The influence of electroencephalographic focus laterality on efficacy of carbamazepine in complex partial and secondarily generalized tonic-clonic seizures.

abstract：:The medical treatment of seizure disorders is a complex process, requiring extensive interaction and co-operation between physician and patient. The physician must have an accurate diagnosis of the patient's illness and a comprehensive understanding of seizures and seizure disorders. The physician must consider specif...

journal_title：Epilepsia

authors： Ferrendelli JA

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Magnetic resonance imaging (MRI) is an essential diagnostic tool for the management of epilepsy at modern epilepsy clinics. This study was conducted to incorporate MRI features into the international classification of epilepsies and epilepsy syndromes (ICEES) proposed by the International League Against Epileps...

journal_title：Epilepsia

authors： Lee BI,Heo K,Kim JS,Kim OJ,Park SA,Lim SR,Kim DI,Yoon PH,Kim DK

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:The present study was undertaken to clarify the effects of (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA), a metabotropic glutamate receptor (mGluR) 1 antagonist, (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate ((2R,4R)-APDC), a mGluR2/3 agonist, and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4), a mGluR4/8 agonis...

journal_title：Epilepsia

authors： Watanabe Y,Kaida Y,Fukuhara S,Takechi K,Uehara T,Kamei C

更新日期：2011-01-01 00:00:00

abstract：:The presence of the excitotoxic and convulsant agent quinolinic acid (QUIN) in human brain has led to the hypothesis that an increase of this tryptophan metabolite could serve as an endogenous epileptogen. A possible mechanism for a pathological accumulation of QUIN being a deficiency in its degradation, we have measu...

journal_title：Epilepsia

authors： Feldblum S,Rougier A,Loiseau H,Loiseau P,Cohadon F,Morselli PL,Lloyd KG

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:Common data elements (CDEs) are standardized questions and answer choices that allow aggregation, analysis, and comparison of observations from multiple sources. Clinical CDEs are foundational for learning health care systems, a data-driven approach to health care focused on continuous improvement of outcomes...

journal_title：Epilepsia

authors： Grinspan ZM,Patel AD,Shellhaas RA,Berg AT,Axeen ET,Bolton J,Clarke DF,Coryell J,Gaillard WD,Goodkin HP,Koh S,Kukla A,Mbwana JS,Morgan LA,Singhal NS,Storey MM,Yozawitz EG,Abend NS,Fitzgerald MP,Fridinger SE,Helbig

更新日期：2021-01-01 00:00:00

abstract：:We present a 4-year-old girl with profound global developmental delay and refractory epilepsy characterized by multiple seizure types (partial complex with secondary generalization, tonic, myoclonic, and atypical absence). Her seizure semiology did not fit within a specific epileptic syndrome. Despite a broad metaboli...

journal_title：Epilepsia

authors： Venkateswaran S,Myers KA,Smith AC,Beaulieu CL,Schwartzentruber JA,FORGE Canada Consortium.,Majewski J,Bulman D,Boycott KM,Dyment DA

更新日期：2014-07-01 00:00:00

abstract：:Fifty-six consecutive epileptic patients with partial seizures (30 temporal, 26 extratemporal) and facial asymmetry were studied. Facial asymmetry was compared with EEG, radiologic, and other clinical findings. Thirty patients had a lesional epilepsy whereas 26 were considered cryptogenic. In lesional epilepsies, 60% ...

journal_title：Epilepsia

authors： Tinuper P,Plazzi G,Provini F,Cerullo A,Leonardi M,Agati R,Righini A,Montagna P

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:The interictal and ictal EEG activity in the basal ganglia in patients with temporal lobe epilepsy were studied during invasive EEG monitoring. METHODS:Eight epilepsy surgery candidates, each with a proven mesiotemporal seizure-onset zone, participated in the study. We used two invasive EEG methods to determin...

journal_title：Epilepsia

authors： Rektor I,Kuba R,Brázdil M

更新日期：2002-03-01 00:00:00

abstract：:It is unclear whether the outcome of status epilepticus (SE), a neurological emergency associated with high mortality and morbidity, has changed over the past decade. We investigated the difference in prognosis (mortality, functional status at discharge) after adult SE episodes in a large registry between 2 time point...

