Rational polypharmacy.

abstract：:Audiogenic seizure-prone mice (DBA/2J) were exposed to a broad band noise source. A reproducible response consisting of wild run, clonus, and tonic stages resulted in all mice. Layers 1 and pyramidal from the parietal cortex and the molecular and Purkinje cell-rich layers from the cerebellar vermis were separately ana...

journal_title：Epilepsia

authors： McCandless DW,Schwartzenburg FC Jr

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:Vigabatrin (VGB) and lamotrigine (LTG) are two new antiepileptic drugs (AEDs) with different mechanisms of action for treatment of refractory epilepsies. Previous reports have indicated efficacy of both drugs in a number of epileptic syndromes. METHODS:We compared these new AEDs drugs to determine their respec...

journal_title：Epilepsia

authors： Bélanger S,Coulombe G,Carmant L

更新日期：1998-08-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults. TLE has a high chance of becoming medically refractory, and as such, is frequently considered for further evaluation and surgical intervention. Up to 30% of TLE cases, however, can have normal ("nonlesional" or negative) magnetic resonance imagi...

journal_title：Epilepsia

authors： Muhlhofer W,Tan YL,Mueller SG,Knowlton R

更新日期：2017-05-01 00:00:00

abstract：:In the nineteenth and early twentieth centuries, many important discoveries in nervous system structure and function involved the electrical properties of nerve tissue. The application of these advances, as well as those in electronic amplification and recording, led to the discovery of the human electroencephalogram ...

journal_title：Epilepsia

authors： Zifkin BG,Avanzini G

更新日期：2009-03-01 00:00:00

abstract：:We studied 47 consecutive patients who underwent temporal resection for seizure control. Nineteen (40%) had febrile convulsions preceding onset of their habitual seizures. In 17 of 18 patients whose disease duration was known, the febrile convulsions were prolonged (mean 4 h). As compared with patients without precedi...

journal_title：Epilepsia

authors： Abou-Khalil B,Andermann E,Andermann F,Olivier A,Quesney LF

更新日期：1993-09-01 00:00:00

abstract：:Transient epileptic amnesia (TEA) is a distinct neurologic condition occurring in late-middle/old age and presenting with amnesic attacks of epileptic nature and interictal memory disturbances. For many years this condition has been associated with the nonepileptic condition of transient global amnesia (TGA) and still...

journal_title：Epilepsia

authors： Bilo L,Meo R,Ruosi P,de Leva MF,Striano S

更新日期：2009-05-01 00:00:00

abstract：:ACC-9653, the disodium phosphate ester of 3-hydroxymethyl-5,5-diphenylhydantoin, is a prodrug of phenytoin with advantageous physicochemical properties. ACC-9653 is rapidly converted enzymatically to phenytoin in vivo. ACC-9653 and phenytoin sodium have equivalent anticonvulsant activity against seizures induced by ma...

journal_title：Epilepsia

authors： Smith RD,Brown BS,Maher RW,Matier WL

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Few reports detailing late-onset epileptic spasms have been published. To determine whether this condition merely represents a late variant of classic West syndrome or exhibits specific features distinct from the latter and related to a later stage of brain maturation, we analyzed the whole population with this...

journal_title：Epilepsia

authors： Eisermann MM,Ville D,Soufflet C,Plouin P,Chiron C,Dulac O,Kaminska A

更新日期：2006-06-01 00:00:00

abstract：:Postictal refractoriness checked by paired stimulations of the limbic structures was demonstrated to fail in rats<2 weeks old. Cortical epileptic afterdischarges were used in our study to examine if this phenomenon is restricted to old cortical structures or if it is a general one. Rats 12, 15, 18, 25, and 90 days old...

journal_title：Epilepsia

authors： Mareš P,Kubová H

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To determine the frequency and predictors of return to driving within 1 year after a diagnosis of epilepsy. METHODS:SEISMIC (the Sydney Epilepsy Incidence Study to Measure Illness Consequences) was a prospective, multicenter, community-wide study of people of all ages with newly diagnosed epilepsy in Sydney,...

journal_title：Epilepsia

authors： Xu Y,Hackett ML,Glozier N,Nikpour A,Somerville E,Bleasel A,Ireland C,Anderson CS

