Abstract:
:Amygdala kindling is used to investigate cerebellar dentate nucleus participation in the neuronal plasticity of the cerebrum. We studied the behavioral change, the occurrence of epileptiform events, and the duration of afterdischarge during amygdaloid kindling under control conditions and after a dentate lesion of the contralateral cerebellum. Our results indicate that the dentate lesion induced the facilitation of the behavioral development of the amygdaloid kindling, whereas there was only a slight increase in the duration of afterdischarge and the spontaneous epileptiform potential of the amygdala. There was a discrepancy between the behavioral kindling and the electroencephalographic epileptic activity. Therefore the dentate lesion must play a role in controlling the generalization mechanism of epilepsy. We also found that on a right amygdala that had been influenced by a left dentate lesion there were few spikes, while on the left amygdala there were frequent spikes. These results suggest that the dentate nucleus plays an important role in amygdaloid kindling as well as in the neuronal plasticity of the amygdala.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Tsuru N,Kawasaki H,Genda S,Hara K,Hashiguchi H,Ueda Ydoi
10.1111/j.1528-1157.1992.tb02309.xkeywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
213-21issue
2eissn
0013-9580issn
1528-1167journal_volume
33pub_type
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