journal_title：Epilepsia

authors： Fatuzzo D,Novy J,Rossetti AO

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:A large number of studies have highlighted the important role of the gut microbiota in the pathophysiology of neurological disorders, suggesting that its manipulation might serve as a treatment strategy. We hypothesized that the gut microbiota participates in absence seizure development and maintenance in the...

journal_title：Epilepsia

authors： Citraro R,Lembo F,De Caro C,Tallarico M,Coretti L,Iannone LF,Leo A,Palumbo D,Cuomo M,Buommino E,Nesci V,Marascio N,Iannone M,Quirino A,Russo R,Calignano A,Constanti A,Russo E,De Sarro G

更新日期：2021-01-11 00:00:00

abstract：OBJECTIVE:Standard mortality ratio for suicide in patients with epilepsy is three times higher than in the general population, and such a risk remains high even after adjusting for clinical and socioeconomic factors. It is thus important to have suitable screening instruments and to implement care pathways for suicide ...

journal_title：Epilepsia

authors： Mula M,McGonigal A,Micoulaud-Franchi JA,May TW,Labudda K,Brandt C

更新日期：2016-06-01 00:00:00

abstract：:Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilep...

journal_title：Epilepsia

authors： Middleton O,Atherton D,Bundock E,Donner E,Friedman D,Hesdorffer D,Jarrell H,McCrillis A,Mena OJ,Morey M,Thurman D,Tian N,Tomson T,Tseng Z,White S,Wright C,Devinsky O

更新日期：2018-03-01 00:00:00

abstract：:The clinical identification of neonatal seizures is critical for the recognition of brain dysfunction; however, diagnosis is often difficult because of the poorly organized and varied nature of these behaviors. Current classification systems are limited in their ability to communicate motor, autonomic, and electroence...

journal_title：Epilepsia

authors： Mizrahi EM

更新日期：1987-01-01 00:00:00

abstract：:Monotherapy is the policy for management of patients with epilepsy. With increasing knowledge of the biology of epilepsy and of the modes of action of antiepileptic drugs (AEDs), this concept must be reevaluated. When monotherapy fails to control seizures, subsequent treatment should be based on "rational pharmacology...

journal_title：Epilepsia

authors： de Bittencourt PR,Mazer S,Marcourakis T,Bigarella MM,Ferreira ZS,Mumford JP

更新日期：1994-03-01 00:00:00

abstract：:The mechanism by which animals develop tolerance to the antiepileptic effects of the carbonic anhydrase (CA) inhibitor, acetazolamide, was explored using a quantitative immunocytochemical method. Cerebral cortex sections of DBA/2J mice susceptible to audiogenic seizures and of C57BL/6J nonsusceptible mice were stained...

journal_title：Epilepsia

authors： Banks DA,Anderson RE,Woodbury DM

更新日期：1986-09-01 00:00:00

abstract：PURPOSE:We studied heart-rate (HR) changes at the transition from the preictal to the ictal state in patients with focal epilepsies to gain some insight into the mechanisms involved in the neuronal regulation of cardiovascular function. METHODS:We assessed ECG changes during 145 seizures recorded with scalp EEG in 58 ...

journal_title：Epilepsia

authors： Leutmezer F,Schernthaner C,Lurger S,Pötzelberger K,Baumgartner C

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:Corpus callosotomy is an effective palliative treatment for drug-resistant Lennox-Gastaut syndrome (LGS). Laser interstitial thermal therapy has been increasingly used in the treatment of epilepsy. Here, we assess the safety and effectiveness of minimally invasive stereotactic laser anterior corpus callosotom...

journal_title：Epilepsia

authors： Tao JX,Satzer D,Issa NP,Collins J,Wu S,Rose S,Henry J,Santos de Lima F,Nordli D,Warnke PC

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Posterior cortex epilepsies (PCEs) encompass a group of epilepsies originating from the occipital, parietal, or occipital border of the temporal lobe, or from any combination of these regions. When their seizures are refractory to pharmacologic treatment, these patients are usually referred for surgery. The aim...

journal_title：Epilepsia

authors： Dalmagro CL,Bianchin MM,Velasco TR,Alexandre V Jr,Walz R,Terra-Bustamante VC,Inuzuka LM,Wichert-Ana L,Araújo D Jr,Serafini LN,Carlotti CG Jr,Assirati JA Jr,Machado HR,Santos AC,Sakamoto AC