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Corpus callosotomy is an effective palliative treatment for drug-resistant Lennox-Gastaut syndrome (LGS). Laser interstitial thermal therapy has been increasingly used in the treatment of epilepsy. Here, we assess the safety and effectiveness of minimally invasive stereotactic laser anterior corpus callosotom...

journal_title：Epilepsia

authors： Tao JX,Satzer D,Issa NP,Collins J,Wu S,Rose S,Henry J,Santos de Lima F,Nordli D,Warnke PC

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:We sought to characterize and compare the histopathologic and clinical changes elicited by subdural and depth electrodes in subjects undergoing epilepsy surgery evaluation. METHODS:A retrospective review of clinical records, imaging and histopathologic studies of epilepsy surgery cases requiring subdural strip...

journal_title：Epilepsia

authors： Stephan CL,Kepes JJ,SantaCruz K,Wilkinson SB,Fegley B,Osorio I

更新日期：2001-07-01 00:00:00

abstract：:Cortical malformations are highly epileptogenic lesions associated with complex, unanticipated, and often aberrant electrophysiologic and functional relationships. These relationships are inextricably linked to widespread cortical networks subserving eloquent functions, particularly language and motor ability. Cytomeg...

journal_title：Epilepsia

authors： Duchowny M

更新日期：2009-10-01 00:00:00

abstract：:DBA/2J (DBA) mice are susceptible to audiogenic seizures (AGSs) in an age-dependent manner, susceptibility being maximal at 21 days and absent at 110 days of age. Previous studies have demonstrated that there is a decrease in anion transport and an increase in carbonic anhydrase (CA) activity in brain from DBA mice as...

journal_title：Epilepsia

authors： Engstrom FL,Kemp JW,Chow SY,Woodbury DM

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:Herein we used electrophysiologic approaches in hippocampal area CA1 to estimate how morphine treatment alters the pentylenetetrazol (PTZ) effects. METHODS:Hippocampal slices taken from either control animals or animals made dependent via chronic morphine administration were examined. Changes in the population...

journal_title：Epilepsia

authors： Jafarzadeh Z,Fathollahi Y,Semnanian S,Omrani A,Salmanzadeh F,Salmani ME

更新日期：2009-04-01 00:00:00

abstract：:Continuous, generalized 2.5 to 3.5-Hz spike-wave (SW) discharges were evident in an EEG performed 13 h after a first seizure associated with a viral illness, in an 8-year-old girl. On eye opening, the EEG abnormality was suppressed and replaced by delta activity and brief spike-wave paroxysms. No alteration in conscio...

journal_title：Epilepsia

authors： Gökyiğit A,Calişkan A

更新日期：1995-02-01 00:00:00

abstract：:Estrogens have previously been reported to be proconvulsants in adult animals. This study evaluated the effects of acute, high-dose estrogen administration on rate of kindling in immature rats. No significant differences in rate of kindling between the estrogen-treated rats and controls were noted. This study, using t...

journal_title：Epilepsia

authors： Schultz-Krohn WA,Thompson J,Holmes GL

更新日期：1986-09-01 00:00:00

abstract：:Nonepileptic seizures (NES) are common and are often diagnosed at epilepsy centers by video-EEG recording of both spontaneous and suggestion-induced episodes, but no study has evaluated provocative testing in a general seizure population. We studied consecutive patients with a tentative diagnosis of epilepsy using sal...

journal_title：Epilepsia

authors： Bazil CW,Kothari M,Luciano D,Moroney J,Song S,Vasquez B,Weinreb HJ,Devinsky O

更新日期：1994-07-01 00:00:00

abstract：:We describe the pattern of early childhood seizures within a family with autosomal dominant chondrocalcinosis (CCAL, which causes adult-onset arthritis). All affected family members with CCAL experienced seizures in early childhood, usually, but not always, associated with fever. Similarities exist to the syndrome of ...

journal_title：Epilepsia

authors： McKee S,Pendleton A,Dixey J,Doherty M,Hughes A

更新日期：2004-10-01 00:00:00

abstract：OBJECTIVE:Previous validation studies assessing the use of administrative data to identify patients with epilepsy have used targeted sampling or have used a reference standard of patients in the neurologist, hospital, or emergency room setting. Therefore, the validity of using administrative data to identify patients w...

