Akamatsu N,Tanaka A,Shouzaki T,Tsuji S,Saito K,Tanaka Y

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Nocturnal frontal lobe seizures (NFLS) show one or all of the following semeiological patterns: (1) paroxysmal arousals (PA: brief and sudden recurrent motor paroxysmal behavior); (2) hyperkinetic seizures (HS: motor attacks with complex dyskinetic features); (3) asymmetric bilateral tonic seizures (ATS: mot...

journal_title：Epilepsia

authors： Vignatelli L,Bisulli F,Provini F,Naldi I,Pittau F,Zaniboni A,Montagna P,Tinuper P

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:A pilot study of the safety, tolerability, dose range and potential efficacy of ganaxolone for the treatment of refractory epilepsy in pediatric and adolescent subjects. METHODS:We report the results of a nonrandomized, nonblinded, open-label, dose-escalation trial of ganaxolone in pediatric subjects (5-15 yea...

journal_title：Epilepsia

authors： Pieribone VA,Tsai J,Soufflet C,Rey E,Shaw K,Giller E,Dulac O

更新日期：2007-10-01 00:00:00

abstract：:The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial. It remains controversial which resection method gives best results for seizure freedom and neuropsychological function. This review of 53 studies addressing extent of resection in surge...

journal_title：Epilepsia

authors： Schramm J

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Hemispherectomy is an established surgical treatment for carefully selected pediatric patients with intractable epilepsy. Published perioperative data report low mortality rates and seizure reduction rates of 50-89%. This study investigates trends in the demographics, hospital utilization, and in-hospital com...

journal_title：Epilepsia

authors： Lin Y,Harris DA,Curry DJ,Lam S

更新日期：2015-01-01 00:00:00

abstract：:The pharmacokinetics of phenylethylmalonamide (PEMA), a major metabolite of primidone, were investigated following administration of single oral doses (400 mg) to six normal subjects and six patients receiving chronic treatment with antiepileptic drugs. Peak serum PEMA levels were usually attained with 2-4 h after int...

journal_title：Epilepsia

authors： Cottrell PR,Streete JM,Berry DJ,Schäfer H,Pisani F,Perucca E,Richens A

更新日期：1982-06-01 00:00:00

abstract：OBJECTIVE:Previous studies examining seizures in patients with 22q11.2 deletion syndrome (22q11.2DS) have focused primarily on children and adolescents. In this study we investigated the prevalence and characteristics of seizures and epilepsy in an adult 22q11.2DS population. METHODS:The medical records of 202 adult p...

journal_title：Epilepsia

authors： Wither RG,Borlot F,MacDonald A,Butcher NJ,Chow EWC,Bassett AS,Andrade DM

更新日期：2017-06-01 00:00:00

abstract：:Amygdala kindling is used to investigate cerebellar dentate nucleus participation in the neuronal plasticity of the cerebrum. We studied the behavioral change, the occurrence of epileptiform events, and the duration of afterdischarge during amygdaloid kindling under control conditions and after a dentate lesion of the...

journal_title：Epilepsia

authors： Tsuru N,Kawasaki H,Genda S,Hara K,Hashiguchi H,Ueda Y

更新日期：1992-03-01 00:00:00