Electroclinical patterns and evolution of epilepsy in the 4p- syndrome.

abstract：PURPOSE:Effects of pre- and postsynaptic γ-aminobutyric acid B (GABA(B)) receptor activation were characterized in human tissue from epilepsy surgery. METHODS:Slices of human cortical tissue were investigated in a submerged-type chamber with intracellular recordings in layers II/III. Parallel experiments were performe...

journal_title：Epilepsia

authors： Teichgräber LA,Lehmann TN,Meencke HJ,Weiss T,Nitsch R,Deisz RA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:We studied heart-rate (HR) changes at the transition from the preictal to the ictal state in patients with focal epilepsies to gain some insight into the mechanisms involved in the neuronal regulation of cardiovascular function. METHODS:We assessed ECG changes during 145 seizures recorded with scalp EEG in 58 ...

journal_title：Epilepsia

authors： Leutmezer F,Schernthaner C,Lurger S,Pötzelberger K,Baumgartner C

更新日期：2003-03-01 00:00:00

abstract：:The duration of epilepsy was evaluated in over 460 previously untreated patients who attended newly established epilepsy clinics in a rural area of Malawi. The mean duration at first attendance was 6.5 years. It was found that as the duration of active epilepsy increased, the number of patients having epilepsy of a gi...

journal_title：Epilepsia

authors： Watts AE

更新日期：1992-05-01 00:00:00

abstract：:The purpose of this study was to determine whether seizure frequency and cycle days with seizure occurrence vary across the menstrual cycle. The subjects were the first 100 women with intractable focal onset seizures, 13-45 years old, who completed the baseline phase of the National Institutes of Health (NIH) Progeste...

journal_title：Epilepsia

authors： Herzog AG,Fowler KM,Sperling MR,Massaro JM,Progesterone Trial Study Group.

更新日期：2015-05-01 00:00:00

abstract：:The longstanding dichotomy between the concepts of "focal" and "primary generalized" epilepsy has become increasingly blurred, raising fundamental questions about the nature of ictal onset in localized brain regions versus large-scale brain networks. We hypothesize that whether an EEG discharge appears focal or genera...

journal_title：Epilepsia

authors： Terry JR,Benjamin O,Richardson MP

更新日期：2012-09-01 00:00:00

abstract：:Before a health education program can be established, one must first know what the target population believes and does with respect to the disease in question. Therefore, we performed a study among Tanzanian rural inhabitants to identify their knowledge, attitude, and practice (KAP) toward epilepsy: 3,256 heads of hou...

journal_title：Epilepsia

authors： Rwiza HT,Matuja WB,Kilonzo GP,Haule J,Mbena P,Mwang'ombola R,Jilek-Aall L

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:We studied cerebral perfusion patterns in the various subtypes of TLE, as determined by pathology and good outcome after temporal lobectomy (as confirmation of temporal origin). METHODS:We studied clinical features and ictal technetium 99m hexamethyl-propyleneamineoxime (99mTc-HM-PAO) single-photon emission-co...

journal_title：Epilepsia

authors： Ho SS,Berkovic SF,McKay WJ,Kalnins RM,Bladin PF

更新日期：1996-08-01 00:00:00

abstract：:A variety of surgical strategies are available to deal with intractable epilepsy. These are resective operations, consisting of the removal of a focus or a discrete lesion, gross removal of malfunctioning brain, and functional operations consisting of division of the pathways of propagation or of an epileptic neuronal...

journal_title：Epilepsia

authors： Polkey CE,Binnie CD

更新日期：1995-01-01 00:00:00

abstract：:Forty-five outpatients with chronic epilepsy with complex partial seizures (CPS) alone or associated with secondarily generalized tonic-clonic seizures (SGTCS) were treated with carbamazepine (CBZ) monotherapy. All patients had only a unilateral scalp electroencephalographic (EEG) focus. Left- (n = 29) and right- (n =...

journal_title：Epilepsia

authors： Defazio G,Lepore V,Specchio LM,Pisani F,Livrea P

更新日期：1991-09-01 00:00:00

abstract：:We performed a retrospective study of 51 consecutive patients who underwent operation for intractable partial epilepsy related to low-grade intracerebral neoplasms between 1984 and 1990. All patients had medically refractory partial seizures and a mass lesion identified on neuroimaging studies. Lesionectomy was perfor...