journal_title：Epilepsia

authors： Tu K,Wang M,Jaakkimainen RL,Butt D,Ivers NM,Young J,Green D,Jetté N

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:Patients with gliomas frequently present with seizures, but the factors associated with seizure development are still poorly understood. In this study, we assessed peritumoral synaptic network activity in a glioma animal model and tested the contribution of aberrant glutamate release from gliomas on glioma-asso...

journal_title：Epilepsia

authors： Campbell SL,Buckingham SC,Sontheimer H

更新日期：2012-08-01 00:00:00

abstract：:The availability of generic products of antiepileptic drugs (AEDs) has been increasing in recent years. In view of the importance of the issue, the Italian League against Epilepsy (LICE) set up an ad hoc working group whose task was to assess available evidence on the efficacy and safety of generic AEDs in the treatme...

journal_title：Epilepsia

authors： Perucca E,Albani F,Capovilla G,Bernardina BD,Michelucci R,Zaccara G

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Previous quantitative trait loci (QTL) mapping studies from our laboratory identified a 6.6 Mb segment of distal chromosome 1 that contains a gene (or genes) having a strong influence on the difference in seizure susceptibility between C57BL/6 (B6) and DBA/2 (D2) mice. A gene transfer strategy involving a bacte...

journal_title：Epilepsia

authors： Ferraro TN,Golden GT,Dahl JP,Smith GG,Schwebel CL,MacDonald R,Lohoff FW,Berrettini WH,Buono RJ

更新日期：2007-09-01 00:00:00

abstract：:The success of surgery for seizure focus resection depends on postoperative reduction or disappearance in number of seizures, improvement in psychosocial functioning, and low morbidity and mortality. Permanent neurologic sequelae are most often not discussed in this context. Deficits more than a superior quadrantanops...

journal_title：Epilepsia

authors： Helgason CM,Bergen D,Bleck TP,Morrell F,Whisler W

更新日期：1987-07-01 00:00:00

abstract：:The blood-brain barrier, a unique feature of the cerebral vasculature, is gaining attention as a feature in common neurologic disorders including stroke, traumatic brain injury, epilepsy, and schizophrenia. Although acute blood-brain barrier dysfunction can induce cerebral edema, seizures, or neuropsychiatric symptoms...

journal_title：Epilepsia

authors： Schoknecht K,Shalev H

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic in...

journal_title：Epilepsia

authors： Ung H,Davis KA,Wulsin D,Wagenaar J,Fox E,McDonnell JJ,Patterson N,Vite CH,Worrell G,Litt B

更新日期：2016-12-01 00:00:00

abstract：:Leucoencephalopathy with vanishing white matter (VWM) is caused by mutations in the genes encoding for one of the five subunits that constitute the eukaryotic initiation factor 2B (eIF2B), and is characterized by a highly suggestive MRI pattern indicating vanishing of the cerebral white matter. Seizures are well known...

journal_title：Epilepsia

authors： Jansen AC,Andermann E,Niel F,Creveaux I,Boespflug-Tanguy O,Andermann F

更新日期：2008-05-01 00:00:00

abstract：:Our study investigated public attitudes toward epilepsy, and knowledge and understanding of epilepsy in Hungary. We compared changes of public attitudes in the last six years, hypothesizing a trend of positive changes because of recent national initiatives for acceptance and integration of people with epilepsy (e.g., ...

journal_title：Epilepsia

authors： Mirnics Z,Czikora G,Závecz T,Halász P

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Higher homocysteine levels were found in actively drinking patients with alcohol dependence. Recent studies have shown that high homocysteine levels are associated with alcohol-withdrawal seizures. The aim of the present study was to calculate the best predictive cutoff value of plasma homocysteine levels in ac...

journal_title：Epilepsia

authors： Bleich S,Bayerlein K,Hillemacher T,Degner D,Kornhuber J,Frieling H

更新日期：2006-05-01 00:00:00

abstract：:The elderly are the most rapidly growing segment of the population and the incidence of epilepsy is higher in the elderly than in any other age group. They have been subdivided into the "young old," 65-74 years, "middle old" 75-84 years, and the "old old," 85 years or older. But further subdivisions are needed: person...

journal_title：Epilepsia

authors： Leppik IE

更新日期：2006-01-01 00:00:00