更新日期：2005-09-01 00:00:00

abstract：:The vagus is a mixed nerve carrying somatic and visceral afferents and efferents. The majority of vagal nerve fibers are visceral afferents and have a wide distribution throughout the central nervous system (CNS) either monosynaptically or via the nucleus of the solitary tract. Besides activation of well-defined refle...

journal_title：Epilepsia

authors： Rutecki P

更新日期：1990-01-01 00:00:00

abstract：:Symptomatic occipital lobe epilepsy is increasingly recognized among patients with partial-onset seizures. Although traditional clinical and electroencephalographic criteria had defined occipital lobe epilepsy in the past, new neuroimaging techniques and the recognition of specific syndromes associated with occipital ...

journal_title：Epilepsia

authors： Kuzniecky R

更新日期：1998-01-01 00:00:00

abstract：:Neuropsychological evaluation differs from other methods used to localize cerebral lesions in that it analyzes cognitive function. Tests sample widely among cognitive abilities, contrasting language proficiency with visuospatial skills. A thorough assessment of memory is crucial in the investigation because of the pro...

journal_title：Epilepsia

authors： Jones-Gotman M

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To evaluate efficacy, tolerability, and safety of adjunctive brivaracetam (BRV) in patients with Unverricht-Lundborg disease (EPM1). METHODS:Two prospective, multicenter, double-blind, phase III trials (N01187/NCT00357669; N01236/NCT00368251) in patients (≥16 years) with genetically ascertained EPM1, showing...

journal_title：Epilepsia

authors： Kälviäinen R,Genton P,Andermann E,Andermann F,Magaudda A,Frucht SJ,Schlit AF,Gerard D,de la Loge C,von Rosenstiel P

更新日期：2016-02-01 00:00:00

abstract：:In this article, we review the incidence and significance of seizures in well-established autoimmune disorders, including multiple sclerosis (MS), diabetes mellitus, celiac disease, thyroid disease, and systemic lupus erythematosus (SLE). The five following presentations discuss the incidence and possible pathogenesis...

journal_title：Epilepsia

authors： Vincent A,Crino PB

更新日期：2011-05-01 00:00:00

abstract：:Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies ha...

journal_title：Epilepsia

authors： Nicita F,Ruggieri M,Polizzi A,Mauceri L,Salpietro V,Briuglia S,Papetti L,Ursitti F,Grosso S,Tarani L,Segni M,Savasta S,Parisi P,Verrotti A,Spalice A

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:To determine whether acute exacerbations of cirrhotic liver disease are associated with higher odds of readmission for epilepsy or status epilepticus. METHODS:The New York State Inpatient Database is a statewide dataset containing data on 97% of hospitalizations for New York State. In this retrospective, cas...

journal_title：Epilepsia

authors： Gursky JM,Rossi KC,Jetté N,Dhamoon MS

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant effects of gabapentin (GBP) in immature animals. METHODS:Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats. Animals pretreated with GBP (15, 30, or 60 mg/kg i.p.) were compared with controls. The incidence and latency of two types of seizur...

journal_title：Epilepsia

authors： Mares P,Haugvicová R

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to evaluate health care expenditures among elderly patients with epilepsy in the United States. METHODS:We performed an analysis of weighted 37 738 607 US participants aged 65 years to estimate health care expenditures in the elderly with and without epilepsy using the Medical E...

journal_title：Epilepsia

authors： Lekoubou A,Bishu KG,Ovbiagele B

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to clarify functional c...

journal_title：Epilepsia

authors： Kanyo R,Wang CK,Locskai LF,Li J,Allison WT,Kurata HT

更新日期：2020-08-01 00:00:00

abstract：:Development of tolerance (i.e., the reduction in response to a drug after repeated administration) is an adaptive response of the body to prolonged exposure to the drug, and tolerance to antiepileptic drugs (AEDs) is no exception. Tolerance develops to some drug effects much more rapidly than to others. The extent of ...

journal_title：Epilepsia

authors： Löscher W,Schmidt D

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:Movement-based wearable sensors are used for detection of convulsive seizures. The identification of the absence of motion following a seizure, known as post-ictal immobility (PI), may represent a potential additional application of wearables. PI has been associated with potentially life-threatening complicat...

journal_title：Epilepsia

authors： Bruno E,Böttcher S,Biondi A,Epitashvili N,Manyakov NV,Lees S,Schulze-Bonhage A,Richardson MP,RADAR-CNS Consortium.

更新日期：2020-07-01 00:00:00