journal_title：Epilepsia

authors： Britton JW,Cascino GD,Sharbrough FW,Kelly PJ

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVES:Patients with temporal lobe epilepsy (TLE) experience significant deficits in category-related object recognition and naming following standard surgical approaches. These deficits may result from a decoupling of core processing modules (e.g., language, visual processing, and semantic memory), due to "collate...

journal_title：Epilepsia

authors： Drane DL,Loring DW,Voets NL,Price M,Ojemann JG,Willie JT,Saindane AM,Phatak V,Ivanisevic M,Millis S,Helmers SL,Miller JW,Meador KJ,Gross RE

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients. METHODS:In this prospective case series, 17 patients with drug-resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 wi...

journal_title：Epilepsia

authors： Rolinski R,Austermuehle A,Wiggs E,Agrawal S,Sepeta LN,Gaillard WD,Zaghloul KA,Inati SK,Theodore WH

更新日期：2019-03-01 00:00:00

abstract：:Why some patients with seizures are successfully treated with antiepileptic drugs (AEDs) and others prove medically intractable is not known. Inadequate intraparenchymal drug concentration is a possible mechanism of resistance to AEDs. The multiple drug resistance gene (MDR1) encodes P-glycoprotein, an energy-dependen...

journal_title：Epilepsia

authors： Tishler DM,Weinberg KI,Hinton DR,Barbaro N,Annett GM,Raffel C

更新日期：1995-01-01 00:00:00

abstract：:Twenty-one cases (12 males, 9 females) of Lafora's disease in 16 families were studied at the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India, from 1982 to 1990. Mean age of onset was 13.5 years (range 9.5-18 years). First symptom was generalized tonic-clonic seizure (17), myoclonus ...

journal_title：Epilepsia

authors： Acharya JN,Satishchandra P,Asha T,Shankar SK

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:Felbamate (FBM) is a new antiepileptic drug (AED) that is often effective in seizure disorders refractory to other treatments; its use has been greatly restricted after cases of aplastic anemia were reported. To elucidate the putative association between FBM and aplastic anemia, we made a detailed evaluation of...

journal_title：Epilepsia

authors： Kaufman DW,Kelly JP,Anderson T,Harmon DC,Shapiro S

更新日期：1997-12-01 00:00:00

abstract：:The performance of a new enzyme multiplied immunoassay technique (EMIT) was compared with other current methods, namely gas-liquid chromatography and thin-layer chromatography, for the determination of phenytoin and phenobarbital in serum. Forty-three serum samples were sent as unknowns to the participating laboratori...

journal_title：Epilepsia

authors： Schmidt D,Goldberg V,Guelen PJ,Johannessen S,Kleijn E,Meijer JW,Meinardi H,Richens A,Schneider H,Stein-Lavie Y,Symann-Louette N

更新日期：1977-09-01 00:00:00

abstract：PURPOSE:To address genetic predisposition to febrile convulsions (FCs) and epilepsy as an etiologic background of severe myoclonic epilepsy in infancy (SMEI). METHODS:Familial antecedents of epilepsy and FCs were analyzed in four groups of patients with SMEI (65 cases), FCs (57 cases), childhood absences (67 cases), a...

journal_title：Epilepsia

authors： Benlounis A,Nabbout R,Feingold J,Parmeggiani A,Guerrini R,Kaminska A,Dulac O

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:The hippocampus is one of the principal target areas for neurosteroidal action, and the major neuroendocrine conversion of progesterone appears to be 5alpha-reduction and 3alpha-hydroxysteroid oxidoreduction, leading to the potent neurosteroid 3alpha,5alpha-tetrahydroxyprogesterone. To investigate whether the h...

journal_title：Epilepsia

authors： Stoffel-Wagner B,Beyenburg S,Watzka M,Blümcke I,Bauer J,Schramm J,Bidlingmaier F,Elger CE

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:To examine antioxidative system in hippocampi of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (mTLE-HS). METHODS:Activity and levels of antioxidative enzymes-catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), manganese superoxide dismutase (MnSOD), ...

journal_title：Epilepsia

authors： Ristić AJ,Savić D,Sokić D,Bogdanović Pristov J,Nestorov J,Baščarević V,Raičević S,Savić S,Spasojević I

更新日期：2015-05-01 00:00:00

abstract：:Between 1929 and 1980, 284 patients with refractory nontumoral frontal lobe epilepsy (FLE) underwent operation at the Montreal Neurological Institute (MNI). We studied 39 patients (14%) who required reoperation. Mean age at the time of first operation was 18 years and at reoperation was 22 years. Clinical manifestatio...

journal_title：Epilepsia

authors： Salanova V,Quesney LF,Rasmussen T,Andermann F,Olivier A

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The use of primary health care personnel to identify cases of epilepsy and initiate simple treatment protocols has been advocated as a solution to the numeric inadequacy and uneven distribution of medical manpower available for the management of epilepsy in developing countries. This study sought to evaluate th...

journal_title：Epilepsia

authors： Adamolekun B,Mielke JK,Ball DE

更新日期：1999-04-01 00:00:00

abstract：:Spontaneously epileptic rats (SER) are a double mutant (zi/zi, tm/tm) spontaneously exhibiting both tonic and absence-like seizures. We examined the long-term effects of continual intake of phenobarbital (PB) on SER as a method of assessing long-term evaluation of antiepileptic drugs (AEDs). Food pellets containing 0....

journal_title：Epilepsia

authors： Serikawa T,Kogishi K,Yamada J,Ohno Y,Ujihara H,Fujita Y,Sasa M,Takaori S

更新日期：1990-01-01 00:00:00

abstract：:The chronic epileptic syndrome induced by injecting tetanus toxin into rat hippocampus causes functional changes that essentially are permanent, outlasting the period of active seizures by at least 1 year. These long-term changes have been characterized by an impaired performance on a range of behavioral tasks, which ...

journal_title：Epilepsia

authors： Francis PT,Lowe SL,Bowen DM,Jefferys JG

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Neuropsychological studies suggest frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy (JME). In this study we investigated whether an underlying mechanism could be a regional neuronal damage not visible with structural magnetic resonance (MR), but detectable with magnetic resonance spectrosc...

journal_title：Epilepsia

authors： Savic I,Lekvall A,Greitz D,Helms G

更新日期：2000-03-01 00:00:00

abstract：:The first description of epileptic encephalopathies dates back to Dr. West who, in 1857, described the syndrome that took his name. In addition to West syndrome, in the last century other epileptic syndromes entered into the chapter of epileptic encephalopathies. Henry Gastaut has the virtue of having created the mode...

journal_title：Epilepsia

authors： Capovilla G,Wolf P,Beccaria F,Avanzini G

更新日期：2013-11-01 00:00:00

abstract：:Patients with epilepsy have 20-fold risk of sudden death when compared to the general population. Uncontrolled seizures is the most consistent risk factor, and death often occurs at night or in relation to sleep. We examined seizure-related respiratory disturbances in sleep versus wakefulness, focusing on periictal ox...

journal_title：Epilepsia

authors： Latreille V,Abdennadher M,Dworetzky BA,Ramel J,White D,Katz E,Zarowski M,Kothare S,Pavlova M

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To describe the behavioral and EEG topographic correlates of absences with 3-Hz generalized spike-waves and partitioned impairment of consciousness. METHODS:Two adult women had so-called "phantom" absences, characterized by brief and mild impairments of consciousness that were previously inconspicuous to both ...

journal_title：Epilepsia

authors： Vuilleumier P,Assal F,Blanke O,Jallon P

更新日期：2000-06-01 00:00:00

abstract：:The in vivo incorporation of [14C] from [U-14C]-glucose into rat brain proteins from different cortical areas was examined in three different experimental focal epilepsies: cobalt, freeze-lesions, and tityustoxin. When [U-14C]-glucose was injected intraperitoneally into awake and unrestrained animals with marked signs...

journal_title：Epilepsia

authors： Coutinho-Netto J,Boyar MM,Abdul-Ghani AS,Bradford HF

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:To evaluate the significance of lateralization of ictal upper limb automatisms in patients with temporal lobe epilepsy (TLE). METHODS:Ictal upper limb automatisms of 28 patients with temporal lobe epilepsy were quantified. Duration of automatisms in relation to total seizure duration, movement speed, extent, l...

journal_title：Epilepsia

authors： Mirzadjanova Z,Peters AS,Rémi J,Bilgin C,Silva Cunha JP,Noachtar S

更新日期：2010-10-01 00:00:00

abstract：:Deletions and duplications/amplifications of the α1-sodium channel subunit (SCN1A) gene occur in about 12% of patients with Dravet syndrome (DS) who are otherwise mutation-negative. Such genomic abnormalities cause loss of function, with severe phenotypes, reproductive disadvantage and, therefore, sporadic occurrence....

journal_title：Epilepsia

authors： Guerrini R,Cellini E,Mei D,Metitieri T,Petrelli C,Pucatti D,Marini C,Zamponi N

更新日期：2010-12-01 00:00:00